scholarly journals Candidemia in an intensive care unit

Medicina ◽  
2008 ◽  
Vol 45 (5) ◽  
pp. 351
Author(s):  
Dalia Adukauskienė ◽  
Aida Kinderytė ◽  
Asta Dambrauskienė ◽  
Astra Vitkauskienė
Keyword(s):  
Intensive Care Unit ◽  
Mechanical Ventilation ◽  
Risk Factor ◽  
Intensive Care ◽  
Urinary Bladder ◽  
Intensive Care Units ◽  
Severe Disease ◽  
Candida Spp ◽  
Lethal Outcome ◽  
Bladder Catheter

Candidemia is becoming more actual because of better survival of even critically ill patients, wide use of antimicrobials, and increased numbers of invasive procedures and manipulations. Diagnosis of candidemia remains complicated, and costs of treatment and mortality rates are increasing. Objective. To evaluate the pathogens of candidemia, risk factors and their influence on outcome. Material and methods. Data of 41 patients with positive blood culture for Candida spp., who were treated in the intensive care units at the Hospital of Kaunas University of Medicine, were analyzed retrospectively. Results. Candidemia was caused by Candida albicans (C. albicans) in 48.8% (n=20) of patients and by non-albicans Candida in 51.2% (n=21) of patients. The main cause of candidemia was C. albicans in 2004 (83.3%, n=5), but in 2005 (63.6%, n=7), in 2006 (57.1%, n=4), and in 2007 (52.9%, n=9), the main cause was non-albicans Candida spp. The number of candidemia cases caused by C. albicans was decreased in 2005, 2006, and 2007 as compared with 2004, and the number of candidemia caused by non-albicans Candida spp. was decreased, respectively (P<0.05). More than 65% (n=34) of patients had severe disease (P<0.05). Lethal outcome was recorded in 58.5% of patients with candidemia. Mechanical ventilation was used in 76.9% (n=20) and urinary bladder catheter in 72.1% (n=19) of non-survivors and in 23.1% (n=6) and 26.9% (n=7) of survivors, respectively (P<0.05). Conclusions. There is an increase in the prevalence of candidemia in the intensive care units during the 4-year period; half of candidemia cases were caused by non-albicans Candida spp., and patients with candidemia caused by non-albicans Candida spp. are at higher risk of mortality. Therefore, for the empirical treatment of septic conditions in an intensive care unit, when invasive fungal infection is suspected, we recommend using an antifungal agent of non-azole class until a pathogen of candidemia is determined. Severe disease is evaluated as a risk factor for candidemia. Patients with oncological diseases are at significantly higher risk for candidemia caused by non-albicans Candida spp. Use of mechanical ventilation and urinary bladder catheter is a risk factor for lethal outcome.

scholarly journals Modifiable risk factors of ventilator-associated pneumonia in non-intensive care unit versus intensive care unit

2021 ◽  
Vol 15 (10) ◽  
pp. 1471-1480
Author(s):  
Patpong Udompat ◽  
Daravan Rongmuang ◽  
Ronald Craig Hershow
Keyword(s):  
Intensive Care Unit ◽  
Mechanical Ventilation ◽  
Risk Factor ◽  
Intensive Care ◽  
Intensive Care Units ◽  
Proton Pump ◽  
Multidrug Resistant ◽  
Surgical Intensive Care Unit ◽  
Ventilator Associated Pneumonia ◽  
Neurosurgical Patients

Introduction: Ventilator-associated pneumonia patients are treated in non-intensive care units because of a shortage of intensive care unit beds in Thailand. Our objective was to assess whether the type of unit and medications prescribed to the patient were associated with ventilator‑associated pneumonia and multidrug resistant ventilator‑associated pneumonia. Methodology: A matched case-control study nested in a prospective cohort of mechanical ventilation adult patients in a medical-surgical intensive care unit and five non-intensive care units from March 1 through October 31, 2013. The controls were randomly selected 1:1 with cases and matched based on duration and start date of mechanical ventilation. Results: 248 ventilator-associated pneumonia and control patients were analyzed. The most common bacteria were multidrug resistant Acinetobacter baumannii (82.4%). Compared with patients in the intensive care unit, those in the neurosurgical/surgical non-intensive care units were at higher risk (p = 0.278). Proton pump inhibitor was a risk factor (p = 0.011), but antibiotic was a protective factor (p = 0.054). Broad spectrum antibiotic was a risk factor (p < 0.001) for multidrug resistant ventilator-associated pneumonia. Conclusions: Post-surgical and neurosurgical patients treated in non-intensive care unit settings were at the highest risk of ventilator-associated pneumonia. Our findings suggest that alternative using proton pump inhibitors should be considered based on the risk-benefit of using this medication. In addition, careful stewardship of antibiotic use should be warranted to prevent multidrug resistant ventilator-associated pneumonia.

scholarly journals Risk factors for severity of COVID-19: a rapid review to inform vaccine prioritisation in Canada

BMJ Open ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. e044684
Author(s):  
Aireen Wingert ◽  
Jennifer Pillay ◽  
Michelle Gates ◽  
Samantha Guitard ◽  
Sholeh Rahman ◽  
...  
Keyword(s):  
Risk Factors ◽  
Intensive Care Unit ◽  
Mechanical Ventilation ◽  
Risk Factor ◽  
Intensive Care ◽  
Low Income ◽  
Severe Disease ◽  
Male Gender ◽  
Rapid Review ◽  
Class Iii

ObjectivesRapid review to determine the magnitude of association between potential risk factors and severity of COVID-19, to inform vaccine prioritisation in Canada.SettingOvid MEDLINE(R) ALL, Epistemonikos COVID-19 in L·OVE Platform, McMaster COVID-19 Evidence Alerts and websites were searched to 15 June 2020. Eligible studies were conducted in high-income countries and used multivariate analyses.ParticipantsAfter piloting, screening, data extraction and quality appraisal were performed by a single experienced reviewer. Of 3740 unique records identified, 34 were included that reported on median 596 (range 44–418 794) participants, aged 42–84 years. 19/34 (56%) were good quality.OutcomesHospitalisation, intensive care unit admission, length of stay in hospital or intensive care unit, mechanical ventilation, severe disease, mortality.ResultsAuthors synthesised findings narratively and appraised the certainty of the evidence for each risk factor–outcome association. There was low or moderate certainty evidence for a large (≥2-fold) magnitude of association between hospitalisation in people with COVID-19, and: obesity class III, heart failure, diabetes, chronic kidney disease, dementia, age >45 years, male gender, black race/ethnicity (vs non-Hispanic white), homelessness and low income. Age >60 and >70 years may be associated with large increases in mechanical ventilation and severe disease, respectively. For mortality, a large magnitude of association may exist with liver disease, Bangladeshi ethnicity (vs British white), age >45 years, age >80 years (vs 65–69 years) and male gender among 20–64 years (but not older). Associations with hospitalisation and mortality may be very large (≥5-fold) for those aged ≥60 years.ConclusionsIncreasing age (especially >60 years) may be the most important risk factor for severe outcomes. High-quality primary research accounting for multiple confounders is needed to better understand the magnitude of associations for severity of COVID-19 with several other factors.PROSPERO registration numberCRD42020198001.

scholarly journals TRAQUEOSTOMÍA TEMPRANA VS TARDÍA EN PACIENTES NEUROQUIRÚRGICOS INTERNADOS EN UNA UNIDAD DE CUIDADOS INTENSIVOS.

2020 ◽  
Vol 5 (4) ◽  
pp. 12
Author(s):  
Freiser Eceomo Cruz Mosquera ◽  
Nathaly Erazo Builes ◽  
Juan Camilo Angulo Cano ◽  
María Paula Solarte-Roa ◽  
Daniel Mauricio Muñoz Piamba ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Mechanical Ventilation ◽  
Intensive Care ◽  
Statistical Analysis ◽  
Intensive Care Units ◽  
Total Sample ◽  
Early Tracheostomy ◽  
Neurosurgical Patients ◽  
Clinical Benefits ◽  
The City

Introducción: Los pacientes neurocríticos por lo general requieren periodos largos de ventilación mecánica, en ese contexto la traqueostomía es un procedimiento frecuente que se realiza para facilitar el destete de la ventilación y se asocia a múltiples beneficios; sin embargo, el momento de su realización sigue siendo objeto de debate. Objetivo: determinar los beneficios clínicos   de la traqueostomía temprana vs la tardía en los pacientes neurocríticos que ingresan a una unidad de cuidados intensivos (UCI) polivalente de una institución de salud de la ciudad de Cali. Metodología: investigación observacional, descriptiva, de serie de casos que incluyó pacientes neuroquirúrgicos, mayores de edad que ingresaron a una UCI durante el periodo 2016 -2018; a partir de la muestra total se estipularon dos grupos: traqueostomía temprana (≤ 9 días) y traqueostomía tardía (≥10 días).  El análisis estadístico se realizó en el programa SPSS versión 24. Resultados: Se incluyeron 20 sujetos con edad de 51.9±17 años, 10 fueron asignados al grupo de traqueostomía temprana y 10 al grupo den traqueostomía tardía. Se evidenció que los pacientes con traqueostomía temprana tienen menos días de sedación (10±2.1 vs 16±9; p=0.02) y los 3 casos que fallecieron habían sido traqueostomizados tardíamente. Conclusiones: La traqueostomía temprana puede traer beneficios clínicos a los pacientes neuroquirúrgicos que ingresan a unidades de cuidados intensivos.                                                                                                                   Palabras claves: Traqueostomía, unidades de cuidados intensivos, paciente, ventilación mecánica. ABSTRACT Introduction: Neurocritical patients generally require long periods of mechanical ventilation. In this context, tracheostomy is a frequent procedure performed to facilitate weaning from ventilation and is associated with multiple benefits; however, the timing of its implementation remains under debate. Objective: to determine the clinical benefits of early vs late tracheostomy in neurocritical patients admitted to a polyvalent intensive care unit (ICU) of a health institution in the city of Cali. Methodology: observational, descriptive investigation of a series of cases that included neurosurgical patients, of legal age who were admitted to an ICU during the period 2016 -2018; From the total sample, two groups were stipulated: early tracheostomy (≤ 9 days) and late tracheostomy (≥10 days). Statistical analysis was performed using SPSS version 24. Results: 20 subjects with an age of 51.9 ± 17 years were included, 10 were assigned to the early tracheostomy group and 10 to the late tracheostomy group. It was evidenced that patients with early tracheostomy had fewer days of sedation (10±2.1 vs 16± 9; p= 0.02) and the 3 cases that died had been tracheostomized late. Conclusions: Early tracheostomy can bring clinical benefits to neurosurgical patients admitted to intensive care units. Keywords: Tracheostomy, intensive care units, patient, mechanic ventilation.

scholarly journals The Negative Impact of Obesity on the Occurrence and Prognosis of the 2019 Novel Coronavirus (COVID-19) Disease: A Systematic Review and Meta-Analysis

2020 ◽  
Author(s):  
Tahereh Raeisi ◽  
Hadis Mozaffari ◽  
Nazaninzahra Sepehri ◽  
Mohammad Alizadeh ◽  
Mina Darand ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Mechanical Ventilation ◽  
Risk Factor ◽  
Intensive Care ◽  
Clinical Outcomes ◽  
Meta Analysis ◽  
Clinical Care ◽  
Icu Admission ◽  
Prevalence Of Obesity ◽  
Novel Coronavirus

Abstract Background: the 2019 novel coronavirus (COVID-19) is an emerging pandemic, with a disease course varying from asymptomatic infection to critical disease resulting to death. Recognition of prognostic factors is essential because of its growing prevalence and high clinical costs. This meta-analysis aimed to evaluate the global prevalence of obesity in COVID-19 patients and to investigate whether obesity is a risk factor for the COVID-19, COVID-19 severity, and its poor clinical outcomes including hospitalization, intensive care unit (ICU) admission, need for mechanical ventilation, and mortality.Methods: The study protocol was registered on to PROSPERO (CRD42020203386). A systematic search of Scopus, Medline, and Web of Sciences was conducted on June 2020, to find pertinent studies. After selection, 54 studies from 10 different countries were included in the quantitative analyses. Pooled odds ratios (OR) with 95% confidence intervals (CIs) were calculated to assess the associations. Results: The prevalence of obesity was 33% (95% CI, 30.0%–35.0%) among patients with COVID-19. Obesity was significantly associated with susceptibility to COVID-19 (OR=2.42, 95% CI: 1.58 to 3.70; moderate certainty) and COVID-19 severity (OR=1.62, 95% CI: 1.48 to 1.76; low certainty). Furthermore, obesity was a significant risk factor for hospitalization (OR=1.75, 95% CI: 1.47 to 2.09; very low certainty), mechanical ventilation (OR=2.24, 95% CI: 1.70 to 2.94; low certainty), intensive care unit (ICU) admission (OR=1.75, 95% CI: 1.38 to 2.22; low certainty), and death (OR=1.23, 95% CI: 1.06 to 1.41; low certainty) in COVID-19 patients. In the subgroup analyses, these associations were supported by the majority of subgroups. Conclusions: Obesity is associated with COVID-19 and its poor clinical outcomes. Thus, it is highly recommended to consider obesity status in prognostic scores and improvement of guidelines for the clinical care of patients with COVID-19.

scholarly journals Perfusion Abnormalities Shown On Subtraction CT Angiography In Apparently Normal Lungs And Their Impact On Patient Outcome. A Prospective Cohort Study: What Could We Be Missing?

2021 ◽  
Author(s):  
Mario G. Santamarina ◽  
Felipe Martinez Lomakin ◽  
Ignacio Beddings ◽  
Dominique Boisier Riscal ◽  
Jose Chang Villacís ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Mechanical Ventilation ◽  
Risk Factor ◽  
Intensive Care ◽  
Clinical Outcomes ◽  
Ct Angiography ◽  
Independent Risk Factor ◽  
Invasive Mechanical Ventilation ◽  
Tertiary Care ◽  
Increased Risk

Abstract Background: COVID-19 pneumonia seems to affect the regulation of pulmonary perfusion. In this study, through iodine distribution maps obtained with subtraction CT angiography, we quantified and analyzed perfusion abnormalities in patients with COVID-19 pneumonia and correlated them with clinical outcomes.Methods: 205 patients were included in this cohort, from two different tertiary-care hospitals in Chile. All patients had RT-PCR confirmed SARS-CoV-2 infection. CT scans were performed within 24 h of admission, in supine position. Airspace compromise was assessed with CT severity score, and the extension of hypoperfusion in apparently healthy lung parenchyma with perfusion score. CT severity and perfusion scores were then correlated with clinical outcomes. Multivariable analyses using Cox Proportional Hazards regression were used to control for clinical confounders.Results: Fourteen patients were excluded due to uninterpretable images. This left 191 patients, 112 males and 79 females. The mean age was 60.8±16.0 years. The median SOFA score on admission was 2 and average PaFi ratio was 250±118. Patients with severe perfusion abnormalities showed significantly higher SOFA scores and lower Pa/Fi ratios when compared to individuals with mild or moderate anomalies. Severe perfusion abnormalities were associated with an increased risk of intensive care unit (ICU) admission and the requirement of invasive mechanical ventilation (IMV).Conclusion: Patients with severe perfusion anomalies have a higher risk of admission to the ICU and IMV. Perfusion alterations could be considered as an independent risk factor in patients with COVID-19 pneumonia.Summary Statement: Lung perfusion abnormalities in patients with COVID-19 pneumonia were associated with admission to Intensive Care Unit and requirement of invasive mechanical ventilation. Perfusion abnormalities could be considered as an independent risk factor in patients with COVID-19 pneumonia.

Some more parameters of utilization of intensive care units in Hungary

2011 ◽  
Vol 152 (45) ◽  
pp. 1813-1817
Author(s):  
Miklós Gresz
Keyword(s):  
Intensive Care Unit ◽  
Mechanical Ventilation ◽  
Intensive Care ◽  
Intensive Care Units ◽  
Mechanically Ventilated ◽  
Mechanically Ventilated Patients ◽  
Institutional Level ◽  
National Network ◽  
Direct Discharge ◽  
Ventilated Patients

According to the “Semmelweis plan for saving health care”, „the capacity of the national network of intensive care units in Hungary is one but not the only bottleneck of emergency care at present”. In an earlier report the author showed, on the basis of data reported to the health insurance that not in a single calendar day more than 75% of beds in intensive care units were occupied. There were about 15 to 20 thousand sick days which could be considered unnecessary, because patients occupying these beds were discharged to their homes directly from the intensive care unit. This study examines the functioning of intensive care units partly at the institutional level. The author shows how the number of days using mechanical ventilation and the number of direct discharges to the home of patients have changed, and proves that those institutions where the proportion of direct discharge to home so overnursing of patients was high, the rate of mechanically ventilated patients was low. Orv. Hetil., 2011, 152, 1813–1817.

scholarly journals The case of severe botulism: artificial ventilation of lungs for 127 days

2013 ◽  
Vol 18 (6) ◽  
pp. 49-57
Author(s):  
V. V. Nikiforov ◽  
Yu. N Tomilin ◽  
A. V. Davydov ◽  
P. E Zimin ◽  
O. I Aleynikova
Keyword(s):  
Mechanical Ventilation ◽  
Intensive Care ◽  
Detailed Analysis ◽  
Intensive Care Units ◽  
Hospital Discharge ◽  
Artificial Ventilation ◽  
Severe Disease ◽  
Course Of Disease ◽  
Hospital Beds ◽  
First Admission

Botulism is a rare but extremely severe disease being difficult to treat and often leading to the death. In this context, undoubted interest is the detailed analysis of the course of disease in a patient with severe botulism, who in the course of therapy in total (from first admission to hospital discharge) spent totally on hospital beds (considering staying in various hospital) 152 days, including in intensive care units - 145 days, out of which 127 days - on a ventilator (the first 93 days of treatment there was carried out in the mode of mechanical ventilation IPPV, the next 34 days there was carried out intermittent mechanical ventilation in mode of BiPaP).

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