Macrocyclic compounds have attracted tremendous attention for their superior
performance in supramolecular recognition, catalysis, and host-guest interaction. With
these admirable properties, macrocyclic compounds were used as modifiers for enhancing
the sensitivity and selectivity of electrodes and optical sensors. The classic macrocyclic
compounds, including crown ethers, cyclodextrins, calixarenes, cucurbiturils, and pillararenes,
were employed as receptors for electrochemical and optical sensors to develop
new analytical methods with the wilder detection range, lower detection limit, and better
tolerance of interference. Macrocyclic molecules functionalized with nanomaterials, the
small entities with dimensions in the nanoscale, realized the versatility and diversification
of the nano-hybrid materials, which improved the capabilities of recognition and response
with the combining characteristics of two components. Herein, this review focused on the development in the
research field of hybridization of organic macrocycles with nanoparticles and their applications for chemosensors,
aiming at both existing researchers in the field and who would like to enter into the research.