Biological Study of Transition Metal Complexes with Adenine Ligand

Adenine complexes were prepared with some of the first series transition metals in a stoichiometric ratio of 1: 2 (Mn+: L), where Mn+ = Mn2+, Fe3+, Co2+, Ni2+, Cu2+, Zn2+, and Cd2+ ions. The Complexes were characterized by the physicochemical and spectroscopic techniques as electric conductivity, metal contents, IR, UV–Visible, and molar conductance techniques. The stoichiometric ratios of the synthesized complexes were confirmed by using molar ratio method. The dissociation constant of adenine ligand was determined spectrophotometrically. Solvent effect on the electronic spectra of the adenine ligand was examined using solvents with different polarities. The biological activity of adenine ligand and its metal complexes were tested in vitro against some selected species of fungi and bacteria. The results showed a satisfactory spectrum against the tested organisms.

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Biological and Spectral Studies of Newly Synthesized Triazole Schiff Bases and Their Si(IV), Sn(IV) Complexes

Bioinorganic Chemistry and Applications ◽

10.1155/2011/654250 ◽

2011 ◽

Vol 2011 ◽

pp. 1-10 ◽

Cited By ~ 4

Author(s):

Kiran Singh ◽

Parvesh Puri ◽

Yogender Kumar ◽

Chetan Sharma ◽

Kamal Rai Aneja

Keyword(s):

Nmr Spectroscopy ◽

Metal Complexes ◽

Schiff Bases ◽

Molar Conductance ◽

Molar Ratio ◽

Spectral Studies ◽

Trigonal Bipyramidal ◽

Elemental Analyses ◽

Bacteria And Fungi

The Schiff bases HL1-3have been prepared by the reaction of 5-bromothiophene-2-carboxaldehyde with 4-amino-5-mercapto-3-methyl/propyl/isopropyl-s-triazole, respectively. Organosilicon(IV) and organotin(IV) complexes of formulae (CH3)2MCl(L1-3), (CH3)2M(L1-3)2were synthesized from the reaction of (CH3)2MCl2and the Schiff bases in 1 : 1 and 1 : 2 molar ratio, where and Sn. The synthesized Schiff bases and their metal complexes have been characterized with the aid of various physicochemical techniques like elemental analyses, molar conductance, UV, IR,1H,13C,29Si, and119Sn NMR spectroscopy. Based on these studies, the trigonal bipyramidal and octahedral geometries have been proposed for these complexes. The ligands and their metal complexes have been screenedin vitroagainst some bacteria and fungi.

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Spectral Characterization and Antibacterial Activities of Benzyloxybenzaldehydethiosemicarbazone, 3,4-Dihydroxybenzaldehydeisonicotinoylhydrazone and their Transitional Metal Complexes

E-Journal of Chemistry ◽

10.1155/2011/579892 ◽

2011 ◽

Vol 8 (4) ◽

pp. 1848-1858

Author(s):

Lakshmi Narayana Suvarapu ◽

A. Varada Reddy ◽

G. Satheesh Kumar ◽

Sung Ok Baek

Keyword(s):

Metal Complexes ◽

Antibacterial Activities ◽

Spectral Characterization ◽

Molar Ratio ◽

Ratio Method ◽

Gram Positive Bacteria ◽

Transitional Metal ◽

Molar Ratio Method ◽

Job's Method

The synthesis and spectral characterization of benzyloxy-benzaldehydethiosemicarbazone (BBTSC) and the study of antibacterial activity of ligands BBTSC, 3,4-dihydroxybenzaldehydeisoni- cotinoylhydrazone (3,4-DHBINH) and their transition metal complexes was studied. The composition of the metal complexes was also evaluated by using Job’s method, molar-ratio method and Asmus’ method. The antibacterial activities of BBTSC, 3,4-DHBINH and their complexesi.e., Cu(II)-BBTSC, Pd(II)-BBTSC, Cr(VI)- 3,4-DHBINH, Ti(IV)- 3,4-DHBINH and Pd(II)-3,4-DHBINH were studied against two gram positive bacteria and two gram negative bacteria. Antibacterial activities were evaluated by agar cup well method with the help of Luria Bertoni plates.

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Preparation, Characterization and Antimicrobial Activity Study of Some Transition Metal Complexes of 4-Flourophenyl -4-Nitrobenzylidene

Baghdad Science Journal ◽

10.21123/bsj.7.2.1006-1013 ◽

2010 ◽

Vol 7 (2) ◽

pp. 1006-1013

Author(s):

Baghdad Science Journal

Keyword(s):

Metal Complexes ◽

Metal Ion ◽

Synergetic Effect ◽

Free Ligand ◽

Molar Ratio ◽

Ratio Method ◽

Flame Atomic Absorption ◽

Vis Spectroscopy ◽

Molar Ratio Method ◽

The Difference

A new Schiff base of 4- flourophenyl-4- nitrobenzyliden (L) ,was prepared and used to prepare a number of metal complexes with Cr (III) , Fe (III), Co(II) ,Ni (II) and Cu (II). These complexes were isolated and characterized by (FITR),UV-Vis spectroscopy and flame atomic absorption techniques in addition to magnetic susceptibility, and conductivity measurements. The study of the nature of the complexes formed in ethanol was done following the molar ratio method gave results, agreed with those obtained from isolated solid state studies. The antibacterial activity for the ligand and its metal complexes were examined against two selected microorganisms, Pseudomonas aeruginosa and Staphylococcus aureus.The results indicated that the complexes show the enhanced activity in comparison to the free ligand; these were attributed to the synergetic effect between the metal ion and the ligand in addition to the difference in the structural varieties.

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Synthesis, Spectral Characterization and Biological Activities of Co(II) and Ni(II) Mixed Ligand Complexes

Molecules ◽

10.3390/molecules26040823 ◽

2021 ◽

Vol 26 (4) ◽

pp. 823

Author(s):

P. Manimaran ◽

S. Balasubramaniyan ◽

Mohammad Azam ◽

D. Rajadurai ◽

Saud I. Al-Resayes ◽

...

Keyword(s):

Metal Complexes ◽

Pathogenic Bacteria ◽

High Efficiency ◽

Biological Activities ◽

Visible Spectrum ◽

Fungal Species ◽

Molar Conductance ◽

Molar Ratio ◽

Cell Parameters

2,4-Dinitrophynylhydrazine and two thiocyanate ions in a (M:L1:L2) 1:2:2 molar ratio was synthesized in the complexes of Co(II) and Ni(II). The prepared compounds were identified through a C.H.N.S. analysis, conductivity measurements, powder X-ray diffraction (PXRD), the infrared spectrum, and a UV-visible spectrum analysis, in addition to the magnetic properties being measured. The measurements of the molar conductance implieda nonelectrolytic nature of compounds Co(II) and Ni(II). The magnetic susceptibility, as well as electronic spectra, represented all the metal complexesthroughoctahedral geometry, respectively. The PXRD patterns suggested that all the complexes were an orthorhombic system with unit cell parameters. The in-vitro biological activity of the ligand and the metal complexes were screened against the Gram-positive and negative pathogenic bacteria Staphylococcus aureus, Bacillus subtilis, Pseudomonas, aeruginosa and Escherichia coli, as well as the fungal species of Aspergillusniger and Candida albicans.Thus, the metal complexes showeda high efficiency of antimicrobial activity compared with the ligand. Furthermore, applications of the ligand, as well as the metal complexes, were tested for in-vitro antioxidant potential in aDPPH assay. The results showed that the activity of the metal complexes with the in-vitro antioxidant was more active than that of 2,4-dinitrophenylhydrazine(DNPH).

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Synthesis and Spectroscopic Characterization for Some Metal ion Complexes with 2-Hydroxy-3-((5-Mercapto-1,3,4-Thiadiazol-2-yl)Diazenyl)-1-Naphthaldehyde

Baghdad Science Journal ◽

10.21123/bsj.13.2.105-114 ◽

2016 ◽

Vol 13 (2) ◽

pp. 105-114

Author(s):

Baghdad Science Journal

Keyword(s):

Metal Complexes ◽

Metal Ion ◽

Mass Spectra ◽

Spectroscopic Characterization ◽

Bidentate Ligand ◽

Molar Ratio ◽

Theoretical Treatment ◽

Spectroscopic Techniques ◽

Metal Ion Complexes ◽

Square Planar

New metal ion complexes were synthesized with the general formula; K[PtLCl4], [ReLCl4] and K[ML(Cl)2] where M = Pd(II), Cd(II), Zn(II) and Hg(II), from the Azo ligand (HL) [2-Hydroxy-3-((5-mercapto-1,3,4-thiadiazol-2-yl)diazenyl)-1-naphth aldehyde] (HL) the ligand was synthesized from (2-hydroxy-1-naphthaldehyde) and (5-amino-1,3,4-thiadiazole-2-thiol). The ligand and its metal complexes are characterized by phisco- chemical spectroscopic techniques (FT.IR, UV-Vis and Mass spectra, elemental analysis, molar conductivity, Atomic Absorption, Chloride contain and magnetic susceptibility). The spectral data suggest that the (HL) behaves as a bidentate ligand in all complexes. These studies revealed tetrahedral geometries for all metal complexes, except square planar for Pd(II) complex and except octahedral geometry for Pt(IV) and Re(V) complexes. The study of complexes formation via molar ratio of (M:L) as (1:1). Theoretical treatment of this ligand and its metal complexes in gas phase using Hyper chem.8 was preformed.

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Potential bioactive mononuclear diorganotin(IV) phenoxyacetohydroxamate complexes: synthesis, characterization and antimicrobial evaluation

Main Group Metal Chemistry ◽

10.1515/mgmc-2017-0056 ◽

2018 ◽

Vol 0 (0) ◽

Author(s):

Vineet Kumar Choudhary ◽

Abhishek Kumar ◽

Neeraj Sharma

Keyword(s):

Antimicrobial Agents ◽

Salmonella Typhi ◽

Molar Ratio ◽

Distorted Octahedral Geometry ◽

Spectroscopic Techniques ◽

Concentration Method ◽

Distorted Octahedral ◽

Elemental Analyses ◽

Antimicrobial Evaluation

AbstractThe new diorganotin(IV) complexes of composition [Me2Sn(C6H5OCH2CONHO)2](I) and [n-Bu2Sn(C6H5OCH2CONHO)2](II) have been synthesized by the reactions of Me2SnCl2andn-Bu2SnCl2with potassium phenoxyacetohydroxamate (PhOAHK=C6H5OCH2CONHOK) in 1:2 molar ratio in methanol and benzene solvent medium and characterized by elemental analyses and spectroscopic techniques (infrared,1H nuclear magnetic resonance and mass spectrometry). The [O,O coordination] through carbonyl and hydroxamic oxygen atoms and distorted octahedral geometry around the mononuclear tin has been inferred. The electrochemical behavior of complexes studied by the cyclic voltammetric technique has shown quasi-irreversible two-step reduction from tin (IV) to tin (II). Thermal behavior of complexes studied by the thermogravimetric technique in N2atmosphere has yielded SnO as the decomposition product. Thein vitroantimicrobial activity assays against various pathogenic Gram-negative bacteria, namely,Salmonella typhi,Escherichia coli; Gram-positiveBacillus cereusandStaphylococcus aureusand fungiAspergillus nigerandAlternaria alternataby the minimum inhibitory concentration method have shown their potential as promising antimicrobial agents compared to the respective standard chloramphenicol and nystatin drugs.

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Physico-chemical and biological studies of Cu(II), Co(II) and Ni(II) complexes of an N4 coordinating ligand derived from diacetylbisethylenediamine and benzoic acid

Journal of the Serbian Chemical Society ◽

10.2298/jsc110412148s ◽

2012 ◽

Vol 77 (5) ◽

pp. 627-637 ◽

Cited By ~ 6

Author(s):

Pal Singh ◽

Nanda Srivastava

Keyword(s):

Benzoic Acid ◽

Metal Complexes ◽

Magnetic Moment ◽

Biological Activities ◽

Molar Conductance ◽

Planar Geometry ◽

Cyclic Voltammetric Study ◽

Biological Studies ◽

Antibacterial And Antifungal

Mononuclear metal complexes of the type [ML1]Cl2 (where, M = = Cu(II), Co(II) or Ni(II) and L1 = ligand) were synthesized by the reaction of a new N4 coordinating ligand, derived from diacetylbisethylenediamine with benzoic acid, and the corresponding hydrated metal chloride salts. The metal complexes were characterized by elemental analysis, melting point determination, molar conductance and magnetic moment measurements, IR, UV-Vis, 1H- and 13C-NMR, and ESR spectroscopy. The ligand and all the metal complexes were stable in the solid state at room temperature. From the analytical and spectroscopic investigations, the stoichiometry of the complexes was found to be 1:1 (metal:ligand). Based on the electronic spectra and magnetic moment data, the metal complexes had a square planar geometry. The molar conductance values show the 1:2 electrolytic nature of the metal complexes. A cyclic voltammetric study of the Cu(II) metal complex has also performed, which showed one electron quasi-reversible reduction around -0.92 to -1.10 V. In vitro biological activities of the ligand and metal complexes was checked against two bacteria Bacillus subtilis and Escherichia coli and two fungi Aspirgillus niger and A. flavus which showed the antibacterial and antifungal properties of the ligand and its metal complexes.

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Biological and Spectroscopic Investigations of New Tenoxicam and 1.10-Phenthroline Metal Complexes

Molecules ◽

10.3390/molecules25051027 ◽

2020 ◽

Vol 25 (5) ◽

pp. 1027

Author(s):

Hazem S. Elshafie ◽

Sadeek A. Sadeek ◽

Ippolito Camele ◽

Amira A. Mohamed

Keyword(s):

Metal Complexes ◽

Xanthomonas Campestris ◽

Molar Conductance ◽

Bidentate Ligand ◽

Proton Nuclear Magnetic Resonance ◽

Lepidium Sativum ◽

Colletotrichum Acutatum ◽

Breast Adenocarcinoma ◽

Antibacterial Screening

In the present work, tenoxicam (H2Ten) reacted with Mn(II), Co(II), Ni(II), Cu(II) and Zn (II) ions in the presence of 1.10-phenthroline (Phen), forming new mixed ligand metal complexes. The properties of the formed complexes were depicted by elemental analyses, infrared, electronic spectra, proton nuclear magnetic resonance (1H NMR), mass spectrometry, thermogravimetric (TGA) and differential thermogravimetric (DTG) analysis, molar conductance and magnetic moment. IR spectra demonstrated that H2Ten acted as a neutral bidentate ligand, coordinated to the metal ions via the pyridine-N and carbonyl group of the amide moiety, and Phen through the nitrogen atoms. Kinetic thermodynamics parameters activation energy (E*), enthalpy of activation (ΔH*), entropy of activation (ΔS*), Gibbs, free energy (ΔG*) associated to the complexes have been evaluated. Antibacterial screening of the compounds was carried out in vitro against Clavibacter michiganensis, Xanthomonas campestris and Bacillus megaterium. Antifungal activity was performed in vitro against Monilinia fructicola, Penicillium digitatum and Colletotrichum acutatum. The possible phytotoxic effect of the studied compounds was also investigated on Solanum lycopersicum (tomatoes) and Lepidium sativum (garden cress) seeds. The anticancer activity was screened against cell cultures of HCT-116 (human colorectal carcinoma), HepG2 (human hepatocellular carcinoma) and MCF-7 (human breast adenocarcinoma).

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Synthesis, Spectroscopic, and Antimicrobial Studies on Bivalent Nickel and Copper Complexes of Bis(thiosemicrbazone)

Bioinorganic Chemistry and Applications ◽

10.1155/2007/51483 ◽

2007 ◽

Vol 2007 ◽

pp. 1-7 ◽

Cited By ~ 27

Author(s):

Sulekh Chandra ◽

Smriti Raizada ◽

Monika Tyagi ◽

Archana Gautam

Keyword(s):

Metal Complexes ◽

Metal Ion ◽

Copper Complexes ◽

Free Ligand ◽

Antimicrobial Properties ◽

Molar Conductance ◽

Spectral Studies ◽

Central Metal ◽

Antimicrobial Studies

A series of metal complexes of Cu(II) and Ni(II) having the general composition[M(L)X2]with benzil bis(thiosemicarbazone) has been prepared and characterized by element chemical analysis, molar conductance, magnetic susceptibility measurements, and spectral (electronic, IR, EPR, mass) studies. The IR spectral data suggest the involvement of sulphur and azomethane nitrogen in coordination to the central metal ion. On the basis of spectral studies, an octahedral geometry has been assigned for Ni(II) complexes but a tetragonal geometry for Cu(II) complexes. The free ligand and its metal complexes have been tested in vitro against a number of microorganisms in order to assess their antimicrobial properties.

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Metal Complexes of a Novel Schiff Base Based on Penicillin: Characterization, Molecular Modeling, and Antibacterial Activity Study

Bioinorganic Chemistry and Applications ◽

10.1155/2017/6927675 ◽

2017 ◽

Vol 2017 ◽

pp. 1-13 ◽

Cited By ~ 16

Author(s):

Narendra Kumar Chaudhary ◽

Parashuram Mishra

Keyword(s):

Thermal Stability ◽

Antibacterial Activity ◽

Schiff Base ◽

Metal Complexes ◽

Parent Drug ◽

Molar Conductance ◽

Kinetic Properties ◽

Field Calculation ◽

Tetrahedral Geometry

A novel Schiff base ligand of type HL was prepared by the condensation of amoxicillin trihydrate and nicotinaldehyde. The metal complexes of Co+2, Ni+2, Cu+2, and Zn+2 were characterized and investigated by physical and spectral techniques, namely, elemental analysis, melting point, conductivity, 1H NMR, IR, UV-Vis spectra, ESR, SEM, and mass spectrometry measurements. They were further analyzed by thermal technique (TGA/DTA) to gain better insight about the thermal stability and kinetic properties of the complexes. Thermal data revealed high thermal stability and nonspontaneous nature of the decomposition steps. The Coats-Redfern method was applied to extract thermodynamic parameters to explain the kinetic behavior. The molar conductance values were relatively low, showing their nonelectrolytic nature. The powder XRD pattern revealed amorphous nature except copper complex (1c) that crystallized in the triclinic crystal system. The EPR study strongly recommends the tetrahedral geometry of 1c. The structure optimization by MM force field calculation through ArgusLab 4.0.1 software program supports the concerned geometry of the complexes. The in vitro antibacterial activity of all the compounds, at their two different concentrations, was screened against four bacterial pathogens, namely, E. coli, P. vulgaris, K. pneumoniae, and S. aureus, and showed better activity compared to parent drug and control drug.

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