scholarly journals Performance of Spectral Photon-Counting Coronary CT Angiography and Comparison with Energy-Integrating-Detector CT: Objective Assessment with Model Observer

Diagnostics ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 2376
Author(s):  
David C. Rotzinger ◽  
Damien Racine ◽  
Fabio Becce ◽  
Elias Lahoud ◽  
Klaus Erhard ◽  
...  
Keyword(s):  
Spatial Resolution ◽  
Transfer Functions ◽  
Objective Assessment ◽  
Photon Counting ◽  
Atherosclerotic Plaques ◽  
Noise Power ◽  
Filter Model ◽  
Model Observer ◽  
Lower Noise

Aims: To evaluate spectral photon-counting CT’s (SPCCT) objective image quality characteristics in vitro, compared with standard-of-care energy-integrating-detector (EID) CT. Methods: We scanned a thorax phantom with a coronary artery module at 10 mGy on a prototype SPCCT and a clinical dual-layer EID-CT under various conditions of simulated patient size (small, medium, and large). We used filtered back-projection with a soft-tissue kernel. We assessed noise and contrast-dependent spatial resolution with noise power spectra (NPS) and target transfer functions (TTF), respectively. Detectability indices (d’) of simulated non-calcified and lipid-rich atherosclerotic plaques were computed using the non-pre-whitening with eye filter model observer. Results: SPCCT provided lower noise magnitude (9–38% lower NPS amplitude) and higher noise frequency peaks (sharper noise texture). Furthermore, SPCCT provided consistently higher spatial resolution (30–33% better TTF10). In the detectability analysis, SPCCT outperformed EID-CT in all investigated conditions, providing superior d’. SPCCT reached almost perfect detectability (AUC ≈ 95%) for simulated 0.5-mm-thick non-calcified plaques (for large-sized patients), whereas EID-CT had lower d’ (AUC ≈ 75%). For lipid-rich atherosclerotic plaques, SPCCT achieved 85% AUC vs. 77.5% with EID-CT. Conclusions: SPCCT outperformed EID-CT in detecting simulated coronary atherosclerosis and might enhance diagnostic accuracy by providing lower noise magnitude, markedly improved spatial resolution, and superior lipid core detectability.

Atherosclerotic Plaques: Classification and Characterization with T2-weighted High-Spatial-Resolution MR Imaging—An in Vitro Study

Radiology ◽  
2001 ◽  
Vol 219 (2) ◽  
pp. 403-410 ◽  
Author(s):  
Jean-Michel Serfaty ◽  
Linda Chaabane ◽  
André Tabib ◽  
Jean-Michel Chevallier ◽  
André Briguet ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Spatial Resolution ◽  
High Spatial Resolution ◽  
In Vitro Study ◽  
Vitro Study ◽  
Atherosclerotic Plaques

The Anticoagulant Effect of Heparinoid Org 10172 During Haemodialysis: An Objective Assessment

1986 ◽  
Vol 55 (02) ◽  
pp. 271-275 ◽  
Author(s):  
Helen Ireland ◽  
D A Lane ◽  
Angela Flynn ◽  
E Anastassiades ◽  
J R Curtis
Keyword(s):  
Renal Failure ◽  
Bolus Dose ◽  
Bolus Injection ◽  
Objective Assessment ◽  
Factor Xa ◽  
Fibrin Clot ◽  
Natural Origin ◽  
Fibrin Formation ◽  
Single Bolus Injection

SummaryThe heparinoid of natural origin Org 10172 has anti-factor Xa activity but minimal anti-thrombin activity, and little effect upon broad spectrum assays such as the KCCT in vitro. Its anticoagulant effects have been compared to those of commercial heparin in 7 patients undergoing haemodialysis for chronic renal failure. Commercial heparin was administered in a dose (5,000 iu bolus + 1,500 iu/hour continuous iv infusion) previously shown to inhibit fibrin formation during haemodialysis. This produced mean anti-factor Xa levels in plasma between 0.7-1.0 iu/ml and largely suppressed fibrin formation for 5 h dialysis measured as mean FPA levels in plasma. Administration of Org 10172 as a bolus of 1,350 anti-factor Xa u or 2,000-2,400 anti-factor Xa u produced plasma anti-factor Xa levels of less than 0.5 u/ml and allowed fibrin clot and FPA generation during dialysis. Org 10172 administered as a bolus dose of 4,000-4,800 anti-factor Xa u produced mean anti-factor Xa levels of greater than 0.5 u/ml, allowed dialysis of 6 patients for 5 h and appreciably suppressed FPA generation during dialysis, with little effect on the KCCT.It is concluded that the anti-factor Xa activity of Org 10172 may reflect its ability to inhibit fibrin during dialysis and that single bolus injection of Org 10172 may be a useful alternative method of achieving anticoagulation.

scholarly journals Functional optical coherence tomography of retinal photoreceptors

2018 ◽  
Vol 243 (17-18) ◽  
pp. 1256-1264 ◽  
Author(s):  
Xincheng Yao ◽  
Taeyoon Son ◽  
Tae-Hoon Kim ◽  
Yiming Lu
Keyword(s):  
Vision Loss ◽  
Objective Assessment ◽  
Age Related Macular Degeneration ◽  
Retinal Stimulation ◽  
Age Related ◽  
Retinal Photoreceptors ◽  
Severe Vision Loss ◽  
Further Development

Age-related macular degeneration (AMD) is the leading cause of severe vision loss and legal blindness. It is known that retinal photoreceptors are the primary target of AMD. Therefore, a reliable method for objective assessment of photoreceptor function is needed for early detection and reliable treatment evaluation of AMD and other eye diseases such as retinitis pigmentosa that are known to cause photoreceptor dysfunctions. Stimulus-evoked intrinsic optical signal (IOS) changes promise a unique opportunity for objective assessment of physiological function of retinal photoreceptor and inner neurons. Instead of a comprehensive review, this mini-review is to provide a brief summary of our recent in vitro and in vivo optical coherence tomography (OCT) studies of stimulus-evoked IOS changes in animal retinas. By providing excellent axial resolution to differentiate individual retinal layers, depth-resolved OCT revealed rapid IOS response at the photoreceptor outer segment. The fast photoreceptor-IOS occurred almost right away (∼ 2 ms) after the onset of retinal stimulation, differentiating itself from slow IOS changes correlated with inner neural and hemodynamic changes. Further development of the functional IOS instruments and retinal stimulation protocols may provide a feasible solution to pursue clinical application of functional IOS imaging for objective assessment of human photoreceptors. Impact statement Retinal photoreceptors are the primary target of age-related macular degeneration (AMD) which is the leading cause of severe vision loss and legal blindness. An objective method for functional assessment of photoreceptor physiology can benefit early detection and better treatment evaluation of AMD and other eye diseases that are known to cause photoreceptor dysfunctions. This article summarizes in vitro study of IOS mechanisms and in vivo demonstration of IOS imaging of intact animals. Further development of the functional IOS imaging may provide a revolutionary solution to achieve objective assessment of human photoreceptors.

Silencing of junctional adhesion molecule-like protein attenuates atherogenesis and enhances plaque stability in ApoE−/− mice

2019 ◽  
Vol 133 (11) ◽  
pp. 1215-1228 ◽  
Author(s):  
Yu Sun ◽  
Juan Guan ◽  
Yunfeng Hou ◽  
Fei Xue ◽  
Wei Huang ◽  
...  
Keyword(s):  
Adhesion Molecule ◽  
Wound Repair ◽  
Inflammatory Responses ◽  
Atherosclerotic Lesion ◽  
Atherosclerotic Plaques ◽  
Plaque Stability ◽  
Fibrous Cap ◽  
Enhanced Expression

Abstract Background: Although junctional adhesion molecule-like protein (JAML) has recently been implicated in leukocyte recruitment during inflammation and wound repair, its role in atherosclerosis remains to be elucidated. Methods and results: First, we showed that JAML was strongly expressed in atherosclerotic plaques of cardiovascular patients. Similar results were obtained with atherosclerotic plaques of ApoE−/− mice. Co-immunofluorescence staining showed that JAML was mainly expressed in macrophages. Enhanced expression of JAML in cultured macrophages was observed following exposure of the cells to oxLDL. The functional role of JAML in atherosclerosis and macrophages function was assessed by interference of JAML with shRNA in vivo and siRNA in vitro. Silencing of JAML in mice significantly attenuated atherosclerotic lesion formation, reduced necrotic core area, increased plaque fibrous cap thickness, decreased macrophages content and inflammation. In addition, histological staining showed that JAML deficiency promoted plaques to stable phenotype. In vitro, JAML siRNA treatment lowered the expression of inflammatory cytokines in macrophages treated with oxLDL. The mechanism by which JAML mediated the inflammatory responses may be related to the ERK/NF-κB activation. Conclusions: Our results demonstrated that therapeutic drugs which antagonize the function of JAML may be a potentially effective approach to attenuate atherogenesis and enhance plaque stability.

scholarly journals Impact of climate change on hydropower production in the Upper Danube

2021 ◽  
Author(s):  
Ignacio Martin Santos ◽  
Mathew Herrnegger ◽  
Hubert Holzmann
Keyword(s):  
Climate Change ◽  
Spatial Resolution ◽  
Transfer Functions ◽  
Danube River ◽  
Emission Scenarios ◽  
Hydropower Generation ◽  
Climate Change Projections ◽  
Impact Of Climate Change ◽  
The Future ◽  
The Impact

<p>In the last two decades, different climate downscaling initiatives provided climate scenarios for Europe. The most recent initiative, CORDEX, provides Regional Climate Model (RCM) data for Europe with a spatial resolution of 12.5 km, while the previous initiative, ENSEMBLES, had a spatial resolution of 25 km. They are based on different emission scenarios, Representative Concentration Pathways (RCPs) and Special Report on Emission Scenarios (SRES) respectively.</p><p>A study carried out by Stanzel et al. (2018) explored the hydrological impact and discharge projections for the Danube basin upstream of Vienna when using either CORDEX and ENSEMBLES data. This basin covers an area of 101.810<sup></sup>km<sup>2</sup> with a mean annual discharge of 1923 m<sup>3</sup>/s at the basin outlet. The basin is dominated by the Alps, large gradients and is characterized by high annual precipitations sums which provides valuable water resources available along the basin. Hydropower therefore plays an important role and accounts for more than half of the installed power generating capacity for this area. The estimation of hydropower generation under climate change is an important task for planning the future electricity supply, also considering the on-going EU efforts and the “Green Deal” initiative.</p><p>Taking as input the results from Stanzel et al. (2018), we use transfer functions derived from historical discharge and hydropower generation data, to estimate potential changes for the future. The impact of climate change projections of ENSEMBLE and CORDEX in respect to hydropower generation for each basin within the study area is determined. In addition, an assessment of the impact on basins dominated by runoff river plants versus basins dominated by storage plants is considered.</p><p>The good correlation between discharge and hydropower generation found in the historical data suggests that discharge projection characteristics directly affect the future expected hydropower generation. Large uncertainties exist and stem from the ensembles of climate runs, but also from the potential operation modes of the (storage) hydropower plants in the future.</p><p> </p><p> </p><p>References:</p><p>Stanzel, P., Kling, H., 2018. From ENSEMBLES to CORDEX: Evolving climate change projections for Upper Danube River flow. J. Hydrol. 563, 987–999. https://doi.org/10.1016/j.jhydrol.2018.06.057</p><p> </p>

Evaluation and comparison of a CdTe based photon counting detector with an energy integrating detector for X-ray phase sensitive imaging of breast cancer

2021 ◽  
pp. 1-13
Author(s):  
Muhammad U. Ghani ◽  
Farid H. Omoumi ◽  
Xizeng Wu ◽  
Laurie L. Fajardo ◽  
Bin Zheng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Spatial Resolution ◽  
Standard Dose ◽  
Photon Counting ◽  
High Energy ◽  
Edge Enhancement ◽  
X Ray ◽  
Photon Counting Detector ◽  
Phase Sensitive ◽  
Observer Studies

PURPOSE: To compare imaging performance of a cadmium telluride (CdTe) based photon counting detector (PCD) with a CMOS based energy integrating detector (EID) for potential phase sensitive imaging of breast cancer. METHODS: A high energy inline phase sensitive imaging prototype consisting of a microfocus X-ray source with geometric magnification of 2 was employed. The pixel pitch of the PCD was 55μm, while 50μm for EID. The spatial resolution was quantitatively and qualitatively assessed through modulation transfer function (MTF) and bar pattern images. The edge enhancement visibility was assessed by measuring edge enhancement index (EEI) using the acrylic edge acquired images. A contrast detail (CD) phantom was utilized to compare detectability of simulated tumors, while an American College of Radiology (ACR) accredited phantom for mammography was used to compare detection of simulated calcification clusters. A custom-built phantom was employed to compare detection of fibrous structures. The PCD images were acquired at equal, and 30% less mean glandular dose (MGD) levels as of EID images. Observer studies along with contrast to noise ratio (CNR) and signal to noise ratio (SNR) analyses were performed for comparison of two detection systems. RESULTS: MTF curves and bar pattern images revealed an improvement of about 40% in the cutoff resolution with the PCD. The excellent spatial resolution offered by PCD system complemented superior detection of the diffraction fringes at boundaries of the acrylic edge and resulted in an EEI value of 3.64 as compared to 1.44 produced with EID image. At MGD levels (standard dose), observer studies along with CNR and SNR analyses revealed a substantial improvement of PCD acquired images in detection of simulated tumors, calcification clusters, and fibrous structures. At 30% less MGD, PCD images preserved image quality to yield equivalent (slightly better) detection as compared to the standard dose EID images. CONCLUSION: CdTe-based PCDs are technically feasible to image breast abnormalities (low/high contrast structures) at low radiation dose levels using the high energy inline phase sensitive imaging technique.

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