scholarly journals Gas6/TAM System: A Key Modulator of the Interplay between Inflammation and Fibrosis

2019 ◽  
Vol 20 (20) ◽  
pp. 5070 ◽  
Author(s):  
Mattia Bellan ◽  
Micol Giulia Cittone ◽  
Stelvio Tonello ◽  
Cristina Rigamonti ◽  
Luigi Mario Castello ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Protein Tyrosine Kinase ◽  
Repair Process ◽  
Human Diseases ◽  
Current Evidence ◽  
System A ◽  
Causative Factors ◽  
Axl Receptor Tyrosine Kinase ◽  
Mer Tyrosine Kinase

Fibrosis is the result of an overly abundant deposition of extracellular matrix (ECM) due to the fact of repetitive tissue injuries and/or dysregulation of the repair process. Fibrogenesis is a pathogenetic phenomenon which is involved in different chronic human diseases, accounting for a high burden of morbidity and mortality. Despite being triggered by different causative factors, fibrogenesis follows common pathways, the knowledge of which is, however, still unsatisfactory. This represents a significant limit for the development of effective antifibrotic drugs. In the present paper, we aimed to review the current evidence regarding the potential role played in fibrogenesis by growth arrest-specific 6 (Gas6) and its receptors Tyro3 protein tyrosine kinase (Tyro3), Axl receptor tyrosine kinase (Axl), and Mer tyrosine kinase protooncogene (MerTK) (TAM). Moreover, we aimed to review data about the pathogenetic role of this system in the development of different human diseases characterized by fibrosis. Finally, we aimed to explore the potential implications of these findings in diagnosis and treatment.

scholarly journals Lymphocyte-Specific Protein Tyrosine Kinase (LCK) is Involved in the Aryl Hydrocarbon Receptor-Mediated Impairment of Immunoglobulin Secretion in Human Primary B Cells

2018 ◽  
Vol 165 (2) ◽  
pp. 322-334
Author(s):  
Jiajun Zhou ◽  
Qiang Zhang ◽  
Joseph E Henriquez ◽  
Robert B Crawford ◽  
Norbert E Kaminski
Keyword(s):  
B Cells ◽  
Tyrosine Kinase ◽  
Aryl Hydrocarbon Receptor ◽  
Protein Tyrosine Kinase ◽  
Specific Protein ◽  
Immunoglobulin M ◽  
Protein Tyrosine ◽  
Immunoglobulin Secretion ◽  
Aryl Hydrocarbon

AbstractThe aryl hydrocarbon receptor (AHR) is a cytosolic ligand-activated transcription factor involved in xenobiotic sensing, cell cycle regulation, and cell development. In humans, the activation of AHR by 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), a high affinity AHR-ligand, impairs the secretion of immunoglobulin M (IgM) to suppress humoral immunity. However, the mechanisms bridging the activation of AHR and the impairment of IgM secretion by human primary B cells remain poorly understood. Recent transcriptomic analysis revealed upregulation of lymphocyte-specific protein tyrosine kinase (LCK) in AHR-activated human primary B cells. LCK is a well-characterized tyrosine kinase that phosphorylates critical signaling proteins involved in activation and cytokine production in T cells. Conversely, the role of LCK in human primary B cells is not well understood. In the current studies, we have verified the transcriptomic finding by detecting AHR-mediated upregulation of LCK protein in human primary B cells. We also confirmed the role of AHR in the upregulation of LCK by using a specific AHR antagonist, which abolished the AHR-mediated increase of LCK. Furthermore, we have confirmed the role of LCK in the AHR-mediated suppression of IgM by using LCK specific inhibitors, which restored the IgM secretion by human B cells in the presence of TCDD. Collectively, the current studies demonstrate a novel role of LCK in IgM response and provide new insights into the mechanism for AHR-mediated impairment of immunoglobulin secretion by human primary B cells.

Current evidence on thyroid related adverse events in patients treated with protein tyrosine kinase inhibitors

2019 ◽  
Vol 51 (4) ◽  
pp. 562-569
Author(s):  
Katalin Gabora ◽  
Andra Piciu ◽  
Iulian Claudiu Bădulescu ◽  
Maria Iulia Larg ◽  
Ioan-Adrian Stoian ◽  
...  
Keyword(s):  
Adverse Events ◽  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitors ◽  
Protein Tyrosine Kinase ◽  
Kinase Inhibitors ◽  
Current Evidence ◽  
Protein Tyrosine

scholarly journals Crucial role of Mer tyrosine kinase in the maintenance of SIGN-R1+ marginal zone macrophages

2018 ◽  
Vol 96 (3) ◽  
pp. 298-315
Author(s):  
Chetna Soni ◽  
Stephanie L Schell ◽  
Melinda J Fasnacht ◽  
Sathi Babu Chodisetti ◽  
Ziaur SM Rahman
Keyword(s):  
Tyrosine Kinase ◽  
Crucial Role ◽  
Marginal Zone ◽  
Mer Tyrosine Kinase ◽  
Marginal Zone Macrophages

scholarly journals Expression and Oncogenic Role of Brk (PTK6/Sik) Protein Tyrosine Kinase in Lymphocytes

2006 ◽  
Vol 168 (5) ◽  
pp. 1631-1641 ◽  
Author(s):  
Monika Kasprzycka ◽  
Miroslaw Majewski ◽  
Zhi-Jong Wang ◽  
Andrzej Ptasznik ◽  
Maria Wysocka ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Protein Tyrosine Kinase ◽  
Protein Tyrosine

scholarly journals Role of the Protein Tyrosine Kinase Syk in Regulating Cell-Cell Adhesion and Motility in Breast Cancer Cells

2009 ◽  
Vol 7 (5) ◽  
pp. 634-644 ◽  
Author(s):  
Xiaoying Zhang ◽  
Ulka Shrikhande ◽  
Bethany M. Alicie ◽  
Qing Zhou ◽  
Robert L. Geahlen
Keyword(s):  
Breast Cancer ◽  
Cell Adhesion ◽  
Tyrosine Kinase ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Protein Tyrosine Kinase ◽  
Protein Tyrosine ◽  
Cell Cell

scholarly journals Mast cell signaling: The role of protein tyrosine kinase Syk, its activation and screening methods for new pathway participants

FEBS Letters ◽  
2010 ◽  
Vol 584 (24) ◽  
pp. 4933-4940 ◽  
Author(s):  
Reuben P. Siraganian ◽  
Rodrigo O. de Castro ◽  
Emilia A. Barbu ◽  
Juan Zhang
Keyword(s):  
Mast Cell ◽  
Tyrosine Kinase ◽  
Cell Signaling ◽  
Protein Tyrosine Kinase ◽  
Screening Methods ◽  
Protein Tyrosine

scholarly journals The Protein Tyrosine Kinase Inhibitor Genistein Suppresses Hypoxia-Induced Atrial Natriuretic Peptide Secretion Mediated by the PI3K/Akt-HIF-1α Pathway in Isolated Beating Rat Atria

2020 ◽  
Author(s):  
Qiu-li Zhang ◽  
Chao-chao Bian ◽  
Ping Li ◽  
Lan Hong ◽  
Li-ping Liu ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Protein Tyrosine Kinase ◽  
Kinase Inhibitor ◽  
Acute Hypoxia ◽  
Hypoxia Inducible Factor ◽  
Protein Tyrosine ◽  
Downstream Signaling ◽  
Radio Immunoassay ◽  
Peptide Secretion

Abstract Background Genistein, an isoflavonoid that can inhibit protein tyrosine kinase (PTK) phosphorylation, was proved to play pivotal roles in the signal transduction pathways of hypoxic disorders. Aim of the stud y: In this study, we established a rat model of isolated beating atrium and investigated the regulator role of genistein and its downstream signaling pathways in acute hypoxia-induced ANP secretion. Methods Radio-immunoassay was used to detect the ANP content in the atrial perfusates. Western blot analysis was used to determine the protein level of hypoxia-inducible factor-1α (HIF-1α), and GATA4 in the atrial tissue. Results The results showed that acute hypoxia substantially promoted ANP secretion, whereas this effect was partly attenuated by the PTKs inhibitor genistein (3 µM). By western blotting analysis, we found that hypoxia-induced the increase in phosphorylation of Akt and transcriptional factors, including HIF-1α, were also reversed by genistein. The perfused HIF-1α inhibitors rotenone (0.5 µM) or CAY10585 (10 µM) plus genistein significantly abolished the enhanced ANP section induced by hypoxia. Additionally, the perfused PI3K/Akt agonist IGF-1 (30 µM) also abolished ANP secretion induced by genistein as well as inhibited expression of HIF-1α. Conclusions In summary, our data suggested that acute hypoxia markedly increased ANP secretion by PTKs through the PI3K/HIF-1α depended pathway.

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