scholarly journals Smartphone-Based Evaluation of Postural Stability in Parkinson’s Disease Patients During Quiet Stance

Electronics ◽  
2020 ◽  
Vol 9 (6) ◽  
pp. 919
Author(s):  
Luigi Borzì ◽  
Silvia Fornara ◽  
Federica Amato ◽  
Gabriella Olmo ◽  
Carlo Alberto Artusi ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Inertial Sensors ◽  
Postural Instability ◽  
Support Vector ◽  
Quiet Stance ◽  
Simple Protocol ◽  
Risk Of Falls

Background: Postural instability is one of the most troublesome motor symptoms of Parkinson’s Disease (PD). It impairs patients’ quality of life and results in high risk of falls. The aim of this study is to provide a reliable tool for the automated assessment of postural instability. Methods: Data acquisition was performed on 42 PD patients and 7 young healthy subjects. They were asked to keep a quiet stance position for at least 30 s while wearing a waist-mounted smartphone. A total number of 414 features was extracted from both time and frequency domain, selected based on Pearson’s correlation, and fed to an optimized Support Vector Machine. Results: The implemented model was able to differentiate patients with mild postural instability from those with severe postural instability and from healthy controls, with 100% accuracy. Conclusion: This study demonstrated the feasibility of using inertial sensors embedded in commercial smartphones and proposed a simple protocol for accurate postural instability scoring. This tool can be used for early detection of PD motor signs, disease follow-up and fall prevention.

scholarly journals Extradural Motor Cortex Stimulation in Parkinson’s Disease: Long-Term Clinical Outcome

2021 ◽  
Vol 11 (4) ◽  
pp. 416
Author(s):  
Carla Piano ◽  
Francesco Bove ◽  
Delia Mulas ◽  
Enrico Di Stasio ◽  
Alfonso Fasano ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Cortex ◽  
Clinical Outcome ◽  
Motor Cortex Stimulation ◽  
Dopaminergic Therapy

Previous investigations have reported on the motor benefits and safety of chronic extradural motor cortex stimulation (EMCS) for patients with Parkinson’s disease (PD), but studies addressing the long-term clinical outcome are still lacking. In this study, nine consecutive PD patients who underwent EMCS were prospectively recruited, with a mean follow-up time of 5.1 ± 2.5 years. As compared to the preoperatory baseline, the Unified Parkinson’s Disease Rating Scale (UPDRS)-III in the off-medication condition significantly decreased by 13.8% at 12 months, 16.1% at 18 months, 18.4% at 24 months, 21% at 36 months, 15.6% at 60 months, and 8.6% at 72 months. The UPDRS-IV decreased by 30.8% at 12 months, 22.1% at 24 months, 25% at 60 months, and 36.5% at 72 months. Dopaminergic therapy showed a progressive reduction, significant at 60 months (11.8%). Quality of life improved by 18.0% at 12 months, and 22.4% at 60 months. No surgical complication, cognitive or behavioral change occurred. The only adverse event reported was an infection of the implantable pulse generator pocket. Even in the long-term follow-up, EMCS was shown to be a safe and effective treatment option in PD patients, resulting in improvements in motor symptoms and quality of life, and reductions in motor complications and dopaminergic therapy.

scholarly journals QUANTITATIVE ASSESSMENT OF DANCE THERAPY INFULENCE ON THE PARKINSON’S DISEASE PATIENTS’ LOWER LIMB BIOMECHANICS / ŠOKIŲ ĮTAKA APATINIŲ GALŪNIŲ BIOMECHANIKAI SERGANT PARKINSONO LIGA

2017 ◽  
Vol 8 (6) ◽  
pp. 583-586
Author(s):  
Donatas Lukšys ◽  
Julius Griškevičius
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Lower Extremity ◽  
Lower Limb ◽  
Dance Therapy ◽  
Inertial Sensors ◽  
Dance Music ◽  
Lindy Hop ◽  
Spatio Temporal

Parkinson’s disease – progressive neurologic disorder that damages a variety of motor function and reduces the quality of life. Patients with PD are subject to various physical therapy exercises, but recently is applied more often the dance – music therapy. This study aims assessing the therapeutic effect of the modified Lindy Hop dance therapy on lower extremity biomechanics. The experimental study was performed using inertial sensors that registered lower extremity biomechanical parameters during gait. Several spatio-temporal parameters of lower limb were calculated and were found statistically significant between groups, which allows quantifying the influence of dance therapy. Parkinsono liga (PL) – progresuojantis neurologinis sutrikimas, kuris pažeidžia įvairias motorines funkcijas ir sumažina gyvenimo kokybę. Sergant PL, taikomos įvairios fizinių pratimų terapijos, bet paskutiniu metu dažniau taikoma šokių – muzikos – terapija. Eksperimentinio tyrimo metu buvo naudojami inerciniai jutikliai, siekiant registruoti apatinių galūnių biomechaninius parametrus eisenos metu. Šio straipsnio tikslas – įvertinti modifikuotos lindihopo šokių terapijos įtaką apatinių galūnių biomechanikai. Buvo apskaičiuoti apatinių galūnių kinematiniai parametrai ir surasti statistiškai reikšmingi skirtumai tarp grupių ir grupių viduje, kurie leidžia kiekybiškai įvertinti šokių įtaką.

scholarly journals Influence of the COVID-19 Pandemic on Quality of Life of Patients with Parkinson’s Disease

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Dengjun Guo ◽  
Bing Han ◽  
Yuqiang Lu ◽  
Chenling Lv ◽  
Xiaoling Fang ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Prevention And Control ◽  
Control Period ◽  
And Control ◽  
Disease Questionnaire ◽  
Gradual Release

Introduction. This study investigated the influence of lockdown during the 2019 coronavirus disease (COVID-19) pandemic on the quality of life of patients with Parkinson’s disease (PD). Methods. We conducted a questionnaire survey involving 113 patients with PD from Xihu District, Hangzhou, Zhejiang. During the epidemic prevention and control period (February 1 to March 31, 2020), patients enrolled were asked to fill out questionnaires, including the “COVID-19 Questionnaire for PD Patients during the Period of Epidemic Prevention and Control” and “39-item Parkinson’s Disease Questionnaire (PDQ-39).” During the phase of gradual release of epidemic prevention and control (April 1 to April 30, 2020), all patients were followed up again, and PDQ-39 questionnaires were completed. Results. The quality of life for patients during the period of epidemic prevention and control was worse than that after epidemic prevention and control (P < 0.001). The biggest problem that they faced was that they could not receive their doctor’s advice or guidance regularly. The quality of life of patients who had difficulty getting doctors’ guidance or those who changed their routine medication due to lockdown was even worse. Telemedicine was quite effective and efficient for patients to get doctors’ guidance during lockdown. Conclusions. The inconvenient treatment during the pandemic directly caused the aggravation of patients’ symptoms and the decline in their quality of life. It is suggested that social media (such as WeChat or Tencent QQ) are used for regular interactions and follow-up appointments for patients with inconvenient medical treatment.

scholarly journals Predictors of Functional and Quality of Life Outcomes following Deep Brain Stimulation Surgery in Parkinson’s Disease Patients: Disease, Patient, and Surgical Factors

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Hesham Abboud ◽  
Gencer Genc ◽  
Nicolas R. Thompson ◽  
Srivadee Oravivattanakul ◽  
Faisal Alsallom ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Postural Instability ◽  
Functional Scores ◽  
Global Impression Of Change ◽  
Deep Brain

Objective. The primary objective was to evaluate predictors of quality of life (QOL) and functional outcomes following deep brain stimulation (DBS) in Parkinson’s disease (PD) patients. The secondary objective was to identify predictors of global improvement. Methods. PD patients who underwent DBS at our Center from 2006 to 2011 were evaluated by chart review and email/phone survey. Postoperative UPDRS II and EQ-5D were analyzed using simple linear regression adjusting for preoperative score. For global outcomes, we utilized the Patient Global Impression of Change Scale (PGIS) and the Clinician Global Impression of Change Scale (CGIS). Results. There were 130 patients in the dataset. Preoperative and postoperative UPDRS II and EQ-5D were available for 45 patients, PGIS for 67 patients, and CGIS for 116 patients. Patients with falls/postural instability had 6-month functional scores and 1-year QOL scores that were significantly worse than patients without falls/postural instability. For every 1-point increase in preoperative UPDRS III and for every 1-unit increase in body mass index (BMI), the 6-month functional scores significantly worsened. Patients with tremors, without dyskinesia, and without gait-freezing were more likely to have “much” or “very much” improved CGIS. Conclusions. Presence of postural instability, high BMI, and worse baseline motor scores were the greatest predictors of poorer functional and QOL outcomes after DBS.

scholarly journals DeepFoG: An IMU-Based Detection of Freezing of Gait Episodes in Parkinson’s Disease Patients via Deep Learning

2021 ◽  
Vol 8 ◽  
Author(s):  
Thomas Bikias ◽  
Dimitrios Iakovakis ◽  
Stelios Hadjidimitriou ◽  
Vasileios Charisis ◽  
Leontios J. Hadjileontiadis
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Learning ◽  
Life Stress ◽  
Freezing Of Gait ◽  
Measurement Unit ◽  
Effective Interventions ◽  
Risk Of Falls

Freezing of Gait (FoG) is a movement disorder that mostly appears in the late stages of Parkinson’s Disease (PD). It causes incapability of walking, despite the PD patient’s intention, resulting in loss of coordination that increases the risk of falls and injuries and severely affects the PD patient’s quality of life. Stress, emotional stimulus, and multitasking have been encountered to be associated with the appearance of FoG episodes, while the patient’s functionality and self-confidence are constantly deteriorating. This study suggests a non-invasive method for detecting FoG episodes, by analyzing inertial measurement unit (IMU) data. Specifically, accelerometer and gyroscope data from 11 PD subjects, as captured from a single wrist-worn IMU sensor during continuous walking, are processed via Deep Learning for window-based detection of the FoG events. The proposed approach, namely DeepFoG, was evaluated in a Leave-One-Subject-Out (LOSO) cross-validation (CV) and 10-fold CV fashion schemes against its ability to correctly estimate the existence or not of a FoG episode at each data window. Experimental results have shown that DeepFoG performs satisfactorily, as it achieves 83%/88% and 86%/90% sensitivity/specificity, for LOSO CV and 10-fold CV schemes, respectively. The promising performance of the proposed DeepFoG reveals the potentiality of single-arm IMU-based real-time FoG detection that could guide effective interventions via stimuli, such as rhythmic auditory stimulation (RAS) and hand vibration. In this way, DeepFoG may scaffold the elimination of risk of falls in PD patients, sustaining their quality of life in everyday living activities.

scholarly journals Orthostatic Hypotension in Patients with Parkinson’s Disease and Atypical Parkinsonism

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Seyed-Mohammad Fereshtehnejad ◽  
Johan Lökk
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Orthostatic Hypotension ◽  
Treatment Options ◽  
Motor Symptoms ◽  
Atypical Parkinsonism ◽  
Medical Databases ◽  
Risk Of Falls ◽  
Review Current

Orthostatic hypotension (OH) is one of the commonly occurring nonmotor symptoms in patients with idiopathic Parkinson’s disease (IPD) and atypical parkinsonism (AP). We aimed to review current evidences on epidemiology, diagnosis, treatment, and prognosis of OH in patients with IPD and AP. Major electronic medical databases were assessed including PubMed/MEDLINE and Embase up to February 2013. English-written original or review articles with keywords such as “Parkinson’s disease,” “atypical parkinsonism,” and “orthostatic hypotension” were searched for relevant evidences. We addressed different issues such as OH definition, epidemiologic characteristics, pathophysiology, testing and diagnosis, risk factors for symptomatic OH, OH as an early sign of IPD, prognosis, and treatment options of OH in parkinsonian syndromes. Symptomatic OH is present in up to 30% of IPD, 80% of multiple system atrophy (MSA), and 27% of other AP patients. OH may herald the onset of PD before cardinal motor symptoms and our review emphasises the importance of its timely diagnosis (even as one preclinical marker) and multifactorial treatment, starting with patient education and lifestyle approach. Advancing age, male sex, disease severity, and duration and subtype of motor symptoms are predisposing factors. OH increases the risk of falls, which affects the quality of life in PD patients.

scholarly journals A Meta-Analysis on the Efficacy of Tai Chi in Patients with Parkinson’s Disease between 2008 and 2014

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Ji Zhou ◽  
Tao Yin ◽  
Qian Gao ◽  
Xiao Cun Yang
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Function ◽  
Tai Chi ◽  
Meta Analysis ◽  
Sufficient Evidence ◽  
Gait Velocity ◽  
Valid Evidence

Objective. The purpose of this systematic review is to evaluate the evidence on the effect of Tai Chi for Parkinson’s disease (PD).Methods. Six electronic databases up to June 2014 were searched. The methodological quality was assessed with PEDro scale. Standardised mean difference and 95% confidence intervals of random-effects model were calculated.Results. Nine studies were included in our review. The aggregated results are in favor of Tai Chi on improving motor function (P=0.002) and balance (P<0.00001) in patients with PD. However, there is no sufficient evidence to support or refute the value of Tai Chi on improving gait velocity (P=0.11), stride length (P=0.21), or quality of life (P=0.40). And there is no valid evidence in follow-up effects of Tai Chi for PD. Conclusion. The current results suggest that Tai Chi can significantly improve the motor function and balance in patients with PD, but there is indeed not enough evidence to conclude that Tai Chi is effective for PD because of the small treatment effect, methodological flaws of eligible studies, and insufficient follow-up. Consequently, high-quality studies with long follow-up are warranted to confirm current beneficial findings.

Sign in / Sign up

Export Citation Format

Share Document