scholarly journals Hyperpolarized 13C Magnetic Resonance Spectroscopic Imaging of Pyruvate Metabolism in Murine Breast Cancer Models of Different Metastatic Potential

Metabolites ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 274
Author(s):  
Erin B. Macdonald ◽  
Paul Begovatz ◽  
Gregory P. Barton ◽  
Sarah Erickson-Bhatt ◽  
David R. Inman ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Blood Glucose ◽  
Lactate Dehydrogenase ◽  
Metastatic Potential ◽  
Magnetic Resonance Spectroscopic Imaging ◽  
Glycolytic Metabolism ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Ldh Activity ◽  
Cancer Models

This study uses dynamic hyperpolarized [1-13C]pyruvate magnetic resonance spectroscopic imaging (MRSI) to estimate differences in glycolytic metabolism between highly metastatic (4T1, n = 7) and metastatically dormant (4T07, n = 7) murine breast cancer models. The apparent conversion rate of pyruvate-to-lactate (kPL) and lactate-to-pyruvate area-under-the-curve ratio (AUCL/P) were estimated from the metabolite images and compared with biochemical metabolic measures and immunohistochemistry (IHC). A non-significant trend of increasing kPL (p = 0.17) and AUCL/P (p = 0.11) from 4T07 to 4T1 tumors was observed. No significant differences in tumor IHC lactate dehydrogenase-A (LDHA), monocarboxylate transporter-1 (MCT1), cluster of differentiation 31 (CD31), and hypoxia inducible factor-α (HIF-1α), tumor lactate-dehydrogenase (LDH) activity, or blood lactate or glucose levels were found between the two tumor lines. However, AUCL/P was significantly correlated with tumor LDH activity (ρspearman = 0.621, p = 0.027) and blood glucose levels (ρspearman = −0.474, p = 0.042). kPL displayed a similar, non-significant trend for LDH activity (ρspearman = 0.480, p = 0.114) and blood glucose levels (ρspearman = −0.414, p = 0.088). Neither kPL nor AUCL/P were significantly correlated with blood lactate levels or tumor LDHA or MCT1. The significant positive correlation between AUCL/P and tumor LDH activity indicates the potential of AUCL/P as a biomarker of glycolytic metabolism in breast cancer models. However, the lack of a significant difference between in vivo tumor metabolism for the two models suggest similar pyruvate-to-lactate conversion despite differing metastatic potential.

scholarly journals 339P Impact of blood glucose levels on the efficacy of everolimus-exemestane in patients with advanced HR-positive/HER2 negative breast cancer: The EVERMET study

2020 ◽  
Vol 31 ◽  
pp. S382-S383
Author(s):  
C. Vernieri ◽  
F. Nichetti ◽  
V. Guarneri ◽  
E. Cortesi ◽  
L. Moscetti ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels

Biochemical Effects of Oxygen at High Pressure in Rats

1973 ◽  
Vol 51 (9) ◽  
pp. 673-678 ◽  
Author(s):  
E. W. Banister ◽  
A. J. Davison ◽  
N. M. G. Bhakthan ◽  
C. Asmundson
Keyword(s):  
High Pressure ◽  
Alkaline Phosphatase ◽  
Blood Glucose ◽  
Lactate Dehydrogenase ◽  
Nadh Dehydrogenase ◽  
Krebs Cycle ◽  
Muscle Lactate ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Hyperbaric Conditions

Changes in brain and muscle lactate dehydrogenase, cytochrome oxidase, and NADH dehydrogenase (cytochrome c reductase) have been measured in rats convulsed by exposure to oxygen at high pressure 6 ATA (OHP). Blood glucose levels and some plasma and serum enzymes (lactate dehydrogenase, alkaline phosphatase, aspartate transaminase, and creatine kinase) were measured simultaneously. The lack of widespread inhibition of several markers for the glycolytic sequence, the Krebs cycle, or the cytochrome chain, together with elevated blood glucose levels in hyperoxia and increased blood alkaline phosphatase and lactate dehydrogenase in all hyperbaric conditions (and as well as oxygen), suggests tissue damage and a generalized etiology for the convulsive state.

scholarly journals Doenças crônicas não transmissíveis em mulheres com câncer de mama

2021 ◽  
Vol 11 (34) ◽  
pp. 100-109
Author(s):  
Lóris Aparecida Prado da Cruz ◽  
Mirele Savegnago Mialich ◽  
Bruna Ramos da Silva ◽  
Thais De Oliveira Gozzo ◽  
Alceu Afonso Jordão ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Waist Circumference ◽  
Arterial Hypertension ◽  
Cáncer De Mama ◽  
Blood Collection ◽  
Cross Sectional ◽  
Glucose Levels ◽  
Blood Glucose Levels

Identificar a ocorrência de obesidade, hipertensão arterial e níveis glicêmicos alterados entre mulheres com câncer de mama; avaliar a distribuição destas comorbidades em relação à idade, tempo de diagnóstico do câncer, circunferência da cintura, hormonioterapia e quimioterapia. Estudo transversal com 67 mulheres com câncer de mama. Utilizou-se um instrumento com variáveis sociodemográficas, clínicas, avaliações antropométricas e coleta de sangue para glicemia de jejum. Utilizou-se teste exato de Fisher, Mann-Whitney e Kruskal-Wallis. Dentre as participantes, 34,3% eram pré-obesas e 29,9% apresentavam parâmetros de obesidade leve a grave, 53,7% hipertensas e 20,9% diabéticas. Encontrou-se associação entre idade e hipertensão arterial; circunferência da cintura e hipertensão arterial; níveis glicêmicos e circunferência da cintura; índice de massa corpórea e circunferência da cintura; idade e diabetes mellitus; e idade e circunferência da cintura. Recomenda-se assistência que contemple ações sistematizadas integrando a avaliação e cuidados do câncer de mama e outras comorbidades.Descritores: Neoplasias Mamárias, Hipertensão, Obesidade, Glicemia. Chronic non-communicable diseases in women with breast cancerAbstract: To identify the occurrence of obesity, high blood pressure, and altered blood glucose levels among women with breast cancer; to evaluate the distribution of these comorbidities in relation to age, time since breast cancer diagnosis, waist circumference, hormone therapy, and chemotherapy. Cross-sectional study with 67 women with breast cancer. An instrument with sociodemographic and clinical variables, anthropometric assessments, and blood collection for fasting glucose was used. Fisher's exact test identified the relationship between qualitative variables and the Mann-Whitney and Kruskal-Wallis tests for continuous and categorical measures. Among the participants, 34.3% were pre-obese and 29.9% had parameters of mild to severe obesity, 53.7% were hypertensive and 20.9% were diabetic. An association was found between age and arterial hypertension; waist circumference and arterial hypertension; blood glucose levels and waist circumference; body mass index and waist circumference; age and diabetes mellitus; and age and waist circumference. The assistance that includes systematized actions is recommended, integrating the assessment and care that includes breast cancer and comorbidities.Descriptors: Mammary Neoplasms, Hypertension, Obesity, Glucose. Enfermedades crónicas no transmisibles en mujeres con cáncer de mamaResumen: Identificar la aparición de obesidad, hipertensión arterial y niveles alterados de glucosa en sangre entre las mujeres con cáncer de seno; evaluar la distribución de estas comorbilidades en relación con la edad, el tiempo transcurrido desde el diagnóstico de cáncer de mama, la circunferencia de la cintura, la terapia hormonal y la quimioterapia. Estudio transversal con 67 mujeres con cáncer de mama. Se utilizó un instrumento con variables sociodemográficas y clínicas, evaluaciones antropométricas y extracción de sangre para glucemia en ayunas. La prueba exacta de Fisher identificó la relación entre las variables cualitativas y las pruebas de Mann-Whitney y Kruskal-Wallis para medidas continuas y categóricas. Entre los participantes, 34.3% eran pre obesos y 29.9% tenían parámetros de obesidad leve a severa, 53.7% eran hipertensos y 20.9% eran diabéticos. Se encontró una asociación entre la edad y la hipertensión arterial; circunferencia de la cintura e hipertensión arterial; niveles de glucosa en sangre y circunferencia de la cintura; índice de masa corporal y circunferencia de la cintura; edad y diabetes mellitus; y edad y circunferencia de la cintura. Se recomienda asistencia que incluya acciones sistematizadas, integrando la evaluación y la atención que incluye el cáncer de mama y las comorbilidades.Descriptores: Neoplasias Mamarias, Hipertensión, Obesidad, Glucemia.

Intraoperative Changes in Blood Glucose Levels Increase the Risk of Death in Cardiac Surgery

2006 ◽  
Vol 31 (03) ◽  
Author(s):  
H Hager ◽  
E Giorni ◽  
A Felli ◽  
B Mora ◽  
M Hiesmayr ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Blood Glucose ◽  
Glucose Levels ◽  
Risk Of Death ◽  
Blood Glucose Levels

2167-PUB: Effect of Low-Available Carbohydrate Diet Containing Okara and Konjac on Blood Glucose Levels in Spontaneous Diabetic Torii Fatty Rats

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 2167-PUB
Author(s):  
KOHEI SURUGA ◽  
TSUYOSHI TOMITA ◽  
MASAKAZU KOBAYASHI ◽  
TADAHIKO MITSUI ◽  
KAZUNARI KADOKURA
Keyword(s):  
Blood Glucose ◽  
Carbohydrate Diet ◽  
Glucose Levels ◽  
Blood Glucose Levels

776-P: Characteristics of Overnight Blood Glucose Levels Are Related to Sleep Quality in People with Type 1 Diabetes

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 776-P
Author(s):  
RACHEL BRANDT ◽  
MINSUN PARK ◽  
LAURIE T. QUINN ◽  
MINSEUNG CHU ◽  
YOUNGKWAN SONG ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Blood Glucose ◽  
Sleep Quality ◽  
Glucose Levels ◽  
Blood Glucose Levels

Study of Diabetic Mellitus and Knowledge of Lotion Foot Care on the Community

2018 ◽  
Vol 9 (3) ◽  
Author(s):  
Hariyadi DM ◽  
Athiyah U ◽  
Hendradi E ◽  
Rosita N ◽  
Erawati T ◽  
...  
Keyword(s):  
Blood Glucose ◽  
T Test ◽  
Small Scale ◽  
Scale Production ◽  
Foot Care ◽  
Diabetic Mellitus ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Before And After ◽  
History Of

The prevention of Diabetic Mellitus (DM) and its complications is the main aim of this study, in addition to the training of lotion foot care application and the development of small scale industry. The research team delivered knowledge in the form of training on Diabetic Mellitus, healthy food, treatment and prevention of complications, and small-scale production of cosmetic products. The aim of this study was to determine the correlation between training on diabetic and lotion foot care application as preventive measures against diabetic complications on the patient's blood glucose levels in the community of residents in Banyuurip Jaya, Surabaya. It was expected from this training that the knowledge of the residents increases and people living with diabetic undergo lifestyle changes and therefore blood sugar levels can be controlled. The parameters measured in this research were blood glucose levels, the anti diabetic drug types consumed, and compliance on diabetics. This study used the data taken from 60 patients with DM over a period of one month. Questionnaires and log books was used to retrieve data and changes in blood glucose levels in diabetic patients. The results showed the demographic data of patients with type 2 diabetic of 85% female and 15% male, with the range of patients aged of 61-70 years of 46.67% and had history of diabetic (90%). The history of drugs consumed by respondents was anti diabetic drugs such as metformin (40%), glimepiride (33.37%) and insulin (6.67%). In addition, the increased knowledge of DM patients after being given the training compared to before training was shown in several questions in the questionnaire. A statistical analysis using t-test analyzed a correlation between training provided in order to enhance understanding of the patient, as well as correlation with blood glucose levels. A paired T-test showed that there was a relationship between the knowledge of trainees before and after training (p less than 0.05). An interesting result was that there was no relationship between blood glucose levels before and after training provided (p> 0.05).

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