scholarly journals 4-[(2-Hydroxy-4-pentadecyl-benzylidene)-amino]-benzoic Acid Methyl Ester

Molbank ◽  
10.3390/m810 ◽  
2013 ◽  
Vol 2013 (4) ◽  
pp. M810
Author(s):  
Gadada Naganagowda ◽  
Sanjit Mahato ◽  
Reinout Meijboom ◽  
Amorn Petsom
Keyword(s):  
Methyl Ester ◽  
Benzoic Acid ◽  
Acid Methyl Ester ◽  
Acid Methyl ◽  
Amino Benzoic Acid

scholarly journals Arylsulfonamides From the Roots and Rhizomes of Tupistra chinensis Baker

2020 ◽  
Vol 15 (4) ◽  
pp. 1934578X2092166
Author(s):  
Yue Xu ◽  
Xiaofei Liang ◽  
Yuze Li ◽  
Zhuofei Liang ◽  
Wenli Huang ◽  
...  
Keyword(s):  
Benzoic Acid ◽  
Cell Lines ◽  
Human Cancer ◽  
Acid Methyl Ester ◽  
Spectroscopic Methods ◽  
Tumor Cell Lines ◽  
Human Cancer Cell Lines ◽  
Acid Methyl ◽  
Amino Benzoic Acid

One new arylsulfonamide (1) and a novel natural product (2) were isolated from the roots and rhizomes of Tupistra chinensis Baker. Their structures were characterized by physicochemical properties and spectroscopic methods, as 2-[2-([1,1′-biphenyl]-4-ylsulfonylamino)-benzoylamino]-benzoic acid methyl ester (1), 2-[([1,1′-biphenyl]-4-ylsulfonyl)amino]-benzoic acid (2), respectively. Additionally, the cytotoxic activity of 1-2 was evaluated on human HCT116, HT29, A549, and H1299 tumor cell lines in vitro, respectively. Whereas, the result showed that these compounds displayed weak cytotoxicity in the human cancer cell lines.

Derivate des Benzo[1.3]dioxols, 431 Über Benzo [1.3] dioxolcarbonsäuren / Derivatives of 1,3-Benzodioxoles, 43 1,3-Benzodioxolecarboxylic Acids

1978 ◽  
Vol 33 (7-8) ◽  
pp. 465-471
Author(s):  
Franz Daliacker ◽  
Volker Mues ◽  
In-O Kim
Keyword(s):  
Carboxylic Acid ◽  
Methyl Ester ◽  
Benzoic Acid ◽  
Myristic Acid ◽  
Good Yield ◽  
Acid Ester ◽  
Acid Methyl Ester ◽  
Acid Methyl ◽  
Derivatives Of

Abstract We describe the possibilities of formation and preparation of the “natural” 1,3-benzodioxolecarboxylic acids 1, 2, 4, 6 b, and 7, already mentioned in literature. Myristic acid (3e) was prepared in good yield from 3-methoxy-4,5-dihydroxy-benzoic acid ester (3c) , which could be easily made from 3-methoxy-2,3-carbonyldioxy-benzoic acid methylester (3b). Myristicic acid methylester (3d) could be subjected to methylation and hydrolysis leading to 3e without any difficulties. 4.6-dimethoxy-1,3-benzodioxole-5-carboxylic acid (5b) was prepared in good yields by oxidation of 4,6-dimethoxy-1,3-benzodioxole-5-aldehyde (5a). 5.7-dimethoxy-1,3-benzodioxole-carboxylic acid (13f), one of the “unnatural” 1,3-benzodioxolecarboxylic acids, derivatives of o-ipiperonylic acid (8), was prepared from 5-amino-7-methoxy-1,3- benzodioxole-4carboxylic acid methyl ester (13b) by diazotisation, elimination of nitrogen, methylation, and hydrolysis. A comparison of our measured pkA-values showed the strongest acidity belonging to 5,6-dimethoxy-1,3-benzodioxole-4-carbocylic acid (11).

Mechanismen der elektronenstoßinduzierten Methanoleliminierung aus ortho- und para-substituierten Benzoesäuremethylestern / Mechanisms of Electron Impact Induced Elimination of Methanol from ortho- and para-Substituted Benzoic Acid Methyl Ester

1976 ◽  
Vol 31 (6) ◽  
pp. 870-875 ◽  
Author(s):  
Rupert Herrmann ◽  
Helmut Schwarz
Keyword(s):  
Mass Spectrometry ◽  
Methyl Ester ◽  
Benzoic Acid ◽  
Electron Impact ◽  
Acid Methyl Ester ◽  
Ring Expansion ◽  
Acid Methyl ◽  
Π Complex ◽  
Fragmentation Reactions ◽  
Ring Expansion Reaction

Using deuterium labelled compounds the mechanisms of methyl as well as methanol elimination from the title compounds have been established. It can be shown that in the case of 4-methoxy-methyl benzoic acid methyl ester the unusual methanol elimination from the [M-methyl]+ ion probably proceeds via the formation of a π-complex and a ring expansion reaction. In addition to this novel fragmentation some ortho-effects and other fragmentation reactions useful for an analytical identification of the ortho/para-isomers by means of mass spectrometry are discussed.

scholarly journals Novel Agents against Miltefosine-Unresponsive Leishmania donovani

2015 ◽  
Vol 59 (12) ◽  
pp. 7826-7829 ◽  
Author(s):  
Mousumi Das ◽  
Gundappa Saha ◽  
Anil K. Saikia ◽  
Vikash Kumar Dubey
Keyword(s):  
Methyl Ester ◽  
Visceral Leishmaniasis ◽  
Benzoic Acid ◽  
Leishmania Donovani ◽  
Acid Methyl Ester ◽  
Novel Agents ◽  
Oral Drug ◽  
Endemic Disease ◽  
Acid Methyl

ABSTRACTVisceral leishmaniasis is a deadly endemic disease. Unresponsiveness to the only available oral drug miltefosine poses a big challenge for the chemotherapy of the disease. We report a novel molecule, PS-203 {4-(4,4,8-trimethyl-7-oxo-3-oxabicyclo[3.3.1]non-2-yl)-benzoic acid methyl ester}, as effective against a miltefosine-unresponsive strain of the parasite. Further, combinations of PS-203 with miltefosine were also evaluated and showed promising results against a miltefosine-unresponsive strain.

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