Neurohormonal Modulation as a Therapeutic Target in Pulmonary Hypertension

The autonomic nervous system (ANS) and renin-angiotensin-aldosterone system (RAAS) are involved in many cardiovascular disorders, including pulmonary hypertension (PH). The current review focuses on the role of the ANS and RAAS activation in PH and updated evidence of potential therapies targeting both systems in this condition, particularly in Groups 1 and 2. State of the art knowledge in preclinical and clinical use of pharmacologic drugs (beta-blockers, beta-three adrenoceptor agonists, or renin-angiotensin-aldosterone signaling drugs) and invasive procedures, such as pulmonary artery denervation, is provided.

Download Full-text

Balloon Pulmonary Angioplasty: State of the Art

Interventional Cardiology Review ◽

10.15420/icr.2020.14 ◽

2021 ◽

Vol 16 ◽

Author(s):

John G Coghlan ◽

Alexander MK Rothman ◽

Stephen P Hoole

Keyword(s):

Pulmonary Hypertension ◽

State Of The Art ◽

Chronic Thromboembolic Pulmonary Hypertension ◽

Evidence Base ◽

Novel Technique ◽

Standard Management ◽

Balloon Pulmonary Angioplasty ◽

Thromboembolic Pulmonary Hypertension ◽

Chronic Thromboembolic Disease

Balloon pulmonary angioplasty (BPA) is a novel technique for the treatment of chronic thromboembolic pulmonary hypertension. While cardiologists need no introduction to the concept of balloon angioplasty, BPA has its own particular challenges. This article aims to provide the reader with an overview of BPA, starting with an introduction to chronic thromboembolic disease (CTED), the standard management of chronic thromboembolic pulmonary hypertension (CTEPH), technical challenges faced when performing BPA and the evidence base supporting its use. The second part of the article will focus on the future of BPA, in particular the areas where research is required to establish an evidence base to justify the role of BPA in CTEPH and CTED treatment.

Download Full-text

Preventive role of beta blockers and renin-angiotensin inhibitors in anthracycline-induced cardiotoxicity among adult cancer patients: A meta-analysis

Annals of Oncology ◽

10.1093/annonc/mdy444.018 ◽

2018 ◽

Vol 29 ◽

pp. ix134

Author(s):

D.B.L. Sacdalan ◽

M.D. Tiongson ◽

K.A. Mondragon ◽

L. Abrahan ◽

J. Añonuevo ◽

...

Keyword(s):

Cancer Patients ◽

Beta Blockers ◽

Meta Analysis ◽

Renin Angiotensin ◽

Preventive Role

Download Full-text

Role of excretion in manganese homeostasis and neurotoxicity: A historical perspective

AJP Gastrointestinal and Liver Physiology ◽

10.1152/ajpgi.00299.2021 ◽

2021 ◽

Author(s):

Kerem Cahit Gurol ◽

Michael Aschner ◽

Donald R Smith ◽

Somshuvra Mukhopadhyay

Keyword(s):

Liver Cirrhosis ◽

Executive Function ◽

Recent Work ◽

Historical Perspective ◽

State Of The Art ◽

Critical Role ◽

Fine Motor ◽

Essential Metal ◽

Current Review

The essential metal manganese (Mn) induces incurable neurotoxicity at elevated levels that manifests as parkinsonism in adults and fine motor and executive function deficits in children. Studies on Mn neurotoxicity have largely focused on the role and mechanisms of disease induced by elevated Mn exposure from occupational or environmental sources. In contrast, the critical role of excretion in regulating Mn homeostasis and neurotoxicity has received less attention although (1) studies on Mn excretion date back to 1920s; (2) elegant radiotracer Mn excretion assays in the 1940s-60s established the routes of Mn excretion; and; (3) studies in patients with liver cirrhosis in the 1990s-2000s identified an association between decreased Mn excretion and the risk of developing Mn-induced parkinsonism in the absence of elevated Mn exposure. Notably, the last few years have seen renewed interest in Mn excretion largely driven by the discovery that hereditary Mn neurotoxicity due to mutations in SLC30A10 or SLC39A14 are caused, at least in part, by deficits in Mn excretion. Quite remarkably, some of the recent results on SLC30A10 and SLC39A14 provide explanations for observations made ~40-50 years ago. The goal of the current review is to integrate the historic studies on Mn excretion with more contemporary recent work, and provide a comprehensive state-of-the-art overview of Mn excretion and its role in regulating Mn homeostasis and neurotoxicity. A related goal is to discuss the significance of some of the foundational studies on Mn excretion so that these highly consequential earlier studies remain influential in the field.

Download Full-text

P1579Preventive role of beta blockers and renin-angiotensin inhibitors in anthracycline-induced cardiotoxicity among adult cancer patients: a meta-analysis

European Heart Journal ◽

10.1093/eurheartj/ehy565.p1579 ◽

2018 ◽

Vol 39 (suppl_1) ◽

Author(s):

M D A Tiongson ◽

D B L Sacdalan ◽

K A M Mondragon ◽

L L I V Abrahan ◽

J C Anonuevo

Keyword(s):

Cancer Patients ◽

Beta Blockers ◽

Meta Analysis ◽

Renin Angiotensin

Download Full-text

Mechanisms underlying pressure-related natriuresis: the role of the renin-angiotensin and prostaglandin systems. State of the art lecture.

Hypertension ◽

10.1161/01.hyp.11.6.724 ◽

1988 ◽

Vol 11 (6_pt_2) ◽

pp. 724-738 ◽

Cited By ~ 100

Author(s):

J C Romero ◽

F G Knox

Keyword(s):

State Of The Art ◽

Renin Angiotensin

Download Full-text

Heart rate variability in severe right or left heart failure: the role of pulmonary hypertension and resistances

European Journal of Heart Failure ◽

10.1016/s1388-9842(03)00168-5 ◽

2003 ◽

Author(s):

L Fauchier

Keyword(s):

Heart Failure ◽

Heart Rate ◽

Pulmonary Hypertension ◽

Heart Rate Variability ◽

Left Heart ◽

Left Heart Failure

Download Full-text

Potential Uses of Vinegar as a Medicine and Related in vivo Mechanisms

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000440 ◽

2016 ◽

Vol 86 (3-4) ◽

pp. 127-151 ◽

Cited By ~ 3

Author(s):

Zeshan Ali ◽

Zhenbin Wang ◽

Rai Muhammad Amir ◽

Shoaib Younas ◽

Asif Wali ◽

...

Keyword(s):

Chemical Structure ◽

Review Paper ◽

Heart Diseases ◽

Folk Medicine ◽

Active Role ◽

Current Review ◽

Different Types ◽

Positive Effect

While the use of vinegar to fi ght against infections and other crucial conditions dates back to Hippocrates, recent research has found that vinegar consumption has a positive effect on biomarkers for diabetes, cancer, and heart diseases. Different types of vinegar have been used in the world during different time periods. Vinegar is produced by a fermentation process. Foods with a high content of carbohydrates are a good source of vinegar. Review of the results of different studies performed on vinegar components reveals that the daily use of these components has a healthy impact on the physiological and chemical structure of the human body. During the era of Hippocrates, people used vinegar as a medicine to treat wounds, which means that vinegar is one of the ancient foods used as folk medicine. The purpose of the current review paper is to provide a detailed summary of the outcome of previous studies emphasizing the role of vinegar in treatment of different diseases both in acute and chronic conditions, its in vivo mechanism and the active role of different bacteria.

Download Full-text