scholarly journals Development of Natural-Drugs-Based Low-Molecular-Weight Supramolecular Gels

Gels ◽  
2021 ◽  
Vol 7 (3) ◽  
pp. 105
Author(s):  
Xiaoyi Feng ◽  
Yuning Luo ◽  
Fangjie Li ◽  
Xueting Jian ◽  
Yang Liu
Keyword(s):  
Molecular Weight ◽  
Self Assembly ◽  
Water Solubility ◽  
Drug Loading ◽  
Building Blocks ◽  
Low Molecular Weight ◽  
Assembly Mechanism ◽  
Supramolecular Gels ◽  
Potential Applications ◽  
Natural Drugs

Natural small molecular drugs with excellent biocompatibility, diverse pharmacological activities, and wide sources play an increasingly important role in the development of new drug and disease treatment. In recent years, the utilization of paclitaxel, camptothecin, rhein, curcumin, and other natural small molecular drugs with unique rigid backbone structures and modifiable multiple sites as building blocks to form gels by self-assembly has attracted widespread attention. The obtained low-molecular-weight supramolecular gel not only retains the general characteristics of the gel but also overcomes the shortcomings of natural drugs, such as poor water solubility and low bioavailability. It has the advantages of high drug loading, low toxicity, and outstanding stimulus responsiveness, which is widely used in biomedical fields. Here, we provided a comprehensive review of natural-drugs-based low-molecular-weight supramolecular gels reported in recent years and summarized their assembly mechanism, gel structure, gel properties, and potential applications. It is expected to provide a reference for further research of natural-drugs-based supramolecular gels.

scholarly journals Cavity-containing supramolecular gels as a crystallization tool for hydrophobic pharmaceuticals

2016 ◽  
Vol 52 (66) ◽  
pp. 10113-10116 ◽  
Author(s):  
Lena Kaufmann ◽  
Stuart R. Kennedy ◽  
Christopher D. Jones ◽  
Jonathan W. Steed
Keyword(s):  
Molecular Weight ◽  
Building Blocks ◽  
Low Molecular Weight ◽  
Supramolecular Gels

We present two approaches to low-molecular-weight supramolecular gels bearing hydrophobic cavities based on calixarene-containing building blocks.

scholarly journals Synthesis and characterization of pH responsive D-glucosamine based molecular gelators

2014 ◽  
Vol 10 ◽  
pp. 3111-3121 ◽  
Author(s):  
Navneet Goyal ◽  
Hari P R Mangunuru ◽  
Bargav Parikh ◽  
Sonu Shrestha ◽  
Guijun Wang
Keyword(s):  
Molecular Weight ◽  
Building Blocks ◽  
Negative Influence ◽  
Low Molecular Weight ◽  
Ph Responsive ◽  
Triggered Release ◽  
Self Assembling ◽  
Potential Applications ◽  
Low Molecular Weight Gelators ◽  
Neutral Conditions

Small molecular gelators are a class of compounds with potential applications for soft biomaterials. Low molecular weight hydrogelators are especially useful for exploring biomedical applications. Previously, we found that 4,6-O-benzylidene acetal protected D-glucose and D-glucosamine are well-suited as building blocks for the construction of low molecular weight gelators. To better understand the scope of D-glucosamine derivatives as gelators, we synthesized and screened a novel class of N-acetylglucosamine derivatives with a p-methoxybenzylidene acetal protective group. This modification did not exert a negative influence on the gelation. On the contrary, it actually enhanced the gelation tendency for many derivatives. The introduction of the additional methoxy group on the phenyl ring led to low molecular weight gelators with a higher pH responsiveness. The resulting gels were stable at neutral pH values but degraded in an acidic environment. The release profiles of naproxen from the pH responsive gels were also analyzed under acidic and neutral conditions. Our findings are useful for the design of novel triggered release self-assembling systems and can provide an insight into the influence of the the structure on gelation.

scholarly journals Hydrogen-bonded liquid crystals with broad-range blue phases

2019 ◽  
Vol 7 (11) ◽  
pp. 3150-3153 ◽  
Author(s):  
Marco Saccone ◽  
Michael Pfletscher ◽  
Ellen Dautzenberg ◽  
Ronald Y. Dong ◽  
Carl A. Michal ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Liquid Crystals ◽  
Self Assembly ◽  
Building Blocks ◽  
Low Molecular Weight ◽  
Blue Phases ◽  
Hydrogen Bonded

A series of hydrogen-bonded liquid crystals with broad blue phases formed by self-assembly of low molecular weight building blocks is described.

On the structural stability of guanosine-based supramolecular hydrogels

Soft Matter ◽  
2018 ◽  
Vol 14 (15) ◽  
pp. 2938-2948 ◽  
Author(s):  
Federica Carducci ◽  
Juliana S. Yoneda ◽  
Rosangela Itri ◽  
Paolo Mariani
Keyword(s):  
Molecular Weight ◽  
Structural Stability ◽  
Self Assembly ◽  
The Self ◽  
Low Molecular Weight ◽  
Potential Applications

Supramolecular hydrogels formed from the self-assembly of low molecular weight derivatives are very attractive systems, because of their potential applications in nano- and bio-technology.

scholarly journals Facile construction of a family of supramolecular gels with good levofloxacin hydrochloride loading capacity

RSC Advances ◽  
2021 ◽  
Vol 11 (21) ◽  
pp. 12641-12648
Author(s):  
Renyuan Chen ◽  
Caidie Xu ◽  
Yihao Lei ◽  
Hongxin Liu ◽  
Yabin Zhu ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Alkyl Chain ◽  
Low Molecular Weight ◽  
Loading Capacity ◽  
Supramolecular Gels ◽  
Low Molecular Weight Gelators ◽  
Chain Lengths

A family of low molecular weight gelators with different alkyl chain lengths was constructed, having excellent gelation ability and antibiotic loading capacity. A low molecular weight hydrogelator was obtained by adjusting the length of alkyl chain.

scholarly journals A Structurally Variable Hinged Tetrahedron Framework from DNA Origami

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
David M. Smith ◽  
Verena Schüller ◽  
Carsten Forthmann ◽  
Robert Schreiber ◽  
Philip Tinnefeld ◽  
...  
Keyword(s):  
Self Assembly ◽  
Gel Electrophoresis ◽  
Imaging Techniques ◽  
Building Blocks ◽  
Dna Origami ◽  
Microscopy Technique ◽  
Wire Frame ◽  
Wide Range ◽  
Potential Applications ◽  
Linker Molecules

Nanometer-sized polyhedral wire-frame objects hold a wide range of potential applications both as structural scaffolds as well as a basis for synthetic nanocontainers. The utilization of DNA as basic building blocks for such structures allows the exploitation of bottom-up self-assembly in order to achieve molecular programmability through the pairing of complementary bases. In this work, we report on a hollow but rigid tetrahedron framework of 75 nm strut length constructed with the DNA origami method. Flexible hinges at each of their four joints provide a means for structural variability of the object. Through the opening of gaps along the struts, four variants can be created as confirmed by both gel electrophoresis and direct imaging techniques. The intrinsic site addressability provided by this technique allows the unique targeted attachment of dye and/or linker molecules at any point on the structure's surface, which we prove through the superresolution fluorescence microscopy technique DNA PAINT.

Access to Metastable Gel States Using Seeded Self‐Assembly of Low‐Molecular‐Weight Gelators

2019 ◽  
Vol 58 (12) ◽  
pp. 3800-3803 ◽  
Author(s):  
Yiming Wang ◽  
Robin M. de Kruijff ◽  
Matija Lovrak ◽  
Xuhong Guo ◽  
Rienk Eelkema ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Self Assembly ◽  
Low Molecular Weight ◽  
Low Molecular Weight Gelators

scholarly journals Thermally tunable selective formation of self-assembled fibers into two orthogonal directions in oriented liquid-crystalline smectic templates

2020 ◽  
Vol 56 (69) ◽  
pp. 9954-9957
Author(s):  
Daisuke Yamaguchi ◽  
Yuka Ikemoto ◽  
Takashi Kato
Keyword(s):  
Molecular Weight ◽  
Self Assembly ◽  
Liquid Crystalline ◽  
Layered Structures ◽  
Low Molecular Weight ◽  
Smectic A ◽  
Orthogonal Grid ◽  
Self Assembled ◽  
Low Molecular Weight Gelators ◽  
Selective Formation

Two orthogonal (grid-like) and one directional fibrous structures are selectively formed through anisotropic self-assembly of low-molecular-weight gelators in liquid-crystalline smectic A templates depending on thermally tuned layered structures.

Amplified Analysis of Low-Molecular-Weight Substrates or Proteins by the Self-Assembly of DNAzyme−Aptamer Conjugates

2007 ◽  
Vol 129 (18) ◽  
pp. 5804-5805 ◽  
Author(s):  
Di Li ◽  
Bella Shlyahovsky ◽  
Johann Elbaz ◽  
Itamar Willner
Keyword(s):  
Molecular Weight ◽  
Self Assembly ◽  
The Self ◽  
Low Molecular Weight
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