Environmentally Friendly Nafion-Catalyzed Synthesis of Substituted 2-Ethyl-3-Methylquinolines from Aniline and Propionaldehyde under Microwave Irradiation
Keyword(s):
X Ray
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Herein, we report a facile synthetic methodology for the preparation of 2,3-dialkylquinolines from anilines and propionaldehydes. This cyclization involved environmentally friendly Nafion® NR50 as an acidic catalyst with microwave irradiation as the heating source. A series of substituted 2-ethyl-3-methylquinolines were prepared from various anilines and propionaldehyde derivatives through this protocol with good to excellent yields. Some new chemical structures were confirmed by X-ray single-crystal diffraction analysis and the related data were provided. The plausible reaction mechanism studies are also discussed.
2011 ◽
Vol 233-235
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pp. 264-268
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2001 ◽
Vol 216
(8)
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Keyword(s):
2013 ◽
Vol 454
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pp. 272-275
2012 ◽
Vol 424-425
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pp. 23-26
2014 ◽
Vol 18
(08n09)
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pp. 721-726