scholarly journals Genetic Association between Swine Leukocyte Antigen Class II Haplotypes and Reproduction Traits in Microminipigs

Cells ◽  
2019 ◽  
Vol 8 (8) ◽  
pp. 783 ◽  
Author(s):  
Ando ◽  
Imaeda ◽  
Matsubara ◽  
Takasu ◽  
Miyamoto ◽  
...  
Keyword(s):  
Litter Size ◽  
Reproductive Traits ◽  
Class Ii ◽  
Swine Leukocyte Antigen ◽  
Low Resolution ◽  
Typing Method ◽  
Leukocyte Antigen ◽  
Fertility Index ◽  
Reproduction Traits ◽  
Small Litter Size

The effects of swine leukocyte antigen (SLA) molecules on numerous production and reproduction performance traits have been mainly reported as associations with specific SLA haplotypes that were assigned using serological typing methods. In this study, we intended to clarify the association between SLA class II genes and reproductive traits in a highly inbred population of 187 Microminipigs (MMP), that have eight different types of SLA class II haplotypes. In doing so, we compared the reproductive performances, such as fertility index, gestation period, litter size, and number of stillbirth among SLA class II low resolution haplotypes (Lrs) that were assigned by a polymerase chain reaction-sequence specific primers (PCR-SSP) typing method. Only low resolution haplotypes were used in this study because the eight SLA class II high-resolution haplotypes had been assigned to the 14 parents or the progenitors of the highly inbred MMP herd in a previous publication. The fertility index of dams with Lr-0.13 was significantly lower than that of dams with Lr-0.16, Lr-0.17, Lr-0.18, or Lr-0.37. Dams with Lr-0.23 had significantly smaller litter size at birth than those with Lr-0.17, Lr-0.18, or Lr-0.37. Furthermore, litter size at weaning of dams with Lr-0.23 was also significantly smaller than those dams with Lr-0.16, Lr-0.17, Lr-0.18, or Lr-0.37. The small litter size of dams with Lr-0.23 correlated with the smaller body sizes of these MMPs. These results suggest that SLA class II haplotypes are useful differential genetic markers for further haplotypic and epistatic studies of reproductive traits, selective breeding programs, and improvements in the production and reproduction performances of MMPs.

scholarly journals Associations between polymorphism of the steroid 21-hydroxylase gene (<i>CYP21</i>) and litter size of Polish Large White × Polish Landrace sows* (short communication)

2006 ◽  
Vol 49 (2) ◽  
pp. 158-164
Author(s):  
J. Ziemak ◽  
W. Grzesiak
Keyword(s):  
Litter Size ◽  
Short Communication ◽  
Reproductive Traits ◽  
Swine Industry ◽  
Large White ◽  
Leukocyte Antigen ◽  
Cyp21 Gene ◽  
Hydroxylase Gene ◽  
Pcr Rflp ◽  
Reproduction Traits

Abstract. research because of the large economic impact these discoveries could have on the swine industry. The steroid 21-hydroxylase (CYP21) gene is located on chromosome 7 in the middle of the swine leukocyte antigen class (SLA) is regarded as a "candidate – gene" reproduction traits. Associations between polymorphism of the steroid 21-hydroxylase gene (CYP21) and litter size of Polish Large White × Polish Landrace sows were analysed. The 21-hydroxylase genotypes of all 286 animals were determined using a PCR-RFLP procedure. The frequencies of genotypes and alleles of CYP21/NciI and CYP21/HaeIII were follows: 0.077 – AA, 0.308 – AB, 0.615 – BB and 0.231 for CYP21/NciIA, 0.769 for CYP21/NciIB; 0.010 – AA, 0.420 – AB, 0.570 – BB and 0.221 for CYP21/HaeIIIA and 0.779 for CYP21/HaeIIIB. The CYP21/NciI genotype was significantly associated with the total number of piglets born, born alive and alive at weaning in the 5th – 10th parities. The sows with BB genotype had significantly (P≤0.01) higher level of traits than the animals with AB genotype. Analysis of reproductive traits in dependence on CYP21/NciI genotypes showed the statistically significant differences (P≤0.05) in number of piglets died before the day of weaned in 2-4 parities. The lowest value of this trait was found for the sows with the AB genotype (2.05%), while the highest – for the pigs with BB genotype (3.54%). Associations between CYP21/HaeIII and reproduction traits were not observed.

scholarly journals Swine leukocyte antigen class II genes (SLA-DRA, SLA-DRB1, SLA-DQA, SLA-DQB1) polymorphism and genotyping in Guizhou minipigs

2015 ◽  
Vol 14 (4) ◽  
pp. 15256-15266 ◽  
Author(s):  
Z.Z. Liu ◽  
J.H. Xia ◽  
L.L. Xin ◽  
Z.G. Wang ◽  
L. Qian ◽  
...  
Keyword(s):  
Class Ii ◽  
Swine Leukocyte Antigen ◽  
Leukocyte Antigen

scholarly journals Examining the Biosynthesis and Xenoantigenicity of Class II Swine Leukocyte Antigen Proteins

2018 ◽  
Vol 200 (8) ◽  
pp. 2957-2964 ◽  
Author(s):  
Joseph M. Ladowski ◽  
Gregory R. Martens ◽  
Luz M. Reyes ◽  
Zheng-Yu Wang ◽  
Devin E. Eckhoff ◽  
...  
Keyword(s):  
Class Ii ◽  
Swine Leukocyte Antigen ◽  
Leukocyte Antigen

scholarly journals Porcine prolactin receptor genotypes and production and reproduction traits in Hungarian Large White and Landrace sows (Brief Report)

2010 ◽  
Vol 53 (4) ◽  
pp. 497-499
Author(s):  
K. Kovacs ◽  
L. Fesus ◽  
A. Zsolnai ◽  
A. Nyiri ◽  
I. Anton
Keyword(s):  
Litter Size ◽  
Receptor Gene ◽  
Mammalian Species ◽  
Prolactin Receptor ◽  
Reproductive Traits ◽  
Pituitary Hormone ◽  
Chromosome 16 ◽  
Large White ◽  
Anterior Pituitary Hormone ◽  
Reproduction Traits

Abstract. Prolactin is an anterior pituitary hormone involved in many endocrine activities and plays and essential role in reproduction. Its receptor (PRLR) was detected in various tissues including brain, ovary, placenta, an uterus in several mammalian species (BOLE-FEYSOT et al. 1998). Reproductive performance of sows is a crutial point in pig production with significant economic importance and may be estimated with the help of markers. Porcine prolactin receptor gene is said to be a candidate genetic marker for reproductive traits. It has been mapped to porcine chromosome 16 (Vincent et al. 1997). There is a C/G SNP in PRLR gene (KMIEC et al. 2001) at the position of 203 (GAN: U96306) which eliminates an AluI cleavage site. The effect of this polymorphism on litter size in various breeds has been estimated (VINCENT et al. 1998, ROTHSCHILD et al. 1998, VAN RENS et al. 2002, KMIEC and TERMAN, 2004, DRÖGEMÜLLER et al. 2001, KORWIN-KOSSAKOWSKA et al. 2003). The influence of the bovine hormone variant was also estimated (RATNA-KUMARI et al. 2008). The aim of the study was to estimate PRLR AluI polymorphism effects on litter size in Hungarian Large White (HLW) and Hungarian Landrace (HL) breeds.

Reproductive performance and genetic parameters for Australian Dorset Sheep

1994 ◽  
Vol 45 (2) ◽  
pp. 427 ◽  
Author(s):  
LD Brash ◽  
NM Fogarty ◽  
AR Gilmour
Keyword(s):  
Litter Size ◽  
Reproductive Performance ◽  
Genetic Improvement ◽  
Genetic Correlations ◽  
Reproductive Traits ◽  
Reproductive Rate ◽  
Parameter Estimates ◽  
Reproduction Traits ◽  
Component Traits ◽  
Lamb Survival

Reproductive performance of ewes in a large Dorset stud flock is reported. The data included 2488 ewes with 10016 joining records over 25 years. Average performance for reproductive traits were: fertility 92%, litter size 1.31, neonatal lamb survival 91%, lamb survival to weaning 85%, with overall lambs born 1.20 and lambs weaned 1.02 per ewe joined. Differences between breeds (Poll Dorset and Dorset Horn), season of birth (spring and autumn) and season of joining (spring and autumn) were significant for most reproduction traits. Linear and quadratic regressions for age of ewe at joining were highly significant for all traits (P < 0.001) with maximum performance between three and six years of age. Estimates of heritability for ewe reproductive traits were: 0.062 � 0-02 for number of lambs born and 0.04 � 0.01 for number of lambs weaned per ewe joined, and component traits, 0.02 �0 -01 for fertility, 0 08 � 0 -02 for litter size and 0.00 � 0.01 for lamb survival. Estimates of repeatability were less than 0.14 for all the reproduction traits, which resulted in substantially higher predicted heritabilities when repeated records were used. Heritability estimates for average ewe lifetime performance, with approximately four records, were 0.08 � 0 06 for lambs born, 0.12 � 0.05 for lambs weaned, 0.08 � 0.04 for fertility, 0.l9 � 0 -04 for litter size and zero for lamb survival. The genetic correlations between litter size and lambs born and weaned were close to unity, whereas those for fertility were lower and declined from lambs born (0.6l � 0.22) to lambs weaned (0-45 � 0.30). The estimated heritability for ewe longevity, defined as the number of years the ewe remained in the breeding flock, was 0.00 � 0.03. The potential for genetic improvement in reproductive rate is discussed in relation to other reports in the literature and in the context of the roles of the Dorset breed in the Australian lamb industry. Increased reproductive rate in Dorset flocks impacts on stud profitability and the rate of genetic improvement from selection for other traits such as liveweight. The parameter estimates derived will be used in compiling breed-specific parameter sets for genetic evaluation in LAMBPLAN.

Genetic variability in swine leukocyte antigen class II and Toll-like receptors affects immune responses to vaccination for bacterial infections in pigs

2012 ◽  
Vol 35 (6) ◽  
pp. 523-532 ◽  
Author(s):  
H. Shinkai ◽  
A. Arakawa ◽  
M. Tanaka-Matsuda ◽  
H. Ide-Okumura ◽  
K. Terada ◽  
...  
Keyword(s):  
Genetic Variability ◽  
Immune Responses ◽  
Bacterial Infections ◽  
Class Ii ◽  
Swine Leukocyte Antigen ◽  
Toll Like Receptors ◽  
Leukocyte Antigen

Comprehensive and high-resolution typing of swine leukocyte antigen DQA from genomic DNA and determination of 25 new SLA class II haplotypes

2012 ◽  
Vol 80 (6) ◽  
pp. 528-535 ◽  
Author(s):  
M. T. Le ◽  
H. Choi ◽  
M.-K. Choi ◽  
D. T. Nguyen ◽  
J.-H. Kim ◽  
...  
Keyword(s):  
High Resolution ◽  
Genomic Dna ◽  
Class Ii ◽  
Swine Leukocyte Antigen ◽  
Leukocyte Antigen

Variation in reproduction and production of Poll Dorset ewes

1994 ◽  
Vol 45 (2) ◽  
pp. 415 ◽  
Author(s):  
DG Hall ◽  
AR Gilmour ◽  
NM Fogarty
Keyword(s):  
Litter Size ◽  
Environmental Effects ◽  
Reproductive Performance ◽  
Reproductive Traits ◽  
Late Summer ◽  
Reproductive History ◽  
Reproduction Traits ◽  
Lamb Survival ◽  
Fleece Weight ◽  
One Year

Poll Dorset ewes were joined to Booroola Merino (n = 22) or Trangie Fertility Merino (n = 26) rams in single sire joinings during late summer/autumn of 1978, 1979, 1980 and 1981. Rams were changed each year and there were 1678 individual ewe joinings. A maximum of 527 ewes were used in any one year, and they represented 14 studs and varied in age, reproductive history and liveweight. The traits, litter size, maternal lamb survival, lambs weaned per ewe lambing and weight of lamb weaned per ewe lambing (kg at 100 days) were analysed for the effect of year, stud, age, lambs born and ewe liveweight. Litter size averaged 1-37, maternal lamb survival 0.70, and number of lambs weaned per ewe was 0.94. There were large variations in the reproductive traits due to year and stud and lesser effects due to age. Each extra kilogram of ewe liveweight at joining increased litter size by 0.012 and weight of lamb weaned by 0.39 kg, but had no significant effect on maternal lamb survival or number of lambs weaned. Multiple-bearing ewes weaned 0.72 more lambs and 16 - 2 kg more lamb weight than single-bearing ewes. Lamb survival was similar for singleand multiple-bearing ewes. Greasy fleece weight averaged 2.2 kg ewe-' and single bearing ewes produced 0.19 kg/ewe more than multiple-bearing ewes. Dystocia caused 53% and starvation/mismothering/exposure caused 23% of lamb deaths; the proportion of deaths due to starvation/mismothering/exposure increased with increasing ewe joining liveweight. The large variation between studs in reproductive performance partly reflected genetic differences between Poll Dorset flocks which could be exploited. Estimates of heritabilities ranged from 0.06 to 0.14 � 0.10 for the reproductive traits and were 0.10 � 0.12 for ewe liveweight and 0.16 � 0.20 for greasy fleece weight. However much of the between stud variation may also have arisen from early environmental effects. Estimates of repeatability ranged from 0.06 to 0.l5 � 0 05 for reproduction traits and were 0.44 � 0.06 for ewe liveweight at joining and 0.56 � 0.08 for greasy fleece weight.

scholarly journals Breeding value evaluation in Polish fur animals: Estimates of (co)variances due to direct and litter effects for fur coat and reproduction traits

2011 ◽  
Vol 51 (No. 1) ◽  
pp. 39-46 ◽  
Author(s):  
H. Wierzbicki ◽  
W. Jagusiak
Keyword(s):  
Litter Size ◽  
Genetic Correlations ◽  
Reproductive Traits ◽  
Original Data ◽  
Breeding Value ◽  
The Arctic ◽  
Data Set ◽  
Value Evaluation ◽  
Reproduction Traits ◽  
Fur Animals

5 540 records of the arctic fox fur coat and reproductive traits collected in 1983&ndash;1999 were studied. The analyzed traits were: body size (BS), colour type (CT), colour purity (CP), coat density (CD), hair length (HL), general appearance (GA), total score (TS), skin length (SL), litter size at birth (LSB), litter size at weaning (LSW), number of dead pups (NPD), pup weight at weaning (PW), and pregnancy length (PL). (Co)variance components were estimated using a derivative-free algorithm of REML and a multi-trait animal model. Random effects were direct additive, common litter environment and residual. The genetic parameters for the fur coat traits (discrete characters) were estimated twice: using the original data set, and the data set in which the distribution of fur coat scores was normalised using a probit link function. Direct heritability estimates obtained from the original data set ranged from 0.108 for SL to 0.276 for HL, and were somewhat lower than those estimated using the transformed data set (they ranged from 0.109 for GA to 0.315 for CT). Reproductive traits were lowly heritable with direct heritabilities ranging from 0.060 for PW to 0.174 for LSB. Estimates of the portion of litter variation calculated from the original and transformed data set were comparable ranging from 0.045 for GA to 0.156 for CP, and from 0.059 for GA to 0.185 for TS, respectively. Genetic correlations between fur coat traits ranged from high favourable (0.948 between SL and BS, original data) to strong negative ones between CP and GA (&ndash;0.405, transformed data). High positive genetic correlations were found between LSB and LSW (0.954), and between LSB and NPD (0.783), whereas PL was negatively correlated with all other reproductive traits. &nbsp;

Association of swine leukocyte antigen class II haplotypes and immune-related traits in a swine line selected for resistance to mycoplasmal pneumonia

2016 ◽  
Vol 48 ◽  
pp. 33-40 ◽  
Author(s):  
Asako Ando ◽  
Atsuko Shigenari ◽  
Chihiro Kojima-Shibata ◽  
Mitsuru Nakajoh ◽  
Keiichi Suzuki ◽  
...  
Keyword(s):  
Class Ii ◽  
Swine Leukocyte Antigen ◽  
Leukocyte Antigen ◽  
Mycoplasmal Pneumonia
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