scholarly journals Association between GnRH Receptor Polymorphisms and Luteinizing Hormone Levels for Low Ovarian Reserve Infertile Women

2021 ◽  
Vol 18 (13) ◽  
pp. 7006
Author(s):  
Shun-Long Weng ◽  
Shu-Ling Tzeng ◽  
Chun-I Lee ◽  
Chung-Hsien Liu ◽  
Chun-Chia Huang ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Ovarian Reserve ◽  
Genetic Variants ◽  
Ovarian Stimulation ◽  
Age Groups ◽  
Recessive Model ◽  
Gnrh Receptor ◽  
Poor Responders ◽  
Nested Case Control ◽  
Control Study

The choice of ovarian stimulation protocols in assisted reproduction technology (ART) cycles for low ovarian reserve patients is challenging. Our previous report indicated that the gonadotrophin-releasing (GnRH) agonist (GnRHa) protocol is better than the GnRH antagonist (GnRHant) protocol for young age poor responders. Here, we recruited 269 patients with anti-Müllerian hormone (AMH) < 1.2 ng/mL undergoing their first ART cycles for this nested case-control study. We investigated the genetic variants of the relevant genes, including follicular stimulating hormone receptor (FSHR; rs6166), AMH (rs10407022), GnRH (rs6185), and GnRH receptor (GnRHR; rs3756159) in patients <35 years (n = 86) and patients ≥35 years of age (n = 183). Only the genotype of GnRHR (rs3756159) is distributed differently in young (CC 39.5%, CT/TT 60.5%) versus advanced (CC 24.0%, CT/TT 76.0%) age groups (recessive model, p = 0.0091). Furthermore, the baseline luteinizing hormone (LH) levels (3.60 (2.45 to 5.40) vs. 4.40 (2.91 to 6.48)) are different between CC and CT/TT genotype of GnRHR (rs3756159). In conclusion, the genetic variants of GnRHR (rs3756159) could modulate the release of LH in the pituitary gland and might then affect the outcome of ovarian stimulation by GnRHant or GnRHa protocols for patients with low AMH levels.

scholarly journals Symptom presentation of SARS-CoV-2-positive and negative patients: a nested case–control study among patients calling the emergency medical service and medical helpline

BMJ Open ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. e044208
Author(s):  
Amalie Lykkemark Moeller ◽  
Elisabeth Helen Anna Mills ◽  
Helle Collatz Christensen ◽  
Filip Gnesin ◽  
Stig Nikolaj Fasmer Nikolaj Blomberg ◽  
...  
Keyword(s):  
Medical Service ◽  
Nasal Congestion ◽  
Age Groups ◽  
Symptom Presentation ◽  
Age Related ◽  
Loss Of Appetite ◽  
Nested Case Control ◽  
Specific Symptoms ◽  
Taste And Smell ◽  
Control Study

ObjectiveCurrently effective symptom-based screening of patients suspected of COVID-19 is limited. We aimed to investigate age-related differences in symptom presentations of patients tested positive and negative for SARS-CoV-2.DesignSettingCalls to the medical helpline (1-8-1-3) and emergency number (1-1-2) in Copenhagen, Denmark. At both medical services all calls are recorded.ParticipantsWe included calls for patients who called for help/guidance at the medical helpline or emergency number prior to receiving a test for SARS-CoV-2 between April 1st and 20th 2020 (8423 patients). Among these calls, we randomly sampled recorded calls from 350 patients who later tested positive and 250 patients tested negative and registered symptoms described in the call.OutcomeResultsAfter exclusions, 544 calls (312 SARS-CoV-2 positive and 232 negative) were included in the analysis. Fever and cough remained the two most common of COVID-19 symptoms across all age groups and approximately 42% of SARS-CoV-2 positive and 20% of negative presented with both fever and cough. Symptoms including nasal congestion, irritation/pain in throat, muscle/joint pain, loss of taste and smell, and headache were common symptoms of COVID-19 for patients younger than 60 years; whereas loss of appetite and feeling unwell were more commonly seen among patients over 60 years. Headache and loss of taste and smell were rare symptoms of COVID-19 among patients over 60 years.ConclusionOur study identified age-related differences in symptom presentations of SARS-CoV-2-positive patients calling for help or medical advice. The specific symptoms of loss of smell or taste almost exclusively reported by patients younger than 60 years. Differences in symptom presentation across age groups must be considered when screening for COVID-19.

Association between CPR-related genetic variants and risk of ischemic stroke: a nested case-control study

2019 ◽  
Vol 41 (12) ◽  
pp. 1090-1096
Author(s):  
Yao Zhu ◽  
Shu-Chang Hu ◽  
Pei-Wen Zheng ◽  
Ming-Juan Jin ◽  
Meng-Ling Tang ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Genetic Variants ◽  
Case Control Study ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study

scholarly journals Comparative Effectiveness of Mild or Conventional GnRH-Antagonist Protocols for Ovarian Stimulation in Poor Responders (Poseidon Group 4)

2020 ◽  
Vol 2 ◽  
Author(s):  
Hoang Le ◽  
Dong D. Nguyen ◽  
Anh T. Cao ◽  
Huong T. L. Nguyen ◽  
Dung C. Tham ◽  
...  
Keyword(s):  
Ovarian Reserve ◽  
Ovarian Stimulation ◽  
Gnrh Antagonist ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Poor Responders ◽  
Research Committee ◽  
Group 4 ◽  
Stimulation Regimen ◽  
Antagonist Protocol

Background and Aims: A panel of experts (the Poseidon Group) introduced a new and more detailed stratification for poor ovarian responders in order to predict the prognosis of IVF outcome according to the sensitivity to FSH. However, various arguments about the management strategy of these patients still remain, including the convenience and the cost. Therefore, this study was conducted to compare the efficacy of mild and conventional GnRH antagonist ovarian stimulation prescribed in patients classified in Poseidon Group 4.Methods: This retrospective cohort study included 359 poor responder patients (Poseidon Group 4) treated with mild or conventional GnRH antagonist stimulation regimens from 8/2017 to 7/2019 at Tam Anh Hospital ART Center. The main outcomes were the index of Follicular Output Rate (FORT) or Follicle to Oocyte Index (FOI), the number of day-2 embryos and top-quality embryos obtained. The t-test and Mann–Whitney U test in SPSS v25.0 was used to analyze the continuous data and Chi-squared/Exact test was used for binary variables. Multiple linear regression analysis was done by using Stata versions 15.0 to measure association between primary endpoints with stimulation regimen controlled for covariates and possible confounding factors.Results: In the overall group of poor responders, the conventional GnRH antagonist protocol performed better than the mild protocol. Subsequently, data were analyzed according to the AFC. In women with AFC &lt; 3, no significant differences were observed between the 2 regimens regarding FORT (p = 0.71), FOI (p = 0.12), the number of day-2-embryos (p = 0.052) and the number of top-quality embryos (p = 0.26). In contrast, in women with AFC ≥ 3, mild stimulation regimen resulted in significantly poorer outcome compared to the conventional GnRH antagonist regimen, regarding FORT (p &lt; 0.01), FOI (p &lt; 0.01), the number of day-2-embryos (p &lt; 0.01) and top-quality embryos (p = 0.01).Conclusions: Considering poor responders classified in Poseidon Group 4, both ovarian stimulation regimens resulted in similar outcome for patients with a very low ovarian reserve (AFC &lt; 3). In contrast, the GnRH conventional antagonist protocol with maximum initial FSH dose (300–375 IU/day) and supplementary LH (75–150 IU/day) was more effective than the mild one for patients whose ovarian reserve was less reduced. The Clinical Trial was approved by the Ethnical Biomedical Research Committee Tam Anh General Hospital.

scholarly journals Use of luteinizing hormone supplementation for ovarian stimulation in IVF/ICSI cycles of women with good ovarian reserve

2019 ◽  
Vol 112 (3) ◽  
pp. e222
Author(s):  
Liang Hsuan Chen ◽  
Tzu-Hsuan Chin ◽  
Ya-Chiung Hsu ◽  
Shang Yu Huang ◽  
Hsing-Tse Yu ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Ovarian Reserve ◽  
Ovarian Stimulation

Genetic variants in the DNA repair gene NEIL3 and the risk of myocardial infarction in a nested case–control study. The HUNT Study

DNA Repair ◽  
2015 ◽  
Vol 28 ◽  
pp. 21-27 ◽  
Author(s):  
Tonje Skarpengland ◽  
Lars Erik Laugsand ◽  
Imre Janszky ◽  
Luisa Luna ◽  
Bente Halvorsen ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Dna Repair ◽  
Genetic Variants ◽  
Case Control Study ◽  
Case Control ◽  
Repair Gene ◽  
Dna Repair Gene ◽  
Hunt Study ◽  
Nested Case Control ◽  
Control Study

scholarly journals FSH versus AMH: age-related relevance to ICSI results

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Sameh Salama ◽  
Marwa Sharaf ◽  
Sondos M. Salem ◽  
Mazen Abdel Rasheed ◽  
Ehab Salama ◽  
...  
Keyword(s):  
Ovarian Reserve ◽  
Ovarian Stimulation ◽  
Age Groups ◽  
Implantation Rate ◽  
Fertilization Rate ◽  
Controlled Ovarian Stimulation ◽  
Predictors Of Response ◽  
Age Related ◽  
Group 2 ◽  
Group 1

Abstract Background Women’s fecundity is known to decrease with the increase in chronologic age. Several biomarkers of the ovarian reserve, including follicle stimulating hormone (FSH), anti Müllerian hormone (AMH), have been proposed as possible predictors for the response to controlled ovarian stimulation (COS). Although there are assumptions indicating that the relationship between age and ovarian reserve is highly variable and the potential different validity of ovarian reserve markers in women in different age groups remains to be demonstrated. The purpose of our study was evaluating FSH and AMH as potential predictors of response to controlled ovarian stimulation and prediction of intracytoplasmic sperm injection (ICSI) outcome according to age. This prospective study has been carried out on 218 women having ICSI cycles. Cases were divided into two groups, group 1 (n 148), their age < 35 years, and group 2 (n 70), their age ≥ 35 years. All women received antagonist protocol during their ICSI cycles. Basal FSH and AMH were measured and correlated to the number of follicles on the day of trigger, the number of oocytes retrieved, chemical, and clinical pregnancies. Results The fertilization rate in group 1 was 68.15%, while in group 2 was 77.82% (p = 0.003) while the implantation rate (number of gestational sacs observed at 6 weeks of pregnancy divided by the number of transferred embryos) was 18.95 and 11.98% in group 1 and group 2, respectively (p = 0.041). The clinical pregnancy rate among both groups was 38.51% in group 1, while 24.29% in group 2 (p = 0.038). Women who got pregnant among those aged < 35 years had significantly lower basal FSH (p < 0.001), while women who got pregnant among those aged ≥ 35 years had significantly higher AMH levels (p value < 0.001) and higher E2 levels on the day of trigger (p = 0.007). Conclusion We found that below the age of 35 years, the chances of pregnancy are more correlated to FSH levels, while above the age of 35 years, AMH was a more relevant test.

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