scholarly journals Basaloid Follicular Hamartoma of the Eyelid: A Case Report and Literature Review about an Unusual Lesion in the Ocular Region

Diagnostics ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. 140
Author(s):  
Nuno Jorge Lamas ◽  
Ana Patrícia Rodrigues ◽  
Maria Araújo ◽  
José Ramón Vizcaíno ◽  
André Coelho
Keyword(s):  
Previous History ◽  
Surgical Excision ◽  
Disease Recurrence ◽  
Hair Follicles ◽  
Desmoid Tumour ◽  
Adenomatous Polyposis ◽  
Malignant Tumours ◽  
History Of ◽  
Mitotic Figures ◽  
One Year

Basaloid follicular hamartoma (BFH) is a normally benign, uncommon, malformative lesion involving the hair follicles, which usually poses challenges in the differential diagnosis with other benign and malignant tumours, especially basal cell carcinoma, due to significant clinical and morphological overlap. Here, we report the case of a 53-year-old male who presented with a mass in the upper left eyelid evolving for one year. The patient had a previous history of total colectomy and an abdominal desmoid tumour within the context of Familial Adenomatous Polyposis (FAP), with a documented germline mutation in the Adenomatous Polyposis Coli (APC) gene. The eyelid lesion was biopsied and the histological analysis of the three small tissue fragments received revealed fragments with cutaneous–conjunctival lining displaying a subepithelial proliferation of basaloid nests with peripheral palisading, compatible with primitive hair follicles. There were images of anastomosis between different basaloid nests, which had their connection to the epithelial lining preserved. The stroma had high cellularity and sometimes primitive mesenchymal papillae were evident. Pleomorphism was absent, mitotic figures were barely identified, and no necrosis was seen. The basaloid nests did not have epithelial–stromal retraction nor mucin deposits. A diagnosis of BFH was proposed, which was later confirmed after surgical excision of the whole eyelid lesion. No evidence of carcinoma was present. This case illustrates the main features of the rare benign eyelid BFH. The standard medical or surgical approach of these lesions remains to be firmly established. Nearly nine months after surgical excision our patient remains well without signs of disease recurrence.

scholarly journals Ameloblastic Fibrosarcoma of the Mandible: A Case Report and Brief Review of the Literature

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Abelardo Loya-Solis ◽  
Karla Judith González-Colunga ◽  
Cynthia M. Pérez-Rodríguez ◽  
Natalie Sofía Ramírez-Ochoa ◽  
Luis Ceceñas-Falcón ◽  
...  
Keyword(s):  
Histopathological Examination ◽  
Surgical Excision ◽  
Second Molar ◽  
Odontogenic Epithelium ◽  
Left Mandible ◽  
Long Term Follow Up ◽  
History Of ◽  
Ameloblastic Fibrosarcoma ◽  
Mitotic Figures ◽  
One Year

Ameloblastic fibrosarcoma is an uncommon odontogenic tumor composed of a benign epithelial component and a malignant ectomesenchymal component most frequently seen in the third and fourth decades of life. It mainly presents as a painful maxillary or mandibular swelling. Radiographs show a radiolucent mass with ill-defined borders. Radical surgical excision and long-term follow-up are the suggested treatment. We report the case of a 22-year-old female with a 2-month history of an asymptomatic swelling in her left mandible. Examination revealed an exophytic growth measuring3×3 cm extending from the mandibular left first premolar to the second molar. The patient underwent a left hemimandibular resection. Histopathological examination revealed a biphasic tumor composed of inconspicuous islands of benign odontogenic epithelium and an abundant malignant mesenchymal component with marked cellularity, nuclear pleomorphism, hyperchromatism, and moderate mitotic figures with clear margins; one year after the surgical procedure, the patient is clinically and radiologically disease-free.

Correlation of abnormal upper tract cytology and tumor histology in patients who have undergone a nephroureterectomy for urothelial carcinoma with disease recurrence in the bladder.

2013 ◽  
Vol 31 (6_suppl) ◽  
pp. 288-288
Author(s):  
Einar Freyr Sverrisson ◽  
Timothy Kim ◽  
Patrick Espiritu ◽  
Wade Jeffers Sexton ◽  
Julio Pow-Sang ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Previous History ◽  
Tumor Grade ◽  
Disease Recurrence ◽  
Intravesical Therapy ◽  
Prior History ◽  
Upper Tract ◽  
History Of ◽  
One Year ◽  
Bladder Recurrence

288 Background: 15-50% of patients with upper tract urothelial carcinomas (UTUC) will have a bladder recurrence. Abnormal upper tract cytology (UTC) is an indicator of higher grade tumors but has not been associated with bladder recurrence. We were interested in investigating the role of UTC as a predictor of bladder cancer recurrences in patients with no prior history of bladder cancer presenting with UTUC. Methods: Of 67 patients who had an UTC collected prior to their nephroureterectomy (NU) in 2004-2012, we identified 17 patients with a recurrent disease in the bladder who met the criteria of having no previous history of bladder cancer at the time of their NU. UTC and histology were reviewed and analyzed with the bladder pathology data. Positive or suspicious cytology was defined as abnormal and atypical or reactive as benign. Results: 15 (88%) of 17 patients (11 men and 6 women) who met our criteria were diagnosed with bladder cancer within one year after their NU (average 7.5 months (range 2-26)). 10 (59%) of 17 patients had abnormal UTC with a calculated sensitivity and specificity of 59% and 22%, respectively. 7 (70%) of 10 patients with abnormal UTC compared to 5 (71%) of 7 patients with benign cytology had high grade (HG) bladder cancer (p=1.0). Muscle invasive tumors were found in 5 (29%) of 17 patients and 3 (60%) of those had abnormal UTC. All six women had HG bladder cancer compared to 6 of 10 men (p=0.23). HG tumors were slightly more common in the bladder compared to the upper tract (75% vs 65%, p=0.70) and 14 (87.5%) of 16 bladder tumors had the same tumor grade in the upper tract. Conclusions: Abnormal UTC is a poor predictor of bladder recurrence in patients with a history of UTUC. The majority of patients who developed bladder recurrence presented within one year from NU with HG disease which underscores the importance of aggressive surveillance and the consideration of prophylactic intravesical therapy at the time of NU in this patient cohort.

SURGICAL MANAGEMENT OF PAINFUL OS SUBFIBULARE: A CASE REPORT

2020 ◽  
Vol 23 (01) ◽  
pp. 2072002
Author(s):  
Kunal A. Shah ◽  
Ajay C. Shah
Keyword(s):  
Ligament Reconstruction ◽  
Ankle Instability ◽  
Previous History ◽  
Rare Condition ◽  
Surgical Excision ◽  
Ossification Center ◽  
Anterior Talofibular Ligament ◽  
Ankle Pain ◽  
Avulsion Fractures ◽  
History Of

Separated ossicle at the tip of lateral malleolus, a rare condition called os subfibulare, sometimes is a cause of ankle pain. There are two theories regarding the origin of os subfibulare. One theory proposes that it is caused by an avulsion fracture attributable to pull of the anterior talofibular ligament, whereas the other theory proposes that it is the result of an accessory ossification center. Accessory bones may be stable or may sustain injuries and become avulsed. Most cases have described the surgical treatment of avulsion fractures with excision of the fragment and anterior talofibular ligament reconstruction. We describe a rare case of a symptomatic Os subfibulare caused by an accessory ossification center in a 27-year-old female with no previous history of trauma. Surgical excision was done without ligament reconstruction and the symptoms resolved completely after the surgery and there was no residual ankle instability.

scholarly journals Primary Malignant Tumours of Bone Following Previous Malignancy

Sarcoma ◽  
2008 ◽  
Vol 2008 ◽  
pp. 1-4 ◽  
Author(s):  
J. T. Patton ◽  
S. M. M. Sommerville ◽  
R. J. Grimer
Keyword(s):  
Bone Lesion ◽  
Previous History ◽  
Previous Treatment ◽  
Bone Lesions ◽  
Limb Salvage Surgery ◽  
Second Malignancies ◽  
Malignant Tumours ◽  
Primary Malignancy ◽  
History Of ◽  
Bone Sarcomas

Destructive bone lesions occurring in patients who have previously had a malignancy are generally assumed to be a metastasis from that malignancy. We reviewed 60 patients with a previous history of malignancy, who presented with a solitary bone lesion that was subsequently found to be a new and different primary sarcoma of bone. These second malignancies occurred in three distinct groups of patients: (1) patients with original tumours well known to be associated with second malignancies (5%); (2) patients whose second malignancies were likely to be due to the previous treatment of their primary malignancy (40%); (3) patients in whom there was no clearly defined association between malignancies (55%). The purpose of this study is to emphasise the necessity for caution in assuming the diagnosis of a metastasis when a solitary bone lesion is identified following a prior malignancy. Inappropriate biopsy and treatment of primary bone sarcomas compromises limb salvage surgery and can affect patient mortality.

scholarly journals The Effects of Ankle Sprain on Balance Tests in Adolescent Volleyball Players with Previous History of Ankle Sprain

2014 ◽  
Vol 2 (11_suppl3) ◽  
pp. 2325967114S0018
Author(s):  
Ceyda Sarıal ◽  
Abdulhamıt Tayfur ◽  
Beyza Kap ◽  
Dılara Donder ◽  
Ozum Melıs Ertuzun ◽  
...  
Keyword(s):  
Ankle Sprain ◽  
Previous History ◽  
Control Group ◽  
Balance Test ◽  
Balance Tests ◽  
Volleyball Players ◽  
History Of ◽  
One Year ◽  
The Right ◽  
The Impact

Objectives: To investigate the impact of having previous history of inversion ankle sprain on balance tests in adolescent volleyball players. Methods: Fourty-five adolescent volleyball players with mean age of 15.26±1.03 participated in our study. Twenty-nine were uninjured (control group) and sixteen had previously experienced inversion injuries on right ankle. 9 players had the injury more than than one year ago and 7 players had it before six to twelf months. Balancing abilities were evaluated by Star Excursion Balance Test (SEBT) and Single Limb Hurdle Test (SLHT). The fact that players with history of injury had the ankle sprain at right foot led us to perform the measurements in the control group also for the right foot. We compared the results of injured and uninjured players on both tests. Results: Uninjured players' reaching distance on right foot was found out to be significantly more than in players with ankle sprain at medial and posteromedial directions of SEBT(p<.05), whereas there were no differences detected for the other directions (p>.05). For comparing athletes' performances with SLHT, finishing time was found significantly better in uninjured players (p<.05). Conclusion: Adolescent volleyball players with history of injury show lower performance on balance tests compared to uninjured players. This demonstrates that they should be given a training including balance and stabilization programs.

Never-smoking women with lung cancer from the Spanish WORLD07 database.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 1531-1531 ◽  
Author(s):  
Dolores Isla ◽  
Mariano Provencio ◽  
Margarita Majem ◽  
Enriqueta Felip ◽  
Nuria Vinolas ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Contraceptive Use ◽  
Previous History ◽  
Stage Iv ◽  
Egfr Mutations ◽  
Malignant Tumours ◽  
Treatment Data ◽  
History Of ◽  
Egfr Tki ◽  
History Of Cancer

1531 Background: Gender differences in lung cancer (LC) have been reported, but with many unresolved issues yet. Tobacco causes the majority of women lung cancer (WLC), although the rate of never-smoking WLC is higher than in men. Several factors may play etiologic roles, and an in-depth understanding is needed. Methods: WORLD07 is a Spanish prospective, multicenter, epidemiologic female-specific LC database sponsored by ICAPEM, a professional association committed with WLC research. In order to improve the knowledge on never-smoking WLC, information has been extracted from WORLD07 database. Results: From October/2007 to October/2011, 1371 newly diagnosed WLC were included in an e-database from 32 centers, 539 (39.3%) never-smoking. Patient (p) characteristics: median age 71.1 years(y); median age of menarche 13y.; motherhood 91.2% (median 2.3 children, median age at first child 26.4y); oral contraceptive use 11.9%; postmenopausal 88.9% (median age of menopause 49y); HRT 5.2%; second-hand smokers 40% (work-exposure 17.1%, home-exposure 88.8%); obesity 16.3%; familiar history of cancer 39.9% (LC 29.8%); previous history of cancer 13% (breast/lung/cervix: 41.4/5.7/2.9%); current LC histology(%): adenocarcinoma/SqCC/LCC/SCLC: 83.4/6.2/5.5/3.9; EGFR mut+ (268 p analyzed): 55.5% (exon 19/20/21(%): 61.1/7.4/36.9); TNM NSCLC I/II/III/IV(%): 14/3.3/19.8/60.3. Treatment: EGFR-TKI in p EGFR mut+, stage IV(1st-/2nd-line)(%): 51.7/15.4; stage IV NSCLC (1st-line/2nd-line): platinum-based CT 42.5%, EGFR-TKI 33.5%, combinations with bevacizumab 2.9% / EGFR-TKI 15.8%. Overall survival: median 27 months(m), 1/2-y(%) 74.8/55.2; stage IV NSCLC: median 20.5m, 1/2-y(%) 67/46; EGFR-mut+ p: median 27.3m, 1/2-y(%) 75/54.3. Conclusions: According to our e-database, WLC showed high rates of never-smokers (39.3%), and of relatives diagnosed with malignant tumours (39.9%, ≅1/3 LC). Adenocarcinoma was the most frequent histology (76.1%), and more than half of the cases analyzed harboured EGFR mutations. Although 40% were second-hand smokers, further investigations are warranted. Survival outcomes remain satisfactory, as expected from this selected subgroup of p. Additional epidemiologic and treatment data will be presented.

Isolated extramedullary plasmacytoma of the true vocal fold

2000 ◽  
Vol 114 (7) ◽  
pp. 540-542 ◽  
Author(s):  
Yoseph Rakover ◽  
Michael Bennett ◽  
Rephael David ◽  
Gabriel Rosen
Keyword(s):  
Vocal Fold ◽  
Plasma Cells ◽  
Surgical Excision ◽  
Extramedullary Plasmacytoma ◽  
Light Chains ◽  
History Of ◽  
Kappa Light Chains ◽  
One Year ◽  
The Right ◽  
Local Surgical Excision

We report a rare case of isolated extramedullary plasmacytoma (EMP) of the right true vocal fold in a 38-year-old male with a one-year history of hoarseness. Immunohistochemical staining of plasma cells in the tumour, showed over 90 per cent of them to be positive for kappa light chains. After two attempts at local surgical excision and recurrence within 10 months, the tumour was irradiated.Only seven reported cases of isolated EMP of the true vocal fold are reported in the literature. The therapeutic options are discussed.

Successful treatment of disseminated granulomatous aspergillosis in an apparently immunocompetent host

2020 ◽  
Vol 50 (4) ◽  
pp. 346-349 ◽  
Author(s):  
Umang Agrawal ◽  
Pratik Savaj ◽  
Kanishka Davda ◽  
Rajeev Soman ◽  
Anjali Shetty ◽  
...  
Keyword(s):  
Granulomatous Inflammation ◽  
Surgical Excision ◽  
Immunocompetent Host ◽  
Short History ◽  
Normal Individuals ◽  
History Of ◽  
One Year ◽  
Work Up ◽  
The Brain

A young Indian man presented elsewhere with a short history of haematuria and cough. Investigations revealed renal and pulmonary lesions. Histopathology of these lesions was reported as mucormycosis. He consulted us two months after onset of symptoms, asymptomatic and clinically well, having received no treatment. In view of clinico-histopathological discordance, a review of the biopsy slides was advised but the patient refused further work-up at that time. One week later, however, he was admitted with left hemiparesis. Brain imaging showed an abscess. He underwent surgical excision of the brain abscess and nephrectomy. Review of previous slides showed septate fungal filaments with granulomatous inflammation. Intraoperative cultures grew Aspergillus flavus. He received voriconazole for one year and is well at his two-year follow-up. His immunological work-up was negative for immunodeficiency. This case illustrates that granulomatous aspergillosis may be an indolent infection in apparently normal individuals and reiterates the importance of interpreting diagnostic reports in conjunction with clinical features.

Tuberculosis of the parotid gland

1998 ◽  
Vol 112 (6) ◽  
pp. 588-591 ◽  
Author(s):  
Yusufhan Süoǧlu ◽  
Burak Erdamar ◽  
İsmail Çölhan ◽  
O. Sami Katircioǧlu ◽  
Uǧur Çevikbas
Keyword(s):  
Lymph Node ◽  
Parotid Gland ◽  
Previous History ◽  
Lymph Node Involvement ◽  
Diagnostic Tools ◽  
Superficial Parotidectomy ◽  
Parotid Neoplasm ◽  
Node Involvement ◽  
History Of ◽  
One Year

AbstractThe presentation of tuberculosis as an isolated parotid lump is rare. In this paper, six cases with tuberculous parotitis are reported which were evaluated as a benign parotid neoplasm in 216 specimens pre-operatively. All but one of them had no previous history of tuberculosis and all had a parotid lump as a sole symptom for at least one year. The diagnosis of tuberculosis was made, after superficial parotidectomy, by histopathology. Parenchymal involvement and intraparotid lymph node involvement with tuberculosis were seen in five and three patients, respectively. Two of the patients had lymph node involvement outside the parotid area. One of six patients had a coincidental Warthin tumour. A surgical approach is not only therapeutic but also diagnostic when other diagnostic tools fail.

scholarly journals Surgical excision of a residual cyst in a patient with previous history of jaw osteonecrosis associated with oral bisphosphonate: A case report

2015 ◽  
Vol 21 (3) ◽  
pp. 191
Author(s):  
Ana Carolina Uchoa Vasconcelos ◽  
Wâneza Dias Borges ◽  
Cláiton Heitz ◽  
Fernanda Gonçalves Salum ◽  
Maria Antonio Zancanaro de Figueiredo ◽  
...  
Keyword(s):  
Case Report ◽  
Surgical Treatment ◽  
Previous History ◽  
Surgical Excision ◽  
Osteonecrosis Of The Jaws ◽  
Oral Bisphosphonate ◽  
Prevention And Treatment ◽  
History Of ◽  
Preoperative Procedures ◽  
Jaw Osteonecrosis

Residual cyst is an inflammatory odontogenic cyst resultant from pulp necrosis, where the tooth has already been removed. Bisphosphonates are drugs used in the prevention and treatment of bone metabolism diseases with intense resorption activity, and they have been associated with osteonecrosis of the jaws, an important side effect. The aim of this study was to report a successful surgical treatment of a residual cyst in a patient who had previously developed jaw osteonecrosis associated with sodium alendronate use. We emphasize here the importance of safe preoperative procedures when approaching these patients. 

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