scholarly journals Clinical and Cytokine Profile in Patients with Early and Late Onset Meniere Disease

2021 ◽  
Vol 10 (18) ◽  
pp. 4052
Author(s):  
Maria-Del-Carmen Moleon ◽  
Estrella Martinez-Gomez ◽  
Marisa Flook ◽  
Andreina Peralta-Leal ◽  
Juan Antonio Gallego ◽  
...  
Keyword(s):  
Autoimmune Diseases ◽  
Early Onset ◽  
Age Of Onset ◽  
Late Onset ◽  
Cross Sectional Study ◽  
Cytokine Profile ◽  
Sectional Study ◽  
Meniere Disease ◽  
Cross Sectional ◽  
Menière Disease

Background: Meniere disease (MD) is an inner ear disorder associated with comorbidities such as autoimmune diseases or migraine. This study describes clinical and cytokine profiles in MD according to the age of onset of the condition. Methods: A cross-sectional study including 83 MD patients: 44 with early-onset MD (EOMD, <35 years old), and 39 with late-onset MD (LOMD, >50 years old), 64 patients with migraine and 55 controls was carried out. Clinical variables and cytokines levels of CCL3, CCL4, CCL18, CCL22, CXCL,1 and IL-1β were compared among the different groups. Results: CCL18 levels were higher in patients with migraine or MD than in controls. Elevated levels of IL-1β were observed in 11.4% EOMD and in 10.3% LOMD patients and these levels were not dependent on the age of individuals. EOMD had a longer duration of the disease (p = 0.004) and a higher prevalence of migraine than LOMD (p = 0.045). Conclusions: Patients with EOMD have a higher prevalence of migraine than LOMD, but migraine is not associated with any cytokine profile in patients with MD. The levels of CCL18, CCL3, and CXCL4 were different between patients with MD or migraine and controls.

scholarly journals Clinical and Cytokine Profile in Patients with Early and Late Onset Meniere Disease

2021 ◽  
Author(s):  
Maria del Carmen Moleon ◽  
Estrella Martinez-Gomez ◽  
Marisa Flook ◽  
Andreina Peralta-Leal ◽  
Juan Antonio Gallego ◽  
...  
Keyword(s):  
Autoimmune Diseases ◽  
Early Onset ◽  
Age Of Onset ◽  
Late Onset ◽  
Cross Sectional Study ◽  
Cytokine Profile ◽  
Sectional Study ◽  
Meniere Disease ◽  
Cross Sectional ◽  
Menière Disease

Background: Meniere disease (MD) is an inner ear disorder associated with comorbidities such as autoimmune diseases or migraine. This study describes clinical and cytokine profile in MD according to the age of onset of the condition. Methods: A cross-sectional study including 83 MD patients: 44 with early onset MD (EOMD, &lt;35 years old), and 39 with late onset MD (LOMD, &gt; 50 years old), 64 patients with migraine and 55 controls was carried out. Clinical variables and cytokines levels of CCL3, CCL4, CCL18, CCL22, CXCL1 and IL-1&beta; were compared among the different groups. Results: CCL18 levels were higher in patients with migraine or MD than in controls. Elevated levels of IL-1&beta; were observed in 11.4% EOMD and in 10.3% LOMD patients and these levels were not dependent on the age of individuals. EOMD had a longer duration of the disease (p=0.004) and a higher prevalence of migraine than LOMD (p=0.045). Conclusions: Patients with EOMD have a higher prevalence of migraine than LOMD, but migraine is not associated with any cytokine profile in patients with MD. The levels of CCL18, CCL3 and CXCL4 were different between patients with MD or migraine and controls.

Extended phenotype and clinical subgroups in unilateral Meniere disease: A cross-sectional study with cluster analysis

2017 ◽  
Vol 42 (6) ◽  
pp. 1172-1180 ◽  
Author(s):  
L. Frejo ◽  
E. Martin-Sanz ◽  
R. Teggi ◽  
G. Trinidad ◽  
A. Soto-Varela ◽  
...  
Keyword(s):  
Cluster Analysis ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Extended Phenotype ◽  
Meniere Disease ◽  
Cross Sectional ◽  
Menière Disease

scholarly journals Prevalence, clinical profile, and severity of nail involvement in psoriasis – A hospital-based cross-sectional study from a tertiary care center in North Kerala

2019 ◽  
Vol 1 ◽  
pp. 72-76
Author(s):  
Vivek Prabhakar ◽  
Bifi Joy ◽  
Anoop Thyvalappil ◽  
Rajiv Sridharan ◽  
Ajayakumar Sreenivasan ◽  
...  
Keyword(s):  
Age Of Onset ◽  
Late Onset ◽  
Tertiary Care ◽  
Severity Index ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Nail Psoriasis ◽  
Nail Changes ◽  
Nail Involvement

Objectives: Nail changes are present in 25–50% of psoriatic cases. Nail Psoriasis Severity Index (NAPSI) assess the extent of the involvement of the psoriatic nail unit. This study was conducted with the aim of finding the prevalence, clinical characteristics and severity of nail psoriasis. Methods and Materials: In this cross-sectional study, a thorough clinical examination was done to determine the type and extent of skin disease including PASI (psoriasis area severity index) score, and all the fingernails and toenails were examined in a well-lit environment, under a magnifying lens to visualize the nail findings, and NAPSI score was calculated for each patient. Statistical Package for the Social Sciences (SPSS v. 11.0) software was used to analyze the data collected. Results: Of the100 patients studied, 73% of patients with psoriasis had nail involvement. Mean total NAPSI was 30.97 ± 30.79. Mean age of onset of psoriasis was 43.62 ± 15.31 and 33.04 ± 12.80 in those with and without nail involvement respectively (P-value 0.002). The majority without nail involvement (77.8%) belonged to the early- onset group, while 22.2% of those without nail involvement had late-onset psoriasis (P-value 0.001). The most common nail pattern in our study was Pitting (93.2%). Limitation: Nail changes in severe forms of disease could not be studied since patients receiving systemic drugs for the disease were excluded from the study. Conclusion: The mean duration of psoriasis in those with nail involvement in our study was 5 years more than in those without nail disease. Our study demonstrated a significant association between higher PASI scores and nail involvement. All patients with severe psoriasis (PASI >20) in our study had nail involvement.

scholarly journals Intra‐individual cytokine profile in peri‐implantitis and periodontitis: a cross‐sectional study

2021 ◽  
Author(s):  
Leif Jansson ◽  
Anna Lundmark ◽  
Carolina Modin ◽  
Denise Abadji ◽  
Tülay Yucel‐Lindberg
Keyword(s):  
Cross Sectional Study ◽  
Cytokine Profile ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Relationship Pattern of Personality Disorder Traits in Major Psychiatric Disorders: A Cross-Sectional Study

2021 ◽  
pp. 025371762199953
Author(s):  
Bhavneesh Saini ◽  
Pir Dutt Bansal ◽  
Mamta Bahetra ◽  
Arvind Sharma ◽  
Priyanka Bansal ◽  
...  
Keyword(s):  
Personality Disorder ◽  
Psychiatric Disorders ◽  
Psychotic Disorders ◽  
Age Of Onset ◽  
Psychiatric Patients ◽  
Cross Sectional Study ◽  
Psychotic Symptoms ◽  
Sectional Study ◽  
Cross Sectional ◽  
Neurotic Disorders

Background: Normal personality development, gone awry due to genetic or environmental factors, results in personality disorders (PD). These often coexist with other psychiatric disorders, affecting their outcome adversely. Considering the heterogeneity of data, more research is warranted. Methods: This was a cross-sectional study on personality traits in psychiatric patients of a tertiary hospital, over 1 year. Five hundred and twenty-five subjects, aged 18–45 years, with substance, psychotic, mood, or neurotic disorders were selected by convenience sampling. They were evaluated for illness-related variables using psychiatric pro forma; diagnostic confirmation and severity assessment were done using ICD-10 criteria and suitable scales. Personality assessment was done using the International Personality Disorder Examination after achieving remission. Results: Prevalence of PD traits and PDs was 56.3% and 4.2%, respectively. While mood disorders were the diagnostic group with the highest prevalence of PD traits, it was neurotic disorders for PDs. Patients with PD traits had a past psychiatric history and upper middle socioeconomic status (SES); patients with PDs were urban and unmarried. Both had a lower age of onset of psychiatric illness. Psychotic patients with PD traits had higher and lower PANSS positive and negative scores, respectively. The severity of personality pathology was highest for mixed cluster and among neurotic patients. Clusterwise prevalence was cluster C > B > mixed > A (47.1%, 25.2%, 16.7%, and 11.4%). Among subtypes, anankastic (18.1%) and mixed (16.7%) had the highest prevalence. Those in the cluster A group were the least educated and with lower SES than others. Conclusions: PD traits were present among 56.3% of the patients, and they had many significant sociodemographic and illness-related differences from those without PD traits. Cluster C had the highest prevalence. Among patients with psychotic disorders, those with PD traits had higher severity of psychotic symptoms.

scholarly journals The characteristics of newly diagnosed adult early-onset diabetes: a population-based cross-sectional study

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Xiantong Zou ◽  
Xianghai Zhou ◽  
Linong Ji ◽  
Wenying Yang ◽  
Juming Lu ◽  
...  
Keyword(s):  
Early Onset ◽  
Population Based ◽  
Cross Sectional Study ◽  
Newly Diagnosed ◽  
Sectional Study ◽  
Cross Sectional ◽  
Onset Diabetes
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