scholarly journals Advances in Chirality Sensing with Macrocyclic Molecules

Chemosensors ◽  
2021 ◽  
Vol 9 (10) ◽  
pp. 279
Author(s):  
Xiaotong Liang ◽  
Wenting Liang ◽  
Pengyue Jin ◽  
Hongtao Wang ◽  
Wanhua Wu ◽  
...  
Keyword(s):  
High Throughput ◽  
Absolute Configuration ◽  
Chemical Sensors ◽  
Organic Molecules ◽  
Macrocyclic Compounds ◽  
Rapid Progress ◽  
Molecular Chirality ◽  
Supramolecular Chirality ◽  
Signal Output ◽  
Macrocyclic Molecules

The construction of chemical sensors that can distinguish molecular chirality has attracted increasing attention in recent years due to the significance of chiral organic molecules and the importance of detecting their absolute configuration and chiroptical purity. The supramolecular chirality sensing strategy has shown promising potential due to its advantages of high throughput, sensitivity, and fast chirality detection. This review focuses on chirality sensors based on macrocyclic compounds. Macrocyclic chirality sensors usually have inherent complexing ability towards certain chiral guests, which combined with the signal output components, could offer many unique advantages/properties compared to traditional chiral sensors. Chirality sensing based on macrocyclic sensors has shown rapid progress in recent years. This review summarizes recent advances in chirality sensing based on both achiral and chiral macrocyclic compounds, especially newly emerged macrocyclic molecules.

scholarly journals Describing chain-like assembly of ethoxygroup-functionalized organic molecules on Au(111) using high-throughput simulations

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Lokamani ◽  
Jeffrey Kelling ◽  
Robin Ohmann ◽  
Jörg Meyer ◽  
Tim Kühne ◽  
...  
Keyword(s):  
High Throughput ◽  
Energy Function ◽  
Organic Molecules ◽  
Molecular Wires ◽  
Scanning Tunneling ◽  
Tunneling Microscopy ◽  
Intermolecular Interaction Energy ◽  
One Dimensional ◽  
Coverage Density ◽  
Clustering Approach

AbstractDue to the low corrugation of the Au(111) surface, 1,4-bis(phenylethynyl)-2,5-bis(ethoxy)benzene (PEEB) molecules can form quasi interlocked lateral patterns, which are observed in scanning tunneling microscopy experiments at low temperatures. We demonstrate a multi-dimensional clustering approach to quantify the anisotropic pair-wise interaction of molecules and explain these patterns. We perform high-throughput calculations to evaluate an energy function, which incorporates the adsorption energy of single PEEB molecules on the metal surface and the intermolecular interaction energy of a pair of PEEB molecules. The analysis of the energy function reveals, that, depending on coverage density, specific types of pattern are preferred which can potentially be exploited to form one-dimensional molecular wires on Au(111).

scholarly journals A deep neural network model for packing density predictions and its application in the study of 1.5 million organic molecules

2019 ◽  
Vol 10 (36) ◽  
pp. 8374-8383 ◽  
Author(s):  
Mohammad Atif Faiz Afzal ◽  
Aditya Sonpal ◽  
Mojtaba Haghighatlari ◽  
Andrew J. Schultz ◽  
Johannes Hachmann
Keyword(s):  
Neural Network ◽  
Machine Learning ◽  
Refractive Index ◽  
High Throughput ◽  
Neural Network Model ◽  
High Throughput Screening ◽  
Deep Neural Network ◽  
Organic Molecules ◽  
High Refractive Index ◽  
Computational Pipeline

Computational pipeline for the accelerated discovery of organic materials with high refractive index via high-throughput screening and machine learning.

Chemical sensors based on π-conjugated organic molecules and gold nanoparticles

2009 ◽  
Vol 52 (6) ◽  
pp. 715-730 ◽  
Author(s):  
MingJian Yuan ◽  
YongJun Li ◽  
HuiBiao Liu ◽  
YuLiang Li
Keyword(s):  
Gold Nanoparticles ◽  
Chemical Sensors ◽  
Organic Molecules ◽  
Conjugated Organic Molecules

scholarly journals Quantification of Intracellular Accumulation and Retention of Lysosomotropic Macrocyclic Compounds by High-Throughput Imaging of Lysosomal Changes

2019 ◽  
Vol 108 (1) ◽  
pp. 652-660 ◽  
Author(s):  
Arrabi Easwaranathan ◽  
Beril Inci ◽  
Sam Ulrich ◽  
Lars Brunken ◽  
Violetta Nikiforova ◽  
...  
Keyword(s):  
High Throughput ◽  
Macrocyclic Compounds ◽  
Intracellular Accumulation ◽  
High Throughput Imaging

Combinatorial Study and High-Throughput Screening of Transparent Barrier Films using Chemical Sensors

2003 ◽  
pp. 289-316
Author(s):  
Jaime C. Grunlan ◽  
Dennis Saunders ◽  
Jay Akhave ◽  
Mark Licon ◽  
Marcel Murga ◽  
...  
Keyword(s):  
High Throughput ◽  
Chemical Sensors ◽  
High Throughput Screening ◽  
Barrier Films ◽  
Transparent Barrier

Shadow Edge Lithography and Application to Nanofluidics

2010 ◽  
Author(s):  
Woon-Hong Yeo ◽  
Dong Won Lee ◽  
Kyong-Hoon Lee ◽  
Jae-Hyun Chung
Keyword(s):  
Fuel Cells ◽  
High Resolution ◽  
High Throughput ◽  
Single Molecule ◽  
Chemical Sensors ◽  
Geometric Distribution ◽  
High Vacuum ◽  
Vacuum Evaporation ◽  
Wafer Scale ◽  
Nanoscale Patterns

Many upcoming applications, such as nanoelectronic circuitry, single-molecule based chips, nanofluidics, chemical sensors, and fuel cells, require large arrays of nanochannels and nanowires. To commercialize such nanostructured devices, a high resolution and high throughput patterning method is essential. For this purpose, we developed the shadow edge lithography (SEL) as a wafer-scale, high-throughput nanomanufacturing method [1]. In the proposed method, the shadow effect in the high-vacuum evaporation was theoretically analyzed to predict the geometric distribution of the nanoscale patterns [2]. In experiment, nanoscale patterns were created by the shadow of aluminum (Al) edges that were prepatterned using a conventional microfabrication method.

Autoamplification of Molecular Chirality through the Induction of Supramolecular Chirality

2014 ◽  
Vol 126 (20) ◽  
pp. 5173-5177 ◽  
Author(s):  
Derk Jan van Dijken ◽  
John M. Beierle ◽  
Marc C. A. Stuart ◽  
Wiktor Szymański ◽  
Wesley R. Browne ◽  
...  
Keyword(s):  
Molecular Chirality ◽  
Supramolecular Chirality

scholarly journals High-throughput sequencing allows the identification of binding molecules isolated from DNA-encoded chemical libraries

2008 ◽  
Vol 105 (46) ◽  
pp. 17670-17675 ◽  
Author(s):  
Luca Mannocci ◽  
Yixin Zhang ◽  
Jörg Scheuermann ◽  
Markus Leimbacher ◽  
Gianluca De Bellis ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
High Throughput ◽  
High Throughput Sequencing ◽  
Organic Molecules ◽  
Relative Quantification ◽  
Dna Encoding ◽  
Chemical Library ◽  
Chemical Libraries ◽  
Matrix Metalloproteinase 3 ◽  
Individual Reaction

DNA encoding facilitates the construction and screening of large chemical libraries. Here, we describe general strategies for the stepwise coupling of coding DNA fragments to nascent organic molecules throughout individual reaction steps as well as the first implementation of high-throughput sequencing for the identification and relative quantification of the library members. The methodology was exemplified in the construction of a DNA-encoded chemical library containing 4,000 compounds and in the discovery of binders to streptavidin, matrix metalloproteinase 3, and polyclonal human IgG.

Phthalocyanine-based hybrid materials for chemosensing

2013 ◽  
Vol 17 (10) ◽  
pp. 913-919 ◽  
Author(s):  
Marcel Bouvet ◽  
Pierre Gaudillat ◽  
Jean-Moïse Suisse
Keyword(s):  
Specific Surface ◽  
Hybrid Materials ◽  
Chemical Sensors ◽  
Morphological Characteristics ◽  
Present Review ◽  
Carbonaceous Materials ◽  
Sensing Material ◽  
Chemical Variability ◽  
Optical Transducers ◽  
Macrocyclic Molecules

In the present review, we show how the chemical variability of phthalocyanines allowed to synthesize a broad range of hybrid materials. The combination of phthalocyanines or related derivatives with polymers or carbonaceous materials led to efficient chemical sensors. It is shown how the incorporation of macrocyclic molecules in hybrid materials highly modifies the structural and morphological characteristics of the materials. Rugosity, specific surface and porosity being key parameters in the analyte-sensing material interactions, these modifications highly improve the performance of chemical sensors. This is the reason why they are particularly promising materials for the development of new chemical sensors, associated with electrochemical, conductometric or optical transducers.

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