Chemical Constituents from the Roots and Rhizomes of Asarum heterotropoides var. mandshuricum and the In Vitro Anti-Inflammatory Activity

Phytochemical investigation of the folk medicinal plant Argyreia acuta Lour. has led to the isolation of a pair of new 3-alkylated coumarin enantiomers, (±)-acutamarin [(±)-1] and 3 known structurally related coumarins (2-4), along with 4 known flavonoids (5-8). The structures of these compounds were elucidated on the basis of extensive spectroscopic (including one-dimensional and two-dimensional nuclear magnetic resonance) analyses and by comparison of their spectral data with those reported in the literature. The absolute configurations of ( − )-1 and ( + )-1 were proposed by comparison of experimental and calculated electronic circular dichroism data. Compounds 5 and 7 exhibited in vitro anti-inflammatory activity by inhibiting the production of nitric oxide with IC50 values of 24.54 ± 0.36 μM and 10.60 ± 0.15 μM, respectively.

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Comparison of in-vitro anti-inflammatory activity of various extracts of Solanum tuberosum

International Research Journal of Pharmaceutical and Applied Sciences ◽

10.26452/irjpas.v9i2.1201 ◽

2020 ◽

Vol 9 (2) ◽

pp. 14-17

Author(s):

Magesh M

Keyword(s):

Solanum Tuberosum ◽

Chemical Constituents ◽

Cardiovascular Complications ◽

The Body ◽

Inflammatory Activity ◽

Albino Rats ◽

Synthetic Drugs ◽

Anti Inflammatory ◽

Staple Crop

Medicinal plants are vital and have been used in traditional systems of medicine of India. Their importance is not restricted to direct usage in the treatment. Still, also their chemical constituents were used as leads for many potential synthetic drugs that are drugs of choice to treat dangerous diseases. Inflammations are the significant sources of diseases and deteriorations in the body that result in body pains, and brain damages too. The inflammation is a body responding to the stimulus that causes harm to the body. Solanum tuberosum is a common staple crop available in the kitchen of every house and is used a food. It had a rich source of starch and anthocyanins. Even though it is used as a food crop, the pharmacological activities of potato had been investigated as IBD (Inflammatory Bowel Disease), various cancers, Hyperlipidemia and growing cardiovascular complications etc. the potato has been selected for the current study to compare the anti-inflammatory activity of various extracts of the plant. The action of the extracts was tested using two methods invivo using albino rats. The extracts showed a better movement, but when compared to the standard, they are less potent. But in consideration of the side effects and toxicity of standard synthetic drug the anti-inflammatory action can be compromised a bit to give a safe and potent activity

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Chemical constituents and in vitro anti-inflammatory activity of Cistanche violacea Desf. (Orobanchaceae) extract

Fitoterapia ◽

10.1016/j.fitote.2016.01.010 ◽

2016 ◽

Vol 109 ◽

pp. 248-253 ◽

Cited By ~ 14

Author(s):

Amina Bougandoura ◽

Brigida D'Abrosca ◽

Souad Ameddah ◽

Monica Scognamiglio ◽

Ratiba Mekkiou ◽

...

Keyword(s):

Chemical Constituents ◽

Inflammatory Activity ◽

Anti Inflammatory

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Evaluation of in- vitro Anti-inflammatory Potential of Grevillea robusta A. Cunn, EX R.BR. Leaves

International Journal of Pharmaceutical Sciences Review and Research ◽

10.47583/ijpsrr.2021.v68i01.020 ◽

2021 ◽

Vol 68 (1) ◽

Author(s):

Samanta Jhuma ◽

Kumar Vineet

Keyword(s):

Side Effects ◽

Chemical Constituents ◽

Fibre Length ◽

Ethanol Extract ◽

Inflammatory Activity ◽

Grevillea Robusta ◽

Inflammatory Drugs ◽

Anti Inflammatory ◽

Microscopic Measurement

Synthetic Non-steroidal anti-inflammatory drugs (NASAIDs) are the choice of drug for inflammation. NASAIDs caused severe side effects like hyperacidity, gastric ulcer and so on. To avoid the side effects of NASAIDs, there is an urgent need for searching new molecule from natural origin. Present study is therefore aimed to explore Grevillea robusta A. Cunn, ex R.Br. Family proteaceae leaves for anti-inflammatory activity. Microscopic measurement (fibre length and width), Ash values and extractive values of Grevillea robusta leaves were determined to set the pharmacognostic standards. Chemical constituents were evaluated through chemical tests. The Ethanol extract of Grevillea robusta leaves (GRLE)) were subjected to evaluate in-vitro anti-inflammatory activity through HRBC method and Heat induced haemolytic method. The leaves of Grevillea robusta showed significant anti-inflammatory activity. The Ethanol extract (GRLE) showed significant anti-inflammatory activities. GRLE was found to contain polyphenols as chemical constituents which was the basis of anti-inflammatory activity. On the basis of result we can conclude that Ethanol extract of leaves of Grevillea robusta has good anti-inflammatory activity. GRLE could be used for treatment of inflammation.

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In silico and In vitro evaluation of the anti-inflammatory and antioxidant potential of Cymbopogon citratus from North-western Himalayas

10.1101/2020.05.31.124982 ◽

2020 ◽

Cited By ~ 1

Author(s):

Deeksha Salaria ◽

Rajan Rolta ◽

Nitin Sharma ◽

Kamal Dev ◽

Anuradha Sourirajan ◽

...

Keyword(s):

In Silico ◽

Chemical Constituents ◽

Radical Scavenging ◽

Inflammatory Activity ◽

Perennial Herb ◽

Binding Potential ◽

Western Himalayas ◽

Cymbopogon Citratus ◽

Anti Inflammatory

AbstractCymbopogon citratus which is an aromatic perennial herb belonging to family Gramineae is known for its application in food and healthcare industry. The present study attempts to evaluate the potential of essential oil from Cymbopogon citratus (CEO) as an anti-inflammatory and antioxidant agent. CEO showed significant DPPH radical scavenging activity (IC50 - 91.0 ± 9.25 µg/ml), as compared to Ascorbic acid (IC50-33.38 ± 2.29 µg/ml). CEO also exhibited significant in-vitro anti-inflammatory activity with IC50 - 397.11± 1.45µg/ml) as compared to diclofenac sodium (IC50 - 682.98 ± 7.47 µg/ml). Chemical constituents of the oil was determined using Gas Chromatography/Mass Spectroscopy, showed that 8-methyl-3,7-Nonadien-2-one (E), α-Pinene, limonene, citral, limonene oxide and Epoxy-α-terpenyl acetate were the major constituents. The in silico molecular docking study showed phytocompounds of CEO (Caryophyllene oxide and β-caryophyllene) have considerable binding potential with 1HD2 and 5IKQ receptors. PASS prediction of these phytocompounds also confirmed strong anti-inflammatory activity of C. citratus. The ADMET analysis also showed that these phytocompounds are safer to replace the synthetic drugs with side effects. This work establishes the anti inflammatory potential of CEO as an alternative to existing therapeutic approach to treatment of inflammation and also natural source of antioxidant compounds.

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