scholarly journals The Profile of Urinary Headspace Volatile Organic Compounds After 12-Week Intake of Oligofructose-Enriched Inulin by Children and Adolescents with Celiac Disease on a Gluten-Free Diet: Results of a Pilot, Randomized, Placebo-Controlled Clinical Trial

Molecules ◽  
2019 ◽  
Vol 24 (7) ◽  
pp. 1341 ◽  
Author(s):  
Natalia Drabińska ◽  
Elżbieta Jarocka-Cyrta ◽  
Norman Ratcliffe ◽  
Urszula Krupa-Kozak
Keyword(s):  
Celiac Disease ◽  
Volatile Organic Compounds ◽  
Children And Adolescents ◽  
Organic Compounds ◽  
Gluten Free Diet ◽  
Urine Samples ◽  
Whole Body ◽  
Gluten Free ◽  
Functional Impairments ◽  
Volatile Organic

The concentration of volatile organic compounds (VOCs) can inform about the metabolic condition of the body. In the small intestine of untreated persons with celiac disease (CD), chronic inflammation can occur, leading to nutritional deficiencies, and consequently to functional impairments of the whole body. Metabolomic studies showed differences in the profile of VOCs in biological fluids of patients with CD in comparison to healthy persons; however, there is scarce quantitative and nutritional intervention information. The aim of this study was to evaluate the effect of the supplementation of a gluten-free diet (GFD) with prebiotic oligofructose-enriched inulin (Synergy 1) on the concentration of VOCs in the urine of children and adolescents with CD. Twenty-three participants were randomized to the group receiving Synergy 1 (10 g per day) or placebo for 12 weeks. Urinary VOCs were analyzed using solid-phase microextraction and gas chromatography–mass spectrometry. Sixteen compounds were identified and quantified in urine samples. The supplementation of GFD with Synergy 1 resulted in an average concentration drop (36%) of benzaldehyde in urine samples. In summary, Synergy 1, applied as a supplement of GFD for 12 weeks had a moderate impact on the VOC concentrations in the urine of children with CD.

Profile of volatile organic compounds in exhaled breath changes as a result of gluten-free diet

2013 ◽  
Vol 7 (3) ◽  
pp. 037104 ◽  
Author(s):  
Agnieszka Baranska ◽  
Ettje Tigchelaar ◽  
Agnieszka Smolinska ◽  
Jan W Dallinga ◽  
Edwin J C Moonen ◽  
...  
Keyword(s):  
Volatile Organic Compounds ◽  
Organic Compounds ◽  
Gluten Free Diet ◽  
Exhaled Breath ◽  
Gluten Free ◽  
Volatile Organic

Effect of formulations and fermentation processes on volatile organic compounds and prebiotic potential of gluten-free bread fortified by spirulina (Arthrospira platensis)

2021 ◽  
Author(s):  
Flavia Casciano ◽  
Lorenzo Nissen ◽  
Andrea Gianotti
Keyword(s):  
Volatile Organic Compounds ◽  
Organic Compounds ◽  
Arthrospira Platensis ◽  
Gluten Free ◽  
Market Segments ◽  
Fermentation Processes ◽  
Volatile Organic

Gluten free (GF) foods, designed and marketed for the needs of people who are unable to metabolize gluten, in recent years have aroused growing interest that has led to the conquest of important market segments, with a strongly growing trend.

scholarly journals Prevalence of low bone mineral density in children and adolescents with celiac disease under treatment

2009 ◽  
Vol 127 (5) ◽  
pp. 278-282 ◽  
Author(s):  
Maria Eugênia Farias Almeida Motta ◽  
Maria Eduarda Nóbrega de Faria ◽  
Gisélia Alves Pontes da Silva
Keyword(s):  
Bone Mineral Density ◽  
Celiac Disease ◽  
Lumbar Spine ◽  
Bone Mineral ◽  
Gluten Free Diet ◽  
Whole Body ◽  
Chronological Age ◽  
Gluten Free ◽  
Mineral Density ◽  
Low Bone Mineral Density

CONTEXT AND OBJECTIVE: Low bone mineral density may be a finding among children and adolescents with celiac disease, including those undergoing treatment with a gluten-free diet, but the data are contradictory. The aim of this study was to determine the frequency of bone mineral density abnormalities in patients on a gluten-free diet, considering age at diagnosis and duration of dietary treatment. DESIGN AND SETTING: Cross-sectional prevalence study at the Pediatric Gastroenterology Outpatient Clinic of Instituto Materno Infantil Professor Fernando Figueira. METHODS: Thirty-one patients over five years of age with celiac disease and on a gluten-free diet were enrolled. Bone mineral density (in g/cm²) was measured in the lumbar spine and whole body using bone densitometry and categorized using the criteria of the International Society for Clinical Densitometry, i.e. low bone mineral density for chronological age < -2.0 Z-scores. Age at diagnosis and duration of dietary treatment were confirmed according to the date of starting the gluten-free diet. RESULTS: Low bone density for chronological age was present in 3/31 patients in the lumbar spine and 1/31 in the whole body (also with lumbar spine abnormality). At diagnosis, three patients with low bone mineral density for the chronological age were more than 7.6 years old. These patients had been on a gluten-free diet for six and seven months and 3.4 years. CONCLUSION: Pediatric patients with celiac disease on long-term treatment are at risk of low bone mineral density. Early diagnosis and long periods of gluten-free diet are directly implicated in bone density normalization.

scholarly journals A targeted metabolomic protocol for quantitative analysis of volatile organic compounds in urine of children with celiac disease

RSC Advances ◽  
2018 ◽  
Vol 8 (64) ◽  
pp. 36534-36541 ◽  
Author(s):  
Natalia Drabińska ◽  
Hafiz Abdul Azeem ◽  
Urszula Krupa-Kozak
Keyword(s):  
Celiac Disease ◽  
Quantitative Analysis ◽  
Volatile Organic Compounds ◽  
Organic Compounds ◽  
Design Of Experiment ◽  
Urinary Biomarkers ◽  
Volatile Organic

An SPME-GCMS method was optimized for quantitative analysis of 15 urinary biomarkers in celiac disease children using multivariate design of experiment.

Bone mineral density and importance of strict gluten-free diet in children and adolescents with celiac disease

Bone ◽  
2010 ◽  
Vol 47 (3) ◽  
pp. 598-603 ◽  
Author(s):  
Štefan Blazina ◽  
Nevenka Bratanič ◽  
Andreja Širca Čampa ◽  
Rok Blagus ◽  
Rok Orel
Keyword(s):  
Bone Mineral Density ◽  
Celiac Disease ◽  
Children And Adolescents ◽  
Bone Mineral ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Mineral Density

scholarly journals Different Fecal Microbiotas and Volatile Organic Compounds in Treated and Untreated Children with Celiac Disease

2009 ◽  
Vol 75 (12) ◽  
pp. 3963-3971 ◽  
Author(s):  
Raffaella Di Cagno ◽  
Carlo G. Rizzello ◽  
Francesca Gagliardi ◽  
Patrizia Ricciuti ◽  
Maurice Ndagijimana ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Volatile Organic Compounds ◽  
Organic Compounds ◽  
Solid Phase ◽  
Lactobacillus Delbrueckii ◽  
Rrna Gene ◽  
Healthy Children ◽  
Fecal Samples ◽  
Dgge Analysis ◽  
Volatile Organic

ABSTRACTThis study aimed at investigating the fecal microbiotas of children with celiac disease (CD) before (U-CD) and after (T-CD) they were fed a gluten-free diet and of healthy children (HC). Brothers or sisters of T-CD were enrolled as HC. Each group consisted of seven children. PCR-denaturing gradient gel electrophoresis (DGGE) analysis with V3 universal primers revealed a unique profile for each fecal sample. PCR-DGGE analysis with group- or genus-specific 16S rRNA gene primers showed that theLactobacilluscommunity of U-CD changed significantly, while the diversity of theLactobacilluscommunity of T-CD was quite comparable to that of HC. Compared to HC, the ratio of cultivable lactic acid bacteria andBifidobacteriumtoBacteroidesand enterobacteria was lower in T-CD and even lower in U-CD. The percentages of strains identified as lactobacilli differed as follows: HC (ca. 38%) > T-CD (ca. 17%) > U-CD (ca. 10%).Lactobacillus brevis,Lactobacillus rossiae, andLactobacillus pentosuswere identified only in fecal samples from T-CD and HC.Lactobacillus fermentum,Lactobacillus delbrueckiisubsp.bulgaricus, andLactobacillus gasseriwere identified only in several fecal samples from HC. Compared to HC, the composition ofBifidobacteriumspecies of T-CD varied, and it varied even more for U-CD. Forty-seven volatile organic compounds (VOCs) belonging to different chemical classes were identified using gas-chromatography mass spectrometry-solid-phase microextraction analysis. The median concentrations varied markedly for HC, T-CD, and U-CD. Overall, ther2values for VOC data for brothers and sisters were equal to or lower than those for unrelated HC and T-CD. This study shows the effect of CD pathology on the fecal microbiotas of children.

The influence of gluten free diet on quantitative ultrasound of proximal phalanxes in children and adolescents with type 1 diabetes mellitus and celiac disease

Bone ◽  
2008 ◽  
Vol 43 (2) ◽  
pp. 322-326 ◽  
Author(s):  
Giuliana Valerio ◽  
Raffaella Spadaro ◽  
Dario Iafusco ◽  
Francesca Lombardi ◽  
Antonio del Puente ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Type 1 Diabetes Mellitus ◽  
Children And Adolescents ◽  
Quantitative Ultrasound ◽  
Gluten Free Diet ◽  
Gluten Free

scholarly journals Differential expression of urinary volatile organic compounds by sex, male reproductive status, and pairing status in the maned wolf (Chrysocyon brachyurus)

PLoS ONE ◽  
2021 ◽  
Vol 16 (8) ◽  
pp. e0256388
Author(s):  
Marieke K. Jones ◽  
Thomas B. Huff ◽  
Elizabeth W. Freeman ◽  
Nucharin Songsasen
Keyword(s):  
Volatile Organic Compounds ◽  
Differential Expression ◽  
Organic Compounds ◽  
Ovulation Induction ◽  
Solid Phase ◽  
Reproductive Status ◽  
Urine Samples ◽  
Maned Wolf ◽  
Volatile Organic ◽  
Chrysocyon Brachyurus

The maned wolf (Chrysocyon brachyurus) is an induced ovulator. Though the mechanism of ovulation induction remains unknown, it is suspected to be urinary chemical signals excreted by males. This study assessed volatile organic compounds (VOCs) in weekly urine samples across 5 months from 13 maned wolves (6 intact males, 1 neutered male, 6 females) with the goal of identifying VOCs that are differentially expressed across sex, reproductive status, and pairing status. Solid-phase microextraction (SPME) and gas chromatography-mass spectrometry (GC-MS) were used to extract and separate VOCs that were identified via spectral matching with authentic standards, with spectral libraries, or with new software that further matches molecular fragment structures with mass spectral peaks. Two VOCs were present across all 317 urine samples: 2,5-dimethyl pyrazine and 2-methyl-6-(1-propenyl)-pyrazine. Fifteen VOCs differed significantly (Adj. P < 0.001 and |log2 fold change| >2.0) between intact males and females. Using partial least squares-discriminant analysis, the compounds with the highest importance to the sex classification were delta-decalactone, delta-dodecalactone, and bis(prenyl) sulfide. Sixty-two VOCs differed between intact males and the neutered male. Important classifier compounds were 3-ethyl 2,5-dimethyl pyrazine, 2-methyl-6-(1-propenyl)-pyrazine, and tetrahydro-2-isopentyl-5-propyl furan. Several VOCs established as important here have been implicated in reproductive communication in other mammals. This study is the most robust examination of differential expression in the maned wolf thus far and provides the most comprehensive analysis of maned wolf urinary VOCs to date, increasing the sample size substantially over previous chemical communication studies in this species. New data analysis software allowed for the identification of compounds in the hormone-producing mevalonate pathway which were previously unreported in maned wolf urine. Several putative semiochemicals were identified as good candidates for behavioral bioassays to determine their role in maned wolf reproduction, and specifically in ovulation induction.

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