scholarly journals Shorter P1m Response in Children with Autism Spectrum Disorder without Intellectual Disabilities

2021 ◽  
Vol 22 (5) ◽  
pp. 2611
Author(s):  
Yuko Yoshimura ◽  
Takashi Ikeda ◽  
Chiaki Hasegawa ◽  
Kyung-Min An ◽  
Sanae Tanaka ◽  
...  

(1) Background: Atypical auditory perception has been reported in individuals with autism spectrum disorder (ASD). Altered auditory evoked brain responses are also associated with childhood ASD. They are likely to be associated with atypical brain maturation. (2) Methods: This study examined children aged 5–8 years old: 29 with ASD but no intellectual disability and 46 age-matched typically developed (TD) control participants. Using magnetoencephalography (MEG) data obtained while participants listened passively to sinusoidal pure tones, bilateral auditory cortical response (P1m) was examined. (3) Results: Significantly shorter P1m latency in the left hemisphere was found for children with ASD without intellectual disabilities than for children with TD. Significant correlation between P1m latency and language conceptual ability was found in children with ASD, but not in children with TD. (4) Conclusions: These findings demonstrated atypical brain maturation in the auditory processing area in children with ASD without intellectual disability. Findings also suggest that ASD has a common neural basis for pure-tone sound processing and language development. Development of brain networks involved in language concepts in early childhood ASD might differ from that in children with TD.

2020 ◽  
Vol 63 (5) ◽  
pp. 1608-1617
Author(s):  
Maranda K. Jones ◽  
Nina Kraus ◽  
Silvia Bonacina ◽  
Trent Nicol ◽  
Sebastian Otto-Meyer ◽  
...  

Purpose Auditory processing measures have been used in an attempt to understand the relationship between neurological mechanisms and autism spectrum disorder (ASD) symptomatology in school-age children. The focus of the current study was to understand neural auditory processing in 2- to 3-year-olds with ASD. Method Auditory processing measures (click auditory brainstem responses and speech-evoked frequency-following responses) were hypothesized to differ between typically developing children ( n = 18) and children with ASD ( n = 18). Auditory processing measures were hypothesized to relate to language development in children with ASD. Results The current study found limited differences in auditory processing measures between the two groups. No relationships were found between auditory processing measures and language development measures. Conclusions Future research is necessary to characterize auditory processing in toddlers with ASD. Longitudinal approaches should be considered when studying auditory processing in children with ASD in order to explore its developmental relationship with ASD symptomatology.


2020 ◽  
Vol 40 (4) ◽  
pp. 98-112
Author(s):  
Tatiana I. Kuzmina ◽  
Olga S. Dukhanina

Background. Distorted development as a variety of psychological dysontogenesis (autism spectrum disorder, among others) can combine elements of general underdevelopment, delayed, damaged and accelerated development of single psychic functions, which brings in considerable difficulties in organizing the study of cognitive and personal features in such children and imposes a number of restrictions on the researcher. Thus the specific kind of personal sphere organization in children with the distorted type of psychological dysontogenesis with its multiple manifestations still remains a subject not yet studied in depth. Objective. Characterizing the specific features of self-image content in primary school aged children who have autism spectrum disorder (ASD) and preserved intelligence in comparison with their coevals who develop normally. Hypotheses put forward: 1) Self-consciousness in children with ASD who have preserved intelligence reveals specific features when confronted with the self-consciousness of their peers who develop normally; 2) Qualitative specificity of self-image content in children with ASD is influenced both by the particularity of mental structure and by whether or not the manifestations of internal representations are intact. Design. The study, which is of the comparative-descriptive nature, was focused on the state of self-image components in children with autism spectrum disorder without intellectual disabilities, on the one hand, and their normally developing peers, on the other hand. The experimental group included 14 boys aged 8 to 11 who have ASD without intellectual disabilities. The control group included 14 boys aged 8 to 11. The methods applied were: conversation, observation, “Sally and Anne” false belief test (Simon Baron-Cohen, Alan M. Leslie, and Uta Frith), “Age-gender identification” method developed by N.L. Belopolskaya and modified by T.I. Kuzmina, “Drawing a human” (with subsequent interpretation according to E.V. Svistunova’s table), “Who am I?” method by Manford H. Kuhn and Thomas S. McPartland in T.V. Rumyantseva’s modified version, “Complete the sentence” method by T.I. Kuzmina (modified version of Sachs–Levi’s “Unfinished sentences” method). Results. Statistically relevant difference between the two groups, the experimental and the control one, was found in the state of the following identity components: perspective I, physical I. The relevance of the difference in the communicative I is not certain. Children with autism spectrum disorder show a variety of manifestations of distorted self-concept formation. Those children whose mental structure has not developed correctly have difficulties in the formation of the perspective I, fragmentary or absent conceptions of themselves in future; they are unable to imagine their social and age group role in the remote future, in contrast to the children with ASD who have an intact mental structure. Children with intact manifestations of internal representations show an ambivalent self-relation: their reflexive I embraces both positive and negative esteems connected to the attempts at assessing their estrangement and differences from the others, especially if their parents are reluctant to reveal their diagnosis and give the reasons for their children’s problems. Conclusions. The results obtained within the present study allow to take a broader view of autism as a distorted variant of psychological dysontogenesis. They also show the necessity of further variative studies that could assess the specific character of such children’s personality structure with respect to gender specificity, as well as the necessity to establish the basis for differentiated organization of person-oriented interaction with the children in question within psycho-correctional, pedagogical and educative contexts.


Author(s):  
Erin C. Schafer ◽  
Lauren Mathews ◽  
Kamakshi Gopal ◽  
Emilee Canale ◽  
Avery Creech ◽  
...  

Abstract Background Auditory-processing deficits are common in children and adults who are diagnosed with autism spectrum disorder (ASD). These deficits are evident across multiple domains as exhibited by the results from subjective questionnaires from parents, teachers, and individuals with ASD and from behavioral auditory-processing testing. Purpose Few studies compare subjective and behavioral performance of adults and children diagnosed with ASD using commercially available tests of auditory processing. The primary goal of the present study is to compare the performance of adults and children with ASD to age-matched, neurotypical peers. The secondary goal is to examine the effect of age on auditory-processing performance in individuals with ASD relative to age-matched peers. Research Design A four-group, quasi-experimental design with repeated measures was used in this study. Study Sample Forty-two adults and children were separated into four groups of participants: (1) 10 children with ASD ages 14 years or younger; (2) 10 age-matched, neurotypical children; (3) 11 adolescents and young adults with ASD ages 16 years and older; and (4) 11 age-matched, neurotypical adolescents or young adults. Data Collection and Analysis Data from each participant were collected in one test session. Data were analyzed with analysis of variance (ANOVA), repeated measures ANOVA, or nonparametric analyses. Effect sizes were calculated to compare performance between those with ASD and those who were neurotypical within each age group. Results Across all the questionnaires and the majority of the behavioral test measures, participants with ASD had significantly poorer ratings or auditory-processing performance than age-matched, neurotypical peers. Adults had more favorable performance than children on several of the test measures. Medium to large effect sizes corroborated the significant results. Conclusion Overall, the questionnaires and behavioral tests used in this study were sensitive to detecting auditory-processing differences between individuals diagnosed with ASD and those who are considered neurotypical. On most test measures, children performed more poorly than adults. The findings in this study support that both children and adults with ASD exhibit auditory-processing difficulties. Appropriate school and work accommodations will be necessary to ensure appropriate access to speech in challenging environments.


2021 ◽  
Author(s):  
Antonia M. H. Piergies ◽  
Tomoya Hirota ◽  
Rei Monden ◽  
Shuting Zheng

Background: Symptom heterogeneity within autism spectrum disorder (ASD) is compounded by co-occurring psychopathology. Considering that some psychiatric disorders present together more often than others, deriving subgroups of individuals with ASD based on co-occurring psychopathology could better our understanding of symptom patterns existing within this population. This study's purpose was to derive subgroups of school-aged children with ASD based on co-occurring psychopathology while controlling for age and sex and to examine correlates of subgroup membership. Method: Six latent class models were estimated with a sample from the Simons Simplex Collection (n = 2,092), using dichotomized categories (borderline/clinical versus normal range) from five of the DSM-Oriented Scales of the Child Behavior Checklist for Ages 6 to 18 as indicator variables. We evaluated the predictive value of intellectual disability and three groups of medical conditions (allergies/autoimmune disorders, gastrointestinal disorders, and neurological disorders) on subgroup membership using multinomial logistic regression. Results: Four subgroups emerged based on the combined presence/absence of psychiatric symptoms: "Low Psychopathology," "Externalizing Problems," "Internalizing Problems," and "High Psychopathology." Gastrointestinal disorders, the strongest predictor, was associated with increased odds of belonging to the "Externalizing Problems," "Internalizing Problems," and "High Psychopathology" subgroups over the "Low Psychopathology" subgroup, whereas intellectual disability was associated with decreased odds. Neurological disorders was also associated with increased odds of belonging to the "Internalizing Problems" and "High Psychopathology" subgroups. Conclusion: Patterns of psychopathology exist within school-aged children with ASD and are correlated with intellectual disability as well as specific medical conditions, providing guidance for clinical practice and etiology-driven research.


2021 ◽  
Vol 15 ◽  
Author(s):  
Girija Kadlaskar ◽  
Sophia Bergmann ◽  
Rebecca McNally Keehn ◽  
Amanda Seidl ◽  
Brandon Keehn

Behavioral differences in responding to tactile and auditory stimuli are widely reported in individuals with autism spectrum disorder (ASD). However, the neural mechanisms underlying distinct tactile and auditory reactivity patterns in ASD remain unclear with theories implicating differences in both perceptual and attentional processes. The current study sought to investigate (1) the neural indices of early perceptual and later attentional factors underlying tactile and auditory processing in children with and without ASD, and (2) the relationship between neural indices of tactile and auditory processing and ASD symptomatology. Participants included 14, 6–12-year-olds with ASD and 14 age- and non-verbal IQ matched typically developing (TD) children. Children participated in an event-related potential (ERP) oddball paradigm during which they watched a silent video while being presented with tactile and auditory stimuli (i.e., 80% standard speech sound/a/; 10% oddball speech sound/i/; 10% novel vibrotactile stimuli on the fingertip with standard speech sound/a/). Children’s early and later ERP responses to tactile (P1 and N2) and auditory stimuli (P1, P3a, and P3b) were examined. Non-parametric analyses showed that children with ASD displayed differences in early perceptual processing of auditory (i.e., lower amplitudes at central region of interest), but not tactile, stimuli. Analysis of later attentional components did not show differences in response to tactile and auditory stimuli in the ASD and TD groups. Together, these results suggest that differences in auditory responsivity patterns could be related to perceptual factors in children with ASD. However, despite differences in caregiver-reported sensory measures, children with ASD did not differ in their neural reactivity to infrequent touch-speech stimuli compared to TD children. Nevertheless, correlational analyses confirmed that inter-individual differences in neural responsivity to tactile and auditory stimuli were related to social skills in all children. Finally, we discuss how the paradigm and stimulus type used in the current study may have impacted our results. These findings have implications for everyday life, where individual differences in responding to tactile and auditory stimuli may impact social functioning.


Educatia 21 ◽  
2021 ◽  
Vol 20 ◽  
pp. 47-55
Author(s):  
Jucan Silvia Alexandrina ◽  
Stan Cristian ◽  
Cornelia Stan

The schooling of children with autism spectrum disorder (ASD) and severe intellectual disability (ID) in special schools, requires personalized professional intervention. Sensory, motor and psychomotor education of the disabled child is an important part of integration in all aspects: educationally, professionally, socially. Activities aimed for the development of the psychomotricity in children with ASD and severe ID are carried out in accordance with the requirements of the national curriculum for special-needs education. The multisensory room is a complex of multifaceted instrument. Our study aims to establish the level of efficacy of an intervention program comprising of activities for the development of psychomotricity carried out in the multisensory room, individualized for children with ASD and severe ID. Keywords: Autism Spectrum Disorder; Psychomotricity; Intellectual Disability; Special-Needs Education; Intervention Plan.


2020 ◽  
Vol 10 (11) ◽  
pp. 880
Author(s):  
Karthikeyan Krishnamurthy ◽  
Michael K. Yeung ◽  
Agnes S. Chan ◽  
Yvonne M. Y. Han

Effortful control (EC) is an important dimension of temperament, but is impaired in autism spectrum disorder (ASD). While EC is associated with the prefrontal cortex (PFC) functioning in typically developing (TD) children, it is unclear whether EC deficits are associated with PFC dysfunction in ASD. This study examines the relationship between EC and PFC activation and connectivity in children with high-functioning ASD. Thirty-nine right-handed children (ASD: n = 20; TD: n = 19) aged 8–12 years were recruited. The EC level was assessed with the Early Adolescent Temperament Questionnaire—Revised (EATQ-R), and PFC functioning, in terms of activation and connectivity during a frontal-sensitive (n-back) task, was assessed using functional near-infrared spectroscopy (fNIRS). Children with ASD showed a significant deficit in EC and its related constructs (i.e., executive, and socioemotional functions) compared to TD controls. They also showed significantly increased overall PFC activation and reduced right frontal connectivity during the n-back task. Among children with ASD, the EC level correlated significantly with neither PFC activation nor connectivity; it significantly correlated with social functioning only. This study demonstrated EC deficits and altered PFC functioning in children with ASD, but the exact neural basis of EC deficits remains to be determined.


Author(s):  
Nicole Papadopoulos ◽  
Chloe Emonson ◽  
Christina Martin ◽  
Emma Sciberras ◽  
Harriet Hiscock ◽  
...  

Sleep problems are common in children with autism spectrum disorder (ASD). However, few studies have undertaken group comparisons of sleep profiles and factors associated with poorer sleep between children with ASD without intellectual disability (ID; hereafter referred to as ASD) and ASD with co-occurring ID (hereafter referred to as ASD + ID). This study aimed to (1) compare child (sleep problems and emotional and behavioural problems (EBPs)) and parent factors (parenting stress and mental health) for children with ASD compared to children with ASD + ID, and (2) examine the associations between sleep problems and child and parent factors in both groups. Parents of 56 children with ASD (22 ASD, 34 ASD + ID) aged 6–13 years took part in the study. No statistically significant differences in sleep problems were found between children with ASD compared to children with ASD + ID. However, total EBPs were independently associated with child sleep problems in both groups. Further, ‘Self-Absorbed’ and ‘Communication Disturbance’ EBPs were significantly greater in the ASD + ID compared to the ASD group. Overall treatment outcomes for children with ASD may be further improved if consideration is given to the specific types of EBPs being experienced by the child and their association with sleep problems.


2020 ◽  
Vol 29 (1) ◽  
pp. 327-334 ◽  
Author(s):  
Allison Gladfelter ◽  
Cassidy VanZuiden

Purpose Although repetitive speech is a hallmark characteristic of autism spectrum disorder (ASD), the contributing factors that influence repetitive speech use remain unknown. The purpose of this exploratory study was to determine if the language context impacts the amount and type of repetitive speech produced by children with ASD. Method As part of a broader word-learning study, 11 school-age children with ASD participated in two different language contexts: storytelling and play. Previously collected language samples were transcribed and coded for four types of repetitive speech: immediate echolalia, delayed echolalia, verbal stereotypy, and vocal stereotypy. The rates and proportions of repetitive speech were compared across the two language contexts using Wilcoxon signed-ranks tests. Individual characteristics were further explored using Spearman correlations. Results The children produced lower rates of repetitive speech during the storytelling context than the play-based context. Only immediate echolalia differed between the two contexts based on rate and approached significance based on proportion, with more immediate echolalia produced in the play-based context than in the storytelling context. There were no significant correlations between repetitive speech and measures of social responsiveness, expressive or receptive vocabulary, or nonverbal intelligence. Conclusions The children with ASD produced less immediate echolalia in the storytelling context than in the play-based context. Immediate echolalia use was not related to social skills, vocabulary, or nonverbal IQ scores. These findings offer valuable insights into better understanding repetitive speech use in children with ASD.


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