scholarly journals Serum Uric Acid Levels and Risk of Rapid Decline of Estimated Glomerular Filtration Rate in Patients with Type 2 Diabetes: Findings from a 5-Year Prospective Cohort Study

Healthcare ◽  
2021 ◽  
Vol 9 (10) ◽  
pp. 1341
Author(s):  
Hoa Tuyet Le ◽  
Tung Thanh Le ◽  
Nguyet Minh Thi Tran ◽  
Thuy Thanh Thi Nguyen ◽  
Ni Chanh Su Minh ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Renal Function ◽  
Uric Acid ◽  
Cohort Study ◽  
Glomerular Filtration Rate ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Rapid Decline ◽  
Rapid Progression

This study investigated the association between serum uric acid (SUA) levels with rapid decline of the estimated glomerular filtration rate (eGFR) in type 2 diabetes (T2 DM) patients. A prospective cohort study was conducted in a community-based hospital in Vietnam. We followed 405 T2DM patients with normal kidney function for five years. Rapid progression of kidney function was defined as an average annual decrease of eGFR of at least 4 mL/min/1.73 m2 and was found in 16.0% of patients. Patients in the SUA high tertile ( ≥6 mg/dL) had higher BMI (p = 0.004), lower HbA1c (p = 0.001), lower eGFR (p < 0.001) and higher rate of hypertension than low and middle tertile. After adjusting for age and sex, rapid progression of renal function was significantly associated with SUA level (OR = 1.22, 95% CI 1.02–1.45, p = 0.026). This association was marginally significant when more covariates were included in the model (OR = 1.20, 95% CI 0.99–1.46, p = 0.065). However, the association between tertiles of SUA and rapid decline of eGFR was not statistically significant. This study demonstrates neither a strong significant association between SUA and rapid decline of eGFR nor evidence to refuse the role of SUA levels in the increased risk of renal function decline in in T2DM patients.

scholarly journals Peripheral Arterial Stiffness Is Independently Associated with a Rapid Decline in Estimated Glomerular Filtration Rate in Patients with Type 2 Diabetes

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Yi-Jing Sheen ◽  
Jiann-Liang Lin ◽  
Tsai-Chung Li ◽  
Cho-Tsan Bau ◽  
Wayne Huey-Herng Sheu
Keyword(s):  
Type 2 Diabetes ◽  
Glomerular Filtration Rate ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Rapid Decline ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Peripheral Arterial ◽  
Type 2 Diabetic

Introduction. Diabetes and its vascular complications are main noncommunicable chronic diseases and major global health issues. Peripheral arterial disease (PAD) is highly prevalent in diabetes with nephropathy. We evaluated the associations of variables of arterial stiffness and the decline in estimated glomerular filtration rate (eGFR) in patients with type 2 diabetes.Materials and Methods. A total of 577 type 2 diabetic patients (mean±SD: age,63±11years) were enrolled. A rapid decline in eGFR was defined as progressively lower eGFR detected at both the 6- and 12-month follow-up visits, plus a reduction in eGFR more than 3 mL·min−1per 1.73 m2per year.Results. Higher glycated hemoglobin (HbA1c), systolic blood pressure (SBP), pulse pressure (PP), and brachial-ankle pulse wave velocity (ba-PWV) at baseline were independently associated with a rapid decline in eGFR. The adjusted odds ratios (95% confidence intervals) for a rapid decline in eGFR for ba-PWV, SBP, and PP were 1.072 (1.011–1.136), 1.014 (1.004–1.025), and 1.025 (1.008–1.041), respectively, after adjustment for gender, age, body mass index, smoking, HbA1c, and baseline eGFR in separated models.Conclusions. Ba-PWV may serve as a simple and noninvasive predictor of rapid renal function progression in type 2 diabetic patients.

Association Between Serum C-Peptide Level and Cardiovascular Autonomic Neuropathy According to Estimated Glomerular Filtration Rate in Individuals with Type 2 Diabetes

2019 ◽  
Vol 128 (09) ◽  
pp. 607-614
Author(s):  
Jin Ook Chung ◽  
Seon-Young Park ◽  
Dong Hyeok Cho ◽  
Dong Jin Chung ◽  
Min Young Chung
Keyword(s):  
Type 2 Diabetes ◽  
Renal Function ◽  
Glomerular Filtration Rate ◽  
Impaired Renal Function ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
C Peptide ◽  
Type 2 Dm ◽  
Peptide Level

Abstract Objective To investigate the association between serum C-peptide level and cardiovascular autonomic neuropathy (CAN) in individuals with type 2 diabetes mellitus (DM) according to estimated glomerular filtration rate (eGFR) Methods In a cross-sectional study, we examined 939 individuals with type 2 DM. We measured fasting C-peptide, 2-hour postprandial C-peptide, and ΔC-peptide (postprandial C-peptide minus fasting C-peptide) levels. The individuals were classified into 2 groups based on eGFR: individuals without impaired renal function (eGFR ≥60 ml∙min−1 1.73m−2) and those with impaired renal function (eGFR <60 ml∙min−1 1.73m−2). Results Individuals with CAN had lower fasting C-peptide, postprandial C-peptide, and ΔC-peptide levels in patients both with and without impaired renal function. Multivariate logistic regression analyses adjusted for gender, age, and other confounders, including eGFR, showed that serum C-peptide level was significantly associated with CAN (odds ratio [OR] per standard deviation increase in the log-transformed value, 0.67; 95% confidence interval [CI], 0.52–0.87 for fasting C-peptide, P < 0.01; OR, 0.62; 95% CI, 0.47–0.83 for postprandial C-peptide, P < 0.01; OR, 0.71; 95% CI, 0.54–0.93 for ΔC-peptide, P < 0.05). Conclusions Serum C-peptide level was negatively associated with CAN in individuals with type 2 DM independent of eGFR.

scholarly journals The Relationship Between Simple Renal Cysts and Renal Function in Patients With Type 2 Diabetes

2020 ◽  
Vol 11 ◽  
Author(s):  
Ling Wei ◽  
Ying Xiao ◽  
Xiaofen Xiong ◽  
Li Li ◽  
Yuan Yang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Renal Function ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Renal Cysts ◽  
The Relationship ◽  
Phosphorus Levels

Introduction: Simple renal cysts (SRCs) are the most common acquired cystic kidney disease, but the relationship between SRCs and renal function has not been clarified in patients with type 2 diabetes mellitus (T2DM).Methods: A retrospective study was conducted to analyze the clinical features of renal cysts and ultrasound data of the kidney in 4,304 patients with T2DM.Results: The prevalence of SRCs in patients with T2DM was 21.1%. Compared to patients with no SRCs, patients with SRCs had worse renal function (estimated glomerular filtration rate: 108.65 ± 40.93 vs. 92.38 ± 42.1 ml/min/1.73 m2, p &lt; 0.05). After adjusting the confounders, SRC was related to estimated glomerular filtration rate in patients with T2DM [odds ratio = 1.49, 95% confidence interval (1.24, 1.79), p &lt; 0.01]. Age, gout, proteinuria, cerebrovascular disease (CVD), and increased serum phosphorus levels were associated with SRCs in patients with T2DM.Conclusion: SRCs are associated with worse renal function in patients with T2DM. More attention should be paid to gout, proteinuria, CVD, serum phosphorus levels, and renal function in T2DM patients with SRCs.

Sign in / Sign up

Export Citation Format

Share Document