scholarly journals Managing of Unassigned Mass Spectrometric Data by Neural Network for Cancer Phenotypes Classification

2021 ◽  
Vol 11 (12) ◽  
pp. 1288
Author(s):  
Denis V. Petrovsky ◽  
Arthur T. Kopylov ◽  
Vladimir R. Rudnev ◽  
Alexander A. Stepanov ◽  
Liudmila I. Kulikova ◽  
...  
Keyword(s):  
Neural Network ◽  
Neural Networks ◽  
Ovarian Cancer ◽  
Kidney Cancer ◽  
Distance Matrix ◽  
Mass Spectrometric ◽  
Weak Efficiency ◽  
Spectrometric Data ◽  
Cancer Phenotypes

Mass spectrometric profiling provides information on the protein and metabolic composition of biological samples. However, the weak efficiency of computational algorithms in correlating tandem spectra to molecular components (proteins and metabolites) dramatically limits the use of “omics” profiling for the classification of nosologies. The development of machine learning methods for the intelligent analysis of raw mass spectrometric (HPLC-MS/MS) measurements without involving the stages of preprocessing and data identification seems promising. In our study, we tested the application of neural networks of two types, a 1D residual convolutional neural network (CNN) and a 3D CNN, for the classification of three cancers by analyzing metabolomic-proteomic HPLC-MS/MS data. In this work, we showed that both neural networks could classify the phenotypes of gender-mixed oncology, kidney cancer, gender-specific oncology, ovarian cancer, and the phenotype of a healthy person by analyzing ‘omics’ data in ‘mgf’ data format. The created models effectively recognized oncopathologies with a model accuracy of 0.95. Information was obtained on the remoteness of the studied phenotypes. The closest in the experiment were ovarian cancer, kidney cancer, and prostate cancer/kidney cancer. In contrast, the healthy phenotype was the most distant from cancer phenotypes and ovarian and prostate cancers. The neural network makes it possible to not only classify the studied phenotypes, but also to determine their similarity (distance matrix), thus overcoming algorithmic barriers in identifying HPLC-MS/MS spectra. Neural networks are versatile and can be applied to standard experimental data formats obtained using different analytical platforms.

Classification of Alloys with an Artificial Neural Network and Multivariate Calibration of Glow-Discharge Emission Spectra

1991 ◽  
Vol 45 (10) ◽  
pp. 1706-1716 ◽  
Author(s):  
Mark Glick ◽  
Gary M. Hieftje
Keyword(s):  
Neural Network ◽  
Neural Networks ◽  
Glow Discharge ◽  
Multivariate Calibration ◽  
Emission Spectra ◽  
K Nearest Neighbor ◽  
The Neural Network ◽  
Calibration Sets ◽  
Artificial Neural

Artificial neural networks were constructed for the classification of metal alloys based on their elemental constituents. Glow discharge-atomic emission spectra obtained with a photodiode array spectrometer were used in multivariate calibrations for 7 elements in 37 Ni-based alloys (different types) and 15 Fe-based alloys. Subsets of the two major classes formed calibration sets for stepwise multiple linear regression. The remaining samples were used to validate the calibration models. Reference data from the calibration sets were then pooled into a single set to train neural networks with different architectures and different training parameters. After the neural networks learned to discriminate correctly among alloy classes in the training set, their ability to classify samples in the testing set was measured. In general, the neural network approach performed slightly better than the K-nearest neighbor method, but it suffered from a hidden classification mechanism and nonunique solutions. The neural network methodology is discussed and compared with conventional sample-classification techniques, and multivariate calibration of glow discharge spectra is compared with conventional univariate calibration.

Inclusion of Multiple Cycling of the Potential into Deep Neural Network Classification of Voltammetric Reaction Mechanisms

2021 ◽  
Author(s):  
Luke Gundry ◽  
Gareth Kennedy ◽  
Alan Bond ◽  
Jie Zhang
Keyword(s):  
Neural Network ◽  
Neural Networks ◽  
Reaction Mechanisms ◽  
Deep Neural Network ◽  
Deep Neural Networks ◽  
Neural Network Classification ◽  
Initial Cycle

The use of Deep Neural Networks (DNNs) for the classification of electrochemical mechanisms based on training with simulations of the initial cycle of potential have been reported. In this paper,...

N. Belknap's Four-Valued Logic, Belknap Computer and New Proximity Functions for Comparing Discrete Objects

2021 ◽  
Vol 1 (2 (6)) ◽  
Author(s):  
Valerii Dmitrienko ◽  
Sergey Leonov ◽  
Mykola Mezentsev
Keyword(s):  
Neural Network ◽  
Neural Networks ◽  
The Other ◽  
Proximity Function ◽  
Input Information ◽  
Proximity Measures ◽  
The One ◽  
True Values

The idea of ​​Belknap's four-valued logic is that modern computers should function normally not only with the true values ​​of the input information, but also under the conditions of inconsistency and incompleteness of true failures. Belknap's logic introduces four true values: T (true - true), F (false - false), N (none - nobody, nothing, none), B (both - the two, not only the one but also the other).  For ease of work with these true values, the following designations are introduced: (1, 0, n, b). Belknap's logic can be used to obtain estimates of proximity measures for discrete objects, for which the functions Jaccard and Needhem, Russel and Rao, Sokal and Michener, Hamming, etc. are used. In this case, it becomes possible to assess the proximity, recognition and classification of objects in conditions of uncertainty when the true values ​​are taken from the set (1, 0, n, b). Based on the architecture of the Hamming neural network, neural networks have been developed that allow calculating the distances between objects described using true values ​​(1, 0, n, b). Keywords: four-valued Belknap logic, Belknap computer, proximity assessment, recognition and classification, proximity function, neural network.

scholarly journals Analysis and classification of tem¬perature measurements during melting and casting of alloys using neural networks

2020 ◽  
Vol 63 (10) ◽  
pp. 856-861
Author(s):  
A. V. Fedosov ◽  
G. V. Chumachenko
Keyword(s):  
Neural Network ◽  
Neural Networks ◽  
Human Factor ◽  
High Efficiency ◽  
Thermal Conditions ◽  
Second Stage ◽  
Three Stages ◽  
Fully Automatic ◽  
Artificial Neural

The article considers the issues of monitoring the thermal conditions of alloys melting and casting at foundries. It is noted that the least reliable method is when the measurement and fixing the temperature is assigned to the worker. On the other hand, a fully automatic approach is not always available for small foundries. In this regard, the expediency of using an automated approach is shown, in which the measurement is assigned to the worker, and the values are recorded automatically. This method assumes implementation of an algorithm for automatic classification of temperature measurements based on an end-to-end array of data obtained in the production stream. The solving of this task is divided into three stages. Preparing of raw data for classification process is provided on the first stage. On the second stage, the task of measurement classification is solved by using neural network principles. Analysis of the results of the artificial neural network has shown its high efficiency and degree of their correspondence with the actual situation on the work site. It was also noted that the application of artificial neural networks principles makes the classification process flexible, due to the ability to easily supplement the process with new parameters and neurons. The final stage is analysis of the obtained results. Correctly performed data classification provides an opportunity not only to assess compliance with technological discipline at the site, but also to improve the process of identifying the causes of casting defects. Application of the proposed approach allows us to reduce the influence of human factor in the analysis of thermal conditions of alloys melting and casting with minimal costs for melting monitoring.

scholarly journals Pattern Recognition by Hierarchical Feature Extraction

2003 ◽  
Vol 15 (3) ◽  
pp. 278-285
Author(s):  
Daigo Misaki ◽  
◽  
Shigeru Aomura ◽  
Noriyuki Aoyama
Keyword(s):  
Neural Network ◽  
Neural Networks ◽  
Pattern Recognition ◽  
Feature Extraction ◽  
Input Data ◽  
Local Features ◽  
Detailed Classification

We discuss effective pattern recognition for contour images by hierarchical feature extraction. When pattern recognition is done for an unlimited object, it is effective to see the object in a perspective manner at the beginning and next to see in detail. General features are used for rough classification and local features are used for a more detailed classification. D-P matching is applied for classification of a typical contour image of individual class, which contains selected points called ""landmark""s, and rough classification is done. Features between these landmarks are analyzed and used as input data of neural networks for more detailed classification. We apply this to an illustrated referenced book of insects in which much information is classified hierarchically to verify the proposed method. By introducing landmarks, a neural network can be used effectively for pattern recognition of contour images.

scholarly journals DESIGN INFORMATION SYSTEM OF EMPLOYEES TARGET WITH NEURAL NETWORK BACKPROPAGATION

2018 ◽  
Vol 2 (1) ◽  
pp. 5
Author(s):  
Agus Sifaunajah ◽  
Kusworo Adi ◽  
Faikhin .
Keyword(s):  
Neural Network ◽  
Neural Networks ◽  
Information System ◽  
Information Systems ◽  
Data Collection ◽  
Data Classification ◽  
Civil Servants ◽  
Web Based ◽  
Design Information

Assessment of the performance of civil servants (PNS) is still considered less objective and subjective tended to by some, so we need a solution to improve the objectivity of assessment. The target of employee work (SKP) is one solution to improve objectivity in the assessment of civil servants. Backpropagation is one of the methods in neural networks which is implemented in the information systems of SKP for used classification of data performance. Observation and literature became the method of data collection in this study. Web-based information systems of skp are facilitated for employees in the preparation of assessments. Backpropagation can be implemented to perform data classification of performance. Keyword: Neural network; Backpropagation, Classification, SKP Received: 2 February, 2017; Accepter: 15 March, 2017

An Artificial Neural Network Classification of Prescription Nonadherence

2020 ◽  
pp. 487-501
Author(s):  
Steven Walczak ◽  
Senanu R. Okuboyejo
Keyword(s):  
Neural Network ◽  
Neural Networks ◽  
Healthcare Providers ◽  
Classification Model ◽  
Survey Method ◽  
Neural Network Classification ◽  
Treatment Plans ◽  
Ann Models ◽  
Artificial Neural

This study investigates the use of artificial neural networks (ANNs) to classify reasons for medication nonadherence. A survey method is used to collect individual reasons for nonadherence to treatment plans. Seven reasons for nonadherence are identified from the survey. ANNs using backpropagation learning are trained and validated to produce a nonadherence classification model. Most patients identified multiple reasons for nonadherence. The ANN models were able to accurately predict almost 63 percent of the reasons identified for each patient. After removal of two highly common nonadherence reasons, new ANN models are able to identify 73 percent of the remaining nonadherence reasons. ANN models of nonadherence are validated as a reliable medical informatics tool for assisting healthcare providers in identifying the most likely reasons for treatment nonadherence. Physicians may use the identified nonadherence reasons to help overcome the causes of nonadherence for each patient.

scholarly journals A Novel Method for Sea-Land Clutter Separation Using Regularized Randomized and Kernel Ridge Neural Networks

Sensors ◽  
2020 ◽  
Vol 20 (22) ◽  
pp. 6491
Author(s):  
Le Zhang ◽  
Jeyan Thiyagalingam ◽  
Anke Xue ◽  
Shuwen Xu
Keyword(s):  
Neural Network ◽  
Machine Learning ◽  
Neural Networks ◽  
Classification Accuracy ◽  
Signal Amplitude ◽  
Statistical Characteristics ◽  
Support Vector ◽  
Amplitude Change ◽  
Novel Method

Classification of clutter, especially in the context of shore based radars, plays a crucial role in several applications. However, the task of distinguishing and classifying the sea clutter from land clutter has been historically performed using clutter models and/or coastal maps. In this paper, we propose two machine learning, particularly neural network, based approaches for sea-land clutter separation, namely the regularized randomized neural network (RRNN) and the kernel ridge regression neural network (KRR). We use a number of features, such as energy variation, discrete signal amplitude change frequency, autocorrelation performance, and other statistical characteristics of the respective clutter distributions, to improve the performance of the classification. Our evaluation based on a unique mixed dataset, which is comprised of partially synthetic clutter data for land and real clutter data from sea, offers improved classification accuracy. More specifically, the RRNN and KRR methods offer 98.50% and 98.75% accuracy, outperforming the conventional support vector machine and extreme learning based solutions.

Neural Networks for the Classification of Benign and Malignant Patters in Digital Mammograms

2006 ◽  
pp. 251-272 ◽  
Author(s):  
Brijesh Verma ◽  
Rinku Panchal
Keyword(s):  
Neural Network ◽  
Neural Networks ◽  
Feature Extraction ◽  
Digital Mammography ◽  
Extensive Review ◽  
Benchmark Database ◽  
Feature Extraction And Selection ◽  
Recent Developments ◽  
Artificial Neural Network Ann

This chapter presents neural network-based techniques for the classification of micro-calcification patterns in digital mammograms. Artificial neural network (ANN) applications in digital mammography are mainly focused on feature extraction, feature selection, and classification of micro-calcification patterns into ‘benign’ and ‘malignant’. An extensive review of neural network based techniques in digital mammography is presented. Recent developments such as auto-associators and evolutionary neural networks for feature extraction and selection are presented. Experimental results using ANN techniques on a benchmark database are described and analysed. Finally, a comparison of various neural network-based techniques is presented.

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