scholarly journals Chronometric vs. Structural Hypercoagulability

Medicina ◽  
2020 ◽  
Vol 57 (1) ◽  
pp. 13
Author(s):  
Carmen Delianu ◽  
Mihaela Moscalu ◽  
Loredana Liliana Hurjui ◽  
Claudia Cristina Tărniceriu ◽  
Oana-Viola Bădulescu ◽  
...  

Prolonged tourniquet stasis induced by venepuncture can lead to the release of the plasma of cell lysis products, as well as tissue factor (TF), impairing the quality of coagulation test results. The accidental presence of TF in vitro can trigger the coagulation mechanism, generating a false decrease in prothrombin time (PT). Background and Objectives: Identification of short PT tests below the normal reference value that could suggest a situation of hypercoagulability. The study aimed to compare the results of the shortened PT tests at their first determination with the eventual correction following duplication of the analysis from the same sample. Materials and methods: Identification of the shortened PT tests has been carried out for a period of 4 months, upon 544 coagulation samples referred to the Hematology department of Sf. Spiridon County Clinical Emergency Hospital from Iasi, Romania. Results: Out of the 544 samples of which the results indicated a state of hypercoagulability, by repeating the determination from the same sample, for 200 (36.76%) PT tests (p = 0.001) the value was corrected, falling within the normal reference range. For 344 (63.24%) tests, the results suggested a situation of hypercoagulability. Conclusions: In order to guarantee the highest quality of the laboratory services, a proper interpretation and report of the patients’ results must be congruent and harmoniously associated to the actual clinical condition of the patient. Duplication of the PT determination from the same sample would exclude situations of false hypercoagulability and would provide significant improvement for the patient’s safety.

2014 ◽  
Vol 5 (1) ◽  
pp. 19-22
Author(s):  
Md Tahminur Rahman ◽  
Tabassum Tahmin Sajani ◽  
Rosy Sultana ◽  
Sohel Reza Choudhury ◽  
Md Mahmudur Rahman Siddiqui

Prostate specific antigen (PSA) is an important tool for the diagnosis, prognosis and follow up of prostatic cancer, the most common malignancy of the male throughout the world. It is safe, reliable, specific, noninvasive test if done properly. However there are many benign, inflammatory and other prostatic conditions which can also give rise to elevated PSA value and thus limits its use. Different methods of estimation may also give rise to variable PSA level. More over the normal reference range may be variable depending on the age, geographic situation, environmental conditions and other factors. The normal reference range mentioned in the texts is based on findings in the developed countries. No effort was made before to see the normal reference PSA value among Bangladeshi male population. With this background the present study was undertaken to determine the normal reference value of PSA in Bangladeshi population. It is evident form the present study that the normal reference PSA value for Bangladeshi male in different age groups are lower in comparison to that of upper limit of normal reference value mentioned in the text. DOI: http://dx.doi.org/10.3329/akmmcj.v5i1.18766 Anwer Khan Modern Medical College Journal Vol. 5, No. 1: January 2014, Pages 19-22


2003 ◽  
Vol 23 (5-6) ◽  
pp. 305-312 ◽  
Author(s):  
Ge Miao

In order to supply a scientific basis for uniting the normal reference value standard of hemoglobin of Chinese older boys. Methods: A research is made about the relationship between the normal reference value of 14751 examples of hemoglobin of older boys and five geographical factors in 92 areas in China, which are determined by the hemoglobincyanide method. Results: It is found that the correlation of geographical factors and the normal reference value of hemoglobin of older boys are quite significant (F = 9.68). By using the method of multiple linear regression analysis, one regression equation is inferred: Ŷ = 108.0 + 0.003633X1 + 0.003945X2 + 0.1680X3 − 0.6310X4 + 0.005518X5 ± 8.3 Conclusion: If geographical values are obtained in some areas, the normal reference value of hemoglobin of older boys of this area can be reckoned by using the regression equation. Furthermore, the depending on the geographical factors, China can be divided into six districts: Qingzang, Southwest, Northwest, Southeast, North and Northeast district.


Materials ◽  
2019 ◽  
Vol 12 (18) ◽  
pp. 2994 ◽  
Author(s):  
Genghua Cao ◽  
Lu Zhang ◽  
Datong Zhang ◽  
Yixiong Liu ◽  
Jixiang Gao ◽  
...  

This research mainly focuses on the successful fabrication of nano-hydroxyapatite (nHA) reinforced WE43 alloy by two-pass friction stir processing (FSP). Microstructure evolution, mechanical properties, and in vitro corrosion behavior of FSPed WE43/nHA composite and FSPed WE43 alloy were studied. The results show that nHA particles are effectively dispersed in the processing zone, and the well-dispersed nHA particles can enhance the grain refine effect of FSP. The average grain sizes of FSPed WE43 alloy and WE43/nHA composite are 5.7 and 3.3 μm, respectively. However, a slight deterioration in tensile strength and yield strength is observed on the WE43/nHA composite, compared to the FSPed WE43 alloy, which is attributed to the locally agglomerated nHA particles and the poor quality of interfacial bonding between nHA particles and matrix. The electrochemical test and in vitro immersion test results reveal that the corrosion resistance of the WE43 alloy is greatly improved after FSP. With the addition of nHA particles, the corrosion resistance of the WE43/nHA composite shows an even greater improvement.


2013 ◽  
Vol 48 (12) ◽  
pp. 1449-1454 ◽  
Author(s):  
Miao Ge ◽  
Linlin Gu ◽  
Jinwei He ◽  
Ranyin Xue ◽  
Shaofang Yang ◽  
...  

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