<strong>Preparation of a New Magnetic Drug Carrier Based on Poly(vinyl alcohol): Synthesis, Characterization, and Drug Release Studies</strong>

Chitosan (CS) and poly (vinyl alcohol) (PVA) hydrogels, a polymeric system that shows a broad potential in biomedical applications, were developed. Despite the advantages they present, their mechanical properties are insufficient to support the loads that appear on the body. Thus, it was proposed to reinforce these gels with inorganic glass particles (BG) in order to improve mechanical properties and bioactivity and to see how this reinforcement affects levofloxacin drug release kinetics. Scanning electron microscopy (SEM), X-ray diffraction (XRD), swelling tests, rheology and drug release studies characterized the resulting hydrogels. The experimental results verified the bioactivity of these gels, showed an improvement of the mechanical properties and proved that the added bioactive glass does affect the release kinetics.

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Effect of freeze-thawing conditions for preparation of chitosan-poly (vinyl alcohol) hydrogels and drug release studies

Carbohydrate Polymers ◽

10.1016/j.carbpol.2018.05.004 ◽

2018 ◽

Vol 195 ◽

pp. 476-485 ◽

Cited By ~ 25

Author(s):

M.D. Figueroa-Pizano ◽

I. Vélaz ◽

F.J. Peñas ◽

P. Zavala-Rivera ◽

A.J. Rosas-Durazo ◽

...

Keyword(s):

Drug Release ◽

Vinyl Alcohol ◽

Poly Vinyl Alcohol ◽

Release Studies

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Poly(acrylic acid)-block-poly(vinyl alcohol) anchored maghemite nanoparticles designed for multi-stimuli triggered drug release

Nanoscale ◽

10.1039/c3nr02861e ◽

2013 ◽

Vol 5 (23) ◽

pp. 11464 ◽

Cited By ~ 31

Author(s):

Ji Liu ◽

Christophe Detrembleur ◽

Antoine Debuigne ◽

Marie-Claire De Pauw-Gillet ◽

Stéphane Mornet ◽

...

Keyword(s):

Drug Release ◽

Acrylic Acid ◽

Vinyl Alcohol ◽

Poly Vinyl Alcohol ◽

Maghemite Nanoparticles ◽

Triggered Drug Release ◽

Poly Acrylic Acid

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Drug-loaded ultrafine poly(vinyl alcohol) fibre mats prepared by electrospinning

e-Polymers ◽

10.1515/epoly.2005.5.1.750 ◽

2005 ◽

Vol 5 (1) ◽

Cited By ~ 4

Author(s):

Chunxue Zhang ◽

Xiaoyan Yuan ◽

Lili Wu ◽

Jing Sheng

Keyword(s):

Drug Release ◽

Photoelectron Spectroscopy ◽

Vinyl Alcohol ◽

Phosphate Buffer Solution ◽

Poly Vinyl Alcohol ◽

High Porosity ◽

Buffer Solution ◽

Drug Molecules ◽

Alcohol Fibre

AbstractSubmicron poly(vinyl alcohol) (PVA) fibre mats embedded with Aspirin and bovine serum albumin (BSA) were prepared by electrospinning of their aqueous solutions. Fibre morphology was investigated by scanning electron microscopy. The composition of the fibre mats was characterized by Fourier transform IR spectroscopy and X-ray photoelectron spectroscopy. The in vitro drug release was investigated by immersing the fibre mats in phosphate buffer solution at 37°C. Results indicated that the morphology of fibre mats was influenced by the amount of drug, and more beaded and irregularly shaped fibres were found with increasing drug amounts. There were drug molecules distributed on the surface of the PVA fibres. Studies of in vitro drug release showed that both Aspirin and BSA were released more quickly from PVA fibre mats than from PVA films because of the large surface area and high porosity of the fibre mats.

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Cellulose acetate/poly(vinyl alcohol) hybrid fibrous mat containing tetracycline hydrochloride and phenytoin sodium: Morphology, drug release, antibacterial, and cell culture studies

Journal of Bioactive and Compatible Polymers ◽

10.1177/0883911518779186 ◽

2018 ◽

Vol 33 (6) ◽

pp. 597-611 ◽

Cited By ~ 4

Author(s):

Hamed Souriyan-Reyhani pour ◽

Ramin Khajavi ◽

Mohammad Esmaeil Yazdanshenas ◽

Payam Zahedi ◽

Mohammad Mirjalili

Keyword(s):

Drug Release ◽

Cellulose Acetate ◽

Vinyl Alcohol ◽

Aqueous Media ◽

Tetracycline Hydrochloride ◽

Diameter Distribution ◽

Poly Vinyl Alcohol ◽

Release Kinetic ◽

Phenytoin Sodium ◽

20 Nm

The objective of this study was to introduce an electrospun hybrid fibrous mat (a dual-fiber drug delivery system) based on cellulose acetate and poly(vinyl alcohol) containing tetracycline hydrochloride and phenytoin sodium, respectively. Characterization of samples was carried by morphology, drug release, cell cytotoxicity, adhesion, antibacterial property, and wettability investigations. The results showed a uniform shape and a narrow diameter distribution of fibers (between 160 ± 20 nm) for fabricated cellulose acetate/poly(vinyl alcohol) hybrid fibrous mat. The tetracycline hydrochloride release from cellulose acetate significantly decreased due to gel formation of poly(vinyl alcohol) in aqueous media. The best fit for drug release kinetic of hybrid sample was Higuchi model. Sample with tetracycline hydrochloride and phenytoin sodium drugs showed improved cell growth, viability, and antibacterial activity against Escherichia coli (~89%) and Staphylococcus aureus (~98%) in comparison with sample without drugs. The hydrophilic property of cellulose acetate/poly(vinyl alcohol) fibrous sample containing the drugs was also remarkable (~45°). To consider the obtained results, the presented hybrid fibrous mat shows a high potent for biomedical applications.

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