scholarly journals Breast Cancer Epidemiology among Lebanese Women: An 11-Year Analysis

Medicina ◽  
2019 ◽  
Vol 55 (8) ◽  
pp. 463 ◽  
Author(s):  
Mohamad Y. Fares ◽  
Hamza A. Salhab ◽  
Hussein H. Khachfe ◽  
Hassan M. Khachfe
Keyword(s):  
Breast Cancer ◽  
Cancer Incidence ◽  
Breast Cancer Incidence ◽  
Age Groups ◽  
Incidence Rates ◽  
Genetic Profile ◽  
World Population ◽  
Annual Percent Change ◽  
Cancer Data ◽  
The World

Background and Objectives: Breast cancer is the most prevalent cancer in women worldwide. Lebanon is a developing country in the Middle East with a prominent breast cancer incidence. The aim of our study was to explore the incidence rates of breast cancer in Lebanon from 2005 to 2015, and compare them to the rates of other countries. Materials and Methods: Breast cancer data for the years 2005–2015 was collected from the National Cancer Registry of Lebanon and stratified by gender and age group. Age-specific and age-standardized incidence rates were calculated and analyzed using joinpoint regression. Age-standardized incidence rates in the world population (ASR(w)) were obtained for other countries, from two online databases. Results: Breast cancer was found to be the most prevalent cancer in Lebanon, accounting for 20% of all cancer cases. The average ASR(w) was 96.5 per 100,000. Over the studied period, breast cancer ASR(w) in Lebanon showed a significantly increasing trend with an annual percent change (APC) of +4.6. Moreover, the APC of breast cancer age-specific rates significantly increased for the age groups 45–49 (p = 0.013), 50–54 (p < 0.001), 55–59 (p = 0.001), 60–64 (p = 0.002), 65–69 (p = 0.003), 70–74 (p < 0.001), and 75+ years (p < 0.001). Lebanon had the highest breast cancer ASR(w), when compared to other regional countries, and trailed only behind Denmark, when compared to selected countries from different parts of the world. Conclusions: Breast cancer incidence in Lebanon is among the highest in the world. Future studies should focus on exploring the genetic profile of the Lebanese population in an aim to extrapolate proper prevention guidelines.

Stage migration in breast cancer: Better detection or semantics in staging?

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e18800-e18800
Author(s):  
Leah Elson ◽  
Nadeem Bilani ◽  
Hong Liang ◽  
Elizabeth Blessing Elimimian ◽  
Diana Saravia ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Incidence ◽  
Late Stage ◽  
Early Stage ◽  
Breast Cancer Incidence ◽  
Incidence Rates ◽  
Information Criteria ◽  
Stage Migration ◽  
Cancer Data ◽  
Best Fit

e18800 Background: As oncology treatment has evolved to become more individualized, prognostic rationale has also undergone important changes. In breast cancer, disease staging was historically based upon anatomic features of the primary tumor, in combination with involvement of adjacent/distant tissues. However, as the understanding of molecular/genomic involvement became more advanced, staging definitions were redefined to incorporate receptors, histologic grade, and genetic expression. In this analysis, we use autoregressive integrated moving average (ARIMA) forecasting to understand how AJCC updates to prognostic definitions have contributed to stage migration, and to comment on whether better detection, or definitional changes, may be responsible for the increasing incidence in early stage breast cancer. Methods: In this time series forecast, ARIMA models, per stage (early: stage I/II vs. late: stage III/IV) were constructed based on 2004-2016 historic breast cancer incidence rates, as reported by the NCDB. Multiple models were generated, using differing autoregressive parameters; the most predictive model was chosen using the lowest Bayesian Information Criteria (BIC), and mean absolute percentage error (MAPE) to ensure best fit. Similar methodology has already been published to predict prostate cancer incidence. The best fit models were applied to forecast annual incidence, in the NCDB, in 2017. These data were compared to the real-world data captured in 2017. Statistics were performed using modeling systems in SPSS, version 27. Results: n=1,661,971 cases were included for these models, and 12 years of pre-AJCC updated NCDB breast cancer data were used. Using ARIMA modeling, best fit, stationary averages were identified, with autoregressive and difference terms which contributed to the lowest BIC, and MAPE < 5%, for both models. The best fit models forecasted 2017 incidence, by stage, without AJCC updates to staging criteria, and this data is compared to actual 2017 incidence with current updated AJCC 8th staging criteria (Table). Conclusions: During 2017, the first year of AJCC staging updates, there was an observed decrease in late stage diagnoses, and increase in early stage diagnoses, when compared with incidence rates that were forecasted using the old, anatomic AJCC criteria. Therefore, part of the stage migration noted may be a product of staging semantics, using updated definitions. Confirming appropriate improvement in long-term outcomes, based on new staging would be helpful. It is also important for clinicians and public health officials to bear this in-mind when interpreting epidemiologic data, for allocating resources, as shifts in staging may be a product of guideline changes, and not necessarily screening efficacy or early detection only.[Table: see text]

scholarly journals Trends in Breast Cancer Incidence Rates by Age and Stage at Diagnosis in Gharbiah, Egypt, over 10 Years (1999–2008)

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Kelly A. Hirko ◽  
Amr S. Soliman ◽  
Ahmed Hablas ◽  
Ibrahim A. Seifeldin ◽  
Mohamed Ramadan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Incidence ◽  
Breast Cancer Incidence ◽  
Incidence Rates ◽  
Stage At Diagnosis ◽  
Treatment Needs ◽  
Annual Percent Change ◽  
Cancer Occurrence ◽  
Health Transitions ◽  
Cancer Incidence Rates

Background. This study was undertaken to evaluate trends in breast cancer incidence in Egypt from 1999 to 2008 and to make projections for breast cancer occurrence for the years 2009–2015.Patients and Methods. We utilized joinpoint regression and average annual percent change (AAPC) measures with 95% confidence intervals (CI) to describe the trends in breast cancer incidence rates from the Gharbiah Cancer Registry by age and stage at diagnosis and to estimate expected breast cancer caseloads for 2009–2015.Results. From 1999 to 2008, the AAPC in breast cancer incidence rates in Gharbiah significantly increased among women 50 years and older and among localized tumors (AAPC %, 95% CI, 3.1% to 8.0%). Our results predict a significant increase in breast cancer caseloads from 2009 to 2015 among women aged 30–39 (AAPC %, 95% CI, 0.9% to 1.1%) and among women aged 40–49 years (AAPC %, 95% CI, 1.0% to 2.6%).Conclusion. These results have important implications for allocating limited resources, managing treatment needs, and exploring the consequences of prior interventions and/or changing risk factors in Egypt and other developing countries at the same stages of demographic and health transitions.

scholarly journals National and Subnational Incidence, Mortality, and Years of Life Lost Due to Breast Cancer in Iran: Trends and Age-Period-Cohort Analysis Since 1990

2021 ◽  
Vol 11 ◽  
Author(s):  
Bahar Ataeinia ◽  
Sahar Saeedi Moghaddam ◽  
Mahsima Shabani ◽  
Kimiya Gohari ◽  
Ali Sheidaei ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Care ◽  
Cancer Incidence ◽  
Cohort Analysis ◽  
Breast Cancer Incidence ◽  
Age Groups ◽  
Years Of Life Lost ◽  
Annual Percent Change ◽  
Low Middle Income Countries

Breast cancer is the most common cancer among women, causing considerable burden and mortality. Demographic and lifestyle transitions in low and low-middle income countries have given rise to its increased incidence. The successful management of cancer relies on evidence-based policies taking into account national epidemiologic settings. We aimed to report the national and subnational trends of breast cancer incidence, mortality, years of life lost (YLL) and mortality to incidence ratio (MIR) since 1990. As part of the National and Subnational Burden of Diseases project, we estimated incidence, mortality and YLL of breast cancer by sex, age, province, and year using a two-stage spatio-temporal model, based on the primary dataset of national cancer and death registry. MIR was calculated as a quality of care indicator. Age-period-cohort analysis was used to distinguish the effects of these three collinear factors. A significant threefold increase in age-specific incidence at national and subnational levels along with a twofold extension of provincial disparity was observed. Although mortality has slightly decreased since 2000, a positive mortality annual percent change was detected in patients aged 25–34 years, leading to raised YLLs. A significant declining pattern of MIR and lower provincial MIR disparity was observed. We observed a secular increase of breast cancer incidence. Further evaluation of risk factors and developing national screening policies is recommended. A descending pattern of mortality, YLL and MIR at national and subnational levels reflects improved quality of care, even though mortality among younger age groups should be specifically addressed.

scholarly journals Breast cancer incidence among women of Branicevo region in the period 1991 - 2000

2004 ◽  
Vol 57 (9-10) ◽  
pp. 467-472 ◽  
Author(s):  
Sandra Sipetic ◽  
Vesna Petrovic ◽  
Zorica Milic ◽  
Hristina Vlajinac
Keyword(s):  
Breast Cancer ◽  
Incidence Rate ◽  
Cancer Incidence ◽  
Breast Cancer Incidence ◽  
Female Breast Cancer ◽  
Incidence Rates ◽  
Cancer Incidence Rate ◽  
Breast Cancer Incidence Rate ◽  
Female Breast ◽  
The World

Introduction Breast cancer is the most common type of cancer in women, the second leading cause of cancer death, and the third most common cancer overall, throughout the world. In 1996, 910.000 new cases were diagnosed worldwide (about 9% of all new cases). Over 50% of breast cancer incidence occurred in the developed world. The aims of this study were to study breast cancer incidence during 1991-2000 in the region of Branicevo and to analyze differences in incidence rate for breast cancer in two periods of time 1991-1991 and 1996-2000. Material and methods This was a descriptive study. Routine national incidence data were used from the Republic Statistical Office. The analysis was restricted to the region of Branicevo. Age adjustment of annual incidence rates was carried out using five-year intervals and the distribution of the World population by Sega as the standard. Results A total of 542 women affected with breast cancer were evidenced in the Region of Branicevo during the period 1991- 2000, accounting for 25.3% of all malignant cases. Over the studied ten-year period the average standardized incidence rate (1:100,000) for breast cancer was 27.4. Based on the average age-specific incidence rates (1:100,000) female breast cancer was least frequently evidenced in women up to 34 years of age, while it was most frequent in groups aged 45 - 49 and 70 - 74 years. Over the period 1991-1995, female breast cancer accounted for 32.0% and in the period 1996-2000 for 22.2% of all mlignancies, with the average standardized incidence rates (1:100,000) being 22.5% and 32.4%, respectively. Discussion The average standardized incidence rate (1:100,000) for breast cancer was 27.4, which is similar to the rates evidenced in Eastern European countries, such as Poland (38.7), Slovakia (34.5), Hungary (29.6), Romania (31.1), Belarus (24.7) and Russia (40.6). Increase of breast cancer incidence rate, evidenced in the Region of Branicevo, is also evidenced in most countries with previously low incidence rates. Increase of breast cancer incidence rate is also detected in our neighboring countries, Bulgaria and Slovenia. Conclusions An increasing trend of breast cancer incidence rate was evidenced in the Region of Branicevo over the period 1991 - 2000, partially due to well kept registries and partially due to actual increase in the number of patients affected with malignant diseases.

scholarly journals Age-specific incidence rates of breast cancer among Japanese women increasing in a conspicuous bimodal distribution pattern

2020 ◽  
pp. 201010582094889
Author(s):  
Nanami Tokutake ◽  
Riona Ushiyama ◽  
Kyoka Matsubayashi ◽  
Yuji Aoki
Keyword(s):  
Breast Cancer ◽  
Distribution Pattern ◽  
Postmenopausal Women ◽  
Cancer Incidence ◽  
Breast Cancer Incidence ◽  
Age Groups ◽  
Bimodal Distribution ◽  
Japanese Women ◽  
Incidence Rates ◽  
Cancer Incidence Rates

Breast cancer incidence rates are increasing in East and Southeast Asia, along with the westernisation of reproductive and lifestyle patterns. Such westernisation is thought to be involved in the cumulative exposure of breast tissue to both endogenous and exogenous oestrogen. Immigrant studies among Asian American women indicate that risk factors for breast cancer can be modified. When breast cancer incidence rates were compared with those of corpus uteri and colon among Japanese women in 2005, 2010 and 2015, it is of note that age-specific incidence rates of breast cancer in 5-year age groups clearly increased during the 10-year period in a bimodal distribution pattern, with two peaks in the 45–49 and 60–64 years age groups. From the relevant literature, it is inferred that the low prevalence of obesity and the intake of soy products or isoflavones among Japanese women may contribute to the bimodal distribution pattern by suppressing the extent of increase in breast cancer incidence rates among Japanese postmenopausal women. With regard to dietary habits relating to obesity, it has been globally reported that the intake of high-calorie foods is associated with the incidence of oestrogen receptor-positive breast cancer in both pre- and postmenopausal women, while high-carbohydrate or -milk intake that can enhance the secretion of insulin or insulin-like growth factor 1 is associated with that of oestrogen receptor-negative breast cancer mostly in postmenopausal women. Studies are needed to clarify the aetiology or modifiable factors behind the bimodal incidence rates of breast cancer among Japanese women.

scholarly journals Global Burden of Female Breast Cancer: Age-period-cohort Analysis of Incidence Trends from 1990 to 2019 and Forecasts for 2035

2021 ◽  
Author(s):  
Yizhen Li ◽  
Jinxin Zheng ◽  
Yujiao Deng ◽  
Xinyue Deng ◽  
Weiyang Lou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cohort Analysis ◽  
Breast Cancer Incidence ◽  
Female Breast Cancer ◽  
Incidence Rates ◽  
Global Burden ◽  
World Population ◽  
Uncertainty Interval ◽  
Incidence Trends ◽  
Female Breast

Abstract Background This study aimed to describe the latest epidemiology of female breast cancer globally, analyze the change pattern of the incidence rates and the disease’s association with age, period, and birth cohort, and subsequently present a forecast of breast cancer incidence.Methods Data for analysis were obtained from Global Burden of Disease (GBD) Study 2019 and World Population Prospects 2019 revision by the United Nations (UN). We described the age-standardized incidence rates (ASIRs) from 1990 to 2019 and then calculated the relative risks of period and cohort using an age-period-cohort model, and predicted the trends of ASIRs to 2035.Results In 2019, the global incidence of breast cancer in women increased to 1,977,212 (95% uncertainty interval = 1 807 615 to 2 145 215), with an ASIR of 45.86 (41.91 to 49.76) per 100 000 persons. Among the six selected countries facing burdensome ASIRs, only the USA showed a downward trend from 1990 to 2019, whereas the others showed an increasing or stable trend. The overall net drift was similar in Japan (1.78%), India (1.66%), and Russia (1.27%), reflecting increasing morbidity from 1990 to 2019. The increase in morbidity was particularly striking in China (2.60%) and not significant in Germany (0.42%). The ASIRs were predicted to continue to increase globally, from 45.26 in 2010 to 47.36 in 2035. In most countries and regions, the age specific incidence rate is the highest in those aged over 70 years and will increase in all age groups until 2035. In high-income regions, the age specific incidence rates are expected to decline in women aged over 50 years. Conclusions The global burden of female breast cancer is becoming more serious, especially in developing countries. Raising awareness of the risk factors and prevention strategies for female breast cancer is necessary to reduce future burden.

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