scholarly journals Biosynthesis of Polyketides in Streptomyces

2019 ◽  
Vol 7 (5) ◽  
pp. 124 ◽  
Author(s):  
Chandra Risdian ◽  
Tjandrawati Mozef ◽  
Joachim Wink
Keyword(s):  
Secondary Metabolites ◽  
Structure And Function ◽  
Polyketide Synthases ◽  
Type I ◽  
Type Ii ◽  
Filamentous Form ◽  
Gram Positive Bacteria ◽  
Wide Range ◽  
Different Types ◽  
And Function

Polyketides are a large group of secondary metabolites that have notable variety in their structure and function. Polyketides exhibit a wide range of bioactivities such as antibacterial, antifungal, anticancer, antiviral, immune-suppressing, anti-cholesterol, and anti-inflammatory activity. Naturally, they are found in bacteria, fungi, plants, protists, insects, mollusks, and sponges. Streptomyces is a genus of Gram-positive bacteria that has a filamentous form like fungi. This genus is best known as one of the polyketides producers. Some examples of polyketides produced by Streptomyces are rapamycin, oleandomycin, actinorhodin, daunorubicin, and caprazamycin. Biosynthesis of polyketides involves a group of enzyme activities called polyketide synthases (PKSs). There are three types of PKSs (type I, type II, and type III) in Streptomyces responsible for producing polyketides. This paper focuses on the biosynthesis of polyketides in Streptomyces with three structurally-different types of PKSs.

scholarly journals Biosynthesis of Polyketides in Streptomyces

2018 ◽  
Author(s):  
Chandra Risdian
Keyword(s):  
Secondary Metabolites ◽  
Structure And Function ◽  
Polyketide Synthases ◽  
Type I ◽  
Type Ii ◽  
Filamentous Form ◽  
Gram Positive Bacteria ◽  
Wide Range ◽  
Different Types ◽  
And Function

Polyketides are large group of secondary metabolites that have notable variety in their structure and function. Polyketides exhibit a wide range of bioactivities such as antibacterial, antifungal, anticancer, antiviral, immune-suppressing, anti-cholesterol and anti-inflammatory activity. Naturally, they are found in bacteria, fungi, plants, protists, insects, mollusks and sponges. Streptomyces is a genus of Gram-positive bacteria that has a filamentous form like fungi. This genus is best known as one of polyketides producers. Some examples of polyketides produced by Streptomyces are rapamycin, oleandomycin, actinorhodin, daunorubicin and caprazamycin. Biosynthesis of polyketides involves a group of enzyme activities called polyketide synthases (PKSs). There are three types of PKSs (type I, type II, and type III) in Streptomyces that responsible for producing polyketides. This paper focuses on biosynthesis of polyketides in Streptomyces with three structurally different types of PKSs.

Dimeric/oligomeric DNA methyltransferases: an unfinished story

2009 ◽  
Vol 390 (9) ◽  
Author(s):  
Ernst G. Malygin ◽  
Alexey A. Evdokimov ◽  
Stanley Hattman
Keyword(s):  
Experimental Data ◽  
Dna Methyltransferases ◽  
Structure And Function ◽  
Type I ◽  
Type Ii ◽  
Kinetic Characteristics ◽  
Biological Substrate ◽  
Oligomeric Dna ◽  
And Function

Abstract DNA methyltransferases (MTases) are enzymes that carry out post-replicative sequence-specific modifications. The initial experimental data on the structure and kinetic characteristics of the EcoRI MTase led to the paradigm that type II systems comprise dimeric endonucleases and monomeric MTases. In retrospect, this was logical because, while the biological substrate of the restriction endonuclease is two-fold symmetrical, the in vivo substrate for the MTase is generally hemi-methylated and, hence, inherently asymmetric. Thus, the paradigm was extended to include all DNA MTases except the more complex bifunctional type I and type III enzymes. Nevertheless, a gradual enlightenment grew over the last decade that has changed the accepted view on the structure of DNA MTases. These results necessitate a more complex view of the structure and function of these important enzymes.

Immunological Determined Plasminogen Groups And Its Possible Biological Relevance

1981 ◽  
Author(s):  
V Sachs ◽  
R Dörner ◽  
E Szirmai
Keyword(s):  
Human Plasma ◽  
Type I ◽  
Type Ii ◽  
Precipitation Line ◽  
Gene Frequencies ◽  
Type Iii ◽  
Different Types ◽  
Human Plasminogen ◽  
Gel Diffusion ◽  
Good Agreement

Anti human plasminogen sera of the rabbit precipitate human plasma in the agar gel diffusion test by means of intra-basin absorption with plasminogenfree human plasma with three different types: type I is represented by one strong precipitation line, type II by two lines, a big one and a small one, and type III by three slight but distinct lines. The following frequencies of the different types have been observed in a sample of 516 human plasmas: type I 65%, type II 33% and type III 2%. Suppose the types are phenotypical groups of a diallelic system where the types I and III represent the homozygous genotypes and the type II the heterozygous the estimated gene frequencies are in good agreement with the expected values. There is also a good agreement of the distribution of plasminogen groups determined by electrofocussing from RAUM et al. and HOBART. The plasminogen groups possibly may have also a biological meaning because the plasmas of type III always have a lesser fibrinolytic activity than the plasmas of the other types.

Influence fast or later: two types of influencers in social networks

2021 ◽  
Author(s):  
Fang Zhou ◽  
Chang Su ◽  
Shuqi Xu ◽  
Linyuan Lü
Keyword(s):  
Final Stage ◽  
Early Stage ◽  
Large Fraction ◽  
Structure And Function ◽  
Spreading Process ◽  
Spreading Effect ◽  
Local Structures ◽  
Different Types ◽  
Small Set ◽  
And Function

Abstract In real-world networks, there usually exist a small set of nodes that play an important role in the structure and function of networks. Those vital nodes can influence most other nodes in the network via a spreading process. While most of the existing works focused on vital nodes that can maximize the spreading size in the final stage, which we call final influencers, recent work proposed the idea of fast influencers, which emphasizes nodes’ spreading capacity at the early stage. Despite the recent surge of efforts in identifying these two types of influencers in networks, there remained limited research on untangling the differences between fast influencers and final influencers. In this paper, we first distinguish the two types of influencers: fast-only influencers and final-only influencers. The former is defined as individuals who can achieve a high spreading effect at the early stage but lose their superiority in the final stage, and the latter are those individuals that fail to exhibit a prominent spreading performance at the early stage but influence a large fraction of nodes at the final stage. Further experiments based on eight empirical datasets, we reveal the key differences between the two types of influencers concerning their spreading capacity and the local structures. We also analyze how network degree assortativity influences the fraction of the proposed two types of influencers. The results demonstrate that with the increase of degree assortativity, the fraction of the fast-only influencers decreases, which indicates that more fast influencers tend to keep their superiority at the final stage. Our study provides insights into the differences and evolution of different types of influencers and has important implications for various empirical applications, such as advertisement marketing, and epidemic suppressing.

Regulation of sperm motility at the axonemal level

1995 ◽  
Vol 7 (4) ◽  
pp. 847 ◽  
Author(s):  
C Gagnon
Keyword(s):  
Direct Action ◽  
Mammalian Species ◽  
Basic Structure ◽  
Structure And Function ◽  
Structural Components ◽  
Long Period ◽  
Different Types ◽  
Radial Spokes ◽  
Dynein Arms ◽  
And Function

With very few exceptions, the basic structure of the 9+2 axoneme has been well preserved over a very long period of evolution from protozoa to mammais. This stability indicates that the basic structural components of the axoneme visible by electron microscopy, as well as most of the other unidentified components, have withstood the passage of time. It also means that components of the 9+2 axoneme have sufficient diversity in function to accommodate the various types of motility patterns encountered in different species of flagella. Several of the 200 polypeptides that constitute the axoneme have been identified as components of the dynein arms, radial spokes etc. but many more remain to be identified and their function(s) remain to be determined. Because this review deals with the regulation of flagellar movement at the axonemal level, it does not include regulation of flagella by extracellular factors unless these factors have a direct action on axonemal components. In this context, it is very important firstly to understand the structural components of the axoneme and how they influence and regulate axonemal movement. Different primitive organisms are mentioned in this review since major breakthroughs in our understanding of how an axoneme generates different types of movement have been made through their study. Despite some variations in structure and function of axonemal components, the basic mechanisms involved in the regulation of flagella from Chlamydomonas or sea urchin spermatozoa should also apply to the more evolved mammalian species, including human spermatozoa.

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