scholarly journals Amyotrophic Lateral Sclerosis and Occupational Exposures: A Systematic Literature Review and Meta-Analyses

2018 ◽  
Vol 15 (11) ◽  
pp. 2371 ◽  
Author(s):  
Lars-Gunnar Gunnarsson ◽  
Lennart Bodin
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Literature Review ◽  
Electromagnetic Fields ◽  
Systematic Literature Review ◽  
Occupational Exposures ◽  
Physical Work ◽  
Scientific Quality ◽  
Occupational Risk Factors ◽  
Meta Analyses ◽  
Lateral Sclerosis

Objectives: We conducted a systematic literature review to identify studies fulfilling good scientific epidemiological standards for use in meta-analyses of occupational risk factors for amyotrophic lateral sclerosis (ALS). Methods: We identified 79 original publications on associations between work and ALS. The MOOSE (Meta-analysis Of Observational Studies in Epidemiology) and GRADE (Grading of Recommendations, Assessment, Development and Evaluations) guidelines were used to ensure high scientific quality, and reliable protocols were applied to classify the articles. Thirty-seven articles fulfilled good scientific standards, while 42 were methodologically deficient and thus were excluded from our meta-analyses. Results: The weighted relative risks for the various occupational exposures were respectively; 1.29 (95% confidence interval (CI): 0.97–1.72; six articles) for heavy physical work, 3.98 (95% CI: 2.04–7.77; three articles) for professional sports, 1.45 (95% CI: 1.07–1.96; six articles) for metals, 1.19 (95% CI: 1.07–1.33; 10 articles) for chemicals, 1.18 (95% CI: 1.07–1.31; 16 articles) for electromagnetic fields or working with electricity, and 1.18 (95% CI: 1.05–1.34; four articles) for working as a nurse or physician. Conclusions: Meta-analyses based only on epidemiologic publications of good scientific quality show that the risk of ALS is statistically significantly elevated for occupational exposures to excessive physical work, chemicals (especially pesticides), metals (especially lead), and possibly also to electromagnetic fields and health care work. These results are not explained by publication bias.

Sexuality and intimacy in ALS: systematic literature review and future perspectives

2018 ◽  
Vol 90 (6) ◽  
pp. 712-719
Author(s):  
Barbara Poletti ◽  
Laura Carelli ◽  
Federica Solca ◽  
Rita Pezzati ◽  
Andrea Faini ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Literature Review ◽  
Systematic Literature Review ◽  
English Literature ◽  
Well Being ◽  
Intimate Relationship ◽  
Level Of Evidence ◽  
Sexual Activities ◽  
Cognitive Behavioural ◽  
Lateral Sclerosis

Several features of amyotrophic lateral sclerosis (ALS) impact on sexuality and intimate relationship; however, the issue has received poor attention so far. We performed a systematic literature review in order to provide an up-to-date account of sexuality in ALS. References were identified by searches of PubMed, Web of Science, Scopus and PsycINFO (1970–2017, English literature). The following were the key terms: ‘sexual’ OR ‘sexuality’ OR ‘intimacy’ OR ‘marital’ AND ‘ALS’ OR ‘Amyotrophic Lateral Sclerosis’ OR ‘Motor Neuron Disease’ OR ‘MND’. Titles and abstracts were screened for relevance and a full-text analysis was performed on the selected articles. Studies were included if they referred to sexual well-being/activities/functions or intimate relationship between patients and their partners and management of such topic by clinicians. Eligibility assessment was performed independently by two reviewers. A thematic and level of evidence classification of studies was performed. Studies’ design, objectives, measurements and outcomes were summarised. Thirty articles were included and four topics were identified: intimacy in the dyads; sexual activities in patients and with their partners; sexual function disturbances; and sexuality and cognitive-behavioural alterations. The quality of the studies varies, with globally poor level of evidence. Some sexuality issues have been only sparsely addressed, such as gender-related differences, same-sex relationships and sexual activities other than intercourse. Sexuality in ALS is still not adequately considered by clinicians and researchers. We present preliminary recommendations for improving sexuality and intimacy at any ALS multidisciplinary clinics.

A-151 Cognitive Impairment in Amyotrophic Lateral Sclerosis

2021 ◽  
Vol 36 (6) ◽  
pp. 1205-1205
Author(s):  
Etiane Navarro ◽  
Charles J Golden
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Cognitive Impairment ◽  
Literature Review ◽  
Cognitive Impairments ◽  
Empirical Literature ◽  
Sporadic Als ◽  
Neuropsychological Assessments ◽  
Familial Als ◽  
Als Patients ◽  
Lateral Sclerosis

Abstract Objective Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease caused by degeneration of the upper and lower motor neurons. This literature review examines the recurring etiology of cognitive impairments in ALS through empirical literature. The current study explores ALS across different subtypes and potential cognitive impairments. Two classifications are primarily examined ALS, and ALS with frontotemporal dementia (ALS-FTD). Involving three categories: familial inheritance pattern, genetic mutation, or sporadic. Neuropsychological studies affirm cognitive impairments in individuals diagnosed with ALS and ALS-FTD. Data Selection Data was culled from the American Psychological Association (PsycInfo), PubMed, Google Scholar. Terms used in this literature review include cognitive impairment in ALS and ALS-FTD, executive function deficiencies in ALS, neuropsychology in ALS, neuropsychological deficits in ALS, neuropsychological assessments for ALS, cognitive impairments in familial ALS, genetic ALS, and sporadic ALS, familial ALS, sporadic ALS, genetic mutations involved in ALS. Search dates December 20–23 of 2020 and March 3–4 of 2021. A total of 40 studies were examined. Data Synthesis ALS-patients demonstrate a significant cognitive impairment. However, influencing comorbidities accompanying the disease may be contributing to these impairments. Researchers employed neuroimaging and neuropsychological batteries to further understand influencing factors involved in ALS and cognition. Conclusions Researchers now understand ALS as a multi-symptomatic disorder and acknowledge the presence of cognitive impairments at various encased levels. There are limitations in neuropsychological batteries that accommodate for executive dysfunctions observed in ALS patients. Future studies should explore neuropsychological assessments that accommodate for motor deficits and dysarthria when assessing cognitive impairment in ALS patients.

scholarly journals Industry 4.0 Readiness Models: A Systematic Literature Review of Model Dimensions

Information ◽  
2020 ◽  
Vol 11 (7) ◽  
pp. 364
Author(s):  
Mohd Hizam-Hanafiah ◽  
Mansoor Ahmed Soomro ◽  
Nor Liza Abdullah
Keyword(s):  
Literature Review ◽  
Systematic Literature Review ◽  
Industry 4.0 ◽  
Industrial Revolution ◽  
Future Research ◽  
Technology Readiness ◽  
Leadership Process ◽  
Unique Model ◽  
Analysis Strategy ◽  
Meta Analyses

It is critical for organizations to self-assess their Industry 4.0 readiness to survive and thrive in the age of the Fourth Industrial Revolution. Thereon, conceptualization or development of an Industry 4.0 readiness model with the fundamental model dimensions is needed. This paper used a systematic literature review (SLR) methodology with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and content analysis strategy to review 97 papers in peer-reviewed academic journals and industry reports published from 2000 to 2019. The review identifies 30 Industry 4.0 readiness models with 158 unique model dimensions. Based on this review, there are two theoretical contributions. First, this paper proposes six dimensions (Technology, People, Strategy, Leadership, Process and Innovation) that can be considered as the most important dimensions for organizations. Second, this review reveals that 70 (44%) out of total 158 total unique dimensions on Industry 4.0 pertain to the assessment of technology alone. This establishes that organizations need to largely improve on their technology readiness, to strengthen their Industry 4.0 readiness. In summary, these six most common dimensions, and in particular, the dominance of the technology dimension provides a research agenda for future research on Industry 4.0 readiness.

scholarly journals Relaxation therapy as a treatment for tics in patients with Tourette syndrome: a systematic literature review

2019 ◽  
Vol 41 (5) ◽  
pp. 1011-1017 ◽  
Author(s):  
Florence Tilling ◽  
Andrea E. Cavanna
Keyword(s):  
Literature Review ◽  
Tourette Syndrome ◽  
Systematic Literature Review ◽  
Treatment Strategies ◽  
Small Sample ◽  
Relaxation Therapy ◽  
Behavioural Treatment ◽  
Study Protocols ◽  
Small Sample Sizes ◽  
Meta Analyses

Abstract Background Tourette syndrome (TS) is a neurodevelopmental condition characterized by the presence of multiple motor and phonic tics, often associated with co-morbid behavioural problems. Tics can be modulated by environmental factors and are characteristically exacerbated by psychological stress, among other factors. This observation has led to the development of specific behavioural treatment strategies, including relaxation therapy. Objective This review aimed to assess the efficacy of relaxation therapy to control or reduce tic symptoms in patients with TS. Methods We conducted a systematic literature review of original studies on the major scientific databases, including Medline, EMBASE, and PsycInfo, according to the standards outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Outcomes measures included both tic severity and tic frequency. Results Our literature search identified three controlled trials, with a total number of 40 participants (range: 6–18 participants). In all three studies, relaxation therapy decreased the severity and/or the frequency of tic symptoms. However, the only trial comparing relaxation therapy to two other behavioural techniques found relaxation therapy to be the least effective intervention, as it reduced the number of tics by 32% compared to 44% with self-monitoring and 55% with habit reversal. Discussion The results of this systematic literature review provide initial evidence for the use of relaxation therapy as a behavioural treatment intervention for tics in patients with TS. Caution is needed in the interpretation of these findings, because the reviewed trials had small sample sizes and there was high heterogeneity across the study protocols.

Environmental and Occupational Risk Factors for Amyotrophic Lateral Sclerosis: A Case-Control Study

2013 ◽  
Vol 14 (1) ◽  
pp. 31-38 ◽  
Author(s):  
Angela M. Malek ◽  
Aaron Barchowsky ◽  
Robert Bowser ◽  
Terry Heiman-Patterson ◽  
David Lacomis ◽  
...  
Keyword(s):  
Risk Factors ◽  
Amyotrophic Lateral Sclerosis ◽  
Case Control Study ◽  
Case Control ◽  
Occupational Risk ◽  
Occupational Risk Factors ◽  
Control Study ◽  
Lateral Sclerosis
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