scholarly journals Regression of Intracranial Meningiomas Following Treatment with Cabozantinib

2021 ◽  
Vol 28 (2) ◽  
pp. 1537-1543
Author(s):  
Rupesh Kotecha ◽  
Raees Tonse ◽  
Haley Appel ◽  
Yazmin Odia ◽  
Ritesh R. Kotecha ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Kinase Inhibitor ◽  
Biological Pathways ◽  
Vegf Receptor ◽  
Experimental Therapeutics ◽  
Prospective Evaluation ◽  
Intracranial Meningiomas ◽  
Oral Therapeutic ◽  
Systemic Therapies

Recurrent meningiomas remain a substantial treatment challenge given the lack of effective therapeutic options aside from surgery and radiation therapy, which yield limited results in the retreatment situation. Systemic therapies have little effect, and responses are rare; the search for effective systemic therapeutics remains elusive. In this case report, we provide data regarding significant responses in two radiographically diagnosed intracranial meningiomas in a patient with concurrent thyroid carcinoma treated with cabozantinib, an oral multitarget tyrosine kinase inhibitor with potent activity against MET and VEGF receptor 2. Given the clinical experience supporting the role of VEGF agents as experimental therapeutics in meningioma and the current understanding of the biological pathways underlying meningioma growth, this may represent a new oral therapeutic alternative, warranting prospective evaluation.

scholarly journals Circulating Fibroblast Growth Factor-2 precipitates HIV-nephropathy in mice

2021 ◽  
Author(s):  
Jharna R. Das ◽  
Marina Jerebtsova ◽  
Pingtao Tang ◽  
Jinliang Li ◽  
Jing Yu ◽  
...  
Keyword(s):  
Kinase Inhibitor ◽  
Chronic Kidney Failure ◽  
High Plasma ◽  
Antiretroviral Drugs ◽  
Vegf Receptor ◽  
Living With Hiv ◽  
Circulating Levels ◽  
Renal Expression ◽  
Hiv 1

Over 80% of all children living with HIV reside in Africa and are at risk of developing HIV-associated nephropathy (HIVAN). Once HIVAN is established in children, it is difficult to revert its progression to chronic kidney failure even using antiretroviral drugs. Therefore, new therapeutic strategies are needed. Previous studies showed that the risk of developing HIVAN increases in children with high circulating levels of FGF-2, but it is unclear whether FGF-2 per se precipitates HIVAN. To unravel the role of circulating FGF-2 in childhood HIVAN, we used the HIV-Tg26 mouse model of HIVAN. Briefly, we demonstrated that circulating FGF-2 was preferentially recruited in the kidney of HIV-Tg26 mice with renal disease, and precipitated HIVAN in young mice without pre-existing kidney disease by activating the pERK pathway in renal epithelial cells without previously inducing the expression of HIV-1 genes. Wild type mice injected with recombinant adenoviral FGF-2 vectors (rAd-FGF-2) carrying a secreted form of human FGF-2 developed transient and reversible HIVAN-like lesions, including proteinuria and glomerular enlargement. HIV-Tg26 mice injected with rAd-FGF-2 developed more significant proliferative and pro-fibrotic inflammatory lesions, similar to those seen in childhood HIVAN. These lesions were partially reversed in mice treated with the FGF/VEGF receptor tyrosine kinase inhibitor PD173074. In conclusion, we developed a new FGF-2-inducible model of childhood HIVAN, and showed that high circulating levels of FGF-2 precipitated HIVAN without inducing the renal expression of HIV-genes. These findings suggest that high plasma FGF-2 levels may be an independent risk factor for precipitating HIVAN in young children.

scholarly journals Current status of radiation therapy and radiosurgery in the treatment of intracranial meningiomas

1997 ◽  
Vol 2 (4) ◽  
pp. E8 ◽  
Author(s):  
Herbert H. Engelhard
Keyword(s):  
Radiation Therapy ◽  
Postoperative Radiotherapy ◽  
Complete Removal ◽  
External Beam Radiation ◽  
Current Status ◽  
Surgical Removal ◽  
Primary Therapy ◽  
Beam Radiation ◽  
Intracranial Meningiomas

Complete surgical removal, including resection of involved bone and dura, is curative of intracranial meningiomas in approximately 90% of cases. However, complete removal may entail unwarranted risk if the tumor involves or is adjacent to critical vascular or neural structures. In addition, it is possible for fragments of tumor to “evade” resection, even with the use of meticulous microsurgical technique. Because of this, clinicians may be faced with the decision of whether to offer or recommend radiation therapy or radiosurgery to a patient with a residual or recurrent meningioma. For many years, it has been recommended that external-beam radiation therapy be considered in the treatment of incompletely resected or malignant meningiomas. More recently, the role of radiosurgery as adjuvant or even primary therapy for meningiomas has attracted considerable attention. This article presents a review of the literature on postoperative radiotherapy of intracranial meningiomas.

scholarly journals The role of radiation therapy and systemic therapies in elderly with breast cancer

2020 ◽  
Vol 9 (S1) ◽  
pp. S97-S109
Author(s):  
Valerio Nardone ◽  
Sara Falivene ◽  
Francesca Maria Giugliano ◽  
Marcella Gaetano ◽  
Pasqualina Giordano ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Systemic Therapies

The Role of Radiation Therapy in the Treatment of Laryngeal Cancer

1984 ◽  
Vol 17 (1) ◽  
pp. 227-235
Author(s):  
Leslie E. Botnick ◽  
Christopher M. Rose ◽  
Izhak Goldberg ◽  
Abraham Recht
Keyword(s):  
Radiation Therapy ◽  
Laryngeal Cancer

The evolving role of pelvic radiation therapy

2003 ◽  
Vol 13 (2) ◽  
pp. 109-120 ◽  
Author(s):  
Terence Roberts ◽  
Mack Roach
Keyword(s):  
Radiation Therapy ◽  
Pelvic Radiation

Rapid evaluation of FDG imaging alternatives using head-to-head comparisons of full ring and gamma camera based PET scanners –

2002 ◽  
Vol 41 (05) ◽  
pp. 208-213 ◽  
Author(s):  
L. M. Haslinghuis-Bajan ◽  
L. Hooft ◽  
A. van Lingen ◽  
M. van Tulder ◽  
W. Devillé ◽  
...  
Keyword(s):  
Methodological Quality ◽  
Gamma Camera ◽  
First Generation ◽  
Prospective Evaluation ◽  
First Approximation ◽  
Variable Head ◽  
Malignant Lesions ◽  
The Impact ◽  
Pet Scanners

SummaryAim: While FDG full ring PET (FRPET) has been gradually accepted in oncology, the role of the cheaper gamma camera based alternatives (GCPET) is less clear. Since technology is evolving rapidly, “tracker trials” would be most helpful to provide a first approximation of the relative merits of these alternatives. As difference in scanner sensitivity is the key variable, head-to-head comparison with FRPET is an attractive study design. This systematic review summarises such studies. Methods: Nine studies were identified until July 1, 2000. Two observers assessed the methodological quality (Cochrane criteria), and extracted data. Results: The studies comprised a variety of tumours and indications. The reported GC- and FRPET agreement for detection of malignant lesions ranged from 55 to 100%, but with methodological limitations (blinding, standardisation, limited patient spectrum). Mean lesion diameter was 2.9 cm (SD 1.8), with only about 20% <1.5 cm. The 3 studies with the highest quality reported concordances of 74-79%, for the studied lesion spectrum. Contrast at GCPET was lower than that of FRPET, contrast and detection agreement were positively related. Logistic regression analysis suggested that pre-test indicators might be used to predict FRPET-GCPET concordance. Conclusion: In spite of methodological limitations, “first generation” GCPET devices detected sufficient FRPET positive lesions to allow prospective evaluation in clinical situations where the impact of FRPET is not confined to detection of small lesions (<1.5 cm). The efficiency of head-to-head comparative studies would benefit from application in a clinically relevant patient spectrum, with proper blinding and standardisation of acquisition procedures.

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