scholarly journals β-Hydroxy-β-Methylbutyrate (HMB) Supplementation Prevents Bone Loss during Pregnancy—Novel Evidence from a Spiny Mouse (Acomys cahirinus) Model

2021 ◽  
Vol 22 (6) ◽  
pp. 3047
Author(s):  
Ewa Tomaszewska ◽  
Janine Donaldson ◽  
Jakub Kosiński ◽  
Piotr Dobrowolski ◽  
Agnieszka Tomczyk-Warunek ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Bone Loss ◽  
Young Modulus ◽  
Compact Bone ◽  
Second Trimester ◽  
Mineral Density ◽  
Tissue Quality ◽  
Cross Sectional ◽  
Acomys Cahirinus ◽  
Trabecular Number

The aim of this study was to determine the effects of ß-hydroxy-ß-methylbutyrate (HMB) supplementation during pregnancy on postpartum bone tissue quality by assessing changes in trabecular and compact bone as well as in hyaline and epiphyseal cartilage. The experiment was carried out on adult 6-month-old female spiny mice (Acomys cahirinus) divided into three groups: pregnant control (PregCont), pregnant HMB-treated (supplemented with 0.02 g/kg b.w of HMB during the second trimester of pregnancy, PregHMB), and non-pregnant females (NonPreg). Cross-sectional area and cortical index of the femoral mid-shaft, stiffness, and Young modulus were significantly greater in the PregHMB group. Whole-bone mineral density was similar in all groups, and HMB supplementation increased trabecular number. Growth plate cartilage was the thinnest, while the articular cartilage was the thickest in the PregHMB group. HMB supplementation increased the content of proteoglycans in the articular cartilage and the percentage of immature collagen content in metaphyseal trabeculae and compact bone. In summary, dietary HMB supplementation during the second trimester of pregnancy intensifies bone metabolic processes and prevents bone loss during pregnancy.

scholarly journals The role of Tai Chi Chuan exercise on osteoporosis prevention and treatment in postmenopausal women

2011 ◽  
Vol 1 (1) ◽  
pp. 10
Author(s):  
Haiyan Chen
Keyword(s):  
Bone Loss ◽  
Postmenopausal Women ◽  
Tai Chi ◽  
Weight Bearing ◽  
Depression And Anxiety ◽  
Osteoporosis Prevention ◽  
Mineral Density ◽  
Cross Sectional ◽  
Tai Chi Chuan

Osteoporosis is a disease characterized by fragile bones and high susceptibility to low trauma fractures. Tai Chi, an ancient Chinese mind-body exercise that is reported to enhance muscle function, balance and flexibility, and to reduce pain, depression and anxiety, may safely and effectively be used to prevent or treat osteoporosis. The aim of this review is to evaluate the evidence for Tai Chi as an intervention to reduce rate of bone loss in postmenopausal women. A literature search on randomized controlled trials (RCTs), prospective cohort studies, and cross-sectional studies that included Tai Chi as an intervention, and had at least 1 outcome related to measurement of bone metabolism were identified in PubMed/Medline. Twenty-one controlled studies were identified in the database, which suggested Tai Chi slowed down the loss of bone mineral density in most postmenopausal women, improved balance and strength, relieves pain from arthritis, and improved mental strength so they can cope better with chronic diseases. Regular Tai Chi Chuan exercise is beneficial for retarding bone loss in the weight-bearing bones of postmenopausal women.

scholarly journals Bone Metabolism in Adolescents Undergoing Bariatric Surgery

2020 ◽  
Author(s):  
Madhusmita Misra ◽  
Miriam A Bredella
Keyword(s):  
Bariatric Surgery ◽  
Sleeve Gastrectomy ◽  
Lumbar Spine ◽  
Bone Loss ◽  
Bone Microarchitecture ◽  
Quantitative Computed Tomography ◽  
Areal Bone Mineral Density ◽  
Mineral Density ◽  
Cross Sectional ◽  
Peripheral Skeleton

Abstract Purpose The prevalence of childhood obesity has increased over past decades with a concomitant increase in metabolic and bariatric surgery (MBS). While MBS in adults is associated with bone loss, only a few studies have examined the effect of MBS on the growing skeleton in adolescents. Methods This mini-review summarizes available data on the effects of the most commonly performed MBS (sleeve gastrectomy and gastric bypass) on bone in adolescents. A literature review was performed using PubMed for English-language articles. Results Dual-energy x-ray absorptiometry (DXA) measures of areal bone mineral density (aBMD) and BMD Z scores decreased following all MBS. Volumetric BMD (vBMD) by quantitative computed tomography (QCT) decreased at the lumbar spine while cortical vBMD of the distal radius and tibia increased over a year following sleeve gastrectomy (total vBMD did not change). Reductions in narrow neck and intertrochanteric cross-sectional area and cortical thickness were observed over this duration, and hip strength estimates were deleteriously impacted. Marrow adipose tissue (MAT) of the lumbar spine increased while MAT of the peripheral skeleton decreased a year following sleeve gastrectomy. The amount of weight loss and reductions in lean and fat mass correlated with bone loss at all sites, and with changes in bone microarchitecture at peripheral sites. Conclusion MBS in adolescents is associated with aBMD reductions, and increases in MAT of the axial skeleton, while sleeve gastrectomy is associated with an increase in cortical vBMD and decrease in MAT of the peripheral skeleton. No reductions have been reported in peripheral strength estimates.

scholarly journals Association of total protein intake with bone mineral density and bone loss in men and women from the Framingham Offspring Study

2013 ◽  
Vol 17 (11) ◽  
pp. 2570-2576 ◽  
Author(s):  
Shivani Sahni ◽  
Kerry E Broe ◽  
Katherine L Tucker ◽  
Robert R McLean ◽  
Douglas P Kiel ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Loss ◽  
Bone Mineral ◽  
Protein Intake ◽  
Mineral Density ◽  
Cross Sectional ◽  
Total Protein Intake ◽  
Multivariable Regression ◽  
The Impact

AbstractObjectiveTo examine (i) the association of percentage of total energy intake from protein (protein intake %) with bone mineral density (BMD, g/cm2) and bone loss at the femoral neck, trochanter and lumbar spine (L2–L4) and (ii) Ca as an effect modifier.SettingThe Framingham Offspring Study.SubjectsMen (n 1280) and women (n 1639) completed an FFQ in 1992–1995 or 1995–1998 and underwent baseline BMD measurement by dual-energy X-ray absorptiometry in 1996–2000. Men (n 495) and women (n 680) had follow-up BMD measured in 2002–2005.DesignCohort study using multivariable regression to examine the association of protein intake % with each BMD, adjusting for covariates. Statistical interaction between protein intake % and Ca (total, dietary, supplemental) intake was examined.ResultsThe mean age at baseline was 61 (sd 9) years. In the cross-sectional analyses, protein intake % was positively associated with all BMD sites (P range: 0·02–0·04) in women but not in men. Significant interactions were observed with total Ca intake (<800 mg/d v. ≥800 mg/d) in women at all bone sites (P range: 0·002–0·02). Upon stratification, protein intake % was positively associated with all BMD sites (P range: 0·04–0·10) in women with low Ca intakes but not in those with high Ca intakes. In the longitudinal analyses, in men, higher protein intake % was associated with more bone loss at the trochanter (P = 0·01) while no associations were seen in women, regardless of Ca intake.ConclusionsThis suggests that greater protein intake benefits women especially those with lower Ca intakes. However, protein effects are not significant for short-term changes in bone density. Contrastingly, in men, higher protein intakes lead to greater bone loss at the trochanter. Longer follow-up is required to examine the impact of protein on bone loss.

scholarly journals Experimental study exploring the factors that promote rib fragility in the elderly

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Christian Liebsch ◽  
Shamila Hübner ◽  
Marco Palanca ◽  
Luca Cristofolini ◽  
Hans-Joachim Wilke
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Cortical Thickness ◽  
Volume Ratio ◽  
The Elderly ◽  
Fracture Load ◽  
Surface Strain ◽  
Mineral Density ◽  
Cross Sectional ◽  
Trabecular Number

AbstractRib fractures represent a common injury type due to blunt chest trauma, affecting hospital stay and mortality especially in elderly patients. Factors promoting rib fragility, however, are little investigated. The purpose of this in vitro study was to explore potential determinants of human rib fragility in the elderly. 89 ribs from 13 human donors (55–99 years) were loaded in antero-posterior compression until fracture using a material testing machine, while surface strains were captured using a digital image correlation system. The effects of age, sex, bone mineral density, rib level and side, four global morphological factors (e.g. rib length), and seven rib cross-sectional morphological factors (e.g. cortical thickness, determined by μCT), on fracture load were statistically examined using Pearson correlation coefficients, Mann–Whitney U test as well as Kruskal–Wallis test with Dunn-Bonferroni post hoc correction. Fracture load showed significant dependencies (p < 0.05) from bone mineral density, age, antero-posterior rib length, cortical thickness, bone volume/tissue volume ratio, trabecular number, trabecular separation, and both cross-sectional area moments of inertia and was significantly higher at rib levels 7 and 8 compared to level 4 (p = 0.001/0.013), whereas side had no significant effect (p = 0.989). Cortical thickness exhibited the highest correlation with fracture load (r = 0.722), followed by the high correlation of fracture load with the area moment of inertia around the longitudinal rib cross-sectional axis (r = 0.687). High correlations with maximum external rib surface strain were detected for bone volume/tissue volume ratio (r = 0.631) and trabecular number (r = 0.648), which both also showed high correlations with the minimum internal rib surface strain (r =  − 0.644/ − 0.559). Together with rib level, the determinants cortical thickness, area moment of inertia around the longitudinal rib cross-sectional axis, as well as bone mineral density exhibited the largest effects on human rib fragility with regard to the fracture load. Sex, rib cage side, and global morphology, in contrast, did not affect rib fragility in this study. When checking elderly patients for rib fractures due to blunt chest trauma, patients with low bone mineral density and the mid-thoracic area should be carefully examined.

scholarly journals Local and generalized bone loss in rheumatoid arthritis

2021 ◽  
Vol 15 (5) ◽  
pp. 103-107
Author(s):  
P. S. Kovalenko ◽  
N. I. Kolganova ◽  
I. S. Dydykina ◽  
P. O. Kozhevnikova ◽  
M. Yu. Blank
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Loss ◽  
Treatment Strategies ◽  
Underlying Disease ◽  
Mineral Density ◽  
Biologic Dmards ◽  
Cross Sectional ◽  
Local Bone ◽  
Immune Mediated ◽  
Antiresorptive Drugs

The article presents a review of cross-sectional studies and long-term prospective observations dedicated to changes in bone mineral density (BMD) in patients with rheumatoid arthritis (RA) and factors influencing it. The relationship between local bone loss (erosion count) and generalized BMD loss was noted. It is indicated that existing RA treatment strategies are aimed at suppressing inflammation rather than preventing bone resorption. There is evidence that anti-inflammatory therapy using glucocorticoids, methotrexate, and biologic DMARDs in combination with antiresorptive drugs (bisphosphonates and denosumab) helps prevent BMD loss and the progression of erosions. It is emphasized that osteoporosis in RA, which belongs to the immune-mediated secondary osteopathies, is one of the most frequent and serious complications of RA, which determine the unfavorable course and prognosis of the underlying disease.

RELATIONSHIP BETWEEN SERUM OC AND SCTX WITH BONE MINERAL DENSITY IN PREDICTING BONE LOSS AND TREATING FOR POSTMENOPAUSAL OSTEOPOROSIS WOMEN OVER 45 YEARS OLD WITH FOSAMAX PLUS THERAPY

2017 ◽  
pp. 126-231
Author(s):  
Van Duc Tran ◽  
Van An Le ◽  
Hai Thuy Nguyen
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Bone Loss ◽  
Prospective Study ◽  
Key Words ◽  
Postmenopausal Osteoporosis ◽  
Negative Correlation ◽  
Mineral Density ◽  
Cross Sectional ◽  
Femur Neck

Backgrounds: Serum OC and ssCTX are correlated with BMD and have early changes under antiresorptive therapies. This study was aimed to find correlations between serum OC, sCTX and BMD changes in women over 45 and evaluated early changes of the two markers in postmenopausal osteoporotic women with Fosamax plus therapy. Materials and Methods: Cross-sectional and prospective study. 142 women over 45 were tested for serum OC and sCTX and determined BMD at lumbar spine and femur neck. 37 postmenopausal osteoporotic women of the group were treated with Fosamax plus therapy. Results: OC and sCTX showed negative correlation with BMD of lumbar spine and femur neck in all of women over 45. The correlation between sCTX and BMD of femur neck was not significant. The lowest values of OC and sCTX to predict bone loss in non-osteoporotic women were 14.46ng/ml (ss = 76.1%, sp = 40%) and 396.25pg/ml (ss = 66%, sp = 52%). The decreasing rates of serum OC and sCTX after 3 and 6 months with Fosamax plus therapy were 41.6%, 55% (p ˂ 0.0001) and 78.3%, 72% (p ˂ 0.0001), respectively. Slow increasing rates of BMD at two sites were 4.2% (p ˂ 0.001) and 3.6% (p ˃ 0.05), irrespectively. Conclusions: OC and sCTX were inversely correlated to BMD of lumbar spine and femur neck in all of women over 45. The lowest values of OC and sCTX to predict bone loss in non-osteoporotic women were 14.46ng/ml and 396.25pg/ml. Serum OC và sCTX decreased early in comparision to BMD improvement in postmenopausal osteoporotic women with Fosamax plus therapy. Key words: oC, sCTX, postmenopausal osteoporotic women, Fosamax plus

scholarly journals Bone Mineral Density in Stroke Survivors: An Observational Study

2021 ◽  
Author(s):  
Sujatha Gorle ◽  
BD Athani ◽  
Sakshi Jain ◽  
Shweta Jain
Keyword(s):  
Bone Mineral Density ◽  
Bone Loss ◽  
Bone Mineral ◽  
Age Groups ◽  
Stroke Survivors ◽  
X Rays ◽  
Mineral Density ◽  
Cross Sectional ◽  
Equal Distribution ◽  
Paretic Side

Introduction: Stroke is frequently followed by bone loss, causing increased fracture risk in patients. Bone loss starts within days of vascular brain injury, progresses till fourth month and then lowers until the end of first year after stroke. Aim: To assess the Bone Mineral Density (BMD) in hip, spine and wrist and its difference between paretic and nonparetic side in ambulatory stroke survivors. Materials and Methods: This hospital-based observational cross-sectional study was conducted on 40 subjects, from January 2015 to June 2016 in the Department of Physical Medicine and Rehabilitation, VMMC and Safdarjung Hospital, New Delhi. Biochemical markers, x-rays and BMD were recorded in all patients along with demographic profile in a pre-structured proforma after taking informed consent. Statistical analysis was done using SPSS Software version 14.0. Results: Out of 40 subjects (mean age: 53.9±10.9 years), 82.5% were males with nearly equal distribution in 41-50, 51-60 and 61-70 years age groups. Around 65% stroke survivors presented within 1-3 years of stroke with 68% having right sided involvement. Bone mineral densities over hip with a mean of -2.14±1.57 and lower end of radius with a mean of -4.85±2.01 were less on paretic side as compared to the nonparetic side. DEXA scanning of spine showed 52.5% subjects were osteopenic and 37.5% were osteoporotic. Conclusion: BMD over hip and lower end of radius was less on paretic side as compared to the nonparetic side but it was insignificant statistically.

scholarly journals Risk Factors of Bone Loss in Spondyloarthritis

2020 ◽  
Author(s):  
Wafa Hamdi ◽  
Meriem Sellami ◽  
Abir Kasraoui ◽  
Kaouther Maatallah ◽  
Hanene Ferjani ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Bone Loss ◽  
Bone Mineral ◽  
Structural Damage ◽  
Joint Involvement ◽  
Mineral Density ◽  
Cross Sectional ◽  
Bone Mineral Status ◽  
The Impact

We aimed to determine the bone mineral status in patients with spondyloarthritis (SA), and to assess the impact of parameters associated with bone loss on bone mineral density (BMD). Seventy-five patients (62 men) with SA fulfilling the modified New York criteria were included in a cross-sectional study during one year. BMD was assessed in all patients using dual-energy X-ray absorptiometry. The patient’s average age was 36.8 years. Sixty-five patients (86.6%) had bone loss. The lumbar spine was the site most affected by osteoporosis (37%). Bone loss was significantly associated with low BMI, peripheral joint involvement, active disease (high ASDASESR and BASDAI), vitamin D insufficiency, elevated erythrocyte sedimentation rate (ESR) and c-reactive protein, as well as high BASRI, high BASMI, and with the use of csDMARDs or anti-TNF alpha therapy. The disease activity, biologic inflammation, low vitamin D level, peripheral joint involvement, and structural damage were the major factors that induce bone loss in SA patients. Multivariate analysis showed that only high ESR level (AOR 19.9, 95% CI) and peripheral arthritis (AOR 14.5, 95% IC) were independent risk factors of bone loss. Our study shows that bone loss was a multifactorial complication of SA.

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