scholarly journals Risk analysis of the mortality from the diseases of the circulatory system in the Ural cohort of emergency-irradiated population for the years 1950–2015

2019 ◽  
Vol 12 (1) ◽  
pp. 52-61 ◽  
Author(s):  
L. Yu. Krestinina ◽  
S. S. Silkin ◽  
M. O. Degteva ◽  
A. V. Akleyev
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Latent Period ◽  
Circulatory System ◽  
Southern Urals ◽  
Cerebrovascular Diseases ◽  
Ischemic Heart ◽  
The Southern Urals ◽  
Techa River ◽  
All Diseases

The paper describes for the first time the results of the radiation effect study using the example of the analysis of circulatory system disease mortality in newly established cohort combining the population exposed in 1950–1960 due to 2 radiation incidents in the Southern Urals (the Techa River and East-Urals radioactive Trace). The cohort consists of 60,205 people. Over a 65-year follow up period 14,830 deaths from all diseases of the circulatory system were registered. Out of this number 6,163 deaths were from ischemic heart disease, and 4,388 deaths were from cerebrovascular diseases. Analysis was performed on the basis of individualized estimates of dose accumulated in muscle tissue (both internal and external components of the dose), calculated with new Techa River Dosimetry System 2016. As per the latest calculations, mean dose to muscle tissue in members of the combined cohort was 34 mGy, maximum dose was 995 mGy. Simple parametric model of excess relative risk (ERR) was used in the analysis. The number of person-years at risk was 1836,203. The findings of the analysis show linear increase of mortality risk per unit dose from all the disease of circulatory system (ERR/100 mGy was 3%; 95% CI: 0,8%; 5,2%) and from ischemic heart disease (ERR/100 mGy was 9,2%; 95% CI: 5,4%; 13,5%). with 15-year latent period. No statistically significant increase in mortality from the cerebrovascular diseases in the combined cohort of the population exposed in the Southern Urals over a 65-year period received evidence. The obtained results are in good agreement with those received in the analysis of the effect in the Techa River Cohort in 2013. The latter covered a 53-year period (with minimum latent period of 15 years) and revealed statistically significant linear dose response for all diseases of the circulatory system (ERR/100 mGy – 0.036) and ischemic heart disease (ERR/100 mGy – 0.056).

scholarly journals AGE/SEX-SPECIFIC MORTALITY RATES FROM CIRCULATORY SYSTEM DISEASES AMONG OUTPATIENTS OF A KRASNODAR POLYCLINIC

2019 ◽  
Vol 26 (3) ◽  
pp. 99-107
Author(s):  
Elena V. Bolotova ◽  
Anna V. Kontsevaya ◽  
Irina V. Kovrigina ◽  
Larisa P. Lyuberitskaya
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Circulatory System ◽  
Mortality Rates ◽  
Cerebrovascular Diseases ◽  
Ischemic Heart ◽  
Medical Documentation ◽  
Chronic Ischemic Heart Disease ◽  
Circulatory System Diseases ◽  
Specific Mortality

Aim.In this work, we undertook a study of age/sex-specific mortality rates from circulatory system diseases and certain nosological forms in 2015 and 2018 among outpatients of Research Institute — Ochapovsky Regional Clinical Hospital No. 1 delivering primary healthcare services.Materials and methods.We studied age/sex-specific mortality rates from circulatory system diseases among adult population using the data from the medical records of deceased outpatients (Form 025/u), extracts from autopsy reports, as well as medical certificates of death for 2015 and 2018. Non-standardised and standardised mortality rates were calculated.Results.In 2015, all-cause mortality rate by the medical organisation reached 6.2 per 1,000 population, with the total number of deaths from circulatory system diseases amounting to 49.6%. The non-standardised mortality rates from the circulatory system diseases totalled 307.81 per 100,000 population, including the non-standardised mortality rates from cerebrovascular diseases (44.68), ischemic heart disease (129.08) and myocardial infarction (4.96). Standardised mortality rates from circulatory system diseases amounted to 201.96 (men — 70.58, women — 131.38). In 2015, chronic ischemic heart disease (41.94%) ranked first as the cause of mortality among circulatory system diseases followed by diagnoses requiring additional interpretation and examination of primary medical documentation (35.48%), i.e. not clearly defined causes of death; and cerebrovascular diseases (14.52%). In 2018, chronic ischemic heart disease also ranked first (47.54%) followed by cerebrovascular (36.21%) and other diseases (16.39%) (ICD codes I26, I71.1, R00.8).Conclusion.It is shown that more attention from the cardiological and therapeutic services of primary health care is required in coding death-causing circulatory system diseases.

Long-Term Mental Disorders in the Accident-Exposed Population of the Southern Urals

2020 ◽  
Vol 65 (4) ◽  
pp. 22-28
Author(s):  
E. Burtovaia ◽  
T. Kantina ◽  
E. Litvinchuk
Keyword(s):  
Heart Disease ◽  
Mental Disorders ◽  
Ischemic Heart Disease ◽  
Brain Ischemia ◽  
Southern Urals ◽  
Cognitive Disorder ◽  
Ischemic Heart ◽  
The Southern Urals ◽  
Chronic Brain Ischemia

Purpose: To study late mental and behavioral disorders (ICD-10) in individuals who were accidentally exposed in the Southern Urals. Material and methods: The research subjects are the persons who were exposed to radiation as a result of dumping of radioactive waste into the Techa River (1949–1956), who were born before 1953 and lived in the Techa River basin between 1950 and 1960. The study group consists of 425 people, women predominate (72.5 %), people with secondary special education make up 44.5 %, and pensioners amount to 89.4 %. Mean age at examination was 67.3 ± 5.3 years. Information on radiation doses included data on the absorbed dose to the stomach, which was considered as an analog of brain exposure (50 ± 3 mGy). The paper uses clinical-anamnestic, clinical-psychopathological, clinical and instrumental methods. Results: It has been demonstrated that in the long-term period, accidentally exposed individuals have organic nonpsychotic mental disorders (72.2 %), with the predominance of organic asthenic (29.6 %) and organic cognitive (36.5 %) disorders. Among the studied individuals, only 20.9 % showed no signs of mental illness. Higher absorbed doses to the stomach (70 ± 8 mGy, p = 0.01) was determined in patients with organic cognitive disorder. Concomitant somatic pathology is present in patients with organic cognitive disorder — hypertension (90.3 %, p = 0.005), ischemic heart disease (56.7, p = 0.004), chronic brain ischemia (43.2 %, p = 0.04). Patients with organic asthenic disorder may have hypertension (94.4 %, p = 0.0002), ischemic heart disease (51.6 %, p = 0.04), chronic brain ischemia (35.7 %, p = 0.02). In the group of patients without mental pathology, the most common were hypertension (76.4 %), diseases of the musculoskeletal system (61.7 %, p = 0.03), and ischemic heart disease (37.1 %). Multiple correlation analysis showed a weak statistically significant association of organic mental disorders with chronic brain ischemia, hypertension, ischemic heart disease and the age of patients. Conclusion: The performed study complements the current understanding of long-term mental disorders in exposed individuals, and requires further research to study the pathogenesis of cerebrovascular and cardiovascular diseases in individuals exposed to radiation.

scholarly journals Effect of High Temperatures on Daily Counts of Mortality from Diseases of Circulatory System in Astana, Kazakhstan

Medicina ◽  
2013 ◽  
Vol 48 (12) ◽  
pp. 94 ◽  
Author(s):  
Andrej Grjibovski ◽  
Nassikhat Nurgaliyeva ◽  
Aliya Kosbayeva ◽  
Altay Sharbakov ◽  
Telman Seysembekov ◽  
...  
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Circulatory System ◽  
Cerebrovascular Diseases ◽  
Ischemic Heart ◽  
Apparent Temperature ◽  
Inverse Association ◽  
Icd 10 ◽  
Hypertensive Diseases ◽  
The City

Background and Objective. Associations between hot temperatures and both overall and cardio- and cerebrovascular mortality have been observed in many European, North American, and Southeastern Asian cities. However, the effects varied among the settings with limited evidence from the countries with arid and semiarid climates. The aim of this study was to assess the effect of air temperature on deaths from the selected diseases of the circulatory system in the city of Astana, Kazakhstan. Material and Methods. The daily counts of deaths from hypertensive diseases (ICD-10 codes, I10–I15), cerebrovascular diseases (ICD-10 codes, I60–I69), and ischemic heart disease (ICD-10 codes, I20–I25) during the warm seasons (April-September) of 2000–2001 and 2006–2010 were obtained from the City Registry Office. The associations between the maximum apparent temperature (average of lags 0–3) and mortality were assessed by a first-order autoregressive Poisson regression with the adjustment for barometric pressure (average of lags 0–3), wind speed, and effects of month, year, holidays, and weekends. Results. Altogether, there were 282, 1177, and 2994 deaths from hypertensive diseases, cerebrovascular diseases, and ischemic heart disease, respectively. The maximum effective temperature varied between –2.2°C and 44.5°C. An increase in temperature by 1°C was associated with a 1.9% (95% CI, 0.3–3.5) increase in the daily number of deaths from cerebrovascular diseases and with a 3.1% (95% CI, 0.2–6.1) decrease in the number of deaths from hypertensive diseases among women. Conclusions. The results suggest a positive association between the maximum apparent temperature and the daily counts of deaths from cerebrovascular diseases and an inverse association between temperature and mortality from hypertensive diseases, but only among women.

The Role of Platelets in Myocardial Infarction, Ischemic Heart Disease, Cerebrovascular Disease, Thromboembolic Disorders and Acute Idiopathic Pericarditis

1977 ◽  
Vol 38 (04) ◽  
pp. 1073-1084 ◽  
Author(s):  
J Zahavi
Keyword(s):  
Myocardial Infarction ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Thrombus Formation ◽  
Adenosine Diphosphate ◽  
Cerebrovascular Diseases ◽  
Ischemic Heart ◽  
Contributory Factor ◽  
Acute Infectious Disease ◽  
Discharge From Hospital

SummaryInitial white thrombus formation, has been attributed to platelet interaction with damaged vessel wall at sites of vascular injury or atherosclerotic plaques in the process of platelet aggregation (PA) and adhesion. Enhancement of PA seems to be an important factor in the development of thrombosis in the coronary and cerebral blood vessels and in embolization of platelet microthrombi to the microcirculation of the vessels. This latter event in turn might lead to serious or fatal arrhythmias or to paroxysms of cerebral ischemia.We have found enhanced PA in 66 patients with acute myocardial infarction (MI) and ischemic heart disease (IHD) which was specifically indicated by 4 distinct abnormalities: a) increased rate and extent of aggregation to 11,1 μM of adenosine diphosphate (ADP). b) Increased platelet responsiveness to 1,11 μM of ADP. c) Spontaneous aggregation which appeared in 95% of the patients compared to less than 5% of controls, d) Prolonged aggregation time indicated by parameter τ, τ = -[dt/dln(T–T ∞ ≤)], In addition, enhanced and occasionally more pronounced PA on the day of discharge from hospital, has been recently observed. The abnormal platelet behaviour was also detected in 10 thromboembolic disorder (TED), 28 acute cerebrovascular accident (CVA) and 24 acute infectious disease (AI) patients. It was, however, more pronounced in MI compared to TED and CVA patients. In AI the curves returned to normal some time after their subsidence, but remained abnormal for up to 2 years in IHD patients. In 10 patients with acute benign idiopathic pericarditis, which were included in the AI patients, PA proved to be a rehable indicator of the course of the disease and its treatment. Early reduction of corticosteroid dosage in the patients, was followed by increased abnormalities in the PA curves.The enhanced PA in these patients is most probably an indicator of a thrombogenic state and seems to be an important contributory factor in the pathogenesis of coronary and cerebrovascular diseases. Preliminary reports of anti-aggregating drugs, wether beneficial or adverse, in these vascular disorders are controversial and further research is needed.

Hypertonic disease and its involvement in the class of diseases of the circulatory system: epidemiological situation in Ukraine

2020 ◽  
Vol 26 (2-3) ◽  
pp. 68-74
Author(s):  
V.V. Ruden' ◽  
◽  
V.I. Diachyschyn ◽  
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Cerebrovascular Disease ◽  
Negative Impact ◽  
Circulatory System ◽  
Well Being ◽  
The State ◽  
Ischemic Heart ◽  
Steady Increase ◽  
Circulatory System Diseases

Aim. A substantiation by the types of morbidity of biostatistic tendencies in the development of hypertonic disease and its involvement in the existing pathologies of the class of diseases of the circulatory system among the population of Ukraine. Material and Methods. An epidemiological, cross-sectional, continuous, prospective study was conducted with the use of statistical data of the Health Statistics Center of the Ministry of Health of Ukraine and the State Statistics Service of Ukraine (1993 and 2017), summarizing and processing them in spreadsheets of Microsoft Office Excel 2016 using retrospective, biostatistical and abstract research methods, as well as methods of copying, deductive awareness, structural-logical analysis and systematic principles. Results and Discussion. The results clearly indicated a steady increase in all forms of hypertonic disease among the population of Ukraine over the studied time period by Рincr=119.8%, when in 2017 this pathology affected ngen=10,388,376 persons, with the prevalence indicator Рgen= 29,844.1о/оооо, which testified that every fourth citizen had a case of hypertonic disease, whereas hypertonic disease accompanied ischemic heart disease in Рpr=40.4% of cases, - cerebrovascular disease in Рpr=23.1% of cases and - strokes in Рpr= 35.8% of cases. Conclusions. It is established that hypertonic disease is one of the most prevalent diseases of the cardiovascular system and has a direct negative impact on of socio-economic well-being and resource provision for society and, based on achievements in etiopathology, diagnostics and treatment, requires the highest governmental structures of the state to undertake prompt and adequate managerial preventive actions aimed at strengthening the health of patients with hypertonic disease and of changing the lifestyle of the population in consideration of established risk factors in the occurrence of this pathology. Keywords: circulatory system diseases, hypertonic disease, general and primary morbidity, tendencies, involvement, ischemic heart disease, cerebrovascular disease, stroke

scholarly journals Phenotypic Disease Network Analysis to Identify Comorbidity Patterns in Hospitalized Patients with Ischemic Heart Disease Using Large-Scale Administrative Data

Healthcare ◽  
2022 ◽  
Vol 10 (1) ◽  
pp. 80
Author(s):  
Dejia Zhou ◽  
Liya Wang ◽  
Shuhan Ding ◽  
Minghui Shen ◽  
Hang Qiu
Keyword(s):  
Heart Disease ◽  
Network Analysis ◽  
Ischemic Heart Disease ◽  
Administrative Data ◽  
Large Scale ◽  
Integrated Management ◽  
Cerebrovascular Diseases ◽  
Hospitalized Patients ◽  
Ischemic Heart ◽  
Healthcare Database

Ischemic heart disease (IHD) exhibits elevated comorbidity. However, few studies have systematically analyzed the comorbid status of IHD patients with respect to the entire spectrum of chronic diseases. This study applied network analysis to provide a complete picture of physical and mental comorbidities in hospitalized patients with IHD using large-scale administrative data. Hospital discharge records from a provincial healthcare database of IHD inpatients (n = 1,035,338) and one-to-one matched controls were included in this retrospective analysis. We constructed the phenotypic disease networks in IHD and control patients and further assessed differences in comorbidity patterns. The community detection method was applied to cluster diagnoses within the comorbidity network. Age- and sex-specific patterns of IHD comorbidities were also analyzed. IHD inpatients showed 50% larger comorbid burden when compared to controls. The IHD comorbidity network consisted of 1941 significant associations between 71 chronic conditions. Notably, the more densely connected comorbidities in IHD patients were not within the highly prevalent ones but the rarely prevalent ones. Two highly interlinked communities were detected in the IHD comorbidity network, where one included hypertension with heart and multi-organ failures, and another included cerebrovascular diseases, cerebrovascular risk factors and anxiety. Males exhibited higher comorbid burden than females, and thus more complex comorbidity relationships were found in males. Sex-specific disease pairs were detected, e.g., 106 and 30 disease pairs separately dominated in males and females. Aging accounts for the majority of comorbid burden, and the complexity of the comorbidity network increased with age. The network-based approach improves our understanding of IHD-related comorbidities and enhances the integrated management of patients with IHD.

scholarly journals Antithrombotic therapy for chronic ischemic heart disease: how to balance risk and benefit in different categories of patients?

2020 ◽  
pp. 76-94
Author(s):  
N. B. Perepech
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Antithrombotic Therapy ◽  
Clinical Manifestations ◽  
Circulatory System ◽  
Coronary Intervention ◽  
Ischemic Heart ◽  
Chronic Ischemic Heart Disease ◽  
Individual Values ◽  
Circulatory System Diseases

The review focuses on current guidelines for the use of medications that affect hemostasis in the treatment of patients with chronic ischemic heart disease (IHD). The review shows the important impact of negative outcomes of IHD on mortality from cardiovascular system diseases in the Russian Federation. The results of the most significant randomised clinical trials, which assessed the efficacy and safety of various antithrombotic therapy options in patients with various clinical manifestations of IHD, as well as methodological methods for individual assessment of ischemic and hemorrhagic risks, were discussed. Theoretically, the use of anticoagulants in combination with antithrombocytic drugs to reduce the risk of atherothrombotic complications in the phase of the stable course of the IHD is justified. The results of the COMPASS study, which proved the positive effect oflow-dose addition of rivaroxaban to acetylsalicylic acid on the risk of cardiovascular events, cardiovascular death and death from all causes in patients with chronic IHD with maintained sinus rhythm, are reviewed in detail. Discussions were held on how to determine the optimal duration of double antithrombocytic therapy in patients with IHD after percutaneous coronary intervention (PCI), taking into account individual values of ischemic and hemorrhagic risks. Long-term antithrombotic therapy schemes for patients with chronic IHD and atrial fibrillation (AF) that have not been exposed to PCI are presented, as well as current recommendations on how to choose the best antithrombotic therapy scheme for patients with IHD that have been exposed to PCI depending on the risk of stent thrombosis and the risk of bleeding. It has been substantiated that active differentiated antithrombotic therapy should be widely used in everyday practice, which, provided that ischemic and hemorrhagic risks are adequately assessed, creates a real prospect of reducing mortality from IHD and circulatory system diseases in general.

scholarly journals Diseases of the circulatory system in the Kyrgyz Republic in the period of 2002–2017

Kardiologiia ◽  
2020 ◽  
Vol 60 (7) ◽  
pp. 72-77
Author(s):  
M. B. Yrysova
Keyword(s):  
Heart Disease ◽  
Essential Hypertension ◽  
Ischemic Heart Disease ◽  
Incidence Rate ◽  
Circulatory System ◽  
Cerebrovascular Diseases ◽  
Kyrgyz Republic ◽  
Primary Disability ◽  
Increment Rate

Aim To analyze a tendency in circulatory system diseases (CSD) in the Kyrgyz Republic (KR).Materials and methods Medical statistics on morbidity, prevalence, mortality, and primary disability related with CSD in the adult population was obtained from the National Health Information Center (NHIC) of the Ministry of Health of the KR and the National Statistical Committee of the KR. For the purpose of comparative analysis, relative values were calculated per 100,000 and 10,000 population. A retrospective epidemiological study of prevalence, morbidity, mortality, and primary disability related with CSD for 2002-2017 was performed with calculation of the increase/decrease rate using the least square method for aligning the dynamic row. Also, the epidemiological situation of CSD was analyzed by sex and in 9 administrative divisions of the KR with calculation of the mean long-term incidence (MLTI) of CSD from 2007 through 2017. Statistical analysis was performed with specialized Statistica 10.0 and SPSS 11.5 software.Results CSD remain the major cause of death (51.6 % in 2017) and primary disability (19.68 % of overall primary disability) in the Kyrgyz population. Prevalence of CSD shows a pronounced upward trend (6.8% increment rate relative to 2002) whereas the incidence rate has increased with a moderate trend (3.5 % increment rate). The major structure of CSD is determined by essential hypertension (51.2 %), ischemic heart disease (28.0 %), and cerebrovascular diseases (10.0 %). CSD is more frequently observed in women (mean value for 2007-2017, 59.0%) than in men (41.0 %) (р<0.001). Mean long-term indexes of CSD significantly differ in different regions and cities of the KR. The highest primary morbidity and prevalence of CSD is observed in Bishkek (1546.90 / 0000 and 12415.40 / 0000). Relatively low levels of these values are found in the Talas Region (720.70 / 0000 and 3675.10 / 0000, respectively).Conclusion CSD remains the major cause of death and primary disability in the population of the KR. Prevalence of CSD shows a pronounced increasing trend whereas the increase in incidence rate is moderate. The major structure of CSD is determined by essential hypertension, ischemic heart disease, and cerebrovascular diseases. Incidence of CSD is statistically significantly higher for women than for men. Mean long-term indexes of CSD significantly differ in different regions and cities of the KR. Therefore, it is essential to enhance preventive measures in the KR; to identify individuals with hypertension at the level of primary care; and to motivate healthcare professionals to improve the quality of healthcare (CSD prevention, detection, and treatment).

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