scholarly journals Stationary Phases for Green Liquid Chromatography

Materials ◽  
2022 ◽  
Vol 15 (2) ◽  
pp. 419
Author(s):  
Mikołaj Dembek ◽  
Szymon Bocian
Keyword(s):  
Liquid Chromatography ◽  
Organic Waste ◽  
Review Paper ◽  
Stationary Phases ◽  
Pure Water ◽  
Pharmaceutical Research ◽  
New Materials ◽  
New Methods ◽  
Separation Temperature ◽  
Aqueous Conditions

Industrial research, including pharmaceutical research, is increasingly using liquid chromatography techniques. This involves the production of large quantities of hazardous and toxic organic waste. Therefore, it is essential at this point to focus interest on solutions proposed by so-called “green chemistry”. One such solution is the search for new methods or the use of new materials that will reduce waste. One of the most promising ideas is to perform chromatographic separation using pure water, without organic solvents, as a mobile phase. Such an approach requires novel stationary phases or specific chromatographic conditions, such as an elevated separation temperature. The following review paper aims to gather information on stationary phases used for separation under purely aqueous conditions at various temperatures.

scholarly journals Chiral Stationary Phases for Liquid Chromatography: Recent Developments

Molecules ◽  
2019 ◽  
Vol 24 (5) ◽  
pp. 865 ◽  
Author(s):  
Joana Teixeira ◽  
Maria Elizabeth Tiritan ◽  
Madalena M. M. Pinto ◽  
Carla Fernandes
Keyword(s):  
Particle Size ◽  
Liquid Chromatography ◽  
High Performance ◽  
Stationary Phases ◽  
Chiral Stationary Phases ◽  
Development Strategies ◽  
New Materials ◽  
Different Types ◽  
Recent Developments ◽  
Synthetic Approaches

The planning and development of new chiral stationary phases (CSPs) for liquid chromatography (LC) are considered as continuous and evolutionary issues since the introduction of the first CSP in 1938. The main objectives of the development strategies were to attempt the improvement of the chromatographic enantioresolution performance of the CSPs as well as enlarge their versatility and range of applications. Additionally, the transition to ultra-high-performance LC were underscored. The most recent strategies have comprised the introduction of new chiral selectors, the use of new materials as chromatographic supports or the reduction of its particle size, and the application of different synthetic approaches for preparation of CSPs. This review gathered the most recent developments associated to the different types of CSPs providing an overview of the relevant advances that are arising on LC.

Hydrophilic Interaction Liquid Chromatography (HILIC): Latest Applications in the Pharmaceutical Researches

2020 ◽  
Vol 16 ◽  
Author(s):  
Cem Erkmen ◽  
Weldejeworgıs Hndeya Gebrehiwot ◽  
Bengi Uslu
Keyword(s):  
Liquid Chromatography ◽  
Stationary Phases ◽  
Pharmaceutical Research ◽  
Polar Compounds ◽  
Separation Method ◽  
Hydrophilic Interaction Liquid Chromatography ◽  
Animal Origin ◽  
Hydrophilic Interaction ◽  
Mobile Phases ◽  
Phase Liquid

Background: Significant advances have been occurred in analytical research since the 1970s by liquid chromatography (LC) as the separation method. Reverse phase liquid chromatography (RPLC) method, using hydrophobic stationary phases and polar mobile phases is the most commonly used chromatographic method. However, it is difficult to analyze some polar compounds with this method. Another separation method, normal phase liquid chromatography (NPLC), which involves polar stationary phases with organic eluents. NPLC presents low-efficiency separations and asymmetric chromatographic peak shapes when analyzing polar compounds. Hydrophilic interaction liquid chromatography (HILIC) is an interesting and promising alternative method for the analysis of polar compounds. HILIC is be defined a separation method which combines stationary phases used in the NPLC method and mobile phases used in RPLC method. HILIC can be successfully applied to all types of liquid chromatographic separations such as pharmaceutical compounds, small molecules, metabolites, drugs of abuse, carbohydrates, toxins, oligosaccharides, peptides, amino acids and proteins. Objective: This paper provides a general overview of the recent application of HILIC in the pharmaceutical research in the different sample matrices such as pharmaceutical dosage form, plasma, serum, environmental samples, animal origin samples, plant origin samples, etc. Also, this review focuses on the most recent and selected papers in the drug research from 2009 to submission date in 2020 dealing with the analysis of different components using HILIC. Results and Conclusion: The literature survey showed that HILIC applications are increasing every year in pharmaceutical research. It was found that HILIC allows simultaneous analysis of many compounds using different detectors.

scholarly journals Development and Application of a Novel Pluri-Residue Method to Determine Polar Pesticides in Fruits and Vegetables through Liquid Chromatography High Resolution Mass Spectrometry

Foods ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 553
Author(s):  
Lorena Manzano-Sánchez ◽  
José Antonio Martínez-Martínez ◽  
Irene Domínguez ◽  
José Luis Martínez Vidal ◽  
Antonia Garrido Frenich ◽  
...  
Keyword(s):  
Liquid Chromatography ◽  
High Resolution ◽  
High Performance ◽  
Fruits And Vegetables ◽  
High Resolution Mass Spectrometry ◽  
Stationary Phases ◽  
Mean Values ◽  
Polar Pesticides ◽  
Relative Standard ◽  
The Matrix

Nowadays, highly polar pesticides are not included in multiresidue methods due to their physico-chemical characteristics and therefore, specific analytical methodologies are required for their analysis. Laboratories are still looking for a pluri-residue method that encompasses the largest number of polar pesticides. The aim of this work was the simultaneous determination of ethephon, 2-hydroxyethylphosphonic acid (HEPA), fosetyl aluminum, glyphosate, aminomethylphosphonic acid (AMPA), N-acetyl-glyphosate and N-acetyl-AMPA in tomatoes, oranges, aubergines and grapes. For that purpose, an ultra high performance liquid chromatography (UHPLC) coupled to a high resolution single mass spectrometer Orbitrap-MS were used. Different stationary phases were evaluated for chromatographic separation, and among them, the stationary phase Torus DEA provided the best separation of the selected compounds. The QuPPe method was used for the extraction of the analytes, but slight modifications were needed depending on the matrix. The developed method was validated, observing matrix effect in all matrices. Intra- and inter-day precision were estimated, and relative standard deviation were lower than 19%. Recoveries were satisfactory, and mean values ranged from 70% to 110%. Limits of quantification were between 25 and 100 µg kg−1. Finally, the analytical method was applied to different fruits and vegetables (oranges, tomatoes, aubergines and grapes).

Carboxylated cyclofructan 6 as a hydrolytically stable high efficiency stationary phase for hydrophilic interaction liquid chromatography and mixed mode separations

2016 ◽  
Vol 8 (31) ◽  
pp. 6038-6045 ◽  
Author(s):  
Yadi Wang ◽  
M. Farooq Wahab ◽  
Zachary S. Breitbach ◽  
Daniel W. Armstrong
Keyword(s):  
Liquid Chromatography ◽  
Benzoic Acid ◽  
Stationary Phase ◽  
Mixed Mode ◽  
High Efficiency ◽  
Stationary Phases ◽  
Hydrophilic Interaction Liquid Chromatography ◽  
Hydrophilic Interaction

Stationary phases composed of native cyclofructan 6 (CF6) and benzoic acid modified CF6 were synthesized and evaluated for hydrophilic interaction liquid chromatography (HILIC).

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