scholarly journals PSYChosomatic Medicine in ONcologIc and Cardiac Disease (PSYCHONIC) Study—A Retrospective and Prospective Observational Research Protocol

2021 ◽  
Vol 10 (24) ◽  
pp. 5786
Author(s):  
Adriana Roncella ◽  
Christian Pristipino ◽  
Oretta Di Carlo ◽  
Matteo Ansuini ◽  
Angela Corbosiero ◽  
...  
Keyword(s):  
Medical Therapy ◽  
Real World ◽  
Metastatic Breast ◽  
Psychological Characteristics ◽  
Observational Research ◽  
Control Group ◽  
Medical Outcomes ◽  
The Real ◽  
Relationship Of ◽  
The Relationship

Psychosocial factors play an important role in non-communicable diseases (NCDs). This observational study is primarily aimed at assessing the relationship of psychological characteristics of patients with the outcomes of different NCDs, and to assess short-term psychotherapy (STP) efficacy in the real world. Methods: One hundred and forty patients with recent acute myocardial infarction, Takotsubo syndrome, or non-metastatic breast cancer and a control group of 140 age and sex-matched healthy subjects, will be enrolled. All subjects will be administered psychometric tests, quality of life tests, a specific body perception questionnaire, a dream questionnaire, and a projective test, the Six Drawing test at baseline and follow-up. All subjects with medical conditions will be asked to freely choose between an ontopsychological STP along with standard medical therapy and, whenever indicated, rehabilitation therapy or medical therapy plus rehabilitation alone. The study endpoints will be to evaluate: the relationship of the psychological characteristics of enrolled subjects with the outcomes of different NCDs, predictors of the choice of psychotherapy, and the efficacy of ontopsychological intervention on psychological and medical outcomes. Conclusion: This study will generate data on distinctive psychological characteristics of patients suffering from different CDs and their relationship with medical outcomes, as well as explore the efficacy of ontopsychological STP in these patients in the real world. (Number of registration: NCT03437642).

scholarly journals On the Relationship of Mathematics to the Real World

Resonance ◽  
2018 ◽  
Vol 23 (2) ◽  
pp. 183-195
Author(s):  
Deepak Dhar
Keyword(s):  
Real World ◽  
The Real ◽  
Relationship Of ◽  
The Relationship

Using Logic Activities to Produce a Class Constitution

1992 ◽  
Vol 40 (3) ◽  
pp. 174-176
Author(s):  
Susan Strand Monchamp
Keyword(s):  
Real World ◽  
Evaluation Standards ◽  
The Real ◽  
Mathematical Connections ◽  
Relationship Of ◽  
The Relationship

One of my major goals in mathematics is to have my student understand the relationship of mathematics to the real world. To this end, we begin the year in my first-gradeclass by doing a series of logic activities that lead to the production of our class constitution. The activities reflect three of the NCTM' curriculum and evaluation standards—Mathematics a Communication, Mathematics as Reasoning, and Mathematical Connections (NCTM 1989).

scholarly journals Vorsprung durch Technik: On Biotechnology, Bioethics, and Its Beneficiaries

2011 ◽  
Vol 20 (2) ◽  
pp. 174-184 ◽  
Author(s):  
NICKY PRIAULX
Keyword(s):  
Real World ◽  
Current Form ◽  
Quiet Revolution ◽  
The Real ◽  
Perceived Need ◽  
Concept Of Health ◽  
Growing Body ◽  
Critical Turn ◽  
Relationship Of ◽  
The Relationship

Bioethics as a distinctive field is undergoing a critical turn. It may be a quiet revolution, but a growing body of scholarship illustrates a perceived need for a rethink of the scope of the field and the approaches and priorities that have carried bioethicists through many heady years of success. Few areas of bioethical practice have been left unexamined, ranging from questions as to the sustainability of the discipline in its current form to the “expertise” of its practitioners; the legitimacy of bioethics in the realms of policymaking; its relationship to philosophy; the purchase of empirical and interdisciplinary method; the relationship of bioethics to the real world; bioethical understandings of the concept of “health” (and methods of attainment); its agenda, priorities, and inclusiveness right up to what might be the overarching question: “What is bioethics all about?” Unsurprisingly, these questions elicit varied responses. Scholars from various disciplines have critiqued fundamental tenets of the “ethics” business, albeit as claims of its “conservatism,” “corruption,” and its questionable “usefulness” suggest, not always with a charitable or constructive eye. But quite crucially and often overlooked, bioethics itself has not shied away from the question as to what bioethics is and what it should become; increasingly apparent is that this kind of self-conscious and reflexive theorizing is regarded as a key priority for taking contemporary ethics forward.

PHILOSOPHICAL AND PSYCHOLOGICAL ASPECTS OF UNCONVENTIONAL HOREOTHERAPY

2021 ◽  
pp. 59-68
Author(s):  
Zhanna Milovatz
Keyword(s):  
Mental Retardation ◽  
Real World ◽  
Psychological Adaptation ◽  
Psychological Aspects ◽  
The Real ◽  
Dance Movements ◽  
Dance Improvisation ◽  
Relationship Of ◽  
The Relationship

The article discusses the role of chemotherapy as a method of socio-psychological adaptation of children with PO. The author suggests a program of horeotherapy aimed at the socialization of children with mental retardation. The essence of spontaneity is revealed in its aesthetic refraction. The question of the relationship of dance movements as a way to adapt children in the real world with the development of their imaginative and emotional thinking in the context of dance improvisation is raised.

Perpetuating ableist constructions of the “real world” through complaints about new communication technologies

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Elizabeth S. Parks ◽  
Jessica S. Robles
Keyword(s):  
Social Participation ◽  
Real World ◽  
Public Discourse ◽  
Language Use ◽  
Communication Technologies ◽  
Daily Lives ◽  
The Real ◽  
Inclusive Language ◽  
Relationship Of ◽  
The Relationship

Abstract Complaints about the use of new communication technologies are frequent in public discourse and work within a broader assemblage of discourses that promote selective ideologies. What is it that people are doing when they produce these complaints, and how might acts of complaining promote equity in our daily lives? We analyse complaints taken from 16 hours of video recorded dialogues and argue that the complaint discourse about the relationship of new communication technologies to people’s expected embodied functioning and idealized social participation reconstitutes and perpetuates broader ableist discourses about preferred engagement in the “real world.” By identifying intertextuality between two different topical discourses, we expand understanding about the reification of cross-cutting ableist discourses and promote more inclusive language use.

scholarly journals Authenticity and Children's Engagement with Writing

2015 ◽  
Vol 17 (1) ◽  
pp. 63 ◽  
Author(s):  
Shelley K Jones
Keyword(s):  
Real World ◽  
Reading And Writing ◽  
The Real ◽  
School Work ◽  
Literacy Activities ◽  
Authentic Literacy ◽  
Relationship Of ◽  
The Relationship ◽  
Writing Activity

Authentic literacy activities engage children with meaningful reading and writing (Duke, Purcell-Gates, Hall, & Tower, 2006), but  little investigation has been conducted into the relationship of the kinds of writing children enjoy and the authenticity of the writing activity and experience. This paper reports findings from a study that investigates the question: How, if at all, does authenticity factor into kinds of writing that children like and/or dislike? Findings indicate that children enjoy writing that purposefully engages them with the real world, and is therefore authentic, and do not enjoy writing that they perceive as merely “school work”.  

Joshua Kates, Essential History: Jacques Derrida and the Development of Deconstruction (Evanston, Illinois: Northwestern University Press, 2005), 352pp, $29.95 (USD), ISBN 10: 0810123274, ISBN-13: 978-0810123274

Derrida Today ◽  
2008 ◽  
Vol 1 (1) ◽  
pp. 131-133
Author(s):  
Gary Banham
Keyword(s):  
Jacques Derrida ◽  
The Real ◽  
Northwestern University ◽  
Relationship Of ◽  
The Relationship

This book promises a ‘radical reappraisal’ (Kates 2005, xv) of Derrida, concentrating particularly on the relationship of Derrida to philosophy, one of the most vexed questions in the reception of his work. The aim of the book is to provide the grounds for this reappraisal through a reinterpretation in particular of two of the major works Derrida published in 1967: Speech and Phenomena and Of Grammatology. However the study of the development of Derrida's work is the real achievement of the book as Kates discusses major works dating from the 1954 study of genesis in Husserl's phenomenology through to the essays on Levinas and Foucault in the early 1960's as part of his story of how Derrida arrived at the writing of the two major works from 1967.

scholarly journals Real-world effectiveness of post-trastuzumab emtansine treatment in patients with HER2-positive, unresectable and/or metastatic breast cancer: a retrospective observational study (KBCSG-TR 1917)

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Takahiro Nakayama ◽  
Tetsuhiro Yoshinami ◽  
Hiroyuki Yasojima ◽  
Nobuyoshi Kittaka ◽  
Masato Takahashi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Observational Study ◽  
Real World ◽  
Metastatic Breast ◽  
Trastuzumab Emtansine ◽  
Her2 Positive ◽  
The Real ◽  
Her2 Positive Breast Cancer ◽  
Positive Breast Cancer

Abstract Background Trastuzumab emtansine (T-DM1) is a second-line standard therapy for patients with human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer. Evidence regarding post–T-DM1 treatments is currently lacking. We evaluated the effectiveness of post–T-DM1 drug therapy in patients with HER2-positive, unresectable and/or metastatic breast cancer. Methods In this multicenter, retrospective, observational study, real-world clinical data of female patients with HER2-positive breast cancer who had a history of T-DM1 treatment were consecutively collected from five sites in Japan. We investigated the effectiveness of post–T-DM1 therapy by evaluating the real-world progression-free survival (rwPFS), time to treatment failure (TTF), overall survival (OS), objective response rate (ORR), and clinical benefit rate (CBR). Tumor response was assessed by investigators according to Response Evaluation Criteria in Solid Tumors (RECIST version 1.1) guidelines. Subgroup and exploratory analyses according to background factors were also undertaken. Results Of the 205 patients who received T-DM1 treatment between 1 January 2014 and 31 December 2018, 128 were included in this study. Among the 128 patients analyzed, 105 (82%) patients received anti-HER2 therapy and 23 (18%) patients received regimens without anti-HER2 therapy. Median (95% confidence interval [CI]) rwPFS, TTF, and OS were 5.7 (4.8–6.9) months, 5.6 (4.6–6.4) months, and 22.8 (18.2–32.4) months, respectively. CBR and ORR (95% CI) were 48% (38.8–56.7) and 23% (15.1–31.4), respectively. Cox-regression analysis showed that an ECOG PS score of 0, a HER2 immunohistochemistry score of 3+, recurrent type, ≥12 month duration of T-DM1 therapy, and anti-HER2 therapy were independent variables for rwPFS. An exploratory subgroup analysis of regimens after T-DM1 showed that those with anti-HER2 therapy had a median rwPFS of 6.3 and those without anti-HER2 therapy had a median rwPFS of 4.8 months. Conclusions In the real-world setting in Japan, several post–T-DM1 regimens for patients with unresectable and/or metastatic HER2-positive breast cancer, including continuation of anti-HER2 therapy, showed some effectiveness; however, this effectiveness was insufficient. Novel therapeutic options are still needed for further improvement of PFS and OS in later treatment settings. Trial registration UMIN000038296; registered on 15 October 2019.

Experimental study of the inhibition effect of CXCL12/CXCR4 in malignant pleural mesothelioma

2018 ◽  
Vol 67 (2) ◽  
pp. 338-345 ◽  
Author(s):  
Jianshuang Li ◽  
Tong Li ◽  
Shuo Li ◽  
Lipeng Xie ◽  
Yi-Lin Yang ◽  
...  
Keyword(s):  
Treatment Group ◽  
Malignant Pleural Mesothelioma ◽  
Synergistic Effects ◽  
Control Group ◽  
Pleural Mesothelioma ◽  
Gene Expressions ◽  
Relationship Of ◽  
The Relationship ◽  
Cxcr4 Axis

Previous studies have demonstrated that CXCL12/CXCR4 axis is closely related to tumors such as malignant pleural mesothelioma (MPM). This research was conducted in order to detect whether CXCL12/CXCR4 inhibitors could restrain MPM and have a synergistic effect with chemotherapy, also to investigate the relationship of CXCL12/CXCR4 with other gene expressions in MPM. Forty mice were injected MPM cells and randomly divided into four groups: the PBS (control group), AMD3100 (CXCR4-CXCL12 antagonist), pemetrexed and AMD3100 plus pemetrexed. The mice were treated respectively for duration of 3 weeks. The size, bioluminescence and weight of tumors were measured. The differences between gene expressions in each group were analyzed. The tumor weights of each treatment group were lower than that of the control group (p<0.05). The bioluminescence of the tumor of the AMD3100 treatment group and the AMD3100 plus pemetrexed treatment group were lower than that of the control group (p<0.05), and AMD3100 was shown to have synergistic effects with pemetrexed (p<0.05). Among the 2.5 billion genes, several hundreds of genes expressed differently between groups. Results show that AMD3100 and pemetrexed can inhibit the growth of MPM in vivo, also that there is a better result if both are used together. Our findings suggest that CXCL12/CXCR4 axis affects a certain amount of gene expression in MPM.

Impacts of online and offline Islamophobia

Islamophobia ◽  
2016 ◽  
Author(s):  
Irene Zempi ◽  
Imran Awan
Keyword(s):  
Real World ◽  
Emotional Responses ◽  
Depression And Anxiety ◽  
The Real ◽  
The Relationship

This chapter examines the implications of online/offline Islamophobia for victims including increased feelings of vulnerability, fear and insecurity. Participants also suffered a range of psychological and emotional responses such as low confidence, depression and anxiety. Additionally, participants highlighted the relationship between online and offline Islamophobia, and described living in fear because of the possibility of online threats materialising in the ‘real world’. Many participants reported taking steps to become less ‘visible’ for example by taking the headscarf or face veil off for women and shaving their beards for men.

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