Association between CPR-related genetic variants and risk of ischemic stroke: a nested case-control study

2019 ◽  
Vol 41 (12) ◽  
pp. 1090-1096
Author(s):  
Yao Zhu ◽  
Shu-Chang Hu ◽  
Pei-Wen Zheng ◽  
Ming-Juan Jin ◽  
Meng-Ling Tang ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Genetic Variants ◽  
Case Control Study ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study

Common genetic variants of homocysteine metabolism in ischemic stroke: a case-control study

2005 ◽  
Vol 12 (8) ◽  
pp. 614-618 ◽  
Author(s):  
M. Linnebank ◽  
M. Montenarh ◽  
H. Kolsch ◽  
A. Linnebank ◽  
K. Schnez ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Genetic Variants ◽  
Case Control Study ◽  
Case Control ◽  
Common Genetic Variants ◽  
Control Study

scholarly journals Relationship between serum lipid levels and ischemic stroke in patients with atrial fibrillation: a nested case–control study based on the China Atrial Fibrillation Registry

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Fei Li ◽  
Xin Du ◽  
Liu He ◽  
Chao Jiang ◽  
Shijun Xia ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Blood Pressure ◽  
Ischemic Stroke ◽  
Case Control Study ◽  
Density Lipoprotein ◽  
Case Control ◽  
Control Group ◽  
Stroke Group ◽  
Nested Case Control ◽  
Control Study

Abstract Background Atrial fibrillation (AF) is an important risk factor for acute ischemic stroke. Methods A nested case–control study was conducted among patients diagnosed with AF, whose information was acquired from the prospective China Atrial Fibrillation Registry (China-AF), from August 2011 to December 2018. Results This study compared patients with stroke group (n = 145) with a matched control group (n = 577). Demographic data were similar except for body mass index (BMI), diastolic blood pressure (DBP) which were higher, and new oral anticoagulant (NOAC) treatment rate which was lower in the stroke group (all P < 0.05). Baseline median [IQR] levels of including triglyceride (TG) were higher in the stroke group (21.96 [16.74, 21.52], mg/dL) than the control group (19.62 [14.76, 27.36], mg/dL) (P = 0.012), while the total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were similar between the two groups. Elevated TG and HDL-C were positively associated with ischemic stroke (OR 1.01, 95% CI 1.00–1.02, P = 0.032; OR 1.03, 95% CI 1.00–1.05, P = 0.025), after adjustment for BMI, systolic blood pressure, DBP, CHA2DS2-VASc score, HAS-BLED score, NOAC, LDL-C and HDL-C. However, NOAC (OR 0.20, 95% CI 0.05–0.84, P = 0.029) could decrease the likelihood of ischemic stroke in patients with AF. In subgroup analysis, higher TG level remained significantly associated with ischemic stroke for AF patients without a history of smoking (OR 1.26, 95% CI 1.02–1.55, P = 0.028). Conclusion Higher level of TG and HDL-C were positively associated with ischemic stroke in patients with AF.

Risk Factor, Pattern, Etiology and Outcome in Ischemic Stroke Patients with Cancer: A Nested Case-Control Study

2006 ◽  
Vol 23 (2-3) ◽  
pp. 181-187 ◽  
Author(s):  
Yun Yun Zhang ◽  
Dennis Cordato ◽  
Qing Shen ◽  
Ai Zhen Sheng ◽  
Wai Tak Hung ◽  
...  
Keyword(s):  
Risk Factor ◽  
Ischemic Stroke ◽  
Case Control Study ◽  
Case Control ◽  
Stroke Patients ◽  
Patients With Cancer ◽  
Factor Pattern ◽  
Nested Case Control ◽  
Control Study

scholarly journals Plasma copper and the risk of first stroke in hypertensive patients: a nested case-control study

2019 ◽  
Vol 110 (1) ◽  
pp. 212-220 ◽  
Author(s):  
Jingping Zhang ◽  
Jingjing Cao ◽  
Hao Zhang ◽  
Chongfei Jiang ◽  
Tengfei Lin ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Ischemic Stroke ◽  
Case Control Study ◽  
Conditional Logistic Regression ◽  
Case Control ◽  
Significant Positive Association ◽  
Hypertensive Patients ◽  
Plasma Copper ◽  
Nested Case Control ◽  
Control Study

ABSTRACT Background Previous studies indicated that trace elements may play an important role in cardiovascular diseases. However, data concerning the association between blood copper and the risk of stroke are limited. Objective The aim of this study was to evaluate the association between plasma copper and the risk of first stroke, and examine any possible effect modifiers in hypertensive patients. Methods We conducted a nested case-control study, using data from the China Stroke Primary Prevention Trial. Hypertension is defined as systolic blood pressure ≥ 140 mm Hg or diastolic blood pressure ≥ 90 mm Hg, or taking antihypertensive medication. A total of 618 first stroke cases and 618 controls matched for age, sex, treatment group, and study site were included in this study. The crude and adjusted risks of first stroke were estimated by ORs and 95% CIs using conditional logistic regression, without or with adjusting for pertinent covariates, respectively. Results There were significant positive associations of plasma copper with risk of first stroke (per SD increment—OR: 1.20; 95% CI: 1.03, 1.39) and first ischemic stroke (OR: 1.26; 95% CI: 1.07, 1.50). When plasma copper was categorized in quartiles, significantly higher risks of first stroke (OR: 1.72; 95% CI: 1.12, 2.65) and first ischemic stroke (OR: 1.91; 95% CI: 1.18, 3.11) were found in participants in quartile 4 (≥ 117.0 μg/dL) than in those in quartile 1 (< 91.2 μg/dL). Furthermore, the plasma copper–first stroke association was significantly stronger in participants with higher BMI (< 25.0 compared with ≥ 25.0 kg/m2, P-interaction = 0.024). However, there was no significant association between plasma copper and first hemorrhagic stroke. Conclusions In Chinese hypertensive patients, there was a significant positive association between baseline plasma copper and the risk of first stroke, especially among those with higher BMI. This trial was registered at clinicaltrials.gov as NCT00794885.

scholarly journals Human Cytomegalovirus Increases the Risk of Future Hemorrhagic But Not Ischemic Stroke　– A Nested Case-Control Study –

2016 ◽  
Vol 80 (10) ◽  
pp. 2235-2239 ◽  
Author(s):  
Liqiang Zheng ◽  
Zhengrong Sun ◽  
Zhaoqing Sun ◽  
Xingang Zhang ◽  
Kai Jing ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Human Cytomegalovirus ◽  
Case Control Study ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study
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