scholarly journals Evolution of Airway Inflammation in Preschoolers with Asthma—Results of a Two-Year Longitudinal Study

2020 ◽  
Vol 9 (1) ◽  
pp. 187 ◽  
Author(s):  
Paraskevi Xepapadaki ◽  
Paraskevi Korovessi ◽  
Claus Bachert ◽  
Susetta Finotto ◽  
Tuomas Jartti ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Disease Activity ◽  
Airway Inflammation ◽  
School Age ◽  
Fractional Exhaled Nitric Oxide ◽  
Recurrent Wheezing ◽  
Asthmatic Children ◽  
Non Invasive ◽  
Asthmatic Group

Fractional exhaled nitric oxide (FeNO) is a non-invasive marker for eosinophilic airway inflammation and has been used for monitoring asthma. Here, we assess the characteristics of FeNO from preschool to school age, in parallel with asthma activity. A total of 167 asthmatic children and 66 healthy, age-matched controls were included in the 2-year prospective PreDicta study evaluating wheeze/asthma persistence in preschool-aged children. Information on asthma/rhinitis activity, infections and atopy was recorded at baseline. Follow-up visits were performed at 6-month intervals, as well as upon exacerbation/cold and 4–6 weeks later in the asthmatic group. We obtained 539 FeNO measurements from asthmatics and 42 from controls. At baseline, FeNO values did not differ between the two groups (median: 3.0 ppb vs. 2.0 ppb, respectively). FeNO values at 6, 12, 18 and 24 months (4.0, CI: 0.0–8.6; 6.0, CI: 2.8–12.0; 8.0, CI: 4.0–14.0; 8.5, CI: 4.4–14.5 ppb, respectively) increased with age (correlation p ≤ 0.001) and atopy (p = 0.03). FeNO was non-significantly increased from baseline to the symptomatic visit, while it decreased after convalescence (p = 0.007). Markers of disease activity, such as wheezing episodes and days with asthma were associated with increased FeNO values during the study (p < 0.05 for all). Age, atopy and disease activity were found to be important FeNO determinants in preschool children. Longitudinal and individualized FeNO assessment may be valuable in monitoring asthmatic children with recurrent wheezing or mild asthma.

Early childhood growth patterns and school-age respiratory resistance, fractional exhaled nitric oxide and asthma

2016 ◽  
Vol 27 (8) ◽  
pp. 854-860 ◽  
Author(s):  
Maribel Casas ◽  
Herman T. den Dekker ◽  
Claudia J. Kruithof ◽  
Irwin K. Reiss ◽  
Martine Vrijheid ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Early Childhood ◽  
Exhaled Nitric Oxide ◽  
Growth Patterns ◽  
School Age ◽  
Respiratory Resistance ◽  
Fractional Exhaled Nitric Oxide ◽  
Childhood Growth

Fractional Exhaled Nitric Oxide (FENO), Lung Function and Airway Hyperresponsiveness in Naïve Atopic Asthmatic Children

2004 ◽  
Vol 41 (7) ◽  
pp. 759-765 ◽  
Author(s):  
Michele Miraglia del Giudice ◽  
F. P. Brunese ◽  
G. L. Piacentini ◽  
M. Pedullà ◽  
C. Capristo ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Lung Function ◽  
Airway Hyperresponsiveness ◽  
Exhaled Nitric Oxide ◽  
Fractional Exhaled Nitric Oxide ◽  
Asthmatic Children

Follow-up of Acute Respiratory Disorders in Cyclists Competing in the 100th Giro d’Italia

2020 ◽  
Author(s):  
Luca Pollastri ◽  
Claudio Macaluso ◽  
Giovanni Vinetti ◽  
Giovanni Tredici ◽  
Francesca Lanfranconi
Keyword(s):  
Nitric Oxide ◽  
Respiratory Symptoms ◽  
Respiratory Infections ◽  
Clinical History ◽  
Exhaled Nitric Oxide ◽  
Respiratory Disorder ◽  
Non Invasive ◽  
Respiratory Inflammation ◽  
Elite Cyclists

AbstractAcute respiratory disorder is a common sub-clinical condition affecting elite cyclists. Monitoring the perturbations of the immunological cells in the respiratory tract, indicative of a likely proinflammatory state, during an International Cycling Union world tour is a challenging task. The aim of this study was to follow up on the sign and symptoms of upper way respiratory infections with or without asthma, using non-invasive methods, during a 21-day race (100° Giro d’Italia, 2017). Nine male elite cyclists of the Bahrain Merida Team were evaluated before the training season and daily during the race. Clinical history, skin prick and spirometric test, acute respiratory symptoms were measured using validated questionnaires, and values of fraction of exhaled nitric oxide were collected longitudinally. Four of the 9 athletes had allergies with/or consistent abnormal spirometric curves before the race. During the race, 5 athletes had a fraction of exhaled nitric oxide values >20 ppb which correlated with respiratory symptoms collected through questionnaires. These were related to the environmental characteristics of the places travelled through in the race. The athletes with a predisposition to chronic respiratory inflammation in the pre-competitive season were more likely to develop acute respiratory symptoms during the race

scholarly journals Fractional Exhaled Nitric Oxide Measurement in Pulmonary Hypertension: A Follow-Up Study

2017 ◽  
Vol 24 (3) ◽  
pp. 483-488 ◽  
Author(s):  
Nilay Orak Akbay ◽  
Zuleyha Bingol ◽  
Esen Kiyan ◽  
Ekrem Bilal Karaayvaz ◽  
Ahmet Kaya Bilge ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Pulmonary Hypertension ◽  
Pulmonary Function Tests ◽  
Exhaled Nitric Oxide ◽  
World Health ◽  
Control Group ◽  
Healthy Controls ◽  
Fractional Exhaled Nitric Oxide

Pulmonary hypertension (PH) is a fatal disease although significant improvements in treatment are achieved. Easily implemented and noninvasive prognostic techniques are needed while following-up these patients. The aim was to investigate the role of fractional exhaled nitric oxide (FeNO) in follow-up for patients with PH. In this longitudinal study, patients with pulmonary arterial hypertension (PAH) and chronic thromboembolic PH (CTEPH) who were seen in PH Outpatient Clinic, Istanbul Faculty of Medicine, Istanbul University, were enrolled in the study. Echocardiography, 6-minute walking test, brain natriuretic peptide, and FeNO measurements were performed, and World Health Organization functional class was evaluated to all patients at baseline, and third, and sixth months. Right-heart catheterization and pulmonary function tests at the time of diagnosis were recorded. The study comprised 31 patients (23 women, 8 men; mean age: 53.4 ± 17.1 years) with PAH (n = 19) and CTEPH (n = 12) and 80 healthy controls. Patients with PH had lower FeNO values than the control group (16.5 ppb vs 19.8 ppb; P < .05). Fractional exhaled nitric oxide values did not change during follow-up and did not correlate with other follow-up measures except tricuspid annular plane systolic excursion values. Fractional exhaled nitric oxide was higher in the idiopathic PAH subgroup at baseline and at third month than patients with PAH associated with other diseases. Fractional exhaled nitric oxide did not change in patients who had clinical deterioration. As a conclusion; Patients with PH had lower FeNO values than healthy controls, but FeNO did not change significantly during follow-up. Large-scale studies with prolonged follow-up periods are needed to understand the role of FeNO in the follow-up of the patients with PH.

Off-Line Fractional Exhaled Nitric Oxide Measurement Is Useful to Screen Allergic Airway Inflammation in an Adult Population

2007 ◽  
Vol 44 (10) ◽  
pp. 805-810 ◽  
Author(s):  
Junpei Saito ◽  
Suguru Sato ◽  
Hideki Hasunuma ◽  
Yasushi Ishimaru ◽  
Hiroshi Kanegae ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Airway Inflammation ◽  
Adult Population ◽  
Allergic Airway Inflammation ◽  
Exhaled Nitric Oxide ◽  
Fractional Exhaled Nitric Oxide

scholarly journals Tai-Chi-Chuan Exercise Improves Pulmonary Function and Decreases Exhaled Nitric Oxide Level in Both Asthmatic and Nonasthmatic Children and Improves Quality of Life in Children with Asthma

2017 ◽  
Vol 2017 ◽  
pp. 1-13 ◽  
Author(s):  
Hsin-Chia Lin ◽  
Hao-Pai Lin ◽  
Hsin-Hui Yu ◽  
Li-Chieh Wang ◽  
Jyh-Hong Lee ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Nitric Oxide ◽  
Pulmonary Function ◽  
Airway Inflammation ◽  
Tai Chi ◽  
Exhaled Nitric Oxide ◽  
Moderate Intensity ◽  
Tai Chi Chuan ◽  
Asthmatic Children

Tai-Chi-Chuan (TCC) is an exercise of low-to-moderate intensity which is suitable for asthmatic patients. The aim of our study is to investigate improvements of the lung function, airway inflammation, and quality of life of asthmatic children after TCC. Participants included sixty-one elementary school students and they were divided into asthmatic (n=29) and nonasthmatic (n=32) groups by the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. Among them, 20 asthmatic and 18 nonasthmatic children volunteered to participate in a 60-minute TCC exercise weekly for 12 weeks. Baseline and postintervention assessments included forced expiratory volume in one second (FEV1), forced vital capacity (FVC), peak expiratory flow rate (PEFR), fractional exhaled nitric oxide (FeNO) level, and Standardised Pediatric Asthma Quality of Life Questionnaire (PAQLQ(S)). After intervention, the level of FeNO decreased significantly; PEFR and the FEV1/FVC also improved significantly in both asthmatic group and nonasthmatic group after TCC. The asthmatic children also had improved quality of life after TCC. The results indicated that TCC could improve the pulmonary function and decrease airway inflammation in both children with mild asthma and those without asthma. It also improves quality of life in mild asthmatic children. Nevertheless, further studies are required to determine the effect of TCC on children with moderate-to-severe asthma.

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