scholarly journals Role of Hydrogen Sulfide, Substance P and Adhesion Molecules in Acute Pancreatitis

2021 ◽  
Vol 22 (22) ◽  
pp. 12136
Author(s):  
Ayush Kumar ◽  
Madhav Bhatia
Keyword(s):  
Acute Pancreatitis ◽  
Hydrogen Sulfide ◽  
Substance P ◽  
Adhesion Molecules ◽  
Inflammatory Disease ◽  
Cell Adhesion Molecules ◽  
Tissue Injury ◽  
Gastrointestinal Disorders ◽  
Natural Response

Inflammation is a natural response to tissue injury. Uncontrolled inflammatory response leads to inflammatory disease. Acute pancreatitis is one of the main reasons for hospitalization amongst gastrointestinal disorders worldwide. It has been demonstrated that endogenous hydrogen sulfide (H2S), a gasotransmitter and substance P, a neuropeptide, are involved in the inflammatory process in acute pancreatitis. Cell adhesion molecules (CAM) are key players in inflammatory disease. Immunoglobulin (Ig) gene superfamily, selectins, and integrins are involved at different steps of leukocyte migration from blood to the site of injury. When the endothelial cells get activated, the CAMs are upregulated which leads to them interacting with leukocytes. This review summarizes our current understanding of the roles H2S, substance P and adhesion molecules play in acute pancreatitis.

P.1.a.012 New insights from cell adhesion molecules in antidepressant action: role of ITGB3 and GAP43 genes

2014 ◽  
Vol 24 ◽  
pp. S160
Author(s):  
C. Fabbri ◽  
C. Crisafulli ◽  
D. Gurwitz ◽  
J. Stingl ◽  
R. Calati ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Cell Adhesion Molecules ◽  
Antidepressant Action

The functional role of cell adhesion molecules in tumor angiogenesis

2009 ◽  
Vol 19 (5) ◽  
pp. 298-309 ◽  
Author(s):  
Chiara Francavilla ◽  
Luigi Maddaluno ◽  
Ugo Cavallaro
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Tumor Angiogenesis ◽  
Cell Adhesion Molecules ◽  
Functional Role

The role of cell adhesion molecules in the pathogenesis of preeclampsia

2021 ◽  
Vol 6_2021 ◽  
pp. 22-28
Author(s):  
Shelekhin A.P. Shelekhin ◽  
Baev O.R. Baev ◽  
Krasnyi A.M. Krasnyi ◽  
◽  
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Cell Adhesion Molecules

scholarly journals The Many Roles of Cell Adhesion Molecules in Hepatic Fibrosis

Cells ◽  
2019 ◽  
Vol 8 (12) ◽  
pp. 1503 ◽  
Author(s):  
Hintermann ◽  
Christen
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Hepatic Fibrosis ◽  
Cell Adhesion Molecules ◽  
Tissue Injury ◽  
Immunoglobulin Superfamily ◽  
Cell Contact ◽  
Matrix Remodeling ◽  
Direct Cell ◽  
The Many

Fibrogenesis is a progressive scarring event resulting from disrupted regular wound healing due to repeated tissue injury and can end in organ failure, like in liver cirrhosis. The protagonists in this process, either liver-resident cells or patrolling leukocytes attracted to the site of tissue damage, interact with each other by soluble factors but also by direct cell–cell contact mediated by cell adhesion molecules. Since cell adhesion molecules also support binding to the extracellular matrix, they represent excellent biosensors, which allow cells to modulate their behavior based on changes in the surrounding microenvironment. In this review, we focus on selectins, cadherins, integrins and members of the immunoglobulin superfamily of adhesion molecules as well as some non-classical cell adhesion molecules in the context of hepatic fibrosis. We describe their liver-specific contributions to leukocyte recruitment, cell differentiation and survival, matrix remodeling or angiogenesis and touch on their suitability as targets in antifibrotic therapies.

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