scholarly journals Driver Genetic Mutations in Spinal Cord Gliomas Direct the Degree of Functional Impairment in Tumor-Associated Spinal Cord Injury

Cells ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 2525
Author(s):  
Yoshitaka Nagashima ◽  
Yusuke Nishimura ◽  
Fumiharu Ohka ◽  
Kaoru Eguchi ◽  
Kosuke Aoki ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Functional Impairment ◽  
The Body ◽  
World Health ◽  
Genetic Mutations ◽  
Idh Mutations ◽  
Cord Injury ◽  
Grade Ii ◽  
Grade Iii

Genetic analysis in glioma has been developed recently. Spinal cord glioma is less common than intracranial glioma. Thus, the clinical significance of genetic mutations in spinal cord gliomas remains unclear. Furthermore, because the spinal cord is an important communication channel between the brain and the rest of the body, increased attention should be paid to its functional prognosis. In this study, we investigated the functional prognosis and driver genetic mutations in eight patients with spinal cord gliomas (World Health Organization grade I, three cases; grade II, two cases; grade III/IV, three cases). IDH mutations were detected in all grade II cases and H3F3A mutations were detected in all grade III/IV cases. The functional status of grade I and II gliomas remained unchanged or improved 1 year after surgery, whereas grade III/IV gliomas remained unchanged or deteriorated. Spinal glioma progenitor cells with H3F3A mutations were associated with accelerated tumor-associated spinal cord injury, which led to functional impairment. Conversely, the presence of IDH mutations, which are rarely reported in spinal gliomas, indicated a relatively favorable functional prognosis.

OPEN HAEMORRHOIDS SURGERY IN SPINAL CORD INJURY PATIENTS

2020 ◽  
Vol 4 (11) ◽  
Author(s):  
Khaled Hassan
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Anal Fissure ◽  
Open Surgery ◽  
Anal Fissures ◽  
Cord Injury ◽  
Long Term Follow Up ◽  
Grade Iii

This Pilot retrospective research conducted on the results of open surgery in patients with Grade III and IV haemorrhoids With SCI. No major complications had arisen at 6 weeks post-operative and all wounds had healed, but 1 patient Anal fissure recurrence. 75% of patients reported a substantial increase in anorectal anorexia during long-term follow-up. With symptoms. Five patients reported recurrences: three haemorrhoids (18 percent) and two anal fissures (25 percent).   Keywords: Haemorrhoids, Pilot retrospective research, Anorectal Anorexia.

scholarly journals Walking with Neuropathic Pain: Paradoxical Shift from Burden to Support?

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
David J. Kopsky ◽  
Jan M. Keppel Hesselink ◽  
Roberto Casale
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neuropathic Pain ◽  
Unusual Case ◽  
Body Schema ◽  
The Body ◽  
Sensory Loss ◽  
Pain Patient ◽  
Rehabilitation Programs ◽  
Cord Injury

Baclofen 5% cream can be used for the treatment of neuropathic pain. We describe an unusual case of a neuropathic pain patient with spinal cord injury. A 71-year-old woman with a partial spinal cord injury lesion at L4 complained of tingling, pins and needles, and burning in her legs. She scored her pain as 6 before adding baclofen 5% cream to her pain medication (pregabalin 450 mg, acetaminophen 3000 mg, and diclofenac 150 mg daily). One month later she experienced complete pain relief, though experienced increased difficulties in walking, leading to frequent falls. Her steadier walking without stumbling and falling was more important to her than pain reduction. Thus she decided to stop using baclofen. This unusual case report discusses two important issues that relate to pain medicine and rehabilitation in patients with painful spinal cord lesions: (1) the presence of wide areas of sensory loss “covered” by the presence of painful sensations and (2) pathological sensations that can be used and integrated in the body schema to create an improved spatiovisual orientation and thus mobility. Both these aspects have to be taken into account when treating pain and design rehabilitation programs.

scholarly journals Validation of the World Health Organization Disability Assessment Schedule 2.0 in adults with spinal cord injury in Taiwan: a psychometric study

Spinal Cord ◽  
2019 ◽  
Vol 57 (6) ◽  
pp. 516-524 ◽  
Author(s):  
Tzu-Ying Chiu ◽  
Monika E. Finger ◽  
Carolina S. Fellinghauer ◽  
Reuben Escorpizo ◽  
Wen-Chou Chi ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
World Health Organization ◽  
World Health ◽  
Disability Assessment ◽  
Psychometric Study ◽  
Cord Injury ◽  
The World ◽  
Health Organization

Structural circumstances in the main types of fatal concomitant injury in children

2014 ◽  
Vol 5 (3) ◽  
pp. 58-63 ◽  
Author(s):  
Vladimir Mikhaylovich Karavayev
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Head Injury ◽  
The Body ◽  
Structure Damage ◽  
Forensic Research ◽  
Concomitant Injury ◽  
Cord Injury ◽  
Aggregate Amount

On the material of forensic research 284 corpses of children (108 own observations, 176 archive acts), died as a result of falling from height, hitting a moving car, drive to the wheels and the injury in a car, a study of the structure damage. Investigated the frequency and distribution of damage to the skin, skeletal and organ separate areas of the body, carried out the combined assessment of the extent of the damage when the considered variants of the circumstances of the injury. It is established that the children injured in the car to head injury in various manifestations, found in 100 % of cases. Damage to other areas of the body are less frequent than when hit by a car, moving its wheels and when falling from a height. In this regard, the aggregate amount of damages in case of injury in a car in children was less than for other types of trauma. The distribution of damage between the areas marked in cases of moving the wheels of the car; on trauma to the head, chest and limbs accounted for the same proportion of the damage. Under the circumstances spine-spinal cord injury, damage, neck, abdomen and pelvis met more frequently than other considered variants of injury. In cases of moving the wheels of the car and marked the largest amount of damage that significantly exceeds (рφ < 0,001) indicators when falling from a height, the shock of your vehicle and injury in his cabin.

Diagnostic accuracy of evoked potentials for functional impairment after contusive spinal cord injury in adult rats

2016 ◽  
Vol 25 ◽  
pp. 122-126 ◽  
Author(s):  
Parthasarathy Thirumala ◽  
James Zhou ◽  
Rohan Krishnan ◽  
Nihita Manem ◽  
Shreya Umredkar ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Diagnostic Accuracy ◽  
Evoked Potentials ◽  
Functional Impairment ◽  
Adult Rats ◽  
Cord Injury ◽  
Contusive Spinal Cord Injury

scholarly journals In vivo and in vitro models of traumatic injuries of the spinal cord

2017 ◽  
Vol 5 (1) ◽  
pp. 87-93
Author(s):  
O. Rybachuk ◽  
I. Arkhypchuk ◽  
Yu. Lazarenko
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Traffic Accidents ◽  
Experimental Models ◽  
The Body ◽  
Nerve Tissue ◽  
Economic Losses ◽  
Cord Injury

In recent years, there is a growing interest in the mechanisms of regeneration of damaged nerve tissue, including the spinal cord, as its injuries are quite common due to traffic accidents, industrial injuries and military actions. Damage to the spinal cord results in the loss of functional activity of the body below the injury site, which affects person’s ability to self-service and significantly reduces its efficiency. The effects of spinal injuries annually cause significant social and economic losses worldwide, including Ukraine. The development of new treatments for pathologies of the central nervous system requires mandatory pre-testing of their effectiveness in experiments in vitro and in vivo. Therefore, searching and creation of optimal animal model of spinal cord injury is in order to it meets most complete picture of the damage characteristic of real conditions in humans. This is an important task of modern neurophysiology. Such models can be used, primarily, for a more detailed clarification of the pathogenesis of all levels of nerve tissue damage and research of its own recovery potential by endogenous reparation mechanisms. In addition, experimental models allow to estimate the safety and predict the effectiveness of various therapeutic approaches to spinal cord injury.

scholarly journals Development and Evaluation of the Korean Version of Hospital-Based Transitional Rehabilitation Program Using Daily Living Home for Spinal Cord Injury

2021 ◽  
Vol 45 (5) ◽  
pp. 379-392
Author(s):  
Chang-Won Moon ◽  
Il-Young Jung ◽  
Ju Young Kim ◽  
Ha Neul Jang ◽  
Kang Hee Cho
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Daily Living ◽  
Significant Degree ◽  
Rehabilitation Program ◽  
World Health ◽  
Functional Improvement ◽  
The Core ◽  
Korean Version ◽  
Cord Injury

Objective To develop and evaluate the Korean version of a hospital-based transitional rehabilitation program (TRP), using daily living home for spinal cord injury (SCI) patients.Methods In this study, we developed the Korean version of a hospital-based TRP through domestic and overseas surveys and focus group meetings. By applying this to chronic SCI patients, we observed the functional and quality of life (QOL) changes and evaluated the degree of achievement of the core goals set for each patient during hospital-based TRP.Results Hospital-based TRP, for 21.8±3.9 days on average, was applied to four chronic SCI patients (two patients with long-term hospital stays and two homebound disabled individuals) with an average injury period of 736.8±185.4 days. The Korean version of the Spinal Cord Independence Measure (49.3±6.9 vs. 62.5±6.0; p<0.05) showed functional improvement at the end of TRP, when compared to that before the TRP. The Korean version of the World Health Organization’s QOL scale, abbreviated version (159.8±36.6 vs. 239.8±36.1; p<0.05), showed improvement in QOL. Goal attainment scaling showed a significant degree of achievement for the core goals through TRP (33.6±4.4 vs. 70.0±2.8; p<0.05). These results confirmed that the effect was maintained 1 month after the end of TRP. Additionally, two patients were successfully discharged after TRP completion, and the other two could start social activities.Conclusion The Korean version of the hospital-based TRP, applied to chronic SCI patients, showed the potential to improve the patients’ functioning and QOL and appeared to be effective in successful discharge and social participation.

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