scholarly journals Phenotypic Disease Network Analysis to Identify Comorbidity Patterns in Hospitalized Patients with Ischemic Heart Disease Using Large-Scale Administrative Data

Healthcare ◽  
2022 ◽  
Vol 10 (1) ◽  
pp. 80
Author(s):  
Dejia Zhou ◽  
Liya Wang ◽  
Shuhan Ding ◽  
Minghui Shen ◽  
Hang Qiu
Keyword(s):  
Heart Disease ◽  
Network Analysis ◽  
Ischemic Heart Disease ◽  
Administrative Data ◽  
Large Scale ◽  
Integrated Management ◽  
Cerebrovascular Diseases ◽  
Hospitalized Patients ◽  
Ischemic Heart ◽  
Healthcare Database

Ischemic heart disease (IHD) exhibits elevated comorbidity. However, few studies have systematically analyzed the comorbid status of IHD patients with respect to the entire spectrum of chronic diseases. This study applied network analysis to provide a complete picture of physical and mental comorbidities in hospitalized patients with IHD using large-scale administrative data. Hospital discharge records from a provincial healthcare database of IHD inpatients (n = 1,035,338) and one-to-one matched controls were included in this retrospective analysis. We constructed the phenotypic disease networks in IHD and control patients and further assessed differences in comorbidity patterns. The community detection method was applied to cluster diagnoses within the comorbidity network. Age- and sex-specific patterns of IHD comorbidities were also analyzed. IHD inpatients showed 50% larger comorbid burden when compared to controls. The IHD comorbidity network consisted of 1941 significant associations between 71 chronic conditions. Notably, the more densely connected comorbidities in IHD patients were not within the highly prevalent ones but the rarely prevalent ones. Two highly interlinked communities were detected in the IHD comorbidity network, where one included hypertension with heart and multi-organ failures, and another included cerebrovascular diseases, cerebrovascular risk factors and anxiety. Males exhibited higher comorbid burden than females, and thus more complex comorbidity relationships were found in males. Sex-specific disease pairs were detected, e.g., 106 and 30 disease pairs separately dominated in males and females. Aging accounts for the majority of comorbid burden, and the complexity of the comorbidity network increased with age. The network-based approach improves our understanding of IHD-related comorbidities and enhances the integrated management of patients with IHD.

Abstract P88: Risk of Stroke in Hospitalized SARS-Cov-2 Infected Patients a Multinational Population-Based Study

Stroke ◽  
2021 ◽  
Vol 52 (Suppl_1) ◽  
Author(s):  
Shima Shahjouei ◽  
Soheil Naderi ◽  
Jiang Li ◽  
Durgesh Chaudhary ◽  
Christoph Griessenauer ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Heart Disease ◽  
Ischemic Stroke ◽  
Ischemic Heart Disease ◽  
Associated Factors ◽  
Sinus Thrombosis ◽  
Hospitalized Patients ◽  
Ischemic Heart ◽  
National Study ◽  
Meta Analyses

The goal of this study was to better depict the short-term risk of stroke and its associated factors among SARS-CoV-2 hospitalized patients. Data Source: This multicenter, multinational observational study includes hospitalized SARS-CoV-2 patients from North and South America (United States, Canada, and Brazil), Europe (Greece, Italy, Finland, and Turkey), Asia (Lebanon, Iran, and India), and Oceania (New Zealand). Main Outcomes and Measures: The outcome was the risk of subsequent stroke (ischemic stroke, intracranial hemorrhage, cerebral venous/sinus thrombosis). The counts and clinical characteristics including laboratory findings and imaging of the patients with and without a subsequent stroke were recorded according to a predefined study protocol. Data Extraction and Synthesis: Quality, risk of bias, and heterogeneity assessments were conducted according to ROBINS-E and Cochrane Q-test. The risk of subsequent stroke was estimated through meta-analyses with random effect models. Binary logistic regression was used to determine the associated factors with the outcome measure. The study was reported according to the STROBE, MOOSE, and EQUATOR guidelines. Results: We received data from 18,311 hospitalized SARS-CoV-2 patients from 77 tertiary centers in 46 regions of 11 countries until May 1 st , 2020. A total of 17,799 patients were included in meta-analyses. Among them, 156(0.9%) patients had a stroke—123(79%) ischemic stroke, 27(17%) intracerebral/subarachnoid hemorrhage, and 6(4%) cerebral sinus thrombosis. Subsequent stroke risks calculated with meta-analyses, under low to moderate heterogeneity, were 0.5% among all centers in all countries, and 0.7% among countries with higher health expenditures. The need for mechanical ventilation (OR: 1.9, 95% CI:1.1-3.5, p = 0.03) and the presence of ischemic heart disease (OR: 2.5, 95% CI:1.4-4.7, p =0·006) were predictive of stroke. Conclusion and Relevance: The results of this multi-national study on hospitalized patients with SARS-CoV-2 infection indicated an overall stroke risk of 0.5% (pooled risk: 0.9%). The need for mechanical ventilation and the history of ischemic heart disease are the independent predictors of stroke among SARS-CoV-2 patients.

Long-term nitrate use may be deleterious in ischemic heart disease: A study using the databases from two large-scale postinfarction studies

1999 ◽  
Vol 138 (3) ◽  
pp. 577-585 ◽  
Author(s):  
Yasuyuki Nakamura ◽  
Arthur J Moss ◽  
Mary W. Brown ◽  
Masahiko Kinoshita ◽  
Chuichi Kawai
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Large Scale ◽  
Ischemic Heart

scholarly journals AGE/SEX-SPECIFIC MORTALITY RATES FROM CIRCULATORY SYSTEM DISEASES AMONG OUTPATIENTS OF A KRASNODAR POLYCLINIC

2019 ◽  
Vol 26 (3) ◽  
pp. 99-107
Author(s):  
Elena V. Bolotova ◽  
Anna V. Kontsevaya ◽  
Irina V. Kovrigina ◽  
Larisa P. Lyuberitskaya
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Circulatory System ◽  
Mortality Rates ◽  
Cerebrovascular Diseases ◽  
Ischemic Heart ◽  
Medical Documentation ◽  
Chronic Ischemic Heart Disease ◽  
Circulatory System Diseases ◽  
Specific Mortality

Aim.In this work, we undertook a study of age/sex-specific mortality rates from circulatory system diseases and certain nosological forms in 2015 and 2018 among outpatients of Research Institute — Ochapovsky Regional Clinical Hospital No. 1 delivering primary healthcare services.Materials and methods.We studied age/sex-specific mortality rates from circulatory system diseases among adult population using the data from the medical records of deceased outpatients (Form 025/u), extracts from autopsy reports, as well as medical certificates of death for 2015 and 2018. Non-standardised and standardised mortality rates were calculated.Results.In 2015, all-cause mortality rate by the medical organisation reached 6.2 per 1,000 population, with the total number of deaths from circulatory system diseases amounting to 49.6%. The non-standardised mortality rates from the circulatory system diseases totalled 307.81 per 100,000 population, including the non-standardised mortality rates from cerebrovascular diseases (44.68), ischemic heart disease (129.08) and myocardial infarction (4.96). Standardised mortality rates from circulatory system diseases amounted to 201.96 (men — 70.58, women — 131.38). In 2015, chronic ischemic heart disease (41.94%) ranked first as the cause of mortality among circulatory system diseases followed by diagnoses requiring additional interpretation and examination of primary medical documentation (35.48%), i.e. not clearly defined causes of death; and cerebrovascular diseases (14.52%). In 2018, chronic ischemic heart disease also ranked first (47.54%) followed by cerebrovascular (36.21%) and other diseases (16.39%) (ICD codes I26, I71.1, R00.8).Conclusion.It is shown that more attention from the cardiological and therapeutic services of primary health care is required in coding death-causing circulatory system diseases.

The Role of Platelets in Myocardial Infarction, Ischemic Heart Disease, Cerebrovascular Disease, Thromboembolic Disorders and Acute Idiopathic Pericarditis

1977 ◽  
Vol 38 (04) ◽  
pp. 1073-1084 ◽  
Author(s):  
J Zahavi
Keyword(s):  
Myocardial Infarction ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Thrombus Formation ◽  
Adenosine Diphosphate ◽  
Cerebrovascular Diseases ◽  
Ischemic Heart ◽  
Contributory Factor ◽  
Acute Infectious Disease ◽  
Discharge From Hospital

SummaryInitial white thrombus formation, has been attributed to platelet interaction with damaged vessel wall at sites of vascular injury or atherosclerotic plaques in the process of platelet aggregation (PA) and adhesion. Enhancement of PA seems to be an important factor in the development of thrombosis in the coronary and cerebral blood vessels and in embolization of platelet microthrombi to the microcirculation of the vessels. This latter event in turn might lead to serious or fatal arrhythmias or to paroxysms of cerebral ischemia.We have found enhanced PA in 66 patients with acute myocardial infarction (MI) and ischemic heart disease (IHD) which was specifically indicated by 4 distinct abnormalities: a) increased rate and extent of aggregation to 11,1 μM of adenosine diphosphate (ADP). b) Increased platelet responsiveness to 1,11 μM of ADP. c) Spontaneous aggregation which appeared in 95% of the patients compared to less than 5% of controls, d) Prolonged aggregation time indicated by parameter τ, τ = -[dt/dln(T–T ∞ ≤)], In addition, enhanced and occasionally more pronounced PA on the day of discharge from hospital, has been recently observed. The abnormal platelet behaviour was also detected in 10 thromboembolic disorder (TED), 28 acute cerebrovascular accident (CVA) and 24 acute infectious disease (AI) patients. It was, however, more pronounced in MI compared to TED and CVA patients. In AI the curves returned to normal some time after their subsidence, but remained abnormal for up to 2 years in IHD patients. In 10 patients with acute benign idiopathic pericarditis, which were included in the AI patients, PA proved to be a rehable indicator of the course of the disease and its treatment. Early reduction of corticosteroid dosage in the patients, was followed by increased abnormalities in the PA curves.The enhanced PA in these patients is most probably an indicator of a thrombogenic state and seems to be an important contributory factor in the pathogenesis of coronary and cerebrovascular diseases. Preliminary reports of anti-aggregating drugs, wether beneficial or adverse, in these vascular disorders are controversial and further research is needed.

scholarly journals Effect of High Temperatures on Daily Counts of Mortality from Diseases of Circulatory System in Astana, Kazakhstan

Medicina ◽  
2013 ◽  
Vol 48 (12) ◽  
pp. 94 ◽  
Author(s):  
Andrej Grjibovski ◽  
Nassikhat Nurgaliyeva ◽  
Aliya Kosbayeva ◽  
Altay Sharbakov ◽  
Telman Seysembekov ◽  
...  
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Circulatory System ◽  
Cerebrovascular Diseases ◽  
Ischemic Heart ◽  
Apparent Temperature ◽  
Inverse Association ◽  
Icd 10 ◽  
Hypertensive Diseases ◽  
The City

Background and Objective. Associations between hot temperatures and both overall and cardio- and cerebrovascular mortality have been observed in many European, North American, and Southeastern Asian cities. However, the effects varied among the settings with limited evidence from the countries with arid and semiarid climates. The aim of this study was to assess the effect of air temperature on deaths from the selected diseases of the circulatory system in the city of Astana, Kazakhstan. Material and Methods. The daily counts of deaths from hypertensive diseases (ICD-10 codes, I10–I15), cerebrovascular diseases (ICD-10 codes, I60–I69), and ischemic heart disease (ICD-10 codes, I20–I25) during the warm seasons (April-September) of 2000–2001 and 2006–2010 were obtained from the City Registry Office. The associations between the maximum apparent temperature (average of lags 0–3) and mortality were assessed by a first-order autoregressive Poisson regression with the adjustment for barometric pressure (average of lags 0–3), wind speed, and effects of month, year, holidays, and weekends. Results. Altogether, there were 282, 1177, and 2994 deaths from hypertensive diseases, cerebrovascular diseases, and ischemic heart disease, respectively. The maximum effective temperature varied between –2.2°C and 44.5°C. An increase in temperature by 1°C was associated with a 1.9% (95% CI, 0.3–3.5) increase in the daily number of deaths from cerebrovascular diseases and with a 3.1% (95% CI, 0.2–6.1) decrease in the number of deaths from hypertensive diseases among women. Conclusions. The results suggest a positive association between the maximum apparent temperature and the daily counts of deaths from cerebrovascular diseases and an inverse association between temperature and mortality from hypertensive diseases, but only among women.

scholarly journals Longitudinal Effects of Serum Calcium and Phosphate Levels and Their Ratio on Incident Ischemic Heart Disease among Korean Adults

Biomolecules ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. 103
Author(s):  
Dong Hyuk Jung ◽  
Byoungjin Park ◽  
Yong Jae Lee
Keyword(s):  
Heart Disease ◽  
Calcium Phosphate ◽  
Ischemic Heart Disease ◽  
Serum Calcium ◽  
Large Scale ◽  
Reference Group ◽  
Cox Proportional Hazards ◽  
Community Dwelling ◽  
Ischemic Heart ◽  
Health Insurance Data

Serum calcium and phosphate levels are controlled by a regulatory system, but their individual concentration tendencies and interactions may affect long-term vascular health. This study aimed to assess the effects of serum calcium and phosphate levels on incident ischemic heart disease (IHD) in a large-scale community-dwelling Korean cohort. We evaluated 15,259 non-diabetic individuals (median age, 45 years; range, 30–85) without previous IHD or ischemic stroke using the Korean National Health Insurance data. The study population was classified based on the calcium, phosphate, and calcium/phosphate ratios. Using Cox proportional hazards regression models, we estimated hazard ratios (HRs) with 95% confidence intervals (CIs) for IHD over 50 months after baseline enrolment. The age- and sex-adjusted incidence of IHD gradually increased with serum calcium and phosphate quartiles and decreased with calcium/phosphate ratio quartiles, with an overall crude rate of 2.1% (315/15,259). After setting the lowest calcium, phosphate, and calcium/phosphate ratio quartiles as a reference group, the HRs (95% CIs) of the highest calcium, phosphate, and calcium/phosphate ratio quartiles for IHD were 1.77 (1.15–2.72), 1.73 (1.18–2.55), and 0.58 (0.39–0.87), respectively, after adjusting for potential confounding variables. Serum calcium and phosphate levels were positively associated with IHD incidence, while the serum calcium/phosphate ratio exhibited an inverse relationship. Serum calcium and phosphate homeostasis may merit serious consideration to understand the pathogenesis of coronary atherosclerosis as a risk modifier for IHD.

scholarly journals Risk analysis of the mortality from the diseases of the circulatory system in the Ural cohort of emergency-irradiated population for the years 1950–2015

2019 ◽  
Vol 12 (1) ◽  
pp. 52-61 ◽  
Author(s):  
L. Yu. Krestinina ◽  
S. S. Silkin ◽  
M. O. Degteva ◽  
A. V. Akleyev
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Latent Period ◽  
Circulatory System ◽  
Southern Urals ◽  
Cerebrovascular Diseases ◽  
Ischemic Heart ◽  
The Southern Urals ◽  
Techa River ◽  
All Diseases

The paper describes for the first time the results of the radiation effect study using the example of the analysis of circulatory system disease mortality in newly established cohort combining the population exposed in 1950–1960 due to 2 radiation incidents in the Southern Urals (the Techa River and East-Urals radioactive Trace). The cohort consists of 60,205 people. Over a 65-year follow up period 14,830 deaths from all diseases of the circulatory system were registered. Out of this number 6,163 deaths were from ischemic heart disease, and 4,388 deaths were from cerebrovascular diseases. Analysis was performed on the basis of individualized estimates of dose accumulated in muscle tissue (both internal and external components of the dose), calculated with new Techa River Dosimetry System 2016. As per the latest calculations, mean dose to muscle tissue in members of the combined cohort was 34 mGy, maximum dose was 995 mGy. Simple parametric model of excess relative risk (ERR) was used in the analysis. The number of person-years at risk was 1836,203. The findings of the analysis show linear increase of mortality risk per unit dose from all the disease of circulatory system (ERR/100 mGy was 3%; 95% CI: 0,8%; 5,2%) and from ischemic heart disease (ERR/100 mGy was 9,2%; 95% CI: 5,4%; 13,5%). with 15-year latent period. No statistically significant increase in mortality from the cerebrovascular diseases in the combined cohort of the population exposed in the Southern Urals over a 65-year period received evidence. The obtained results are in good agreement with those received in the analysis of the effect in the Techa River Cohort in 2013. The latter covered a 53-year period (with minimum latent period of 15 years) and revealed statistically significant linear dose response for all diseases of the circulatory system (ERR/100 mGy – 0.036) and ischemic heart disease (ERR/100 mGy – 0.056).

Sign in / Sign up

Export Citation Format

Share Document