scholarly journals Pharmacokinetic Properties of Arsenic Species after Intravenous and Intragastrical Administration of Arsenic Trioxide Solution in Cynomolgus Macaques Using HPLC-ICP-MS

Molecules ◽  
2019 ◽  
Vol 24 (2) ◽  
pp. 241 ◽  
Author(s):  
Qiaoli Shi ◽  
Mingyan Ju ◽  
Xiaoxia Zhu ◽  
Hui Gan ◽  
Ruolan Gu ◽  
...  
Keyword(s):  
Arsenic Trioxide ◽  
Inductively Coupled Plasma ◽  
High Performance ◽  
Cynomolgus Macaque ◽  
Arsenic Species ◽  
Dimethylarsinic Acid ◽  
Inductively Coupled ◽  
Monomethylarsonic Acid ◽  
Icp Ms ◽  
Plasma Mass Spectrometry

A rapid and sensitive method was established for arsenic (As) speciation based on high performance liquid chromatography coupled to inductively coupled plasma mass spectrometry (HPLC-ICP-MS). This method was validated for the quantification of four arsenic species, including arsenite (AsIII), arsenate (AsV), monomethylarsonic acid (MMAV) and dimethylarsinic acid (DMAV) in cynomolgus macaque plasma. Separation was achieved in just 3.7 min with an alkyl reverse phase column and highly aqueous mobile phase containing 20 mM citric acid and 5 mM sodium hexanesulfonate (pH = 4.3). The calibration curves were linear over the range of 5–500 ng·mL−1 (measured as As), with r > 0.99. The above method was validated for selectivity, precision, accuracy, matrix effect, recovery, carryover effect and stability, and applied in a comparative pharmacokinetic study of arsenic species in cynomolgus macaque samples following intravenous and intragastrical administration of arsenic trioxide solution (0.80 mg·kg−1; 0.61 mg·kg−1 of arsenic); in addition, the absolute oral bioavailability of the active ingredient AsIII of arsenic trioxide in cynomolgus macaque samples was derived as 60.9 ± 16.1%.

scholarly journals Arsenic Species Analysis at Trace Level by High Performance Liquid Chromatography with Inductively Coupled Plasma Mass Spectrometry

2019 ◽  
Vol 2019 ◽  
pp. 1-6 ◽  
Author(s):  
Hongfang Hou ◽  
Wanjing Cui ◽  
Qing Xu ◽  
Zhanhui Tao ◽  
Yafei Guo ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Inductively Coupled Plasma ◽  
Mobile Phase ◽  
High Performance ◽  
Arsenic Species ◽  
Dimethylarsinic Acid ◽  
Inductively Coupled ◽  
Plasma Mass Spectrometry

A sensitive and accurate simultaneous continuous analysis for six arsenic species including arsenobetaine (AsB), arsenocholine (AsC), monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), arsenite (AsIII), and arsenate (AsV) has been developed by high performance liquid chromatography with inductively coupled plasma mass spectrometry (HPLC-ICP-MS). An anion-exchange column of Hamilton PRP-X100 (Switzerland) was applied for separation of the six arsenic species with gradient elution of 1.25 mmol/L Na2HPO4 and 11.0 mmol/L KH2PO4 as the mobile phase A and 2.5 mmol/L Na2HPO4 and 22.0 mmol/L KH2PO4 as the mobile phase B. The linearity ranges for AsB, AsC, MMA, DMA, AsIII, and AsV were between 0.5 and 50.0 μg/L, and the detection limits of the six arsenic species were all within 0.01–0.35 ng/L. The relative standard deviations (RSDs) were within 2.26–3.68% and the recovery rates of samples ranged from 95 to 103%. The proposed method was applied for the arsenic speciation analysis of sediment pore-water samples, which were taken from the supernatant after centrifugation and filtration.

A microdialysis-based analytical system for dynamic monitoring of arsenic transformation under microbial activity

The Analyst ◽  
2017 ◽  
Vol 142 (24) ◽  
pp. 4737-4743
Author(s):  
Keng-Chang Hsu ◽  
Jing-Ru Hsieh ◽  
Ya-Ching Chen ◽  
Pi-Fu Hsu ◽  
Chih-Chang Hung ◽  
...  
Keyword(s):  
Inductively Coupled Plasma ◽  
High Performance ◽  
Arsenic Species ◽  
Culture Broth ◽  
Dynamic Monitoring ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry ◽  
Arsenic Transformation ◽  
Analytical System

In this study, a microdialysis (MD) technique was combined with high-performance liquid chromatography/inductively coupled plasma mass spectrometry (HPLC-ICP-MS) for continuous monitoring of the dynamic variations of arsenic species in a microbe-inoculated culture broth.

scholarly journals Characterization of Arsenic Biotransformation Products from an Open Anaerobic Degradation of Fucus distichus by Hydride Generation Gas Chromatography Atomic Absorption Spectrometry and High Performance Liquid Chromatography Inductively Coupled Plasma Mass Spectrometry

2013 ◽  
Vol 2013 ◽  
pp. 1-6
Author(s):  
Abiodun A. Ojo ◽  
Amos Onasanya
Keyword(s):  
Inductively Coupled Plasma ◽  
High Performance ◽  
Hydride Generation ◽  
Absorption Spectrometry ◽  
Arsenic Species ◽  
Water Soluble ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry ◽  
Biotransformation Products

This work reports on the isolation and determination of biotransformation products obtained from the organoarsenic compounds that are present in Fucus distichus when it was subjected to an open anaerobic decomposition by using the Hydride Generation Gas Chromatography Atomic Absorption Spectrometry (HG-GC-AAS) and High Performance Liquid Chromatography Inductively Coupled Plasma Mass Spectrometry (HPLC-ICP-MS). The seaweed and filtrate residues obtained from the open anaerobic degradation procedure were extracted in methanol and partitioned in phenol-ether-water mixtures to obtain water soluble extracts. The water soluble extracts were cleaned up and separated on a gel permeation Sephadex G15 column. Arsenic species concentrations were determined by using HG-GC-AAS. Final characterization of the biotransformation isolates was carried out on HPLC-ICP-MS. Only two arsenic species, 2-dimethylarsinoyl ethanol (DMAE) and dimethylarsinic acid (DMAA), were positively identified in the water soluble extract of the marine brown algae. The two arsenic species are strong intermediate candidates in the biosynthesis of arsenobetaine from oceanic arsenate in marine food webs.

scholarly journals Concrete Examination of 100-Year-Old Bridge Structure above the Kłodnica River Flowing through the Agglomeration of Upper Silesia in Gliwice: A Case Study

Materials ◽  
2021 ◽  
Vol 14 (4) ◽  
pp. 981
Author(s):  
Barbara Słomka-Słupik ◽  
Jacek Podwórny ◽  
Beata Grynkiewicz-Bylina ◽  
Marek Salamak ◽  
Bibianna Bartoszek ◽  
...  
Keyword(s):  
Inductively Coupled Plasma ◽  
High Performance ◽  
Chloride Content ◽  
Technical Condition ◽  
Inductively Coupled ◽  
Bridge Safety ◽  
Free Chloride ◽  
Management Processes ◽  
Icp Ms ◽  
Plasma Mass Spectrometry

The article analyzes the composition of concrete taken from various elements from a 100-year-old bridge in South Poland, so as to analyze its technical condition. The main methods applied during experimental work were: Designation of pH, free chloride content, salinity, XRD and SEM examinations, as well as metals determination using inductively coupled plasma mass spectrometry (ICP­MS), high-performance liquid chromatography (HPLC)-ICP-MS, and cold-vapor atomic absorption spectroscopy (CV-AAS). The concrete of the bridge was strongly carbonated and decalcified with an extremely high content of chlorides. The pH of the concrete was in a range from 10.5 to 12.0. Acid soluble components were between 9.9% and 17.6%. Typical sulfate corrosion phases of concrete were not detected. Friedels’ salt was found only at the extremity of an arch. The crown block was corroded to the greatest extent. Various heavy metals were absorbed into the concrete, likely from previous centuries, when environmental protection policy was poor. The applied research methodology can be used on bridges exposed to specific external influences. The acquired knowledge can be useful in the management processes of the bridge infrastructure. It can help in making decisions about decommissioning or extending the life cycle of the bridge. This work should also sensitize researchers and decision-makers to the context of “bridge safety”.

scholarly journals Elemental and Speciation Analyses of Different Brands of Yerba Mate (Ilex paraguariensis)

Foods ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 2925
Author(s):  
Jędrzej Proch ◽  
Aleksandra Orłowska ◽  
Przemysław Niedzielski
Keyword(s):  
Inductively Coupled Plasma ◽  
High Performance ◽  
Optical Emission ◽  
Arsenic Species ◽  
Emission Spectrometry ◽  
Ilex Paraguariensis ◽  
Dimethylarsinic Acid ◽  
Yerba Mate ◽  
Inductively Coupled ◽  
Plasma Optical Emission Spectrometry

In this work, a methodology for determination of As(III), As(V), dimethylarsinic acid (DMA), Fe(II) and Fe(III) in fifty-eight samples (forty-nine products of thirteen brands from three countries) commercial yerba mate (Ilex paraguariensis) was performed. The hyphenated high performance liquid chromatography inductively coupled plasma optical emission spectrometry (HPLC-ICP OES) technique was used. Arsenic was determined below the quantification limit in 38 samples of yerba mate. As(III) was found at the level 0.09 and 0.08 mg kg−1. The As(V) content was in the range: 0.21 to 0.28 mg kg−1. The content of DMA was found the highest of the three arsenic species in the range: 0.21 to 0.47 mg kg−1. The content of Fe(II) and Fe(III) was found in the range: 0.61 to 15.4 mg kg−1 and 0.66 to 43.1 mg kg−1, respectively and the dominance of Fe(III) was observed. Moreover, total and extractable content of 16 elements were determined. The results have been subjected to statistical analysis in order to establish relationships between samples of the same origin (country), kind (type) and composition (purity).

Sign in / Sign up

Export Citation Format

Share Document