Enterococcal Infections the First Year after Liver—A Prospective Cohort Study

This study aimed to investigate the incidence of enterococcal infections and determine risk factors associated with enterococcal bloodstream infection (BSI) within the first year post-liver transplantation (LTx). We included 321 adult liver transplant recipients transplanted from 2011 to 2019 in a prospective cohort study. Cumulative incidence of enterococcal infections and risk factors associated with BSI were investigated in a competing risk model and time-updated Cox models, respectively. A total of 223 enterococcal infections were identified in 89 recipients. The cumulative incidences of first enterococcal infection and first enterococcal BSI were 28% (95% CI (23–33)) and 11% (CI (7–14)), respectively. Risk factors associated with enterococcal BSI were previous infections in the biliary tract (HR, 33; CI (15–74); p < 0.001), peritoneum (HR, 8.1; CI (3–23); p < 0.001) or surgical site (HR, 5.5; CI (1.4–22); p = 0.02), recipient age (HR per 10 years increase, 1.2; CI (1.03–1.6); p = 0.03), and cold ischemia time (HR per one hour increase, 1.2; CI (1.1–1.3); p < 0.01). Enterococcal infections are highly prevalent the first year post-LTx, and recipients with enterococcal infections in the biliary tract, peritoneum, or surgical site are at increased risk of BSI. These findings may have implications for the choice of empiric antibiotics early post-LTx.

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Risk factors associated with adverse outcomes in a population-based prospective cohort study of people with their first diabetic foot ulcer

Journal of Diabetes and its Complications ◽

10.1016/j.jdiacomp.2007.09.004 ◽

2007 ◽

Vol 21 (6) ◽

pp. 341-349 ◽

Cited By ~ 84

Author(s):

Kirsty Winkley ◽

Daniel Stahl ◽

Trudie Chalder ◽

Michael E. Edmonds ◽

Khalida Ismail

Keyword(s):

Risk Factors ◽

Cohort Study ◽

Prospective Cohort Study ◽

Diabetic Foot ◽

Prospective Cohort ◽

Foot Ulcer ◽

Diabetic Foot Ulcer ◽

Population Based ◽

Adverse Outcomes ◽

Factors Associated

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SYMPTOMS AND RISK FACTORS ASSOCIATED WITH FIRST UTI IN COLLEGE-AGED WOMEN: A PROSPECTIVE COHORT STUDY

The Journal of Urology ◽

10.1016/s0022-5347(09)60410-9 ◽

2009 ◽

Vol 181 (4S) ◽

pp. 142-142

Author(s):

Charles R Vincent ◽

Mary Brown ◽

Leticia Reyes ◽

Benjamin K Canales ◽

Keith Muller ◽

...

Keyword(s):

Risk Factors ◽

Cohort Study ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Factors Associated

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Epidemiological correlates with communicable viral co-infections of hepatitis B and hepatitis C and non-communicable diabetes among HIV ART naïve rural patients of Kanchipuram district: a prospective cohort study

International Journal of Community Medicine and Public Health ◽

10.18203/2394-6040.ijcmph20182949 ◽

2018 ◽

Vol 5 (8) ◽

pp. 3283

Author(s):

A. Kasthuri ◽

K. Mohana Krishnan ◽

S. K. Amsavathani

Keyword(s):

Risk Factors ◽

Cohort Study ◽

Hepatitis C ◽

Hepatitis B ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Diabetic Patients ◽

Increased Risk ◽

Significant Difference ◽

Onset Of Diabetes

Background: The objectives of the study were to study the epidemiological correlates of ART Naïve HIV cases; to study the incidence of co–infections among them; to find the incidence of onset of diabetes among them. Concomitant infection of hepatitis B virus, hepatitis C virus viruses leads to higher frequency of carrier state and severe manifestations of the disease in HIV patients. There is general agreement that the traditional risk factors for DM (increasing age, minority race, obesity) are still responsible for most of the increased risk in the HIV infected population.Methods: This study was designed as a prospective cohort study and was done at the Meenakshi Medical College & Research institute, an academic and Tertiary medical centre in Kanchipuram, Tamil Nadu, South India. The study duration was from June 2004 to June 2010. SPSS 13 was used in the calculation of chi-square and percentages.Results: Among 207 participants, mean age is 36.04 and the SD is 10.895. There is significant difference between the incidence of viral co-infections like hepatitis B and hepatitis C (p<0.001). There is significant difference between the incidence of onset of diabetes (p<0.001). The HbsAg and HCV co infection was comparatively lower than the urban population. Among the 50 HIV reactive, non diabetic patients without risk factors, only one found to be Diabetic and another found to be Pre diabetic after 6 months follow-up.Conclusions: The cost of treatment escalates, when PLHA is co-infected either with viral infections or diabetes, and also their quality of life becomes poor. So, monitoring of CD4 and CD8 should be done as a routine and screening and early treatment should be made mandatory.

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Risk Factors for Relapse of Antineutrophil Cytoplasmic Antibody-associated Vasculitis in Japan: A Nationwide, Prospective Cohort Study

The Journal of Rheumatology ◽

10.3899/jrheum.170508 ◽

2018 ◽

Vol 45 (4) ◽

pp. 521-528 ◽

Cited By ~ 4

Author(s):

Akinori Hara ◽

Takashi Wada ◽

Ken-ei Sada ◽

Koichi Amano ◽

Hiroaki Dobashi ◽

...

Keyword(s):

Risk Factors ◽

Cohort Study ◽

Maintenance Therapy ◽

Prospective Cohort Study ◽

Induction Therapy ◽

Prospective Cohort ◽

Oral Prednisolone ◽

Antineutrophil Cytoplasmic Antibody ◽

Remission Induction ◽

Factors Associated

Objective.The aim was to elucidate the prognosis and risk factors associated with relapse during longterm remission maintenance therapy for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).Methods.Patients with newly diagnosed AAV (n = 156) were registered in the Remission Induction Therapy in Japanese patients with ANCA-associated Vasculitides (RemIT-JAV) study, and among them, 83 patients who achieved remission were enrolled and followed up for 24 additional months in our nationwide, prospective cohort study (Co-RemIT-JAV; registration number UMIN 000006373). Patterns of maintenance therapy, effectiveness, and safety were evaluated from months 25 to 48 after the RemIT-JAV. The primary outcome measure was the rate of relapse. Secondary outcome measures included overall and renal survival, risk factors associated with relapse, and incidence rates of serious infections.Results.The patients comprised 35 men and 48 women aged 65.3 ± 12.6 years. Between months 25 and 48, the survival rate was 95% (79/83). Causes of death included 1 thyroid cancer, 1 infection, and 2 unknown reasons. Four patients had developed endstage renal disease (ESRD) by Month 24; 1 developed ESRD beyond Month 25. The relapse rate was 24% (20/83) from months 25 to 48. Multivariable analysis revealed that oral prednisolone ≤ 2.5 mg/day at Month 24 was a significant risk factor for relapse between months 25 and 48 (HR = 3.1, 95% CI 1.1–8.5).Conclusion.One-quarter of patients with AAV relapsed during maintenance therapy, and relapse was associated with the dose of oral prednisolone 24 months after the initiation of remission induction therapy in Japan.

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