Hyaluronic Acid Gel-Based Scaffolds as Potential Carrier for Growth Factors: An In Vitro Bioassay on Its Osteogenic Potential

Background and Objectives: Wound healing is a dynamic process that can be compromised in patients with chronic and metabolic conditions or unhealthy lifestyles. Numerous medical substances designed for topical use, charged with compounds that promote the healing process, have been developed to improve wound healing, especially in compromised subjects. The present study aimed to extend our understanding of the in vivo effects of a hyaluronic acid gel charged with amino acids (HAplus gel, Aminogam gel® Errekappa Euroterapici spa, Milan, Italy) and study the in vitro effects of the same gel charged with additional substances in an attempt to optimize its formulation. Materials and Methods: In a randomized controlled split-mouth clinical and histological trial, HAplus gel was tested on the gingival tissue of the lower third molar post-extraction socket. The gingiva was collected at the time of extraction (T0) and ten days after the extraction (T1) to be histologically analyzed. During the second stage of the study, culture media with HAplus gel and vitamin C and E at different concentrations (TEST) were tested on human gingival fibroblasts and compared to the HAplus-enriched medium (HA-Control). Results: Histological and immunohistochemical analysis of collected gingiva showed higher microvascular density and collagen fibers organized in closely packed and well-oriented bundles in sites treated with HAplus gel. In the in vitro study, all TEST groups showed an increased viability from 24 h to 48 h. After 24 h, the viability percentage in all experimental groups was below 100% of the HA-Control, demonstrating a mild toxicity. After 48 h from seeding, the TEST groups’ viability grew significantly compared to HA-Control. Conclusions: These encouraging preliminary results suggest that the use of HAplus gel enriched with vitamins C and E may be beneficial in patients with conditions that impair soft tissue healing.

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Nonsurgical Treatment of Abnormal Eyelid Position Using Hyaluronic Acid Gel

Journal of the Korean Ophthalmological Society ◽

10.3341/jkos.2012.53.3.357 ◽

2012 ◽

Vol 53 (3) ◽

pp. 357

Author(s):

Seok Joong Chung ◽

Hyun Min Shin ◽

Helen Lew

Keyword(s):

Hyaluronic Acid ◽

Nonsurgical Treatment ◽

Acid Gel ◽

Hyaluronic Acid Gel

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Does Adjunctive Use of Hyaluronic Acid Improve Clinical Outcome of Mechanical Therapy for Cases of Mild Aggressive Periodontitis

Revista de Chimie ◽

10.37358/rc.17.3.5513 ◽

2017 ◽

Vol 68 (3) ◽

pp. 612-614

Author(s):

Andreea A. Pogan ◽

Roxana Buzatu ◽

Dan Onisei ◽

Doina Onisei

Keyword(s):

Hyaluronic Acid ◽

Antimicrobial Effect ◽

Aggressive Periodontitis ◽

Gingival Tissue ◽

Potential Benefits ◽

Therapeutic Properties ◽

Acid Gel ◽

Mechanical Therapy ◽

Improve Clinical Outcome ◽

Hyaluronic Acid Gel

Hyaluronic acid is an essential component of the periodontal ligament matrix and it has shown a number of clinical therapeutic properties, especially an anti-inflammatory effect on the gingival tissue. The aim of this study is to evaluate the potential benefits of using hyaluronic acid gel in topical application as an adjunct to mechanical therapy in the management of aggressive periodontitis. Results show an obvious improvement of clinical parameters, especially regarding the evolution of healing of the gingival tissue after periodontal therapy. Nevertheless, the antimicrobial effect needs to be proven in further studies.

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CLINICAL APPLICATION OF RADIESSE AND HYALURONIC ACID GEL FOR TREATMENT OF PAPILLAE DEFICIENCIES IN THE ESTHETIC ZONE

Egyptian Dental Journal ◽

10.21608/edj.2017.75003 ◽

2017 ◽

Vol 63 (1) ◽

pp. 533-545

Author(s):

Heba Shawky ◽

Mahinour Darwish

Keyword(s):

Hyaluronic Acid ◽

Clinical Application ◽

Acid Gel ◽

Hyaluronic Acid Gel

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Adolescents and primary herpetic gingivostomatitis: an Italian overview

Irish Journal of Medical Science (1971 -) ◽

10.1007/s11845-021-02621-3 ◽

2021 ◽

Author(s):

Elena Bardellini ◽

Francesca Amadori ◽

Federica Veneri ◽

Giulio Conti ◽

Alberto Paderno ◽

...

Keyword(s):

Hyaluronic Acid ◽

Antibiotic Therapy ◽

Medical Records ◽

Bacterial Infections ◽

Group A ◽

Acid Gel ◽

Herpetic Gingivostomatitis ◽

Group B ◽

Italian Adolescents ◽

Hyaluronic Acid Gel

Abstract Aim The aim of this study was to investigate the therapies administered to Italian adolescents with primary herpetic gingivostomatitis (PHGS) Methods The medical records of 74 adolescents with PHSG were reviewed. The following data were recorded: age, gender, day of onset, type of treatment, lesions’ severity, pain scoring, eating, and drinking ability. The oral examination was performed at the first evaluation (T0) and after one week (T1). Results All patients showed up at the first visit at least 48 h after the onset of symptoms. No patient was prescribed an antiviral therapy. An antibiotic therapy was prescribed in order to prevent secondary bacterial infections. Fifteen patients had been treated with non alcoholic chlorhexidine rinses (group A), 29 patients with non alcoholic chlorhexidine rinses plus hyaluronic acid gel (group B); 30 patients with non alcoholic chlorhexidine rinses plus Mucosyte® (group C). A significant improvement of the pain scoring and lesions’ severity was noted in group C. Conclusion In Italian adolescents, PHGS is diagnosed at least 48 h after onset and the antibiotic therapy is widely prescribed in order to prevent overinfections. Among topical therapies, an association of verbascoside and sodium hyaluronhate seems to favour a faster healing.

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