scholarly journals Rosmarinic Acid Methyl Ester Inhibits LPS-Induced NO Production via Suppression of MyD88- Dependent and -Independent Pathways and Induction of HO-1 in RAW 264.7 Cells

Molecules ◽  
2016 ◽  
Vol 21 (8) ◽  
pp. 1083 ◽  
Author(s):  
Yangkang So ◽  
Seung Lee ◽  
Ah-Reum Han ◽  
Jin-Baek Kim ◽  
Hye Jeong ◽  
...  
Keyword(s):  
Methyl Ester ◽  
Rosmarinic Acid ◽  
Acid Methyl Ester ◽  
Raw 264.7 Cells ◽  
No Production ◽  
Raw 264.7 ◽  
Acid Methyl

scholarly journals Azukisapogenol Triterpene Glycosides from Oxytropis chiliophylla Royle

Molecules ◽  
2018 ◽  
Vol 23 (10) ◽  
pp. 2448
Author(s):  
Jun Wang ◽  
Hongshuai Yang ◽  
Yang Liu ◽  
Kelsang Norbo ◽  
Kewu Zeng ◽  
...  
Keyword(s):  
Methyl Ester ◽  
Glucuronic Acid ◽  
Acid Methyl Ester ◽  
Triterpene Glycosides ◽  
Raw 264.7 Cells ◽  
No Production ◽  
Acid Methyl ◽  
Potent Inhibition ◽  
New Compounds ◽  
First Time

Eight azukisapogenol triterpene glycosides, including five new compounds, oxychiliotriterpenosides A–E (1–5), two new methyl glucuronide derivatives that proved to be artifacts, oxychiliotriterpenoside E-glucuronic acid methyl ester (6) and myrioside B-glucuronic acid methyl ester (7), and a known one, myrioside B (8), was isolated from the aerial part of Oxytropis chiliophylla Royle. Their structures were elucidated based on extensive spectroscopic analyses and chemical methods. Triterpene glycosides were first obtained from O. chiliophylla, and those containing a galactose unit (1, 2, 5 and 6) and diglucosidic or triglucosidic linkage at C-29 (1–4), were reported from Oxytropis species for the first time, which might be recognized as a chemotaxonomic feature of O. chiliophylla. All isolated compounds were evaluated for their anti-inflammatory activities against NO production using lipopolysaccharide (LPS)-induced RAW 264.7 cells, but no compounds showed potent inhibition on NO production.

scholarly journals Identification of a novel S6K1 inhibitor, rosmarinic acid methyl ester, for treating cisplatin-resistant cervical cancer

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Ki Hong Nam ◽  
Sang Ah Yi ◽  
Gibeom Nam ◽  
Jae Sung Noh ◽  
Jong Woo Park ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Methyl Ester ◽  
Rosmarinic Acid ◽  
Acid Methyl Ester ◽  
Acid Methyl

Antioxidant and antimelanogenic properties of rosmarinic acid methyl ester from Origanum vulgare

2010 ◽  
Vol 123 (2) ◽  
pp. 254-262 ◽  
Author(s):  
Hsiou-Yu Ding ◽  
Tzung-Han Chou ◽  
Chia-Hua Liang
Keyword(s):  
Methyl Ester ◽  
Rosmarinic Acid ◽  
Acid Methyl Ester ◽  
Origanum Vulgare ◽  
Acid Methyl

scholarly journals Rosmarinic Acid Methyl Ester Regulates Ovarian Cancer Cell Migration and Reverses Cisplatin Resistance by Inhibiting the Expression of Forkhead Box M1

2020 ◽  
Vol 13 (10) ◽  
pp. 302
Author(s):  
Soo Hyun Lim ◽  
Ki Hong Nam ◽  
Kyungtae Kim ◽  
Sang Ah Yi ◽  
Jaecheol Lee ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Methyl Ester ◽  
Cancer Cells ◽  
Rosmarinic Acid ◽  
Target Genes ◽  
Acid Methyl Ester ◽  
Ovarian Cancer Cells ◽  
Forkhead Box ◽  
Acid Methyl ◽  
Forkhead Box M1

Rosmarinic acid methyl ester (RAME), a derivative of rosmarinic acid (RA), is reported to have several therapeutic effects, including anti-tumor effects against cervical cancer. However, its anti-tumor effects in ovarian cancer is unclear. In this study, we studied the molecular pathways associated with the anti-tumor effects of RAME in ovarian cancer. To identify the effects of RAME in ovarian cancer, RNA sequencing was performed in RAME-treated ovarian cancer cells; we found that RAME treatment downregulated the genes closely involved with the target genes of the transcription factor Forkhead box M1 (FOXM1). It was reported that FOXM1 is overexpressed in a variety of cancer cells and is associated with cell proliferation and tumorigenesis. Therefore, we hypothesized that FOXM1 is a key target of RAME; this could result in its anti-tumor effects. Treatment of ovarian cancer cells with RAME-inhibited cell migration and invasion, as shown by wound healing and transwell migration assays. To examine whether RAME represses the action of FOXM1, we performed quantitative RT-PCR and ChIP-qPCR. Treatment of ovarian cancer cells with RAME decreased the mRNA expression of FOXM1 target genes and the binding of FOXM1 to its target genes. Moreover, FOXM1 expression was increased in cisplatin-resistant ovarian cancer cells, and combination treatment with RAME and cisplatin sensitized the cisplatin-resistant ovarian cancer cells, which was likely due to FOXM1 inhibition. Our research suggests that RAME is a promising option in treating ovarian cancer patients, as it revealed a novel molecular pathway underlying its anti-tumor effects.

Sign in / Sign up

Export Citation Format

Share Document