scholarly journals Amnesia after Midazolam and Ketamine Sedation in Children: A Secondary Analysis of a Randomized Controlled Trial

2021 ◽  
Vol 10 (22) ◽  
pp. 5430
Author(s):  
Karolline A. Viana ◽  
Mônica M. Moterane ◽  
Steven M. Green ◽  
Keira P. Mason ◽  
Luciane R. Costa
Keyword(s):  
Controlled Trial ◽  
Secondary Analysis ◽  
Structured Interview ◽  
Major Theme ◽  
Dental Procedure ◽  
Qualitative Approaches ◽  
Institutional Review ◽  
Dental Procedures ◽  
Oral Midazolam ◽  
Children's Memory

The incidence of peri-procedural amnesia following procedural sedation in children is unclear and difficult to determine. This study aimed to apply quantitative and qualitative approaches to better understand amnesia following dental sedation of children. After Institutional Review Board Approval, children scheduled for sedation for dental procedures with oral midazolam (OM), oral midazolam and ketamine (OMK), or intranasal midazolam and ketamine (IMK) were recruited for examination of peri-procedural amnesia. Amnesia during the dental session was assessed using a three-stage method, using identification of pictures and an animal toy. On the day following the sedation, primary caregivers answered two questions about their children’s memory. One week later, the children received a semi-structured interview. Behavior and level of sedation during the dental session were recorded. Quantitative data were analyzed using descriptive statistics and comparison tests. Qualitative data were analyzed using content analysis. Triangulation was used. Thirty-five children (age: 36 to 76 months) participated in the quantitative analysis. Most children showed amnesia for the dental procedure (82.9%, n = 29/35) and remembered receiving the sedation (82.1%, n = 23/28 for oral administration; 59.3%, n = 16/27 for intranasal administration). The occurrence of amnesia for the dental procedure was slightly higher in the oral midazolam group compared with the other groups (44.8%, n = 13/29 for OM, 13.8%, n = 4/29 for OMK, and 41.4%, n = 12/29 for IMK). Twenty-eight children participated in the qualitative approach. The major theme identified was that some children could remember their procedures in detail. We conclude that peri-procedural amnesia of the dental procedure was common following sedation.

scholarly journals Motivation and personal challenges while enrolled in higher education: The pathway to becoming a baccalaureate nurse

2017 ◽  
Vol 7 (11) ◽  
pp. 14 ◽  
Author(s):  
Sarah Kelly ◽  
Kathleen Evanovick Zavotsky ◽  
Erin Delany ◽  
Claudia Pagani ◽  
Christopher P. Duffy ◽  
...  
Keyword(s):  
Higher Education ◽  
Registered Nurse ◽  
Structured Interview ◽  
Student Experiences ◽  
Major Theme ◽  
College Degree ◽  
Focus Group Research ◽  
Institutional Review ◽  
Grant Program ◽  
Personal Challenges

Background: The exploration of the non-traditional or self-sufficient financially independent student experiences in higher education are considerably less researched, specifically addressing personal experience while pursuing higher education, when compared to traditional, those who recently graduated from high school, college students. Therefore, the objective of this study was to explore non-licensed hospital employees’ (paraprofessional) perceptions related to their motivation to obtain a baccalaureate degree and overcome personal challenges to become a registered nurse.Methods: A qualitative descriptive focus group research design was used to explore the perceptions of minority paraprofessional employees had related to their motivations and challenges to become a registered nurse. All student- paraprofessionals, who were funded through the Robert Wood Johnson grant program, were invited to participate in this study. A semi-structured interview guide was used to explore the participants’ thoughts about obtaining a college degree and what their motivation is for obtaining a college degree in nursing. Informal questions were used to involve the participants in the discussion. The study was approved by the university’s institutional review board and participants completed an informed consent prior to any data collection.Results: Five participants were engaged in this study. The major theme that these participants reported was the different challenges and sacrifices (finances and life situations) that they had to deal with prior to starting courses and while they were currently taking courses. The second theme was motivation; these participants were motivated to have a better life.Conclusions: These participants had to deal with certain challenges and make sacrifices in order to pursue their dream; however, the participants were able to find the needed motivation to achieve their dreams and become a registered nurse. 

Liraglutide Reduces Cardiac Adipose Tissue in Type 2 Diabetes: A secondary analysis of the LIRAFLAME Randomized Placebo‐Controlled Trial

2021 ◽  
Author(s):  
Ida K.B. Rasmussen ◽  
Emilie H. Zobel ◽  
Rasmus S. Ripa ◽  
Bernt J. von Scholten ◽  
Viktor R. Curovic ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Adipose Tissue ◽  
Controlled Trial ◽  
Secondary Analysis

The Safety of Low-Dose Aspirin on the Mode of Delivery: Secondary Analysis of the Effect of Aspirin in Gestation and Reproduction Randomized Controlled Trial

2020 ◽  
Author(s):  
Allison A. Eubanks ◽  
Carrie J. Nobles ◽  
Sunni L. Mumford ◽  
Keewan Kim ◽  
Micah J. Hill ◽  
...  
Keyword(s):  
Vaginal Delivery ◽  
Live Birth ◽  
Low Dose ◽  
Controlled Trial ◽  
Mode Of Delivery ◽  
Secondary Analysis ◽  
Clinical Effects ◽  
Dose Aspirin ◽  
Low Dose Aspirin ◽  
Intent To Treat

Objective This study aimed to examine whether prenatal low-dose aspirin (LDA) therapy affects risk of cesarean versus vaginal delivery. Study Design This study is a secondary analysis of the randomized clinical effects of aspirin in gestation and reproduction (EAGeR) trial. Women received 81-mg daily aspirin or placebo from preconception to 36 weeks of gestation. Mode of delivery and obstetric complications were abstracted from records. Log-binomial regression models estimated relative risk (RR) of cesarean versus vaginal delivery. Data were analyzed among the total preconception cohort, as well as restricted to women who had a live birth. Results Among 1,228 women, 597 had a live birth. In the intent-to-treat analysis, preconception-initiated LDA was not associated with risk of cesarean (RR = 1.02; 95% confidence interval [CI]: 0.98–1.07) compared with placebo. Findings were similar in just women with a live birth and when accounting prior cesarean delivery and parity. Conclusion Preconception-initiated daily LDA was not associated with mode of delivery among women with one to two prior losses. Key Points

scholarly journals Social Influence and Uptake of Couples HIV Testing and Counselling in KwaZulu-Natal, South Africa

2021 ◽  
Author(s):  
Matthew J. Johnson ◽  
Lynae A. Darbes ◽  
Victoria Hosegood ◽  
Mallory O. Johnson ◽  
Katherine Fritz ◽  
...  
Keyword(s):  
Hiv Testing ◽  
Peer Support ◽  
Social Influences ◽  
Controlled Trial ◽  
Secondary Analysis ◽  
Sub Saharan Africa ◽  
Survival Models ◽  
Hiv Testing And Counselling ◽  
Randomised Controlled ◽  
Support Score

AbstractSocial influences may create a barrier to couples HIV testing and counselling (CHTC) uptake in sub-Saharan Africa. This secondary analysis of data collected in the ‘Uthando Lwethu’ randomised controlled trial used discrete-time survival models to evaluate the association between within-couple average ‘peer support’ score and uptake of CHTC by the end of nine months’ follow-up. Peer support was conceptualised by self-rated strength of agreement with two statements describing friendships outside of the primary partnership. Eighty-eight couples (26.9%) took up CHTC. Results tended towards a dichotomous trend in models adjusted only for trial arm, with uptake significantly less likely amongst couples in the higher of four peer support score categories (OR 0.34, 95% CI 0.18, 0.68 [7–10 points]; OR 0.53, 95% CI 0.28, 0.99 [≥ 11 points]). A similar trend remained in the final multivariable model, but was no longer significant (AOR 0.59, 95% CI 0.25, 1.42 [7–10 points]; AOR 0.88, 95% CI 0.36, 2.10 [≥ 11 points]). Accounting for social influences in the design of couples-focused interventions may increase their success.

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