scholarly journals Interval Cancer Rate and Diagnostic Performance of Fecal Immunochemical Test According to Family History of Colorectal Cancer

2020 ◽  
Vol 9 (10) ◽  
pp. 3302
Author(s):  
Yoon Suk Jung ◽  
Jinhee Lee ◽  
Hye Ah Lee ◽  
Chang Mo Moon
Keyword(s):  
Colorectal Cancer ◽  
Family History ◽  
Diagnostic Performance ◽  
Interval Cancer ◽  
Fecal Immunochemical Test ◽  
Adjusted Relative Risk ◽  
Cancer Rate ◽  
Interval Cancer Rate ◽  
History Of ◽  
Immunochemical Test

Background: The potential role of the fecal immunochemical test (FIT) in individuals with a family history of colorectal cancer (CRC) remains unclear. We assessed interval cancer rate (ICR) after the FIT and FIT diagnostic performance according to family history of CRC. Methods: Using the Korean National Cancer Screening Program Database, we collected data on subjects who underwent the FIT between 2009 and 2011. The interval cancer rate (ICR) was defined as the number of subjects diagnosed with CRC within 1 year after the FIT per 1000 subjects with negative FIT results. Results: Of 5,643,438 subjects, 224,178 (3.97%) had a family history of CRC. FIT positivity rate (6.4% vs. 5.9%; adjusted relative risk (aRR) 1.11; 95% confidence interval (CI) 1.09–1.13) and ICR (1.4 vs. 1.1; aRR 1.43 (95% CI 1.27–1.60)) were higher in these subjects than in those with no such history. These results were the same regardless of whether subjects had undergone colonoscopy within the last 5 years before the FIT. However, the diagnostic performance of the FIT for CRC, as measured using the area under the operating characteristic curve, was similar between subjects without a family history and those with one (85.5% and 84.6%, respectively; p = 0.259). Conclusion: the FIT was 1.4 times more likely to miss CRC in subjects with a family history than in those without (aRR 1.43 for ICR), although its diagnostic performance was similar between the two groups. Our results suggest that for individuals with a family history of CRC, colonoscopy should be preferred over FIT for both screening and surveillance.

Su1038 Performance of Fecal Immunochemical Test (FIT) in Patients With a Family History of Colorectal Cancer

2016 ◽  
Vol 150 (4) ◽  
pp. S452
Author(s):  
Sarvenaz Moosavi ◽  
Laura Gentile ◽  
Lovedeep Gondara ◽  
Colleen McGahan ◽  
Robert A. Enns ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Family History ◽  
Fecal Immunochemical Test ◽  
History Of ◽  
Immunochemical Test

Factors Associated with Participation in Colorectal Cancer Screening Using a Fecal Immunochemical Test (FIT) in Thai Population Aged 45 to 74 years in Namphong District, Khon Kaen Province

2021 ◽  
Vol 104 (7) ◽  
pp. 1067-1072
Keyword(s):  
Public Health ◽  
Colorectal Cancer ◽  
Fecal Immunochemical Test ◽  
Thai Population ◽  
Screening Programs ◽  
Crc Screening ◽  
Factors Associated ◽  
History Of ◽  
Public Health Officials ◽  
Immunochemical Test

Background: Presently, the level of participation in screening programs for colorectal cancer (CRC) with Fecal Immunochemical Test (FIT) is considerably low. Objective: To investigate factors associated with participation in CRC screening using a FIT in the Thai population age 45 to 74 years in the Namphong District of Khon Kaen Province. Materials and Methods: In the present study, the unmatched case-control study design was applied. Three hundred ten participants were equally divided into two groups with 155 participants in the study group and the other 155 in the control group. The data were collected by conducting interviews. Moreover, to explain the association between the factors, multiple logistic regressions were used with adjusted odds ratio (ORadj), a confidence level at 95%, and with p<0.05. Results: It was found that ages were equal to or higher than 60 years (ORadj 2.08; 95%CI 1.19 to 3.63), the lower education level (ORadj 3.70; 95% CI 1.86 to 7.33), a family history of cancer (ORadj 5.25; 95% CI 2.14 to 12.86), receiving advice from public health officials regarding CRC screening (ORadj 3.09; 95% CI 1.81 to 5.27), and high level of knowledge about CRC (ORadj 4.01; 95% CI 2.09 to 7.69) had all been related to participation in the CRC screening program with a statistical significance (p<0.05). Conclusion: The results revealed that receiving advice from public health officials regarding CRC screening and that proper knowledge had been related to participation in screening programs for CRC with the FIT. Thus, to raise awareness and create a greater understanding, public health officers should disseminate knowledge about CRC. Information about the colorectal screening with the FIT should especially be spread to those people who are younger than 60 years of age, have educational levels higher than the primary level, and to those, who have no family history of CRC. Keywords: Colorectal Cancer Screening; Fecal Immunochemical Test (FIT); Thai population

scholarly journals Performance of the Fecal Immunochemical Test in Patients With a Family History of Colorectal Cancer

2019 ◽  
Author(s):  
Sarvee Moosavi ◽  
Laura Gentile ◽  
Lovedeep Gondara ◽  
Colleen Mcgahan ◽  
Robert Alan Enns ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Logistic Regression ◽  
Family History ◽  
High Risk ◽  
Screening Program ◽  
Fecal Immunochemical Test ◽  
Study Cohort ◽  
Predictive Values ◽  
Two Samples ◽  
Immunochemical Test

Abstract Objective To assess the performance of a fecal immunochemical test (FIT) among participants of a population-based colorectal cancer (CRC) screening program with one or more first-degree relatives (FDR) with CRC. Methods Asymptomatic 50 to 74 years olds with a FDR diagnosed with CRC, enrolled in a colon screening program completed FIT (two samples, cut-off 20 µg Hemoglobin/gram feces) and underwent colonoscopy. FIT-interval CRCs were identified from the British Columbia cancer registry. Logistic regression analysis was used to identify variables associated with the detection of CRC and high-risk polyps (nonmalignant findings that required a 3-year surveillance colonoscopy) in those patients undergoing FIT and colonoscopy. Results Of the 1387 participants with a FDR with CRC, 1244 completed FIT with a positivity rate of 10.8%, 52 declined FIT but underwent colonoscopy and 90 declined screening. Seven CRCs were identified: six in patients with a positive FIT, one in a patient who only had colonoscopy. No CRCs were found in patients with a negative FIT. The positive and negative predictive values of FIT in the detection of CRC were 4.8% and 100%, respectively. On multivariate logistic regression, positive FIT, and not type of family history, was the only variable associated with detection of CRC or high-risk polyps. At 2-year follow-up, there was no FIT interval cancer detected in the study cohort. Conclusion FIT is more strongly associated with high-risk findings on colonoscopy than type of family history. FIT may be an alternative screening strategy to colonoscopy in individuals with a single FDR with CRC.

Diagnostic accuracy of faecal immunochemical test for screening individuals with a family history of colorectal cancer

2013 ◽  
Vol 38 (7) ◽  
pp. 835-841 ◽  
Author(s):  
S. C. Ng ◽  
J. Y. L. Ching ◽  
V. Chan ◽  
M. C. S. Wong ◽  
B. Y. Suen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Family History ◽  
Diagnostic Accuracy ◽  
Faecal Immunochemical Test ◽  
History Of ◽  
Immunochemical Test

Classifying interval cancers as false negatives or newly occurring in fecal immunochemical testing

2021 ◽  
pp. 096914132098683
Author(s):  
Wen-Feng Hsu ◽  
Chen-Yang Hsu ◽  
Amy Ming-Fang Yen ◽  
Sam Li-Sheng Chen ◽  
Sherry Yueh-Hsia Chiu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Incidence Rate ◽  
Screening Program ◽  
False Negative ◽  
Interval Cancer ◽  
Fecal Immunochemical Test ◽  
Colorectal Cancers ◽  
Interval Cancers ◽  
False Negatives ◽  
Immunochemical Test

Objective To classify interval colorectal cancers as false negatives or newly occurring cases in a biennial Fecal immunochemical test (FIT) screening program and by various interscreening intervals. Setting Data from the Taiwanese biennial colorectal cancer screening program involving FIT from 2004 to 2014 were used to estimate the incidence rate of asymptomatic colorectal cancer and the rate of its subsequent progression to clinical mode. Methods The sensitivity of detecting asymptomatic colorectal cancers excluding newly developed colorectal cancers was compared to the conventional estimate of sensitivity, the complementary FIT interval cancer rate as a percentage of the expected incidence rate ((1-I/E)%). The relative contribution of newly developed or false-negative cases to FIT interval colorectal cancers was estimated by age and interscreening intervals. Results The Taiwanese biennial fecal immunochemical test screening program had a conventional sensitivity estimate of 70.2%. After newly developed colorectal cancers were separated from FIT interval cancers, the ability to detect asymptomatic colorectal cancers increased to 75.5%. FIT interval colorectal cancers from the biennial program mainly resulted from newly developed colorectal cancers (68.8%). The corresponding figures decreased to 61.1% for the annual program but increased to 74.7% for the triennial program. The preponderance of newly developed colorectal cancers among FIT interval cancers was more prominent in screenees aged 50–59  than in those aged 60–69. Conclusions Newly developed colorectal cancers showed a predominance among the FIT interval colorectal cancers in particular in the younger population screened. It is desirable to identify high-risk individuals to offer them a short interscreening interval or advanced detection methods to reduce their odds of developing interval cancer.

Incidence of interval cancer on follow-up colonoscopy in individuals with a family history of colorectal cancer undergoing colonoscopic surveillance

2000 ◽  
Vol 118 (4) ◽  
pp. A41
Author(s):  
Isis Dove-Edwin ◽  
Sheila Goff ◽  
Dm Bradburn ◽  
Christopher B. Williams ◽  
Huw J. Thomas
Keyword(s):  
Colorectal Cancer ◽  
Family History ◽  
Interval Cancer ◽  
Colonoscopic Surveillance ◽  
History Of

Diagnostic performances of supplemental breast ultrasound screening in women with personal history of breast cancer

2017 ◽  
Vol 59 (5) ◽  
pp. 533-539 ◽  
Author(s):  
Sung Eun Song ◽  
Nariya Cho ◽  
Jung Min Chang ◽  
A Jung Chu ◽  
Ann Yi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Detection ◽  
Detection Rate ◽  
Interval Cancer ◽  
Cancer Detection Rate ◽  
Personal History ◽  
Ultrasound Screening ◽  
Cancer Rate ◽  
Interval Cancer Rate ◽  
History Of

Background Supplemental breast ultrasonography (US) has been used as a surveillance imaging method in women with personal history of breast cancer (PHBC). However, there have been limited data regarding diagnostic performances. Purpose To evaluate diagnostic performances of supplemental breast US screening for women with PHBC and to compare with those for women without PHBC. Material and Methods Between 2011 and 2012, 12,230 supplemental US exams were performed in 12,230 women with negative mammograms: 6584 women with PHBC and 5646 women without PHBC. Cancer detection rate, interval cancer rate, abnormal interpretation rate, positive predictive values (PPVs), sensitivity, and specificity were calculated and compared. Results Overall cancer detection rate and first-year interval cancer rate were 1.80/1000 exams and 0.91/1000 negative exams, both of which were higher in women with PHBC than in women without PHBC (2.88 vs. 0.53 per 1000, P = 0.003; 1.50 vs. 0.20 per 1000, P = 0.027). Abnormal interpretation rate was lower in the women with PHBC than in women without PHBC (9.1% vs. 12.1%, P < 0.001). Sensitivity was not different (67.9% vs. 75.0%, P = 1.000), whereas specificity and PPV3 were higher in women with PHBC than in women without PHBC (91.2% vs. 88.0%, P < 0.001; 22.6% vs. 3.1%, P < 0.001). The majority of detected cancers in women with PHBC (78.9%, 15/19) were stage 0 or 1. Conclusion Supplemental breast US screening increases early stage second breast cancers with high specificity and PPV3 in women with PHBC, however, high interval cancer rate in younger women with PHBC should be noted.

Interval colorectal cancers after negative faecal immunochemical test in a 13-year screening programme

2020 ◽  
pp. 096914132091861
Author(s):  
Manuel Zorzi ◽  
Cesare Hassan ◽  
Carlo Senore ◽  
Giulia Capodaglio ◽  
Anna Turrin ◽  
...  
Keyword(s):  
Rate Ratio ◽  
Large Population ◽  
Interval Cancer ◽  
Colorectal Cancers ◽  
Cancer Rate ◽  
Faecal Immunochemical Test ◽  
Test Sensitivity ◽  
Interval Cancer Rate ◽  
Proportion Method ◽  
Immunochemical Test

Objective To assess faecal immunochemical test sensitivity for cancer in a very large population-based cohort followed up for six rounds with biennial faecal immunochemical test repetition. Methods This study is based on interval colorectal cancers diagnosed in a cohort of subjects aged 50–69 undergoing repeated faecal immunochemical test screening (six rounds) from 2002 to 2015. Test sensitivity was calculated using both the Proportional Interval Cancer Rate and the Interval Cancer Proportion method. Results Among 441,647 faecal immunochemical tests (123,347 individuals), 150 interval colorectal cancers were detected after a negative faecal immunochemical test. Interval colorectal cancer incidence rate was 1.87 per 10,000 person-years (95%CI: 1.60–2.20), and it was higher during the second interval year (rate ratio: 1.78; 95%CI: 1.28–2.47), for proximal locations (rate ratio: 3.00; 95%CI: 1.92–4.68), and among 60–71 year old subjects (rate ratio: 2.37; 95%CI: 1.61–3.50). The Proportional Interval Cancer Rate was 13.1%, with an overall faecal immunochemical test sensitivity of 86.9% (95%CI: 84.7–89.0). Sensitivity was lowest at the first round (81.5%; 95%CI: 75.6–86.2), and increased to 91.9% (95%CI: 83.9–96.5) for subsequent rounds. Applying the Interval Cancer Proportion method, sensitivity was 83.9% (95%CI: 81.3–86.2), and it was highest at the first round (89.0%; 95%CI: 85.7–91.6), ranging between 73% and 83.1% at subsequent rounds. Conclusions A faecal immunochemical test sensitivity for cancer higher than 80% resulted in a low incidence of interval colorectal cancers, representing an accurate estimate of one of the major limits of screening programmes. Due to intrinsic biases, the Proportional Interval Cancer Rate and the Interval Cancer Proportion methods generated different trends in faecal immunochemical test sensitivity by screening round.

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