scholarly journals Primary Malignant Tumours of Bone Following Previous Malignancy

Sarcoma ◽  
2008 ◽  
Vol 2008 ◽  
pp. 1-4 ◽  
Author(s):  
J. T. Patton ◽  
S. M. M. Sommerville ◽  
R. J. Grimer
Keyword(s):  
Bone Lesion ◽  
Previous History ◽  
Previous Treatment ◽  
Bone Lesions ◽  
Limb Salvage Surgery ◽  
Second Malignancies ◽  
Malignant Tumours ◽  
Primary Malignancy ◽  
History Of ◽  
Bone Sarcomas

Destructive bone lesions occurring in patients who have previously had a malignancy are generally assumed to be a metastasis from that malignancy. We reviewed 60 patients with a previous history of malignancy, who presented with a solitary bone lesion that was subsequently found to be a new and different primary sarcoma of bone. These second malignancies occurred in three distinct groups of patients: (1) patients with original tumours well known to be associated with second malignancies (5%); (2) patients whose second malignancies were likely to be due to the previous treatment of their primary malignancy (40%); (3) patients in whom there was no clearly defined association between malignancies (55%). The purpose of this study is to emphasise the necessity for caution in assuming the diagnosis of a metastasis when a solitary bone lesion is identified following a prior malignancy. Inappropriate biopsy and treatment of primary bone sarcomas compromises limb salvage surgery and can affect patient mortality.

Never-smoking women with lung cancer from the Spanish WORLD07 database.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 1531-1531 ◽  
Author(s):  
Dolores Isla ◽  
Mariano Provencio ◽  
Margarita Majem ◽  
Enriqueta Felip ◽  
Nuria Vinolas ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Contraceptive Use ◽  
Previous History ◽  
Stage Iv ◽  
Egfr Mutations ◽  
Malignant Tumours ◽  
Treatment Data ◽  
History Of ◽  
Egfr Tki ◽  
History Of Cancer

1531 Background: Gender differences in lung cancer (LC) have been reported, but with many unresolved issues yet. Tobacco causes the majority of women lung cancer (WLC), although the rate of never-smoking WLC is higher than in men. Several factors may play etiologic roles, and an in-depth understanding is needed. Methods: WORLD07 is a Spanish prospective, multicenter, epidemiologic female-specific LC database sponsored by ICAPEM, a professional association committed with WLC research. In order to improve the knowledge on never-smoking WLC, information has been extracted from WORLD07 database. Results: From October/2007 to October/2011, 1371 newly diagnosed WLC were included in an e-database from 32 centers, 539 (39.3%) never-smoking. Patient (p) characteristics: median age 71.1 years(y); median age of menarche 13y.; motherhood 91.2% (median 2.3 children, median age at first child 26.4y); oral contraceptive use 11.9%; postmenopausal 88.9% (median age of menopause 49y); HRT 5.2%; second-hand smokers 40% (work-exposure 17.1%, home-exposure 88.8%); obesity 16.3%; familiar history of cancer 39.9% (LC 29.8%); previous history of cancer 13% (breast/lung/cervix: 41.4/5.7/2.9%); current LC histology(%): adenocarcinoma/SqCC/LCC/SCLC: 83.4/6.2/5.5/3.9; EGFR mut+ (268 p analyzed): 55.5% (exon 19/20/21(%): 61.1/7.4/36.9); TNM NSCLC I/II/III/IV(%): 14/3.3/19.8/60.3. Treatment: EGFR-TKI in p EGFR mut+, stage IV(1st-/2nd-line)(%): 51.7/15.4; stage IV NSCLC (1st-line/2nd-line): platinum-based CT 42.5%, EGFR-TKI 33.5%, combinations with bevacizumab 2.9% / EGFR-TKI 15.8%. Overall survival: median 27 months(m), 1/2-y(%) 74.8/55.2; stage IV NSCLC: median 20.5m, 1/2-y(%) 67/46; EGFR-mut+ p: median 27.3m, 1/2-y(%) 75/54.3. Conclusions: According to our e-database, WLC showed high rates of never-smokers (39.3%), and of relatives diagnosed with malignant tumours (39.9%, ≅1/3 LC). Adenocarcinoma was the most frequent histology (76.1%), and more than half of the cases analyzed harboured EGFR mutations. Although 40% were second-hand smokers, further investigations are warranted. Survival outcomes remain satisfactory, as expected from this selected subgroup of p. Additional epidemiologic and treatment data will be presented.

scholarly journals Prevalence of Hyperthyroidism and its Impact on Quality of Life Among Students of the Islamia University of Bahawalpur Pakistan

2020 ◽  
Vol 8 (2) ◽  
pp. 85-90
Author(s):  
Shifa Shaffique ◽  
Haseeb Anwar ◽  
Hafiz Muhammad Asif ◽  
Imran ul Haq ◽  
Muhammad Akram
Keyword(s):  
Quality Of Life ◽  
Family History ◽  
Previous History ◽  
Previous Treatment ◽  
Population Based ◽  
Causative Factors ◽  
Associated Symptoms ◽  
History Of ◽  
Middle Class Families

Aim: Population based studies on prevalence of hyperthyroidism and its impact on quality of life, with variability of weight, height and distribution, their associated symptoms are limited. Knowledge and awareness about the prevalence of hyperthyroidism and their associated symptoms and its treatment option is necessary for the patient education and evaluation of underlying causative factors of this disease. Methodology: Apopulation-based study was conducted from October 2018 to May 2019 to determine the prevalence of hyperthyroidism and its impact on quality of life among the students of The Islamia University Bahawalpur. Questioner were developed and distributed among the consenting participants. Thirty-six males and one hundred and six females were included in this study. Results: Our study concluded that prevalence of hyperthyroidism is n=10(6.6%) and its prevalence ishigher in middle class families. Hyperthyroidism has a positive link with family history and previous history as shown in the results i.e. n=8 (5.3%) with family history and n=5 (3.3%) linked with previoushistory. It is the leading cause of morbidity and its prevalence is raised day by day. We studied that hyperthyroidism produces following effects on quality of life; n=10 (6.6%) participants were presented with loss of concentration in work / studies=10 (6.6%) with body ache, n=8 (5.3%) with social isolation, n=10 (6.6%) with mental health changes, n=6 (4%) with a history of previous treatment, n=8 (5.3%) with need of repeated checkups. Conclusion: It is concluded from present study that the hypehyperthyroidism significantly affects the quality of life and it is positively linked with the family history and history.

scholarly journals OCCURRENCE OF OBSTRUCTIVE AIRWAY DISEASE IN TREATED PATIENTS OF PULMONARY TUBERCULOSIS : A RETROSPECTIVE STUDY

2020 ◽  
pp. 1-2
Author(s):  
Shivprasad Kasat ◽  
Ashish Deshmukh ◽  
Sunil Jadhav ◽  
Hafiz Deshmukh ◽  
Ashish Kendre
Keyword(s):  
Pulmonary Tuberculosis ◽  
Previous History ◽  
Previous Treatment ◽  
Airway Disease ◽  
Clinical Findings ◽  
Obstructive Airway Disease ◽  
Medical College ◽  
Duration Of Illness ◽  
History Of ◽  
Obstructive Airway Diseases

Aim: To study occurence of obstructive airway disease in treated patients of pulmonary tuberculosis. Materials and methods: 50 patients data collected from Respiratory medicine department, MGM medical college, Aurangabad, who visited OPD for various respiratory symptoms. It is ensured that patients who are participated in the study are non smokers. Previous history of pulmonary tuberculosis and treatment history is noted. Evidences of previous treatment and radiological images were collected. Each patient was subjected to a thorough clinical examination and spirometry. Results: Based on clinical findings, radiological findings, and spirometry findings, of the 50 patients studied, it is observed that 11(22%) patients had developed obstructive airway disease.4 (8%) patients have developed extensive fibrosis post tuberculosis. 3 (6%) patients have developed cavitation with fibrosis. 4 (8%) patients have developed bronchiectasis. Conclusion: It is not uncommon that obstructive airway disease occurs as a complication of post tuberculosis sequale. 22 percent of the patients studied, have developed different types of obstructive airway diseases. Many factors may influence in post tuberculosis complications such as extensiveness of parenchymal involvement, duration of illness, socio-economic factors. Obstructive airway disease can be a sequel of pulmonary tuberculosis and should be overlooked, especially in those patients complaining of dyspnea even in the absence of any history of smoking. Post-tuberculous obstructive airway disease as a cause of COPD in nonsmokers should be now more recognized in countries where the prevalence of pulmonary tuberculosis is still high.

Diagnostic role of fine-needle aspiration of bone lesions in patients with a previous history of malignancy

2002 ◽  
Vol 26 (6) ◽  
pp. 380-383 ◽  
Author(s):  
Diana Treaba ◽  
Lina Assad ◽  
Hema Govil ◽  
Dinesh Sariya ◽  
Vijaya B. Reddy ◽  
...  
Keyword(s):  
Fine Needle Aspiration ◽  
Previous History ◽  
Needle Aspiration ◽  
Bone Lesions ◽  
Fine Needle ◽  
Diagnostic Role ◽  
History Of

scholarly journals Computed Tomograpy Venography diagnosis of iliocaval venous obstruction in advanced chronic venous insufficiency

2014 ◽  
Vol 13 (4) ◽  
pp. 306-311 ◽  
Author(s):  
Fabio Henrique Rossi ◽  
Carlos Alexandre Rosa Gama ◽  
Igor Yoshio Imagawa Fonseca ◽  
Keilyanne Jaira Ferreira Barros ◽  
Thiago Osawa Rodrigues ◽  
...  
Keyword(s):  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Medical History ◽  
Linear Trend ◽  
Previous History ◽  
Previous Treatment ◽  
Positive Association ◽  
Venous Hypertension ◽  
Venous Obstruction ◽  
History Of

Objective:Iliocaval obstruction is associated with venous hypertension symptoms and may predispose to deep venous thrombosis (DVT). Ultrasonography may fail to achieve noninvasive diagnosis of these obstructions. The possibility of using Computed Tomography Venography (CTV) for these diagnoses is under investigation.Methods:Patients with CVI graded at CEAP clinical classes 3 to 6 and previous treatment failure underwent evaluation with CTV. Percentage obstruction was rated by two independent examiners. Obstruction prevalence and its associations with risk factors and CEAP classification were analyzed.Results:A total of 112 limbs were prospectively evaluated. Mean patient age was 55.8 years and 75.4% were women. Obstructions involved the left lower limb in 71.8% of cases and 35.8% of patients reported a medical history of deep venous thrombosis. Overall, 57.1% of imaging studies demonstrated venous obstruction of at least 50% and 10.7% showed obstruction of >80%. The only risk factor that was found to be independently associated with a significantly higher incidence of >50% venous obstruction was a medical history of DVT (p=0.035) (Fisher's exact test). There was a positive relationship between clinical classification (CEAP) and degree of venous obstruction in the limbs studied (Chi-square test for linear trend; p=0.011).Conclusion:Patients with advanced CVI are often affected by obstructions in the iliocaval venous territory and CTV is able to diagnose the degree of obstruction. There is a positive association between degree of obstruction and both previous history of DVT and severity of symptoms of CVI.

scholarly journals A prospective observational study to evaluate a simple airway management algorithm in the austere environment using the McCoy laryngoscope

2020 ◽  
Author(s):  
Daniel Perin ◽  
Gustavo Inoue ◽  
Camila S. Campana ◽  
Maria J. C. Carmona
Keyword(s):  
General Anesthesia ◽  
Success Rate ◽  
Previous History ◽  
Mouth Opening ◽  
Previous Treatment ◽  
Daily Practice ◽  
Face Mask ◽  
Management Algorithm ◽  
History Of ◽  
Patient’S Outcome

Abstract Background Problems related to inadequate oxygen or ventilation remain an important issue regarding anesthesia care, representing more than 30% of primary airway complications in both North America and United Kingdom. Several guidelines have been proposed since the early 1990's. Although they have had important effects on patient's outcome and survival, it is difficult to identify the optimal guideline. This project prospectively evaluated the success rate of a simple intubation management algorithm with costless and low learning curve equipment.Methods this study included all adult patients (18 years or older) who underwent induction of elective general anesthesia performed by the researchers. A total of 293 patients were included. Their ASA physical status ranged from 1 to 4. After induction of general anesthesia and confirmation of adequate ventilation the algorithm was followed. If ventilation with face mask was impossible or oxygen saturation reached below 90%, the protocol was interrupted. The algorithm was centered on the use of McCoy laryngoscope, "backward, upward and right upward and rightward pressure" BURP maneuver and bougie. All patients were evaluated before the induction of anesthesia. The following characteristics were noted: age, sex, dental status (good, regular and poor, defined by the patients themselves), Mallampati index, personal history of apnea or snoring, mouth opening (mm), body mass index (m2/kg), cervical circumference (cm), previous history of difficult airway, thyromental distance and previous treatment with cervical radiation.Results all patients were successfully intubated following the algorithm.Conclusions this algorithm, centered on the use of McCoy laryngoscope, BURP maneuver and bougie, was able to be used successfully in patients of daily practice with a high success rate.

scholarly journals Basaloid Follicular Hamartoma of the Eyelid: A Case Report and Literature Review about an Unusual Lesion in the Ocular Region

Diagnostics ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. 140
Author(s):  
Nuno Jorge Lamas ◽  
Ana Patrícia Rodrigues ◽  
Maria Araújo ◽  
José Ramón Vizcaíno ◽  
André Coelho
Keyword(s):  
Previous History ◽  
Surgical Excision ◽  
Disease Recurrence ◽  
Hair Follicles ◽  
Desmoid Tumour ◽  
Adenomatous Polyposis ◽  
Malignant Tumours ◽  
History Of ◽  
Mitotic Figures ◽  
One Year

Basaloid follicular hamartoma (BFH) is a normally benign, uncommon, malformative lesion involving the hair follicles, which usually poses challenges in the differential diagnosis with other benign and malignant tumours, especially basal cell carcinoma, due to significant clinical and morphological overlap. Here, we report the case of a 53-year-old male who presented with a mass in the upper left eyelid evolving for one year. The patient had a previous history of total colectomy and an abdominal desmoid tumour within the context of Familial Adenomatous Polyposis (FAP), with a documented germline mutation in the Adenomatous Polyposis Coli (APC) gene. The eyelid lesion was biopsied and the histological analysis of the three small tissue fragments received revealed fragments with cutaneous–conjunctival lining displaying a subepithelial proliferation of basaloid nests with peripheral palisading, compatible with primitive hair follicles. There were images of anastomosis between different basaloid nests, which had their connection to the epithelial lining preserved. The stroma had high cellularity and sometimes primitive mesenchymal papillae were evident. Pleomorphism was absent, mitotic figures were barely identified, and no necrosis was seen. The basaloid nests did not have epithelial–stromal retraction nor mucin deposits. A diagnosis of BFH was proposed, which was later confirmed after surgical excision of the whole eyelid lesion. No evidence of carcinoma was present. This case illustrates the main features of the rare benign eyelid BFH. The standard medical or surgical approach of these lesions remains to be firmly established. Nearly nine months after surgical excision our patient remains well without signs of disease recurrence.

scholarly journals Unilateral tonsillar swelling: role and urgency of tonsillectomy  

2021 ◽  
Vol 13 (1) ◽  
pp. 10-11
Author(s):  
J Kynaston ◽  
S Drever ◽  
M Shakeel ◽  
M Supriya ◽  
Mc Cluney
Keyword(s):  
Previous History ◽  
Primary Malignancy ◽  
Papilloma Virus ◽  
Retention Cyst ◽  
History Of ◽  
Red Flag ◽  
Rising Incidence ◽  
Excessive Alcohol ◽  
Nose And Throat ◽  
Underlying Risk

Unilateral tonsillar swelling is a fairly common presenting complaint in an Ear, Nose and Throat (ENT) department. It may or may not be associated with any other symptoms. Most of the time, the tonsil asymmetry is secondary to previous history of tonsillitis, quinsy, and tonsil stones. Other benign lesions to cause tonsil swelling may include a mucus retention cyst, lipoma, polyp or papilloma. Sometimes, it is the site of primary malignancy but in these situations, it is often associated with red flag symptoms like pain in the mouth, dysphagia, odynophagia, referred otalgia, weight loss, night sweating, haemoptysis, haematemesis, hoarseness or neck nodes. Most of the patients with suspected tonsillar malignancy have underlying risk factors like smoking and excessive alcohol intake. However, lately, the tonsil squamous cell carcinoma can be found in younger patients with no history of smoking or drinking as there is rising incidence of human papilloma virus related oropharyngeal malignancy. Sometimes, lymphoma may manifest as a tonsil enlargement. If, after detailed history and examination, there remains any doubt about the underlying cause of unilateral tonsil swelling then tonsillectomy should be considered for histological analysis. it is our practice to perform bilateral tonsillectomy in such cases. We present a case of unilateral tonsillar swelling and discuss its management.

Response Predictive Factors to Anagrelide in Essential Thrombocythemia Diagnosed Patients.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 4649-4649
Author(s):  
Carlos Besses ◽  
Manuel Giralt ◽  
Luis Hernandez-Nieto ◽  
Carmen Burgaleta ◽  
Victor Navas ◽  
...  
Keyword(s):  
Objective Response ◽  
Previous History ◽  
Retrospective Chart Review ◽  
Previous Treatment ◽  
First Line ◽  
Chi Square ◽  
Chi Square Test ◽  
History Of ◽  
Potential Factors ◽  
Different Response

Abstract We performed a retrospective analysis of our Spanish database of patients with ET in order to assess the role of different response predictive potential factors to anagrelide treatment. 411 ET patients from 54 sites from February 2005 to August 2006 were included in a retrospective chart review. ET was diagnosed according to PVSG criteria (1997). All patients had started treatment with anagrelide before December 2004, either as a first line or as a second line therapy. The population was divided itself in three groups of risk at diagnosis: of high Risk: those patients older than 60 years or with previous history of thrombosis (40.6%); of low Risk: patients younger than 60 years with thrombocytosis lower than 1.5· 109/L, without cardiovascular risk factors and previous history of thrombosis (35.8%); intermediate risk: those patients who did not reunite the criteria of previously mentioned groups (23.6%). The response to the treatment was defined as complete remission (CR), when a reduction of platelets′ count were equal or less than 400×109/L, or a reduction higher than 50% with respect to the basal numbers; partial remission (PR), when the platelets′ count was between 400× 109/L and 600×109/L with respect to the basal numbers; and no response, those with a lower reduction than PR or increasing their platelets′count. CR was obtained in 219 patients (53.6%; 95%CI = 48.6–58.5) and PR in 113 (27.6%; 95%CI = 23.4–32.2), giving an overall response (OR) rate of 81.2% [95%CI = 77.0–84.9]. The influence of certain factors (such as age, gender, risk group, platelets levels before treatment with anagrelide, previous cytoreductive untreated patients and maximum anagrelide dose), in the objective response was explored. A chi-square test and a multivariate analysis (logistic regression) were performed. A worse response (p = 0.021) was associated with a higher dose (≥ 2.5 mg per day). A trend (p = 0.103) to better response in patients without previous treatment (anagrelide as a first line) was detected. Additionally a significant association (p = 0.02) between the previously treated with hydroxyurea and the presence of evolutive hematological transformations (myelofibrosis and acute myeloid leukemia/myelodysplastic syndrome) was observed. It is difficult to set a cause effect relation in all these findings due to the retrospective design of the analysis. As a conclusion, the response to anagrelide in ET patients was demonstrated to be independent of the age, gender, platelets′ count and level of previous risk.

scholarly journals ATTITUDES AND BELIEFS OF PATIENTS OF NON-CODIFIED TRADITIONAL MEDICINE IN BELAGAVI REGION

2018 ◽  
Vol 6 (1) ◽  
pp. 354-361
Author(s):  
Shripad Bhat ◽  
Ashok C. Naik ◽  
Sanjiva D. Kholkute
Keyword(s):  
Traditional Medicine ◽  
Previous History ◽  
Previous Treatment ◽  
Life Time ◽  
Traditional Healers ◽  
Modern Medicine ◽  
Attitudes And Beliefs ◽  
Positive Attitudes ◽  
Traditional Practitioner ◽  
History Of

Traditional Medicine (TM) medicine is a health care system that has ancient roots, faith of the rural community and cultural background. The study was conducted to out the attitudes and beliefs of patients visiting traditional healers. Ten traditional healers in rural area of Belagavi district representing different categories of non-codified traditional healing practices were included in the study. The data was collected on patients who were willing and agreed to answer the questionnaire. Forty questionnaires were tested and the preliminary results were assessed for validity. The questionnaire data was entered in Microsoft Excel and analysis was carried out using Statistical Package for Social Sciences (SPSS) version16.0 software. The results are based on the descriptive data of 322 patients. Most of the participants were younger than 40 years old (62.1%). 201 (62.4%) patients visited traditional practitioner minimum 2 times in their life time. Among them, 94.5% of patients reported satisfaction with TM. 263 (81.7%) patients had previous history of treatment from other systems of medicine for the same health problems before visiting traditional healers. Among them 191 (72.6%) patients were dissatisfied with previous treatment, out of which 181 (94.8%) had taken modern medicine. The majority 256 (79.5%) patients visited because of their positive attitudes and beliefs towards traditional medicine. The study indicates that people do visits traditional healers and have a faith in traditional healers and their medicine.

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