scholarly journals Biocompatibility and Effectiveness of a Novel, Organic Olive Oil-Based Denture Adhesive: A Multicenter Randomized and Placebo-Controlled Clinical Trial

2021 ◽  
Vol 18 (7) ◽  
pp. 3398
Author(s):  
Luís Azevedo ◽  
André Correia ◽  
Carlos F. Almeida ◽  
Pedro Molinero-Mourelle ◽  
Maria Correia ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Olive Oil ◽  
Controlled Clinical Trial ◽  
The Novel ◽  
Complete Dentures ◽  
Denture Adhesive ◽  
Subjective Analysis ◽  
Standardized Protocol ◽  
Product Test ◽  
Dental Schools

To assess the clinical efficacy of a novel, organic olive oil-based denture adhesive and its effect on Candida albicans growth in maxillary edentulous individuals wearing complete dentures, individuals were selected from two dental schools in Portugal and Spain. Twenty-eight complete dentures were relined, following a standardized protocol. The novel product (test) was compared with a commercialized adhesive (control) and Vaseline (placebo) randomly assigned in a cross-study design. The retention resistance was measured with a gnathometer and a dynamometer. The patients related outcome evaluations with a five-point questionnaire, and the Candida albicans growth in a Sabouraud dextrose agar (SDA) medium was used to evaluate differences between the placebo and experimental product. Twenty-three participants were included. The dynamometer evaluation showed significant differences between not using a denture adhesive and using either (experimental, p = 0.03; control, p = 0.04) and no significant differences between the two adhesives (p > 0.05). In the subjective analysis, the experimental adhesive showed a significantly longer effectiveness (p = 0.001), and the control reported better results in taste (p = 0.03) and in chewing (p = 0.001). The test adhesive showed better (p < 0.001) Candida albicans growth inhibition. The experimental adhesive showed longer effectiveness than the control and the placebo with a better inhibition capacity for the growth of Candida albicans. Patients reported better abilities for speech, chewing, taste, and retirement in the control adhesive.

scholarly journals Biocompatibility and Effectiveness of a Novel Organic Olive Oil-Based Denture Adhesive: A Multicenter Randomized and Placebo-Controlled Clinical Trial

2021 ◽  
Author(s):  
Luís Azevedo ◽  
André Correia ◽  
Carlos F. Almeida ◽  
Pedro Molinero-Mourelle ◽  
Maria Correia ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Olive Oil ◽  
Controlled Clinical Trial ◽  
Complete Dentures ◽  
Denture Adhesive ◽  
Subjective Analysis ◽  
Standardized Protocol ◽  
Product Test ◽  
Patient Related Outcome ◽  
Dental Schools

To assess the clinical efficacy of a novel organic olive oil-based denture adhesive and its effect on Candida Albicans growth in maxillary edentulous individuals wearing complete dentures. Individuals were selected from two Dental Schools in Portugal and Spain. Twenty-eight complete dentures were relined, following a standardized protocol. The novel product (Test) was compared with a commercialized adhesive (Control) and Vaseline (Placebo) randomly assigned in a cross-study design. The retention resistance was measured with a Gnathometer and a dynamometer, the patient related outcome evaluations with a 5-points questionnaire and the Candida albicans growth in a Sabouraud dextrose agar (SDA) medium in order to evaluate differences between the placebo and experimental product. Twenty-three participants were included. Dynamometer evaluation showed significant differences between not using a denture adhesive and using either (experimental, p = .03; control, p = .04), no significant differences between the two adhesives (p &amp;gt; .05). In the subjective analysis, the experimental adhesive showed a significantly longer effectiveness (p = .001); the control reported better results at taste (p = .03) in chewing (p = .001). The test adhesive showed better (p &amp;lt; .001) Candida albicans growth inhibition. The experimental adhesive showed longer effectiveness than the control and placebo with a better inhibition capacity for the growth of Candida albicans, patients reported better abilities for speech, chewing, taste and retirement in the control adhesive.

scholarly journals The Novel Arylamidine T-2307 MaintainsIn VitroandIn VivoActivity against Echinocandin-Resistant Candida albicans

2014 ◽  
Vol 59 (2) ◽  
pp. 1341-1343 ◽  
Author(s):  
Nathan P. Wiederhold ◽  
Laura K. Najvar ◽  
Annette W. Fothergill ◽  
Rosie Bocanegra ◽  
Marcos Olivo ◽  
...  
Keyword(s):  
Body Weight ◽  
Candida Albicans ◽  
Invasive Candidiasis ◽  
Placebo Control ◽  
The Novel ◽  
Content Type ◽  
Fungal Burden ◽  
Potential Use

ABSTRACTWe evaluated thein vitroandin vivoactivities of the investigational arylamidine T-2307 against echinocandin-resistantCandida albicans. T-2307 demonstrated potentin vitroactivity, and daily subcutaneous doses between 0.75 and 6 mg/kg of body weight significantly improved survival and reduced fungal burden compared to placebo control and caspofungin (10 mg/kg/day) in mice with invasive candidiasis caused by an echinocandin-resistant strain. Thus, T-2307 may have potential use in the treatment of echinocandin-resistantC. albicansinfections.

Chewing ability and oral health‐related quality of life in frail elders after new complete dentures insertion: A paired controlled clinical trial

2020 ◽  
Vol 40 (2) ◽  
pp. 168-174 ◽  
Author(s):  
Olívia Maria Costa Figueredo ◽  
Mariana Barbosa Câmara‐Souza ◽  
Talita Malini Carletti ◽  
Renata Cunha Matheus Rodrigues Garcia
Keyword(s):  
Quality Of Life ◽  
Clinical Trial ◽  
Controlled Clinical Trial ◽  
Complete Dentures ◽  
Health Related Quality ◽  
Frail Elders ◽  
Chewing Ability ◽  
Related Quality ◽  
Health Related

scholarly journals Sensitive Assay for Antifungal Activity of Glucan Synthase Inhibitors That Uses Germ Tube Formation in Candida albicans as an End Point

2003 ◽  
Vol 47 (10) ◽  
pp. 3305-3310 ◽  
Author(s):  
Timothy G. Brayman ◽  
John W. Wilks
Keyword(s):  
Candida Albicans ◽  
Drug Discovery ◽  
Antifungal Activity ◽  
Germ Tube ◽  
Early Stage ◽  
Tube Formation ◽  
The Novel ◽  
Glucan Synthase ◽  
Drug Concentrations ◽  
Coefficients Of Variation

ABSTRACT We implemented a simple, sensitive, objective, and rapid cellular assay to reveal the antifungal activity of a novel class of glucan synthase inhibitors. The assay, especially useful for early drug discovery, measures the transformation of Candida albicans from the yeast form to the hyphal form. Test compounds were ranked by potency (50% inhibitory concentration) and efficacy (percent inhibition of germ tube formation); the intra-assay coefficients of variation for these parameters were 17 and 5%, respectively. The germ tube formation assay proved useful for the early-stage antifungal characterization of a novel class of glucan synthase inhibitors discovered at Pharmacia. Drug concentrations required in this assay to inhibit germ tube formation were lower for 90% of the novel compounds than the concentrations required to determine MICs. The method may have utility for other mechanistic classes of antifungal compounds during the hit-to-lead transition of drug discovery.

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