scholarly journals What Is a Solitary Keratoacanthoma? A Benign Follicular Neoplasm, Frequently Associated with Squamous Cell Carcinoma

Diagnostics ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 1848
Author(s):  
Azusa Ogita ◽  
Shin-ichi Ansai
Keyword(s):  
Elderly Patient ◽  
Follicular Neoplasm ◽  
Histopathological Diagnosis ◽  
Complete Excision ◽  
Exposed Area ◽  
Pale Pink ◽  
Proliferative Stage ◽  
Epithelial Neoplasms ◽  
Residual Tissue ◽  
Careful Investigation

We present histopathological criteria for diagnosing keratoacanthoma (KA). In KA, four histological stages are recognized, which are the early/proliferative stage, well-developed stage, regressing stage and regressed stage. In diagnosing KA, we emphasize that KA consists of the proliferation of enlarged pale pink cells with ground glass-like cytoplasm without nuclear atypia, other than crateriform architecture. KA sometimes exhibits malignant transformation within the lesions. We describe the characteristics of benign and malignant epithelial crateriform tumors that should be differentiated from KA. We also present the data of histopathological diagnosis of lesions clinically diagnosed as KA, its natural course and related lesions after partial biopsy, and incidence of crateriform epithelial neoplasms. Based on these data, we recommend complete excision of the lesion when KA is clinically suspected, especially when the lesion is located on a sun-exposed area of an elderly patient. If complete excision is impossible, partial excision of a sufficient specimen with intact architecture is required. In such a case, however, careful investigation after biopsy will be needed, even if the histopathological diagnosis is KA, because there is some possibility that a conventional SCC lesion remains in the residual tissue.

scholarly journals Clinicopathological study of thyroid swelling and its management

2020 ◽  
Vol 6 (4) ◽  
pp. 727
Author(s):  
Seema Patel ◽  
Varsha J. Gattani ◽  
Ashok Z. Nitnaware
Keyword(s):  
Papillary Carcinoma ◽  
Surgical Management ◽  
False Negative ◽  
Malignant Lesion ◽  
Nodular Goiter ◽  
Follicular Neoplasm ◽  
Histopathological Diagnosis ◽  
Predictive Values ◽  
Neoplastic Lesion ◽  
Thyroid Swelling

<p class="abstract"><strong>Background:</strong> There is high prevalence of thyroid lesions in India. In this study, an attempt is made to find out the clinical spectrum of thyroid swellings in central India, diagnostic accuracy of fine needle aspiration cytology (FNAC), appropriate surgical management and to compare it with postoperative histopathological diagnosis so as to determine its role in surgical management.</p><p class="abstract"><strong>Methods:</strong> In this prospective study, 100 subjects presenting to ENT OPD of GMC, Nagpur during the period from September 2017 to August 2019 with thyroid swelling who were fit to undergo surgery and willing to participate in the study were selected. After detailed evaluation and routine investigations, thyroid function test (TFT), FNAC, ultrasonography (USG) neck, all the subjects underwent required thyroidectomy. The postoperative histopathological examination (HPE) report was correlated with cytological report.  </p><p class="abstract"><strong>Results:</strong> In 100 subjects, majority of subjects were from 4th decade (32%) with female: male ratio=6.14:1. FNAC findings were colloid goiter (61%), nodular goiter (19%), follicular neoplasm (10%), and papillary carcinoma (9%). On HPE, colloid goitre (57%) was most common non-neoplastic lesion and papillary carcinoma (65.21 %) was most common malignant lesion. Hemithyroidectomy (70%) was most common procedure done. Transient hypocalcemia (5%), recurrent laryngeal nerve (RLN) paresis (2%) were the postoperative complications encountered. Sensitivity, specificity, accuracy, positive and negative predictive values of FNAC to diagnose malignancy were 55.6%, 100%, 91%, 100% and 90% respectively.</p><p class="abstract"><strong>Conclusions:</strong> FNAC is an easy, rapid, reliable, cost-effective, minimally invasive and readily repeatable technique for diagnosis of thyroid swellings. The common false negative diagnosis is seen in follicular pattern cases, cystic papillary thyroid carcinoma (PTC) and papillary microcarcinoma.  </p>

scholarly journals Upper eyelid and medial canthus reconstructive surgery after histiocytoma resection in a dog: a case report

2010 ◽  
Vol 55 (No. 3) ◽  
pp. 137-143 ◽  
Author(s):  
M. Lew ◽  
S. Lew ◽  
A. Rozicka
Keyword(s):  
Histopathological Examination ◽  
Donor Site ◽  
Medial Canthus ◽  
Pedicle Flap ◽  
Upper Eyelid ◽  
Complete Excision ◽  
Pale Pink ◽  
Skin Loss ◽  
Graft Donor ◽  
Treatment Surgery

A six year old crossbred male dog presented with non-pigmented, pale pink, unhaired, ulcerative tumor of the medial canthus and upper eyelid region. As treatment, surgery was proposed. During the surgery complete excision of the tumor was performed. The extent of skin loss, especially in the upper eyelid required plastic reconstruction by pedicle flap transposition. The soft skin of the cheek was chosen as a graft donor site. The postoperative period proceeded without any complications and ended with successful engraftment. The soft cheek skin did not impede movement of the upper eyelid. Histopathological examination indicated histiocytoma and tumor-free excisional margins were confirmed. There has been no recurrence during the subsequent 12&nbsp;month period.

scholarly journals A Rare Case of Pyogenic Granuloma in the Tooth Extraction Socket

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Yosuke Iijima ◽  
Nami Nakayama ◽  
Leona Kashimata ◽  
Miki Yamada ◽  
Ryutaro Kawano ◽  
...  
Keyword(s):  
Rare Case ◽  
Tooth Extraction ◽  
Dentigerous Cyst ◽  
Excisional Biopsy ◽  
Pyogenic Granuloma ◽  
Histopathological Diagnosis ◽  
Wisdom Tooth ◽  
Complete Excision ◽  
Extraction Socket ◽  
Second Molar

Pyogenic granuloma (PG) refers to a common, acquired, benign, and vascular tumor that arises in tissues such as the skin and mucous membranes. However, it is extremely rare for PG to arise from an empty socket after tooth extraction. Herein, we describe a rare case of PG that arose from the empty extraction socket of the second molar adjacent to a dentigerous cyst of the left mandibular wisdom tooth in a 57-year-old man. The patient’s second molar was extracted during the same procedure in which the wisdom tooth and cyst were removed. Subsequently, at 42 days after surgery, an exophytic mass was found in the socket of the second molar. An excisional biopsy was performed, and the histopathological diagnosis was PG. Since the PG recurred 90 days after the surgery, a complete excision with bone curettage was performed. During the 12 months of follow-up, there has been no recurrence observed. In conclusion, as tooth extraction is a routine dental practice, clinicians should be aware that PGs can also develop from an extraction socket.

scholarly journals Primary Episcleral Melanoma Consistent with Uveal Melanoma Mutations Treated by Excision and Gamma Knife Stereotactic Radiosurgery

2019 ◽  
Vol 6 (2) ◽  
pp. 93-98
Author(s):  
Spencer T. Langevin ◽  
Eileen Chang ◽  
Tony J.C. Wang ◽  
Israel Deutsch ◽  
Marc Otten ◽  
...  
Keyword(s):  
Gamma Knife ◽  
Uveal Melanoma ◽  
Molecular Genetic ◽  
Complete Excision ◽  
First Case ◽  
Increased Risk ◽  
Orbital Tissue ◽  
Residual Tissue ◽  
Gamma Knife Stereotactic Radiosurgery ◽  
Ocular Melanocytosis

Ocular melanocytosis has traditionally been associated with increased risk of developing uveal melanoma; however, rarely primary episcleral melanoma has been reported in the literature. Herein, we present the third case of primary episcleral melanoma treated by complete excision and cryotherapy. In contrast to previous cases, we obtained molecular genetic testing which revealed a GNA-11 mutation, and gene expression profiling resulted in a Class 2 PRAME positive tumor diagnosis. These two tests which have never been performed on previous cases, support lineage similar to uveal melanoma. In addition, we are the first case to report treatment of the surgical bed and surrounding orbital tissue with Gamma Knife stereotactic radiotherapy to both treat residual tissue and decrease risk of recurrence.

scholarly journals CYTO-HISTOPATHOLOGICAL CORRELATION OF THYROID LESIONS

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Dharmendra Singh Bhadouria ◽  
Shikha Raghuwanshi ◽  
Arun Saxena
Keyword(s):  
Papillary Carcinoma ◽  
Thyroid Nodules ◽  
Needle Aspiration ◽  
Follicular Neoplasm ◽  
Patient Acceptance ◽  
Histopathological Diagnosis ◽  
Thyroid Lesion ◽  
Follicular Hyperplasia ◽  
Neoplastic Lesion ◽  
Thyroid Lesions

Introduction: Thyroid nodules show an overall incidence rate of 4-7% & high probability of malignancy, constituting 5% to 35%. FNAC of Thyroid is most economical and reliable preoperative procedure to distinguish between neoplastic and non- neoplastic lesion. Objectives: To Study Cyto-Morphology of Fine Needle Aspiration of Thyroid nodules. To find out incidence of various types of lesions as per age & sex and to confirm the findings with Histomorphological diagnosis of same nodule. Material & Methods: 100 patients with Thyroid nodule who underwent FNAC & Thyroidectomy taken for an observational study from January 2019 to June 2020. The cytological findings were correlated with histopathological diagnosis. Results: Out of 100 cases 14 cases were  found to be malignant and 86 were found to be benign on histology while cytology showed 93 cases benign and 7  malignant cases .Out of 5 cases suspicious for neoplasm and 3 cases were of follicular neoplasm on cytology which confirmed as papillary carcinoma on histopathology.2 cases which were diagnosed as Benign Thyroid lesion turned out to be papillary carcinoma and 2 cases which were diagnosed as colloid goitre on cytology turned out to be papillary carcinoma on histo pathology .1 case diagnosed as follicular hyperplasia turned out to be papillary carcinoma on histology.1 case diagnosed as MNG in cytology was turned out to be papillary carcinoma on histo pathology. Conclusion: Thyroid cytology proves to be a reliable, simple and cost-effective first line diagnostic procedure with high patient acceptance and without complications. FNAC serves as useful screening test for thyroid lesions. However, inability in distinguishing follicular lesion and inadequate sampling in cystic lesion lead to false diagnosis. Keywords: Histopathology, Thyroid , Lesion.

A rare tumor of external auditory canal originated from ceruminous glands: A case raport

2018 ◽  
Vol 7 (1) ◽  
pp. 1-5
Author(s):  
Katarzyna Amernik ◽  
Aleksandra Kłodawska ◽  
Ewa Jaworowska
Keyword(s):  
Surgical Resection ◽  
External Auditory Canal ◽  
Tumor Resection ◽  
Surgical Excision ◽  
Histopathological Diagnosis ◽  
Complete Excision ◽  
Neck Tumors ◽  
Subtotal Petrosectomy ◽  
One Year ◽  
Specific Symptoms

The external auditory canal neoplasms comprise less than 1 percent of all head and neck tumors. 2,4 percent of them originate from ceruminous glands. In the past all these tumours were called ceruminomas. In 1972 Wetli et al. classiffed these neoplasms into four groups: ceruminous adenomas, ceruminous carcinoma, adenoid cystic carcinomas and pleomorphic adenomas. Ceruminous adenocarcinoma is very rare. It has no specific symptoms, so an appropriate, quick diagnosis is difficult. It is very agressive. The treatment should be based on tumor resection and radiotherapy afterwards. We presented a case of 56 years old female with a mass in external ear canal, who underwent diagnostic surgical excision of external auditor canal tumour. The postoperative histopathological diagnosis was ceruminous adenocarcinoma (complete excision) and the patient received radiation therapy. Control CT and MR - performed one year after the surgery - showed possible local recurrence of pathology. The patient undergo maximal surgical resection with subtotal petrosectomy but in the postoperative histological examination there was no malignant cells. Treatment of neoplasms of external auditory canal should be based on radical surgical resection. Imaging diagnostic is very important in follow up but it can have limited value in term of its specifity.

scholarly journals Comparative Study of Neck Swelling by Clinical, Cytological and Histopathological Examination

2020 ◽  
Vol 26 (1) ◽  
pp. 24-30
Author(s):  
Mohammad Idrish Ali ◽  
Md Mahmudul Huq ◽  
Momenul Haque ◽  
Kamrul Hasan Tarafder
Keyword(s):  
Cell Carcinoma ◽  
Histopathological Examination ◽  
Correct Diagnosis ◽  
Follicular Adenoma ◽  
Nodular Goiter ◽  
Metastatic Carcinoma ◽  
Follicular Neoplasm ◽  
Histopathological Diagnosis ◽  
Neck Swelling ◽  
Female Ratio

Objective: In this study 50 patients of neck swelling were studied to compare the findings with clinical diagnosis and histopathological report for its diagnostic compatibility. Methods: This cross sectional study was done in Department of Otolaryngology –Head & Neck Surgery, Bangabandhu Sheikh Mujib Medical University, Dhaka from July 2015 to June 2017. Fine needle aspiration cytology, MRI, CT scan, and histopathological examination of postoperative specimen of neck swelling, analyzed data presented by various tables, graphs and figures. Results:In the present series 50 cases of neck swelling were studied. Out of these 50 cases 19 were male and 31 were female. The male, female ratio was 1:1.63. Age range was 4 – 60 years with maximum frequency in the 4th decade with the 3rd and 2nd in the following suit. Most of the patient were poor. Clinical, cytological and histopathological diagnosis were available in all the cases. The three sorts of diagnoses were compared with each other. Histopathologically 12 cases were tubercular lymphadenopathy. Metastatic carcinoma and lymphoma 5 cases for each. Twelve were nodular goiter, 5 were thyroid carcinoma. Rest were benign, congenital and nonspecific inflammatory conditions. Correct diagnosis were made by FNAC in 45 cases. In the rest 5 cases smear were unsatisfactory in 2 cases and gives inconclusive result, remaining 3 were follicular neoplasm and no definitive result were made which were subsequently diagnosed by histopathological examination as a follicular adenoma in 1 and follicular carcinoma in 2. Sensitivity of FNAC in the diagnosis of neck masses were found 91% for tuberculosis, 100% for metastatic carcinoma also for salivary gland tumour. In case of nodular goiter sensitivity was 92%. But it is only 60% sensitive in case of thyroid malignancy, as FNAC can not demarcate clearly between follicular adenoma and follicular cell carcinoma. But its accuracy in diagnosing papillary cell carcinoma of thyroid was 100%. Conclusion: Keeping the limitations in mind, FNAC can reduce substantially the need of open biopsy for histopathological examination. Last of all I wish to conclude the study with the popular saying of Stewart “Diagnosis by aspiration is as reliable as the combined intelligence of the clinician and pathologist makes it”. Bangladesh J Otorhinolaryngol; April 2020; 26(1): 24-30

scholarly journals Diagnostic Value of Six Thyroid Imaging Reporting and Data Systems (TIRADS) in Cytologically Equivocal Thyroid Nodules

2020 ◽  
Vol 9 (7) ◽  
pp. 2281 ◽  
Author(s):  
Dorota Słowińska-Klencka ◽  
Kamila Wysocka-Konieczna ◽  
Mariusz Klencki ◽  
Bożena Popowicz
Keyword(s):  
Thyroid Carcinoma ◽  
Follicular Neoplasm ◽  
Malignant Neoplasms ◽  
Histopathological Diagnosis ◽  
American Thyroid Association ◽  
Data Systems ◽  
Malignancy Risk ◽  
Thyroid Imaging ◽  
Hürthle Cell ◽  
Undetermined Significance

The aim was to compare the usefulness of selected thyroid sonographic risk-stratification systems in the diagnostics of nodules with indeterminate/suspicious cytology or unequivocal cytology in a population with a history of iodine deficiency. The diagnostic efficacy of ACR-TIRADS (the American College of Radiology Thyroid Imaging Reporting and Data Systems), EU-TIRADS (European Thyroid Association TIRADS), Korean-TIRADS, Kwak-TIRADS, AACE/ACE-AME-guidelines (American Association of Clinical Endocrinologists/ American College of Endocrinology-Associazione Medici Endocrinologi guidelines) and ATA-guidelines (American Thyroid Association guidelines) was evaluated in 1000 nodules with determined histopathological diagnosis: 329 FLUS/AUS (10.6% cancers), 167 SFN/SHT (11.6% cancers), 44 SM (77.3% cancers), 298 BL (benign lesions), 162 MN (malignant neoplasms). The percentage of PTC (papillary thyroid carcinoma) among cancers was higher in Bethesda MN (86.4%) and SM (suspicion of malignancy) nodules (91.2%) than in FLUS/AUS (57.1%, p < 0.005) and SFN/SHT (suspicion of follicular neoplasm/ suspicion of Hürthle cell tumor) nodules (36.8%, p < 0.001). TIRADS efficacy was higher for MN (AUC: 0.827–0.874) and SM nodules (AUC: 0.775–0.851) than for FLUS/AUS (AUC: 0.655–0.701) or SFN/SHT nodules (AUC: 0.593–0.621). FLUS/AUS (follicular lesion of undetermined significance/ atypia of undetermined significance) nodules assigned to a high risk TIRADS category had malignancy risk of 25%. In the SFN/SHT subgroup none TIRADS category changed nodule’s malignancy risk. EU-TIRADS and AACE/ACE-AME-guidelines would allow diagnosing the highest number of PTC, FTC (follicular thyroid carcinoma), HTC (Hürthle cell carcinoma), MTC (medullary thyroid carcinoma). The highest OR value was for Kwak-TIRADS (12.6) and Korean-TIRADS (12.0). Conclusions: TIRADS efficacy depends on the incidence of PTC among cancers. All evaluated TIRADS facilitate the selection of FLUS/AUS nodules for the surgical treatment but these systems are not efficient in the management of SFN/SHT nodules.

Nuclear morphometry of mammary tumors of dogs and histopathological diagnosis

2020 ◽  
Vol 22 (100) ◽  
pp. 123-128
Author(s):  
O. M. Fedets ◽  
O. I. Zayats ◽  
O. O. Zaitsev ◽  
M. V. Zakrevska ◽  
I. M. Kurlyak ◽  
...  
Keyword(s):  
Spindle Cell ◽  
Mammary Tumors ◽  
Malignant Neoplasms ◽  
Histopathological Diagnosis ◽  
Nuclear Area ◽  
Malignant Tumours ◽  
Nuclear Morphometry ◽  
Significant Difference ◽  
Epithelial Neoplasms ◽  
Benign Tumours

For dog’s mammary tumors diagnostics scientists need researches, which can adopt and use methods developed for humans. The aim of this research paper is to set the inter relation between the parameters of nuclear morphometry (nuclear area, diameter, perimeter) and histopathological type of mammary tumors of dogs. Animals aged from 6 to 12 (medium meaning 9.2 ± 1.6 years). According to histopathological research 3 tumors were benign and 25 were malignant, 18 of them – malignant epithelial neoplasms (3 tubular carcinomas, 13 tubulopapillary carcinomas, 1 cystic-papillary carcinoma, 3 colid carcinomas, 1 micropapillary carcinoma), 3 malignant epithelial neoplasms of special type (mucinous, lipid-rich, spindle cell carcinomas) and 4 malignant mesenchymal neoplasms (chondrosarcoma). Nuclear morphometry parameters (nuclear area, perimeter and diameter) of benign tumours (20.48 ± 1.22, 19.13–21.50 µm2; 19.27 ± 0.10, 19.17–19.36 µm and 5.09 ± 0.16, 4.92–5.22 µm) were probably smaller than in malignant tumours, for example in simple carcinoma (38.61 ± 5.61, 29.26–46.16 µm2; 26.42 ± 2.32, 22.10–29.60 µm and 6.96 ± 0.52, 6.03–7.62 µm), tubular (37.89 ± 7.30, 29.94–46.16 µm2, 26.34 ± 2.83, 22,98–29,60 µm and 6.90 ± 0.70, 6.16–7.62 µm), tubulopapillary (40.22 ± 3.48, 34.38–44.75 µm2, 27.02 ± 1.49, 24.41–28.97 µm and 7.12 ± 0.31, 6.58–7.52 µm), colid (43.57 ± 5.54, 37.71–48.73 µm2, 28.05 ± 1.88, 26.54–30.15 µm and 7.41 ± 0.47, 6.91–7.85 µm), other malignant epithelial neoplasms (39.99 ± 5.15, 29.94–48.73 µm2; 26.85 ± 2.03, 22.98–30.15 µm and 7.09 ± 0.50, 6.16–7.85 µm) and malignant epithelial neoplasms of special types (45.89 ± 4.12, 43.41–50.65 µm2; 29.92 ± 0.21, 29.68–30.06 µm and 7.60 ± 0.34, 7.41–8.00 µm). However, there was not statistically significant difference in comparison between benign tumours and sarcomas (25.95 ± 5.21, 21.64–33.00 µm2; 21.85 ± 1.79, 20.21–24.05 µm and 5.68 ± 0.56, 5.21–6.42 µm). Among the different groups of malignant neoplasms lower rates were in sarcoma, the other groups had no difference. Taking into consideration the indicators of nuclear morphometry (nuclear area, diameter and perimeter) different types of neoplasms can be differentiated: benign from malignant tumours and sarcomas from malignant epithelial neoplasms (tubular, tubulopapillary, cystic-papillary, colid, micropapillary, mucinous, lipid-rich and spindle cell carcinomas).

scholarly journals The Bethesda system for reporting thyroid cytology: a prospective study in a tertiary care institute along with review of literature

2020 ◽  
Vol 8 (10) ◽  
pp. 3670
Author(s):  
Avni Bhatnagar ◽  
Kavita Mardi ◽  
Shivani Sood ◽  
Vijay Kaushal ◽  
Kanishk Gupta
Keyword(s):  
Tertiary Care ◽  
Follicular Neoplasm ◽  
Histopathological Diagnosis ◽  
Predictive Values ◽  
Malignancy Risk ◽  
Thyroid Cytology ◽  
Management Protocol ◽  
Bethesda System ◽  
The Bethesda System ◽  
Undetermined Significance

Background: The Bethesda system for reporting thyroid cytology (TSBRTC) was devised by the National Cancer Institute (NCI) to obtain uniformity, reproducibility and a defined management protocol while dealing with thyroid lesions. This study was undertaken with the aim to see the benefits of adopting TBSRTC in the diagnosis of thyroid FNAC, and identify the malignancy risk of each category.Methods: This cross-sectional study was conducted in Indira Gandhi Medical College, Shimla, Himachal Pradesh from June 2016 to July 2017 on 181 thyroid FNACs which were reported according to the Bethesda system for reporting thyroid cytopathology (TBSRTC) under six categories: (I) non-diagnostic/unsatisfactory (II) benign (III) atypia of undetermined significance/follicular lesion of undetermined significance (IV) follicular neoplasm/suspicious for follicular neoplasm (specify if Hurthle cell (oncocytic) type (V) suspicious for malignancy (VI) malignant. Histopathological diagnosis was available for 65 cases where thyroidectomy was performed. Malignancy risk was calculated for each category. Sensitivity, specificity, positive and negative predictive values for TBSRCT were also calculated. All the data was analyzed in SPSS software version 22.0 (IBM, USA).Results: Benign lesions constituted the major bulk. After the use of TBSRTC, there was increased ability to look for follicular neoplasms, improvement in making definitive diagnosis of the cases, an improvement in diagnostic accuracy, and we were in line with the implied risk outlined by TBSRTC in most of the cases.Conclusions: Application of TBSRTC results in uniformity in reporting among pathologists and better interdisciplinary communication and patient management.

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