Flexible Magnifying Endoscopy with Narrow Band Imaging for Diagnosing Uterine Cervical Neoplasms: A Multicenter Prospective Study

We aimed to investigate the diagnostic ability of magnifying endoscopy with narrow band imaging (ME-NBI) for cervical intraepithelial neoplasia grade 2 or worse (CIN2+). This was a multicenter prospective study. Eligible patients had positive Pap smear results or follow-up high-grade cytology or CIN3 diagnosed in referring hospitals. Patients underwent ME-NBI by a gastrointestinal endoscopist, followed by colposcopy by a gynecologist. One lesion with the worst finding was considered the main lesion. Punch biopsies were collected from all indicated areas and one normal area. The reference standard was the highest histological grade among all biopsy specimens. The primary endpoint was the detection rate of patients with CIN2+ in the main lesion. The secondary endpoints were diagnostic ability for CIN2+ lesions and patients’ acceptability. We enrolled 88 patients. The detection rate of ME-NBI for patients with CIN2+ was 79% (95% CI: 66–88%; p = 1.000), which was comparable to that of colposcopy (79%; p = 1.000). For diagnosing CIN2+ lesions, ME-NBI showed a better sensitivity than colposcopy (87% vs. 74%, respectively; p = 0.302) but a lower specificity (50% vs. 68%, respectively; p = 0.210). Patients graded ME-NBI as having significantly less discomfort and involving less embarrassment than colposcopy. ME-NBI did not show a higher detection ability than colposcopy for patients with CIN2+, whereas it did show a better patient acceptability.

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Faculty Opinions recommendation of A multicenter prospective study of the real-time use of narrow-band imaging in the diagnosis of premalignant gastric conditions and lesions.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726410872.793546545 ◽

2018 ◽

Author(s):

Marnix Jansen

Keyword(s):

Prospective Study ◽

Real Time ◽

Time Use ◽

Narrow Band ◽

Narrow Band Imaging ◽

The Real ◽

Multicenter Prospective Study

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Uterine Cervical Neoplasm Diagnosed by Flexible Magnifying Endoscopy with Narrow Band Imaging

Diagnostics ◽

10.3390/diagnostics10110903 ◽

2020 ◽

Vol 10 (11) ◽

pp. 903

Author(s):

Hideki Kobara ◽

Kunihisa Uchita ◽

Noriya Uedo ◽

Noriko Matsuura ◽

Noriko Nishiyama ◽

...

Keyword(s):

Cervical Cancer ◽

Pap Smear ◽

Narrow Band ◽

Narrow Band Imaging ◽

Early Stage ◽

Magnifying Endoscopy ◽

Diagnostic Tools ◽

Gastrointestinal Neoplasms ◽

Cervical Neoplasm ◽

Uterine Cervical Neoplasm

When detected early, uterine cervical cancer is one of the most successfully treatable forms of cancer. The diagnostic accuracy of the standard method, the Pap smear test followed by colposcopy, remains unsatisfactory. To improve detection of early-stage cervical cancer, new diagnostic tools for uterine cervical intraepithelial neoplasm (CIN) need to be developed. Magnifying endoscopy with narrow- band imaging (ME-NBI), which allows the visualization of the micro-structure as well as micro-vascularity of the mucosal surface, has excellent diagnostic ability for early gastrointestinal neoplasms. In our previous investigation, ME-NBI was efficacious for diagnosis of CIN. We herein report two notable cases of CIN3 that were diagnosed by ME-NBI that were not detected by colposcopy. These cases illustrate the usefulness of ME-NBI for diagnosis of early-stage uterine cervical neoplasms.

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Application of magnifying endoscopy with narrow-band imaging in diagnosing gastric lesions: a prospective study

Gastrointestinal Endoscopy ◽

10.1016/j.gie.2012.08.015 ◽

2012 ◽

Vol 76 (6) ◽

pp. 1124-1132 ◽

Cited By ~ 34

Author(s):

H-y. Li ◽

J. Dai ◽

H-b. Xue ◽

Y-j Zhao ◽

X-y. Chen ◽

...

Keyword(s):

Prospective Study ◽

Narrow Band ◽

Narrow Band Imaging ◽

Magnifying Endoscopy ◽

Gastric Lesions ◽

A Prospective Study

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Su1650 The Efficacy and Safety of Jumbo Forceps Biopsy Using Narrow Band Imaging Endoscopy in Patients With Diminutive Polyps: A Multicenter Prospective Study in Japan

Gastrointestinal Endoscopy ◽

10.1016/j.gie.2017.03.879 ◽

2017 ◽

Vol 85 (5) ◽

pp. AB380

Author(s):

Takuya Yamada ◽

Toshio Kuwai ◽

Tatsuya Toyokawa ◽

Hiroaki Iwase ◽

Tomohiro Kudo ◽

...

Keyword(s):

Prospective Study ◽

Narrow Band ◽

Narrow Band Imaging ◽

Efficacy And Safety ◽

Forceps Biopsy ◽

Multicenter Prospective Study

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Diagnostic ability of Japan Narrow-Band Imaging Expert Team classification for colorectal lesions by magnifying endoscopy with blue laser imaging versus narrow-band imaging

Endoscopy International Open ◽

10.1055/a-1324-3083 ◽

2021 ◽

Vol 09 (02) ◽

pp. E271-E277

Author(s):

Renma Ito ◽

Hiroaki Ikematsu ◽

Tatsuro Murano ◽

Kensuke Shinmura ◽

Motohiro Kojima ◽

...

Keyword(s):

Narrow Band ◽

Narrow Band Imaging ◽

Magnifying Endoscopy ◽

Blue Laser ◽

Laser Imaging ◽

Diagnostic Ability ◽

Blue Laser Imaging ◽

Expert Team ◽

Type 3

Abstract Background and study aims The Japan Narrow-band imaging (NBI) Expert Team (JNET) classification was proposed for evaluating colorectal lesions. However, it remains unknown whether the JNET classification can be applied to magnifying endoscopy with image-enhanced endoscopies other than NBI. This study aimed to compare the diagnostic ability of JNET classification by magnifying endoscopy with blue laser imaging (ME-BLI) and with ME-NBI. Patients and methods We retrospectively assessed consecutive patients diagnosed per the JNET classification by ME-BLI (BLI group) or ME-NBI (NBI group) between March 2014 and June 2017. We compared the diagnostic value of JNET classification between the groups with one-to-one propensity score matching. Results Four hundred and seventy-one propensity score-matched pairs of lesions were analyzed. In the BLI and NBI groups, the overall diagnostic accuracies were 92.1 % and 91.7 %, respectively, and those for differentiating between neoplastic and non-neoplastic polyps were 96.6 % and 96.8 %, respectively. The positive predictive value by each JNET classification in BLI vs. NBI group was 90.6 % vs. 96.2 % in Type 1, 94.3 % vs. 94.6 % in Type 2A, 57.7 % vs. 42.3 % in Type 2B, and 100 % vs. 91.7 % in Type 3. The negative predictive value was 97.0 % vs. 96.9 % in Type 1, 88.1 % vs. 82.8 % in Type 2A, 98.0 % vs. 98.2 % in Type 2B, and 98.5 % vs. 98.7 % in Type 3. No statistical difference in the diagnostic results was found between the groups. Conclusions The diagnostic ability of the JNET classification by ME-BLI and ME-NBI was comparable, with the former also applicable for diagnosis of colorectal lesions.

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Diagnosis of histological type of early gastric cancer by magnifying narrow‐band imaging: A multicenter prospective study

DEN Open ◽

10.1002/deo2.61 ◽

2021 ◽

Vol 2 (1) ◽

Author(s):

Takashi Kanesaka ◽

Noriya Uedo ◽

Hisashi Doyama ◽

Naohiro Yoshida ◽

Takashi Nagahama ◽

...

Keyword(s):

Gastric Cancer ◽

Early Gastric Cancer ◽

Prospective Study ◽

Narrow Band ◽

Narrow Band Imaging ◽

Histological Type ◽

Multicenter Prospective Study

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Flexible magnifying endoscopy with narrow band imaging versus colposcopy for diagnosing uterine cervical neoplasms: a multicenter, prospective, non-randomized, paired comparison study

10.22541/au.160969743.30963125/v1 ◽

2021 ◽

Author(s):

Hideki Kobara ◽

Kunihisa Uchita ◽

Noriya Uedo ◽

Jun Kunikata ◽

Kenji Yorita ◽

...

Keyword(s):

Pap Smear ◽

Narrow Band ◽

Narrow Band Imaging ◽

Paired Comparison ◽

Intraepithelial Neoplasia ◽

Punch Biopsy ◽

Magnifying Endoscopy ◽

Detection Sensitivity ◽

Comparison Study ◽

Cervical Intraepithelial Neoplasia Grade

Objective To investigate the detection ability of flexible magnifying endoscopy with narrow band imaging (ME-NBI) for cervical intraepithelial neoplasia grade two or worse (CIN2+) compared with colposcopy. Design Multicenter, prospective, non-randomized, paired comparison study. Setting Three Japanese medical centers. Population Japanese women. Methods Eligible patients had positive PAP smear test results, suspicious high-grade CIN in previous colposcopy, or definitive CIN3 diagnosed previously. A gastrointestinal endoscopist examined the cervix using ME-NBI in an endoscopy room and, subsequently, a gynecologist blinded to the ME-NBI findings performed colposcopy in a different room. CIN2+ locations were documented in a scheme immediately after each examination. Punch biopsy samples were obtained from all areas diagnosed as CIN2+ with both methods and from one normal area. The reference standard was the presence of at least one histological diagnosis of CIN2+ among all biopsy specimens. Main outcome measures The primary outcome was the detection sensitivity of patients with CIN2+, comparing ME-NBI and colposcopy. Results We enrolled 88 patients. The detection sensitivity for patients with CIN2+ was not statistically different between the two methods (both: 79%, 95% CI: 66%–88%). For diagnosing CIN2+, ME-NBI tended to show a higher sensitivity than colposcopy (69% vs. 58%, respectively), while its specificity tended to be lower vs. colposcopy (55% vs. 70%, respectively). Patients reported significantly less discomfort and embarrassment with ME-NBI vs. colposcopy. Conclusion ME-NBI showed comparable sensitivity to colposcopy for detecting CIN2+ lesions, and ME-NBI was more patient-acceptable.

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