scholarly journals Dissipation in Non-Steady State Regulatory Circuits

Entropy ◽  
2019 ◽  
Vol 21 (12) ◽  
pp. 1212
Author(s):  
Paulina Szymańska-Rożek ◽  
Dario Villamaina ◽  
Jacek Miȩkisz ◽  
Aleksandra M. Walczak
Keyword(s):  
Steady State ◽  
Initial Conditions ◽  
Limit Function ◽  
Environmental Signals ◽  
Additional Information ◽  
Fast Switching ◽  
Regulatory Circuits ◽  
Trade Offs ◽  
Biological Circuits ◽  
Gene Regulatory Circuits

In order to respond to environmental signals, cells often use small molecular circuits to transmit information about their surroundings. Recently, motivated by specific examples in signaling and gene regulation, a body of work has focused on the properties of circuits that function out of equilibrium and dissipate energy. We briefly review the probabilistic measures of information and dissipation and use simple models to discuss and illustrate trade-offs between information and dissipation in biological circuits. We find that circuits with non-steady state initial conditions can transmit more information at small readout delays than steady state circuits. The dissipative cost of this additional information proves marginal compared to the steady state dissipation. Feedback does not significantly increase the transmitted information for out of steady state circuits but does decrease dissipative costs. Lastly, we discuss the case of bursty gene regulatory circuits that, even in the fast switching limit, function out of equilibrium.

scholarly journals Adult body growth and reproductive investment vary markedly within and across Atlantic and Pacific herring: a meta-analysis and review of 26 stocks

2021 ◽  
Author(s):  
Thassya C. dos Santos Schmidt ◽  
Doug E. Hay ◽  
Svein Sundby ◽  
Jennifer A. Devine ◽  
Guðmundur J. Óskarsson ◽  
...  
Keyword(s):  
Egg Size ◽  
Meta Analysis ◽  
Reproductive Investment ◽  
Body Growth ◽  
Clupea Harengus ◽  
Pacific Herring ◽  
Atlantic Herring ◽  
Additional Information ◽  
Trade Offs ◽  
Investment In Reproduction

AbstractLife-history traits of Pacific (Clupea pallasii) and Atlantic (Clupea harengus) herring, comprising both local and oceanic stocks subdivided into summer-autumn and spring spawners, were extensively reviewed. The main parameters investigated were body growth, condition, and reproductive investment. Body size of Pacific herring increased with increasing latitude. This pattern was inconsistent for Atlantic herring. Pacific and local Norwegian herring showed comparable body conditions, whereas oceanic Atlantic herring generally appeared stouter. Among Atlantic herring, summer and autumn spawners produced many small eggs compared to spring spawners, which had fewer but larger eggs—findings agreeing with statements given several decades ago. The 26 herring stocks we analysed, when combined across distant waters, showed clear evidence of a trade-off between fecundity and egg size. The size-specific individual variation, often ignored, was substantial. Additional information on biometrics clarified that oceanic stocks were generally larger and had longer life spans than local herring stocks, probably related to their longer feeding migrations. Body condition was only weakly, positively related to assumingly in situ annual temperatures (0–30 m depth). Contrarily, body growth (cm × y−1), taken as an integrator of ambient environmental conditions, closely reflected the extent of investment in reproduction. Overall, Pacific and local Norwegian herring tended to cluster based on morphometric and reproductive features, whereas oceanic Atlantic herring clustered separately. Our work underlines that herring stocks are uniquely adapted to their habitats in terms of trade-offs between fecundity and egg size whereas reproductive investment mimics the productivity of the water in question.

Steady-State Dynamic Response of a Limited Slip System

1968 ◽  
Vol 35 (2) ◽  
pp. 322-326 ◽  
Author(s):  
W. D. Iwan
Keyword(s):  
Steady State ◽  
Dynamic Response ◽  
Slip System ◽  
External Load ◽  
Initial Conditions ◽  
Viscous Damping ◽  
Steady State Response ◽  
Response Curves ◽  
State Response ◽  
System Nonlinearity

The steady-state response of a system constrained by a limited slip joint and excited by a trigonometrically varying external load is discussed. It is shown that the system may possess such features as disconnected response curves and jumps in response depending on the strength of the system nonlinearity, the level of excitation, the amount of viscous damping, and the initial conditions of the system.

scholarly journals Stability and Instability in the Lysogenic State of Phage Lambda

2010 ◽  
Vol 192 (22) ◽  
pp. 6064-6076 ◽  
Author(s):  
John W. Little ◽  
Christine B. Michalowski
Keyword(s):  
Intrinsic Rate ◽  
Growth Conditions ◽  
Emergent Properties ◽  
Regulatory Circuits ◽  
Stability And Instability ◽  
Natural Range ◽  
Analysis Of Stability ◽  
Stable Association ◽  
The Stability ◽  
Gene Regulatory Circuits

ABSTRACT Complex gene regulatory circuits exhibit emergent properties that are difficult to predict from the behavior of the components. One such property is the stability of regulatory states. Here we analyze the stability of the lysogenic state of phage λ. In this state, the virus maintains a stable association with the host, and the lytic functions of the virus are repressed by the viral CI repressor. This state readily switches to the lytic pathway when the host SOS system is induced. A low level of SOS-dependent switching occurs without an overt stimulus. We found that the intrinsic rate of switching to the lytic pathway, measured in a host lacking the SOS response, was almost undetectably low, probably less than 10−8/generation. We surmise that this low rate has not been selected directly during evolution but results from optimizing the rate of switching in a wild-type host over the natural range of SOS-inducing conditions. We also analyzed a mutant, λprm240, in which the promoter controlling CI expression was weakened, rendering lysogens unstable. Strikingly, the intrinsic stability of λprm240 lysogens depended markedly on the growth conditions; lysogens grown in minimal medium were nearly stable but switched at high rates when grown in rich medium. These effects on stability likely reflect corresponding effects on the strength of the prm240 promoter, measured in an uncoupled assay system. Several derivatives of λprm240 with altered stabilities were characterized. This mutant and its derivatives afford a model system for further analysis of stability.

Exact Dynamics in a Model of the Bimolecular Reaction A+B→ 0

1992 ◽  
Vol 290 ◽  
Author(s):  
Eric Clément ◽  
Patrick Leroux-Hugon ◽  
Leonard M. Sander
Keyword(s):  
Exact Solution ◽  
Steady State ◽  
Initial Conditions ◽  
Finite Size ◽  
Bimolecular Reaction ◽  
Reaction Model

AbstractWe have previously given an exact solution [1] for the steady state of a model of the bimolecular reaction model A+B→ 0 due to Fichthorn et al. [2]. The dimensionality of the substrate plays a central role, and below d=2 segregation on macroscopic scales becomes important: above d=2 saturation sets in for finite size systems. Here we extend our treatment to give an exact account of the dynamics and show how various initial conditions develop into the segregated and saturated regimes. In certain conditions we find logarithmic relaxation which is related to the dimensionality.

Dynamics of Dual-Cell Series Miura-Ori Structures With Different Types of Inter-Cell Connections

2021 ◽  
Author(s):  
Hai Zhou ◽  
Haiping Wu ◽  
Jian Xu ◽  
Hongbin Fang
Keyword(s):  
Steady State ◽  
Numerical Simulations ◽  
Theoretical Basis ◽  
Initial Conditions ◽  
Cell Structure ◽  
Dynamic Responses ◽  
Complex Environment ◽  
Current State ◽  
Different Types ◽  
Cell Series

Abstract Origami-inspired structures and materials have shown remarkable properties and performances originating from the intricate geometries of folding. Origami folding could be a dynamic process and origami structures could possess rich dynamic characteristics under external excitations. However, the current state of dynamics of origami has mostly focused on the dynamics of a single cell. This research has performed numerical simulations on multi-stable dual-cell series Miura-Ori structures with different types of inter-cell connections based on a dynamic model that does not neglect in-plane mass. We introduce a concept of equivalent constraint stiffness k* to distinguish different types of inter-cell connections. Results of numerical simulations reveal the multi-stable dual-cell structure will exhibit a variety of complex nonlinear dynamic responses with the increasing of connection stiffness because of the deeper energy well it has. The connection stiffness has a strong effect on the steady-state dynamic responses under different excitation amplitudes and a variety of initial conditions. This effect makes us able to adjust the dynamic behaviors of dual-cell series Miura-Ori structure to our needs in a complex environment. Furthermore, the results of this research could provide us a theoretical basis for the dynamics of origami folding and serve as guidelines for designing dynamic applications of origami metastructures and metamaterials.

Nonlinear Rolling Motion of a Statically Biased Ship Under the Effect of External and Parametric Excitation

1993 ◽  
Author(s):  
Isaac Esparza ◽  
Jeffrey Falzarano
Keyword(s):  
Steady State ◽  
Parametric Excitation ◽  
Poincaré Map ◽  
Initial Conditions ◽  
Global Analysis ◽  
Wave Train ◽  
Periodic Wave ◽  
Rolling Motion ◽  
Poincare Map ◽  
Safe Basin

Abstract In this work, global analysis of ship rolling motion as effected by parametric excitation is studied. The parametric excitation results from the roll restoring moment variation as a wave train passes. In addition to the parametric excitation, an external periodic wave excitation and steady wind bias are also included in the analysis. The roll motion is the most critical motion for a ship because of the possibility of capsizing. The boundaries in the Poincaré map which separate initial conditions which eventually evolve to bounded steady state solutions and those which lead to unbounded capsizing motion are studied. The changes in these boundaries or manifolds as effected by changes in the ship and environmental conditions are analyzed. The region in the Poincaré map which lead to bounded steady state motions is called the safe basin. The size of this safe basin is a measure of the vessel’s resistance to capsizing.

A Decentralized Neuro-Adaptive Control Scheme to Suppress Chaotic/Hyperchaotic Dynamics of Smart Valves Network

2018 ◽  
Vol 13 (5) ◽  
Author(s):  
Peiman Naseradinmousavi ◽  
Hashem Ashrafiuon ◽  
Mostafa Bagheri
Keyword(s):  
Initial Conditions ◽  
Adaptive Method ◽  
Critical Parameters ◽  
Computationally Efficient ◽  
Adaptive Scheme ◽  
Computational Burden ◽  
Trade Offs ◽  
Control Scheme ◽  
Practical Feasibility ◽  
Adaptive Control Scheme

In this effort, we utilize a decentralized neuro-adaptive scheme in extinguishing both the chaotic and hyperchaotic dynamics of the so-called “Smart Valves” network. In particular, a network of two dynamically interconnected bidirectional solenoid actuated butterfly valves undergoes the harmful chaotic/hyperchaotic dynamics subject to some initial conditions and critical parameters. Crucial trade-offs, including robustness, computational burden, and practical feasibility of the control scheme, are thoroughly investigated. The advantages and shortcomings of the decentralized neuro-adaptive method are compared with those of the direct decentralized adaptive one to yield a computationally efficient, practically feasible, and robust scheme in the presence of the coupled harmful responses.

Time-dependent process of M/G/1 vacation models with exhaustive service

1992 ◽  
Vol 29 (02) ◽  
pp. 418-429 ◽  
Author(s):  
Hideaki Takagi
Keyword(s):  
Steady State ◽  
Initial Conditions ◽  
Setup Time ◽  
Time Dependent ◽  
Time Model ◽  
Vacation Models ◽  
Single Vacation ◽  
Multiple Vacation ◽  
Virtual Waiting Time ◽  
Vacation Model

Generalized M/G/1 vacation systems with exhaustive service include multiple and single vacation models and a setup time model possibly combined with an N-policy. In these models with given initial conditions, the time-dependent joint distribution of the server's state, the queue size, and the remaining vacation or service time is known (Takagi (1990)). In this paper, capitalizing on the above results, we obtain the Laplace transforms (with respect to time) for the distributions of the virtual waiting time, the unfinished work (backlog), and the depletion time. The steady-state limits of those transforms are also derived. An erroneous expression for the steady-state distribution of the depletion time in a multiple vacation model given by Keilson and Ramaswamy (1988) is corrected.

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