scholarly journals Multifocality and Multicentrality in Breast Cancer: Comparison of the Efficiency of Mammography, Contrast-Enhanced Spectral Mammography, and Magnetic Resonance Imaging in a Group of Patients with Primarily Operable Breast Cancer

2021 ◽  
Vol 28 (5) ◽  
pp. 4016-4030
Author(s):  
Katarzyna Steinhof-Radwańska ◽  
Andrzej Lorek ◽  
Michał Holecki ◽  
Anna Barczyk-Gutkowska ◽  
Anna Grażyńska ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Surgical Intervention ◽  
Histopathological Examination ◽  
Breast Conserving Therapy ◽  
Resonance Imaging ◽  
Contrast Enhanced ◽  
Highly Sensitive ◽  
Magnetic Resonance Imaging Mri

Background: The multifocality and multicentrality of breast cancer (MFMCC) are the significant aspects that determine a specialist’s choice between applying breast-conserving therapy (BCT) or performing a mastectomy. This study aimed to assess the usefulness of mammography (MG), contrast-enhanced spectral mammography (CESM), and magnetic resonance imaging (MRI) in women diagnosed with breast cancer before qualifying for surgical intervention to visualize other (additional) cancer foci. Methods: The study included 60 breast cancer cases out of 630 patients initially who underwent surgery due to breast cancer from January 2015 to April 2019. MG, CESM, and MRI were compared with each other in terms of the presence of MFMCC and assessed for compliance with the postoperative histopathological examination (HP). Results: Histopathological examination confirmed the presence of MFMCC in 33/60 (55%) patients. The sensitivity of MG in detecting MFMCC was 50%, and its specificity was 95.83%. For CESM, the sensitivity was 85.29%, and the specificity was 96.15%. For MRI, all the above-mentioned parameters were higher as follows: sensitivity—91.18%; specificity—92.31%. Conclusions: In patients with MFMCC, both CESM and MRI are highly sensitive in the detection of additional cancer foci. Both CESM and MRI change the extent of surgical intervention in every fourth patient.

scholarly journals Comparison of the Efficiency of Mammography, Contrast-Enhanced Spectral Mammography and Magnetic Resonance Imaging in Female Patients with Multifocal and Multicentral Breast Cancer

2021 ◽  
Author(s):  
Katarzyna Steinhof-Radwańska ◽  
Andrzej Lorek ◽  
Michał Holecki ◽  
Anna Barczyk-Gutkowska ◽  
Anna Grażyńska ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Surgical Intervention ◽  
Histopathological Examination ◽  
Breast Conserving Therapy ◽  
Breast Cancers ◽  
Resonance Imaging ◽  
Factors Influencing ◽  
Contrast Enhanced ◽  
Highly Sensitive ◽  
General Number

Abstract Background. The multifocality and multicentrality of breast cancer are the decisive factors influencing surgeon’s choice between breast conserving therapy (BCT) and mastectomy.Methods. The analysis included 71 breast cancer subjects out of 727 patients initially operated on due to breast cancer from January 2013 to April 2019. MG, CESM and MRI were compared with one another in terms of the presence of multifocal/multicentral breast cancers (MFMCC), and assessed for compliance with the postoperative histopathological examination (HP), by calculating the sensitivity and specificity for each of the methods. The aim was to examine which histopathological types of breast cancer were characterised by a more frequent occurrence of MFMCC in relation to the general number of cancers identified in HP. It was also analysed if MRI and CESM changed the planned scope of surgery. Results. The sensitivity of MG in detecting MFMCC was 42.1% (26.31 – 59.18), its specificity, positive (PPV) and negative predictive value (NPV) were 93.9% (79.77 – 99.26), 88.8% and 58.5%, respectively. For CESM, the sensitivity was 84.2% (68.75 – 93.98), its specificity, PVV and NPV were 90.9% (75.67 – 98.08), 91.4%, and 83.3%, respectively. For MRI, all above mentioned parameters were higher, as follow: level of sensitivity 94.7% (82.25 – 99.36), specificity – 93.9% (79.77 – 99.26), PPV – 94.7%, and NPV – 93.9%. In 38 out of 71 patients (53.5%), histopathological examination (HP) confirmed the multifocal and multicentral nature of the breast cancer. Conclusion1. In patients with multifocal/multicentral breast cancer both CESM and MRI are highly sensitive in detection of additional cancer foci. 2. Both CESM and MRI change the extent of surgical intervention in every fourth patient. Trial registration: retrospectively registered

scholarly journals Haemorrhage Detection in Brain Metastases of Lung Cancer Patients using Magnetic Resonance Imaging

2009 ◽  
Vol 37 (4) ◽  
pp. 1139-1144 ◽  
Author(s):  
W Zhang ◽  
X-X Ma ◽  
Y-M Ji ◽  
X-S Kang ◽  
C-F Li
Keyword(s):  
Magnetic Resonance Imaging ◽  
Lung Cancer ◽  
Magnetic Resonance ◽  
Brain Metastases ◽  
Cancer Patients ◽  
Resonance Imaging ◽  
Lung Cancer Patients ◽  
Contrast Enhanced ◽  
Highly Sensitive ◽  
Magnetic Resonance Imaging Mri

Magnetic resonance susceptibility-weighted imaging (SWI) is a new, highly-sensitive technique used to detect haemorrhage. This study evaluated the ability of magnetic resonance imaging (MRI) to detect haemorrhage in 45 lung cancer patients with brain metastases and compared the results with T2*-weighted imaging (T2*WI) and contrast-enhanced T1-weighted imaging (CE-T1WI). Eighty-nine haemorrhagic brain metastases were identified in 31 patients using SWI, 68 were identified in 23 patients using T2*WI and 46 were identified in 14 patients using CE-T1WI. Most micro-bleeds could only be identified by SWI. It was concluded that haemorrhage is a frequent occurrence in brain metastases originating from lung cancer and that haemorrhage can be detected using SWI in a majority of brain metastases patients.

scholarly journals The value of contrast-enhanced FLAIR magnetic resonance imaging in detecting meningeal abnormalities in suspected cases of meningitis compared to conventional contrast-enhanced T1WI sequences

2020 ◽  
Vol 51 (1) ◽  
Author(s):  
Wael Hamza Kamr ◽  
Mohamed Gaber Eissawy ◽  
Amr Saadawy
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Early Diagnosis ◽  
Diagnosis And Treatment ◽  
Effective Management ◽  
Resonance Imaging ◽  
Flair Sequence ◽  
Csf Analysis ◽  
Contrast Enhanced ◽  
Magnetic Resonance Imaging Mri

Abstract Background Early diagnosis of meningitis with magnetic resonance imaging (MRI) would be useful for appropriate and effective management, decrease morbidity and mortality, and provide better diagnosis and treatment. The objective of the current study is to compare the accuracy of contrast-enhanced FLAIR (CE-FLAIR) and contrast-enhanced T1WI (CE-T1WI) in the detection of meningeal abnormalities in suspected cases of meningitis. Results Out of 45 patients, 37 patients were confirmed to have meningitis on CSF analysis. Out of the 37 patients, 34 patients were positive on CE-FLAIR sequence and 27 were positive on CE-T1WI. The sensitivity of CE-FLAIR sequence was 91.9% and specificity 100%, while the sensitivity of CE-T1WI sequence was 73% and specificity 100%. Conclusion CE-FLAIR is more sensitive than CE-T1WI in diagnosis of meningitis. It is recommended to be used in any cases with clinically suspected meningitis.

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