scholarly journals The Clinical and Theranostic Values of Activated Leukocyte Cell Adhesion Molecule (ALCAM)/CD166 in Human Solid Cancers

Cancers ◽  
2021 ◽  
Vol 13 (20) ◽  
pp. 5187
Author(s):  
Yiming Yang ◽  
Andrew J. Sanders ◽  
Q. Ping Dou ◽  
David G. Jiang ◽  
Amber Xinyu Li ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Cell Types ◽  
Potential Therapeutic Target ◽  
Adhesion Protein ◽  
Pathological Conditions ◽  
A Cell ◽  
Multiple Cell ◽  
Primary Focus

Activated leukocyte cell adhesion molecule (ALCAM), also known as CD166, is a cell adhesion protein that is found in multiple cell types. ALCAM has multiple and diverse roles in various physiological and pathological conditions, including inflammation and cancer. There has been compelling evidence of ALCAM’s prognostic value in solid cancers, indicating that it is a potential therapeutic target. The present article overviews the recent findings and progress in ALCAM and its involvement in cancer, with a primary focus on its clinical connections in cancer and therapeutic values.

Function and Histopathology of a Cell Adhesion Molecule TSLC1 in Cancer

2011 ◽  
Vol 29 (2) ◽  
pp. 107-112 ◽  
Author(s):  
Qi-Lian Liang ◽  
Guo-Qiang Chen ◽  
Zhou-Yu Li ◽  
Bi-Rong Wang
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
A Cell

Design of a Calcium-Binding Protein with Desired Structure in a Cell Adhesion Molecule

2005 ◽  
Vol 127 (7) ◽  
pp. 2085-2093 ◽  
Author(s):  
Wei Yang ◽  
Anna L. Wilkins ◽  
Yiming Ye ◽  
Zhi-ren Liu ◽  
Shun-yi Li ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Calcium Binding ◽  
Cell Adhesion Molecule ◽  
Binding Protein ◽  
Calcium Binding Protein ◽  
A Cell

scholarly journals Potential role of SC1, a cell adhesion molecule, in mammary gland tumors

2008 ◽  
Author(s):  
Kenji Hagimori ◽  
Hidenori Kato ◽  
Keiko Fukuda ◽  
Masaharu Kikuta ◽  
Yasuhiro Tsukamoto ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Mammary Gland ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Potential Role ◽  
Mammary Gland Tumors ◽  
A Cell

scholarly journals EpCAM as Modulator of Tissue Plasticity

Cells ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 2128
Author(s):  
François Fagotto
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Cancer Prognosis ◽  
Potential Significance ◽  
Cell Adhesion And Migration ◽  
A Cell ◽  
Embryonic Morphogenesis ◽  
And Migration ◽  
Signalling Cascade

The Epithelial Cell Adhesion Molecule or EpCAM is a well-known marker highly expressed in carcinomas and showing a strong correlation with poor cancer prognosis. While its name relates to its proposed function as a cell adhesion molecule, EpCAM has been shown to have various signalling functions. In particular, it has been identified as an important positive regulator of cell adhesion and migration, playing an essential role in embryonic morphogenesis as well as intestinal homeostasis. This activity is not due to its putative adhesive function, but rather to its ability to repress myosin contractility by impinging on a PKC signalling cascade. This mechanism confers EpCAM the unique property of favouring tissue plasticity. I review here the currently available data, comment on possible connections with other properties of EpCAM, and discuss the potential significance in the context of cancer invasion.

Computational Analysis of Isoform-Specific Signal Regulation by CEACAM1-A Cell Adhesion Molecule Expressed in PC12 Cells

2002 ◽  
Vol 971 (1) ◽  
pp. 597-607 ◽  
Author(s):  
BJÖRN ÖBRINK ◽  
HIROKI SAWA ◽  
INKA SCHEFFRAHN ◽  
BERNHARD B. SINGER ◽  
KRISTMUNDUR SIGMUNDSSON ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Pc12 Cells ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Computational Analysis ◽  
Specific Signal ◽  
A Cell ◽  
Signal Regulation

scholarly journals Periostin, a Cell Adhesion Molecule, Facilitates Invasion in the Tumor Microenvironment and Annotates a Novel Tumor-Invasive Signature in Esophageal Cancer

2010 ◽  
Vol 70 (13) ◽  
pp. 5281-5292 ◽  
Author(s):  
Carmen Z. Michaylira ◽  
Gabrielle S. Wong ◽  
Charles G. Miller ◽  
Christie M. Gutierrez ◽  
Hiroshi Nakagawa ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Cell Adhesion ◽  
Tumor Microenvironment ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
A Cell
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