Relationship between Air Pollutant Exposure and Gynecologic Cancer Risk

Exposure to air pollution has been suggested to be associated with an increased risk of women’s health disorders. However, it remains unknown to what extent changes in ambient air pollution affect gynecological cancer. In our case–control study, the logistic regression model was combined with the restricted cubic spline to examine the association of short-term exposure to air pollution with gynecological cancer events using the clinical data of 35,989 women in Beijing from December 2008 to December 2017. We assessed the women’s exposure to air pollutants using the monitor located nearest to each woman’s residence and working places, adjusting for age, occupation, ambient temperature, and ambient humidity. The adjusted odds ratios (ORs) were examined to evaluate gynecologic cancer risk in six time windows (Phase 1–Phase 6) of women’s exposure to air pollutants (PM2.5, CO, O3, and SO2) and the highest ORs were found in Phase 4 (240 days). Then, the higher adjusted ORs were found associated with the increased concentrations of each pollutant (PM2.5, CO, O3, and SO2) in Phase 4. For instance, the adjusted OR of gynecological cancer risk for a 1.0-mg m−3 increase in CO exposures was 1.010 (95% CI: 0.881–1.139) below 0.8 mg m−3, 1.032 (95% CI: 0.871–1.194) at 0.8–1.0 mg m−3, 1.059 (95% CI: 0.973–1.145) at 1.0–1.4 mg m−3, and 1.120 (95% CI: 0.993–1.246) above 1.4 mg m−3. The ORs calculated in different air pollution levels accessed us to identify the nonlinear association between women’s exposure to air pollutants (PM2.5, CO, O3, and SO2) and the gynecological cancer risk. This study supports that the gynecologic risks associated with air pollution should be considered in improved public health preventive measures and policymaking to minimize the dangerous effects of air pollution.

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Short-term effects of air pollution on blood pressure

Scientific Reports ◽

10.1038/s41598-019-56413-y ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 1

Author(s):

You-Jung Choi ◽

Sun-Hwa Kim ◽

Si-Hyuck Kang ◽

Sun-Young Kim ◽

Ok-Jin Kim ◽

...

Keyword(s):

Blood Pressure ◽

Air Pollution ◽

Air Pollutants ◽

Ambient Air ◽

Ambient Air Pollution ◽

Pathophysiological Mechanism ◽

Short Term ◽

Mortality And Morbidity ◽

Short Term Exposure ◽

Increased Risk

AbstractElevated blood pressure (BP) has been proposed as a possible pathophysiological mechanism linking exposure to ambient air pollution and the increased risk of cardiovascular mortality and morbidity. In this study, we investigated the hourly relationship between ambient air pollutants and BP. BP measurements were extracted from the electronic health record database of the Seoul National University Bundang Hospital from February 2015 to June 2017. A total of 98,577 individual BP measurements were matched to the hourly levels of air pollutants. A generalized additive model was constructed for hour lags of 0–8 of air pollutants adjusting for age, sex, meteorological variables, and time trend. Systolic BP was shown to be significantly lower at 2–4 hours and 3–5 hours after increased levels of SO2 and CO, respectively (0.24 mmHg and 0.26 mmHg for an interquartile range, respectively). In contrast, O3 and NO2 were associated with significantly increased systolic BP at 3–5 lag hours and at 0–2 lag hours, respectively. BP elevation in association with O3 and NO2 was shown to be significantly greater in hypertensive patients than normotensive subjects. Our findings suggest that short-term exposure to air pollution may be associated with elevated BP.

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Ambient Air Pollution and Hospital Admissions for Peptic Ulcers in Taipei: A Time-Stratified Case-Crossover Study

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph16111916 ◽

2019 ◽

Vol 16 (11) ◽

pp. 1916 ◽

Cited By ~ 5

Author(s):

Shang-Shyue Tsai ◽

Hui-Fen Chiu ◽

Chun-Yuh Yang

Keyword(s):

Air Pollution ◽

Peptic Ulcer ◽

Crossover Study ◽

Air Pollutants ◽

Hospital Admissions ◽

Ambient Air ◽

Air Pollutant ◽

Ambient Air Pollution ◽

Research Database ◽

Case Crossover

Very few studies have been performed to determine whether there is a relationship between air pollution and increases in hospitalizations for peptic ulcer, and for those that have occurred, their results may not be completely relevant to Taiwan, where the mixture of ambient air pollutants differ. We performed a time-stratified case-crossover study to investigate the possible association between air pollutant levels and hospital admissions for peptic ulcer in Taipei, Taiwan. To do this, we collected air pollution data from Taiwan's Environmental Protection Agency and hospital admissions for peptic ulcer data for the years 2009–2013 from Taiwan's National Health Insurance's research database. We used conditional logistic regression to analyze the possible association between the two, taking temperature and relative humidity into account. Risk was expressed as odds ratios and significance was expressed with 95% confidence intervals. In our single pollutant model, peptic ulcer admissions were significantly associated with all pollutants (PM10, PM2.5, SO2, NO2, CO, and O3) on warm days (>23 °C). On cool days (<23 °C), peptic ulcer admissions were significantly associated with PM10, NO2, and O3. In our two-pollutant models, peptic ulcer admissions were significantly associated NO2 and O3 when combined with each of the other pollutants on warm days, and with PM10, NO2, and O3 on cool days. It was concluded that the likelihood of peptic ulcer hospitalizations in Taipei rose significantly with increases in air pollutants during the study period.

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The Impact of Air Pollution on Hospitalization for Cardiovascular and Cerebrovascular Disease in Shenyang, China

Iranian Journal of Public Health ◽

10.18502/ijph.v49i8.3891 ◽

2020 ◽

Cited By ~ 1

Author(s):

Qingquan REN ◽

Shuyin LI ◽

Chunling XIAO ◽

Jiazhi ZHANG ◽

Hong LIN ◽

...

Keyword(s):

Air Pollution ◽

Cerebrovascular Disease ◽

Additive Model ◽

Ambient Air ◽

Cerebrovascular Diseases ◽

Ambient Air Pollution ◽

Lag Effects ◽

Short Term Exposure ◽

Increased Risk ◽

The Impact

Background: The aim of this study was to investigate the overall impact of PM2.5, PM10, NO2, SO2, CO, and O3 on the admission of cardiovascular and cerebrovascular disease. Methods: We collected data on cardiovascular and cerebrovascular disease admissions from two hospitals in Shenyang Liaoning, China from Jan 2014 to Dec 2017, as well as daily measurements of six pollutants at 11 sites in Shenyang. The generalized additive model was used to assess the association between daily contaminants and admission to cardiovascular and cerebrovascular disease. Results: The single-contamination model showed a significant correlation between NO2, O3, PM10 and cardiovascular and cerebrovascular diseases at lag0 day. Air pollutants had lag effects on different gender groups. Excess relative risks (ERs) associated with a 10 μg/m3 increase were 1.522(1.057, 1.988) on lag02 for NO2, 0.547% (0.367%, 0.728%), 0.133% (0.061%, 0.205%) on lag3 for O3 and PM10. The dual pollutant model showed that the effects of NO2, O3, and PM10 after adjusting the influence of other pollutants were still statistically significant. Conclusion: Short-term exposure to ambient air pollution (NO2, O3, and PM10) may be associated with an increased risk of daily cardiovascular and cerebrovascular admission, which may provide reliable evidence for further understanding of the potential adverse effects of air pollution on cardiovascular and cerebrovascular diseases.

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Ambient Air Pollution Increases the Risk of Cerebrovascular and Neuropsychiatric Disorders through Induction of Inflammation and Oxidative Stress

International Journal of Molecular Sciences ◽

10.3390/ijms21124306 ◽

2020 ◽

Vol 21 (12) ◽

pp. 4306 ◽

Cited By ~ 6

Author(s):

Omar Hahad ◽

Jos Lelieveld ◽

Frank Birklein ◽

Klaus Lieb ◽

Andreas Daiber ◽

...

Keyword(s):

Oxidative Stress ◽

Air Pollution ◽

Air Pollutants ◽

Molecular Mechanisms ◽

Ambient Air ◽

Neuropsychiatric Disorders ◽

Ambient Air Pollution ◽

Enhanced Production ◽

Increased Risk ◽

And Oxidative Stress

Exposure to ambient air pollution is a well-established determinant of health and disease. The Lancet Commission on pollution and health concludes that air pollution is the leading environmental cause of global disease and premature death. Indeed, there is a growing body of evidence that links air pollution not only to adverse cardiorespiratory effects but also to increased risk of cerebrovascular and neuropsychiatric disorders. Despite being a relatively new area of investigation, overall, there is mounting recent evidence showing that exposure to multiple air pollutants, in particular to fine particles, may affect the central nervous system (CNS) and brain health, thereby contributing to increased risk of stroke, dementia, Parkinson’s disease, cognitive dysfunction, neurodevelopmental disorders, depression and other related conditions. The underlying molecular mechanisms of susceptibility and disease remain largely elusive. However, emerging evidence suggests inflammation and oxidative stress to be crucial factors in the pathogenesis of air pollution-induced disorders, driven by the enhanced production of proinflammatory mediators and reactive oxygen species in response to exposure to various air pollutants. From a public health perspective, mitigation measures are urgent to reduce the burden of disease and premature mortality from ambient air pollution.

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Ambient air pollution and emergency department visits in Toronto, Canada

Environmental Science and Pollution Research ◽

10.1007/s11356-021-12519-3 ◽

2021 ◽

Author(s):

Mieczysław Szyszkowicz ◽

Nicholas de Angelis

Keyword(s):

Emergency Department ◽

Air Pollution ◽

Carbon Monoxide ◽

Nitrogen Dioxide ◽

Air Pollutants ◽

Ambient Air ◽

Emergency Department Visits ◽

Air Pollutant ◽

Ambient Air Pollution ◽

A Value

AbstractTo investigate the acute impact of various air pollutants on various disease groups in the urban area of the city of Toronto, Canada. Statistical models were developed to estimate the relative risk of an emergency department visit associated with ambient air pollution concentration levels. These models were generated for 8 air pollutants (lagged from 0 to 14 days) and for 18 strata (based on sex, age group, and season). Twelve disease groups extracted from the International Classification of Diseases 10th Revision (ICD-10) were used as health classifications in the models. The qualitative results were collected in matrices composed of 18 rows (strata) and 15 columns (lags) for each air pollutant and the 12 health classifications. The matrix cells were assigned a value of 1 if the association was positively statistically significant; otherwise, they were assigned to a value of 0. The constructed matrices were totalized separately for each air pollutant. The resulting matrices show qualitative associations for grouped diseases, air pollutants, and their corresponding lagged concentrations and indicate the frequency of statistically significant positive associations. The results are presented in colour-gradient matrices with the number of associations for every combination of patient strata, pollutant, and lag in corresponding cells. The highest number of the associations was 8 (of 12 possible) obtained for the same day exposure to carbon monoxide, nitrogen dioxide, and days with elevated air quality health index (AQHI) values. For carbon monoxide, the number of the associations decreases with the increasing lags. For this air pollutant, there were almost no associations after 8 days of lag. In the case of nitrogen dioxide, the associations persist even for longer lags. The numerical values obtained from the models are provided for every pollutant. The constructed matrices are a useful tool to analyze the impact of ambient air pollution concentrations on public health.

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Association between Ambient Air Pollution and MRI-Defined Brain Infarcts in Health Examinations in China

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18084325 ◽

2021 ◽

Vol 18 (8) ◽

pp. 4325

Author(s):

Jing Wu ◽

Yi Ning ◽

Yongxiang Gao ◽

Ruiqi Shan ◽

Bo Wang ◽

...

Keyword(s):

Air Pollution ◽

Air Pollutants ◽

Brain Mri ◽

Ambient Air ◽

The Elderly ◽

Air Pollutant ◽

Ambient Air Pollution ◽

Brain Infarcts ◽

Pollutant Concentrations ◽

Mri Scans

The study aimed to evaluate the relationships between air pollutants and risk of magnetic resonance imaging (MRI)-defined brain infarcts (BI). We used data from routine health examinations of 1,400,503 participants aged ≥18 years who underwent brain MRI scans in 174 cities in 30 provinces in China in 2018. We assessed exposures to particulate matter (PM)2.5, PM10, nitrogen dioxide (NO2), and carbon monoxide (CO) from 2015 to 2017. MRI-defined BI was defined as lesions ≥3 mm in diameter. Air pollutants were associated with a higher risk of MRI-defined BI. The odds ratio (OR) (95% CI) for MRI-defined BI comparing the highest with the lowest tertiles of air pollutant concentrations was 2.00 (1.96–2.03) for PM2.5, 1.68 (1.65–1.71) for PM10, 1.58 (1.55–1.61) for NO2, and 1.57 (1.54–1.60) for CO. Each SD increase in air pollutants was associated with 16–42% increases in the risk of MRI-defined BI. The associations were stronger in the elderly subgroup. This is the largest survey to evaluate the association between air pollution and MRI-defined BI. Our findings indicate that ambient air pollution was significantly associated with a higher risk of MRI-defined BI.

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Remarks on Ambient Air Pollution and Health Outcomes

ISRN Public Health ◽

10.1155/2013/846297 ◽

2013 ◽

Vol 2013 ◽

pp. 1-5 ◽

Cited By ~ 1

Author(s):

Mieczysław Szyszkowicz

Keyword(s):

Air Pollution ◽

Health Outcomes ◽

Air Pollutants ◽

Conditional Logistic Regression ◽

Ambient Air ◽

Air Pollutant ◽

Ambient Air Pollution ◽

Health Conditions ◽

Ed Visits ◽

The Impact

Background. Ambient air pollution is a recognized risk factor for multiple health conditions. For some health problems, the impact of air pollution is particularly evident to the patients in a specific age range. Nonsimultaneous exposures to two or more air pollutants may have different relationships with health outcomes than do simultaneous exposures. Methods. Case-crossover technique was used to analyze data on emergency department (ED) visits for ischemic heart disease (IHD), epistaxis, and upper respiratory infection (URI). Conditional logistic regression models were used to estimate odds ratios and their 95% confidence intervals corresponding to an increase in an interquartile range of air pollutant concentrations. Results. The results for IHD show that for older patients (age 60+ years), the association between sulphur dioxide (SO2) exposure and IHD is weak. For ED visits for epistaxis (O3 and SO2 in one model) and URI (O3 and NO2 in one model), air pollutants lagged differently in the common model indicated significant statistical associations but not for common lags. Conclusion. The study findings, based on analyzed examples, suggest that (i) IHD cases in older age are less related to air pollution and (ii) air pollutants may affect some health conditions by a specific sequence of exposure occurrences.

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Association between short-term exposure to ambient air pollution and hospital admissions for transient ischemic attacks in Beijing, China

Environmental Science and Pollution Research ◽

10.1007/s11356-020-10963-1 ◽

2020 ◽

Author(s):

Runhua Zhang ◽

Yong Jiang ◽

Guitao Zhang ◽

Miaoxin Yu ◽

Yongjun Wang ◽

...

Keyword(s):

Air Pollution ◽

Air Pollutants ◽

Hospital Admissions ◽

Ambient Air ◽

Additive Models ◽

Pollution Monitoring ◽

Ambient Air Pollution ◽

Exposure Response ◽

Short Term Exposure ◽

Beijing China

Abstract Numerous studies have examined the associations between air pollution and stroke. However, little is known about the associations between air pollution and transient ischemic attack (TIA). In this study, we aimed to conduct a time-series study to systematically examine the associations between hospital admissions for TIA and air pollutants. Admissions for TIA (ICD-10: G45) from 1 January 2014 to 31 December 2016 were identified based on the primary diagnosis from 134 hospitals in Beijing, China. Hourly measurements of air pollutants were obtained from the National Air Pollution Monitoring System. Generalized additive models with quasi-Poisson regression were used to determine the associations for each pollutant. Additionally, stratified analysis was implemented to examine whether age, gender, temperature, and season were the potential effect modifiers. Restricted cubic spline was applied to investigate the exposure-response curve. In total, 109,975 hospital admissions for TIA were included. The positive associations were detected between PM2.5, PM10, SO2, NO2, and CO and hospital admissions for TIA. The effects of PM2.5 and PM10 in men are stronger than in women. Additionally, the effects of PM2.5, PM10, SO2, and O3 are more pronounced on warm days than cool days. From exposure-response curves, we observe a nearly linear relationship for PM2.5, PM10, CO, and NO2. Further studies are needed to verify the association. This research contributes evidence on the association between air pollution and admissions for TIA in the low- and middle-income countries and may promote related public health policy development.

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The Association Between Short-term Exposure to Ambient Air Pollution and Patient-Level Home Blood Pressure Among Patients With Chronic Cardiovascular Diseases in a Web-Based Synchronous Telehealth Care Program: Retrospective Study (Preprint)

10.2196/preprints.26605 ◽

2020 ◽

Author(s):

Ching-Chang Huang ◽

Ying-Hsien Chen ◽

Chi-Sheng Hung ◽

Jen-Kuang Lee ◽

Tse-Pin Hsu ◽

...

Keyword(s):

Blood Pressure ◽

Air Pollution ◽

Air Pollutants ◽

Meteorological Factors ◽

Care Program ◽

Ambient Air ◽

Home Blood Pressure ◽

Ambient Air Pollution ◽

Short Term ◽

Short Term Exposure

BACKGROUND The association between short-term exposure to ambient air pollution and blood pressure has been inconsistent, as reported in the literature. OBJECTIVE This study aimed to investigate the relationship between short-term ambient air pollution exposure and patient-level home blood pressure (HBP). METHODS Patients with chronic cardiovascular diseases from a telehealth care program at a university-affiliated hospital were enrolled as the study population. HBP was measured by patients or their caregivers. Hourly meteorological data (including temperature, relative humidity, wind speed, and rainfall) and ambient air pollution monitoring data (including CO, NO<sub>2</sub>, particulate matter with a diameter of <10 µm, particulate matter with a diameter of <2.5 µm, and SO<sub>2</sub>) during the same time period were obtained from the Central Weather Bureau and the Environmental Protection Administration in Taiwan, respectively. A stepwise multivariate repeated generalized estimating equation model was used to assess the significant factors for predicting systolic and diastolic blood pressure (SBP and DBP). RESULTS A total of 253 patients and 110,715 HBP measurements were evaluated in this study. On multivariate analysis, demographic, clinical, meteorological factors, and air pollutants significantly affected the HBP (both SBP and DBP). All 5 air pollutants evaluated in this study showed a significant, nonlinear association with both home SBP and DBP. Compared with demographic and clinical factors, environmental factors (meteorological factors and air pollutants) played a minor yet significant role in the regulation of HBP. CONCLUSIONS Short-term exposure to ambient air pollution significantly affects HBP in patients with chronic cardiovascular disease.

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1271Short-term effects of exposure to ambient fine particulate matter on out-of-hospital cardiac arrest: a nationwide case-crossover study in Japan

European Heart Journal ◽

10.1093/eurheartj/ehz748.0041 ◽

2019 ◽

Vol 40 (Supplement_1) ◽

Author(s):

B Zhao ◽

F H Johnston ◽

F Salimi ◽

K Negishi

Keyword(s):

Air Pollution ◽

Cardiac Arrest ◽

Particulate Matter ◽

Ambient Air ◽

Ambient Air Pollution ◽

Short Term ◽

Case Crossover ◽

Short Term Exposure ◽

Increased Risk ◽

Hospital Cardiac Arrest

Abstract Introduction The cardiovascular health consequences of ambient air pollution generally equal or exceed those due to pulmonary diseases and cancers. Particulate matter less than 2.5μm in aerodynamic diameter (PM2.5) has become a major focus of research on the short-term exposure to air pollution and cardiovascular disease. However, the evidence regarding the association between several air pollutants and out-of-hospital cardiac arrest (OHCA), has been inconsistent, which could be due to limited sample sizes (∼11,000). Thus, a larger study may assist in characterising possible associations. Purpose This study aimed to identify the associations between exposure to ambient air pollution and the incidence of OHCA in Japan. Methods A case-crossover design was used to determine the odds ratio (OR) of OHCA across Japan with daily exposure of PM2.5, carbon monoxide (CO), photochemical oxidants (Ox), and sulfur dioxide (SO2) on the day of the arrest or 1–3 days before it (lag 0–3). OHCA cases were identified through the All-Japan Utstein registry of the Fire and Disaster Management Agency from January 1, 2014 to December 31, 2015. All cause OHCAs were investigated by conditional logistic regression adjusted for daily temperature and relative humidity. Results A total of 249,372 OHCAs were included during study period. Each 10 μg/m3 increase in daily PM2.5 exposure over 4 days was associated with all cause OHCA risk (lag 0: OR 1.017, 95% confidence interval (CI) 1.010, 1.024; lag 1: OR 1.015, 95% CI 1.008, 1.022; lag 2: OR 1.018, 95% CI 1.011, 1.025; lag 3: OR 1.021, 95% CI 1.014, 1.028; lag 0–1: OR 1.022, 95% CI 1.014, 1.030). CO, Ox and SO2 also showed significant associations with OHCAs. In the multi-pollutant model, the effects of PM2.5 remained independent of CO, Ox and SO2 (Table). Conclusion Short-term exposure to PM2.5 was independently associated with an increased risk of OHCA.

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